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The map label for this gene is gabP [H]

Identifier: 189352753

GI number: 189352753

Start: 862616

End: 864037

Strand: Direct

Name: gabP [H]

Synonym: BMULJ_03985

Alternate gene names: 189352753

Gene position: 862616-864037 (Clockwise)

Preceding gene: 189352752

Following gene: 189352754

Centisome position: 34.88

GC content: 66.74

Gene sequence:

>1422_bases
ATGCAACCCTCGAATCAGAGTGACCTGAAATGTGGCCTCAAGCAGCGCCACATGACGATGATCGCGCTTGGCGGCGTGAT
CGGTGCCGGGCTGTTCGTCGGCAGCGGCGTGGTGATTCAGCAGACGGGGCCGGCAGCGATCCTGTCGTTCCTGATCACGG
GCGGGCTCGTCGTGCTCGTGATGCGCATGCTCGGCGAGATGGCCTGCGCGATGCCGGCCGTCGGTTCGTTCTATGAATAT
GCGCGGCTCGCGTTCGGCACCTGGCGCGGGCCGGGCAGGATGGCCGGTTTCCTGACCGGCTGGATGTACTGGTATTTCTG
GGTGATCGTGGTCGCGCTCGAAGCGGTCGCGGGCGCGAAGCTGATCCAGTTCTGGCTACCCGACGTGCCCGCATGGATCA
TCAGTCTCGCGCTGCTGGTCGTGCTGACGCTGACGAACCTGATCTCGGTCGGCAGCTACGGGGAATTCGAGTTCTGGTTC
TCGTCGATCAAGGTCGGCGCGATCATCGTGTTCCTGTTCCTCGGCGGCCTCTACGTGCTCGGCCTGTGGCCGTCGTCGAT
GCATACCACGGCGGTGCTGCCGACGCTGCTCGGCCACGGCGGCTTCATGCCGCTCGGCATCGGACCCGTGATGAGCGGGG
CCGTCGCGGCGACCGGTTTCTATTTCGGCGCCGAGATCGTCACGATCGCGGCGGCCGAGGCGCGCGAGCCGGCCAAGGCC
GTTGCGAAGGCAACCAACTCGGTGATCACGCGCGTACTGGTGTTCTACGTCGGCTCGGTCGCGCTCGTCGTCGCGCTGGT
GCCGTGGAATTCGCCGCAGATGTCGACGCCGTACGTCAGTGCGCTCGAAGTGATGGGGCTGCCGGCCGCAGCGAACGTGA
TGAACGCGATCGTGCTGACGGCCGTGCTGTCCGCGCTGAACTCGGGGCTGTACGCGGCGTCGCGGATGCTGTTCGCGCTG
ACGCGCCACGGCGACGCGCCGGCTGCGCTCGCGAAGGTCAGCAAGCGCGGCGTGCCGGTGCGCGCGATCCTGCTCGGCAC
GGTGTTCGGCTACGTGTCGGTCGTGATGTCCTACGTGTCGCCCGATACCGTCTTCGCGTTCCTCGTCAACTCGTACGGCA
CCGTCGCGATCTTCGTCTACGTGCTGATCGCGTTCTCGCAGCTGCGCCTGCGCAAGCGCCTCGATGCGGCCGCCGCCGCG
AAGCTGCGCGTGAAGATGTGGGCGTATCCGTACCTGACGTGGGTCGCGATCGCCGGGATGATCAGCATCCTCGTCGCGAT
GGCCTTCATTCCCGATCAGCGCAAGCCGCTGTGGCTCGGCGTCGCGAGCCTCGCGGTGCTGCTCGTCGCCTATGCGCTCA
CGCGCCGCGGCCGCCGCGAGCATCTCGATGAAAGCGACCTGATCGCGTATCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGGGGTCGCAGGACCTCGCTCGCCCGTCGACGGCGGCGCTCGCGCGATGCATCCCGTGTCGCGCGGTCGGCACCGGAC
AACCAGGATATGGAGAAGAC

Downstream 100 bases:

>100_bases
GGCACGGCCGTACGCAGCGCCGAAGGCCCGGCGTTCCCGCCGGGCCTTTGCATGGGTGCGGCGCGTATCGATGCGCAAAC
AACTATCGCGCCGGCCGATA

Product: AAT family amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQPSNQSDLKCGLKQRHMTMIALGGVIGAGLFVGSGVVIQQTGPAAILSFLITGGLVVLVMRMLGEMACAMPAVGSFYEY
ARLAFGTWRGPGRMAGFLTGWMYWYFWVIVVALEAVAGAKLIQFWLPDVPAWIISLALLVVLTLTNLISVGSYGEFEFWF
SSIKVGAIIVFLFLGGLYVLGLWPSSMHTTAVLPTLLGHGGFMPLGIGPVMSGAVAATGFYFGAEIVTIAAAEAREPAKA
VAKATNSVITRVLVFYVGSVALVVALVPWNSPQMSTPYVSALEVMGLPAAANVMNAIVLTAVLSALNSGLYAASRMLFAL
TRHGDAPAALAKVSKRGVPVRAILLGTVFGYVSVVMSYVSPDTVFAFLVNSYGTVAIFVYVLIAFSQLRLRKRLDAAAAA
KLRVKMWAYPYLTWVAIAGMISILVAMAFIPDQRKPLWLGVASLAVLLVAYALTRRGRREHLDESDLIAYPPR

Sequences:

>Translated_473_residues
MQPSNQSDLKCGLKQRHMTMIALGGVIGAGLFVGSGVVIQQTGPAAILSFLITGGLVVLVMRMLGEMACAMPAVGSFYEY
ARLAFGTWRGPGRMAGFLTGWMYWYFWVIVVALEAVAGAKLIQFWLPDVPAWIISLALLVVLTLTNLISVGSYGEFEFWF
SSIKVGAIIVFLFLGGLYVLGLWPSSMHTTAVLPTLLGHGGFMPLGIGPVMSGAVAATGFYFGAEIVTIAAAEAREPAKA
VAKATNSVITRVLVFYVGSVALVVALVPWNSPQMSTPYVSALEVMGLPAAANVMNAIVLTAVLSALNSGLYAASRMLFAL
TRHGDAPAALAKVSKRGVPVRAILLGTVFGYVSVVMSYVSPDTVFAFLVNSYGTVAIFVYVLIAFSQLRLRKRLDAAAAA
KLRVKMWAYPYLTWVAIAGMISILVAMAFIPDQRKPLWLGVASLAVLLVAYALTRRGRREHLDESDLIAYPPR
>Mature_473_residues
MQPSNQSDLKCGLKQRHMTMIALGGVIGAGLFVGSGVVIQQTGPAAILSFLITGGLVVLVMRMLGEMACAMPAVGSFYEY
ARLAFGTWRGPGRMAGFLTGWMYWYFWVIVVALEAVAGAKLIQFWLPDVPAWIISLALLVVLTLTNLISVGSYGEFEFWF
SSIKVGAIIVFLFLGGLYVLGLWPSSMHTTAVLPTLLGHGGFMPLGIGPVMSGAVAATGFYFGAEIVTIAAAEAREPAKA
VAKATNSVITRVLVFYVGSVALVVALVPWNSPQMSTPYVSALEVMGLPAAANVMNAIVLTAVLSALNSGLYAASRMLFAL
TRHGDAPAALAKVSKRGVPVRAILLGTVFGYVSVVMSYVSPDTVFAFLVNSYGTVAIFVYVLIAFSQLRLRKRLDAAAAA
KLRVKMWAYPYLTWVAIAGMISILVAMAFIPDQRKPLWLGVASLAVLLVAYALTRRGRREHLDESDLIAYPPR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=393, Percent_Identity=26.2086513994911, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI110347453, Length=360, Percent_Identity=23.8888888888889, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789017, Length=435, Percent_Identity=46.6666666666667, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1786302, Length=458, Percent_Identity=38.2096069868996, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786789, Length=464, Percent_Identity=37.7155172413793, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87081708, Length=476, Percent_Identity=35.5042016806723, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1790653, Length=446, Percent_Identity=36.322869955157, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI48994972, Length=468, Percent_Identity=34.4017094017094, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1786602, Length=462, Percent_Identity=35.0649350649351, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=38.4615384615385, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI87081915, Length=434, Percent_Identity=36.6359447004608, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17532491, Length=376, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533459, Length=466, Percent_Identity=25.1072961373391, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=448, Percent_Identity=34.8214285714286, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=474, Percent_Identity=30.379746835443, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=458, Percent_Identity=30.7860262008734, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=455, Percent_Identity=34.2857142857143, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321053, Length=398, Percent_Identity=32.1608040201005, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=31.6049382716049, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=436, Percent_Identity=30.7339449541284, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=475, Percent_Identity=27.1578947368421, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=431, Percent_Identity=30.1624129930394, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324553, Length=404, Percent_Identity=30.1980198019802, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=457, Percent_Identity=26.9146608315098, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=28.6069651741293, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=406, Percent_Identity=30.0492610837438, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=459, Percent_Identity=27.2331154684096, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=416, Percent_Identity=26.6826923076923, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=476, Percent_Identity=28.781512605042, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=457, Percent_Identity=24.945295404814, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=22.2222222222222, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24666159, Length=423, Percent_Identity=22.2222222222222, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50630; Mature: 50630

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEECCCC
>Mature Secondary Structure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HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]