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The map label for this gene is xanP [H]

Identifier: 189352698

GI number: 189352698

Start: 798096

End: 799484

Strand: Reverse

Name: xanP [H]

Synonym: BMULJ_03930

Alternate gene names: 189352698

Gene position: 799484-798096 (Counterclockwise)

Preceding gene: 189352706

Following gene: 189352697

Centisome position: 32.33

GC content: 67.24

Gene sequence:

>1389_bases
ATGCAACCCGCCTCCCACGCCCAATCCGCCTCCCACGGCGCCGACGATGCAGAATCGGCGCGCGACCTCGTCTACGGCCC
GAACGACCGCCCTGCGCCGATGGTCGCGTTCGTCGCCGCGCTCCAGCATCTGCTCGCGATCATCGTGCCGATCGTCACGC
CCGGCCTGCTGATCTGCCAGGCGCTCGGCGTGTCGAGCCACGACACGACGCTGATCGTCTCGATGTCGCTCGTCATCTCG
GGCATCGCGACCTTCGTCCAGTGCAAACGTTTCGGCCCGCTCGGCGCCGGGCTGCTGATCGTCCAGGGCACGAGCTTCAA
CTTCGTCGGCCCGCTGATCGCGGGCGGCAGCCTGATTGTCAAGCAAGGCACGCCGGTCGAGACCGTGATGGCCGCGATTT
TCGGCGTCGTGATCGCGGGTTCGTTCGTCGAAATGGGCGTGTCGCGCATCCTGCCGTTCGTGAAGCGGCTGATCACGCCG
CTCGTCACGGGCATCGTCGTGCTGCTGATCGGCCTCACGCTGATCAAGGTCGGGCTCATCAGCATGGGCGGCGGCTACGG
CGCGATGGCGAAAGGCACATTCGCGAGCGCGCAAAACCTGACGCTGTCGTGCCTCGTGCTCGGCACGATCATCCTGCTGA
ACCGCGTGCCCGTCGTCTGGGTGCGCAGCACCGCGCTCGTCATCGCGCTCGCGATCGGCTACGCCGCCGCCGCGTTCCTC
GGCCGCCTCGACTTCACCGGCATGCATCAGGCCGCCGTGTTCCAGGTGCCGACGCCGCTGCATTTCGGGATCGGCTTCTC
GTGGTCGCTGTTCGTGCCGATGCTGATCATCTACCTCGTCACCTCGCTCGAGGCGATCGGCGACGTCACGGCCACCAGCA
AGATCTCGAAGGAGCCCGTCGAAGGCCCGGTGTGGATGCAGCGGATCAAGGGCGGCGTGCTCGTGAACGGCGCGAACTCG
CTGCTCGCCGGCGTGTTCAACACGTTCCCGAGCTCGGTGTTCGCGCAGAACAACGGCGTGATCCAGATCACGGGCGTCGC
GAGCCGCTACGTCGGCATCTGGATCGCGGCGATGCTCGTCGTGCTCGGCCTCTTCCCCGTCGTCGCCGGCGCGCTGCAGG
CGGTTCCGGAACCGGTCCTGGGCGGCGCGGCGATGGTGATGTTCGGCGCGGTCGCGGCCTCCGGCATCAACATCCTCGCG
GGCATCCAGCTCGATCGGCGCGCGCTGCTGATCATCGCGGTGTCGCTCGCGCTCGGTCTCGGCGTATCGCAGGTGCCCGA
CATCCTGAACAGCCTGCCGCACGCGCTGAAGAACGTGCTGGAATCGGGCGTCGCGACGGGCGGCATCTGCGCGCTGGTCA
TGAACTGGTTCTTGCCTGAGAAGAAGTAA

Upstream 100 bases:

>100_bases
GTCGCCCCACCGAATCCCGAGGATTCGCATCGCACCGCCCGGCGCCCTCGAGTCCTTCGGCTAAAATGCCGCACTTTCCA
TCCTGTCCGGCCCGCTCGCC

Downstream 100 bases:

>100_bases
TCAAAACAACACTGCGGCCCGCAGCGCGGGCCGCTTATTCCCCGCTTTCCCCATCGCCATGTCCGCCGCATGCGGCCGCG
CGTCTCGTCCCTTAATTCCG

Product: NCS2 family nucleobase:cation symporter-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQPASHAQSASHGADDAESARDLVYGPNDRPAPMVAFVAALQHLLAIIVPIVTPGLLICQALGVSSHDTTLIVSMSLVIS
GIATFVQCKRFGPLGAGLLIVQGTSFNFVGPLIAGGSLIVKQGTPVETVMAAIFGVVIAGSFVEMGVSRILPFVKRLITP
LVTGIVVLLIGLTLIKVGLISMGGGYGAMAKGTFASAQNLTLSCLVLGTIILLNRVPVVWVRSTALVIALAIGYAAAAFL
GRLDFTGMHQAAVFQVPTPLHFGIGFSWSLFVPMLIIYLVTSLEAIGDVTATSKISKEPVEGPVWMQRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQITGVASRYVGIWIAAMLVVLGLFPVVAGALQAVPEPVLGGAAMVMFGAVAASGINILA
GIQLDRRALLIIAVSLALGLGVSQVPDILNSLPHALKNVLESGVATGGICALVMNWFLPEKK

Sequences:

>Translated_462_residues
MQPASHAQSASHGADDAESARDLVYGPNDRPAPMVAFVAALQHLLAIIVPIVTPGLLICQALGVSSHDTTLIVSMSLVIS
GIATFVQCKRFGPLGAGLLIVQGTSFNFVGPLIAGGSLIVKQGTPVETVMAAIFGVVIAGSFVEMGVSRILPFVKRLITP
LVTGIVVLLIGLTLIKVGLISMGGGYGAMAKGTFASAQNLTLSCLVLGTIILLNRVPVVWVRSTALVIALAIGYAAAAFL
GRLDFTGMHQAAVFQVPTPLHFGIGFSWSLFVPMLIIYLVTSLEAIGDVTATSKISKEPVEGPVWMQRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQITGVASRYVGIWIAAMLVVLGLFPVVAGALQAVPEPVLGGAAMVMFGAVAASGINILA
GIQLDRRALLIIAVSLALGLGVSQVPDILNSLPHALKNVLESGVATGGICALVMNWFLPEKK
>Mature_462_residues
MQPASHAQSASHGADDAESARDLVYGPNDRPAPMVAFVAALQHLLAIIVPIVTPGLLICQALGVSSHDTTLIVSMSLVIS
GIATFVQCKRFGPLGAGLLIVQGTSFNFVGPLIAGGSLIVKQGTPVETVMAAIFGVVIAGSFVEMGVSRILPFVKRLITP
LVTGIVVLLIGLTLIKVGLISMGGGYGAMAKGTFASAQNLTLSCLVLGTIILLNRVPVVWVRSTALVIALAIGYAAAAFL
GRLDFTGMHQAAVFQVPTPLHFGIGFSWSLFVPMLIIYLVTSLEAIGDVTATSKISKEPVEGPVWMQRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQITGVASRYVGIWIAAMLVVLGLFPVVAGALQAVPEPVLGGAAMVMFGAVAASGINILA
GIQLDRRALLIIAVSLALGLGVSQVPDILNSLPHALKNVLESGVATGGICALVMNWFLPEKK

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=497, Percent_Identity=23.943661971831, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI44680143, Length=501, Percent_Identity=23.75249500998, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI44680148, Length=504, Percent_Identity=23.4126984126984, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI40316845, Length=504, Percent_Identity=23.4126984126984, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790087, Length=463, Percent_Identity=53.9956803455724, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI87082178, Length=446, Percent_Identity=44.1704035874439, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI87082181, Length=453, Percent_Identity=29.3598233995585, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=26.8115942028986, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081818, Length=319, Percent_Identity=25.3918495297806, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=488, Percent_Identity=22.9508196721311, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47711; Mature: 47711

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00879 ODR_DC_2_2 ; PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPASHAQSASHGADDAESARDLVYGPNDRPAPMVAFVAALQHLLAIIVPIVTPGLLICQ
CCCCCHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGVSSHDTTLIVSMSLVISGIATFVQCKRFGPLGAGLLIVQGTSFNFVGPLIAGGSLIV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHCCCCEEE
KQGTPVETVMAAIFGVVIAGSFVEMGVSRILPFVKRLITPLVTGIVVLLIGLTLIKVGLI
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMGGGYGAMAKGTFASAQNLTLSCLVLGTIILLNRVPVVWVRSTALVIALAIGYAAAAFL
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
GRLDFTGMHQAAVFQVPTPLHFGIGFSWSLFVPMLIIYLVTSLEAIGDVTATSKISKEPV
HHCCCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGPVWMQRIKGGVLVNGANSLLAGVFNTFPSSVFAQNNGVIQITGVASRYVGIWIAAMLV
CCHHHHHHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPVVAGALQAVPEPVLGGAAMVMFGAVAASGINILAGIQLDRRALLIIAVSLALGL
HHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
GVSQVPDILNSLPHALKNVLESGVATGGICALVMNWFLPEKK
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQPASHAQSASHGADDAESARDLVYGPNDRPAPMVAFVAALQHLLAIIVPIVTPGLLICQ
CCCCCHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGVSSHDTTLIVSMSLVISGIATFVQCKRFGPLGAGLLIVQGTSFNFVGPLIAGGSLIV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHCCCCEEE
KQGTPVETVMAAIFGVVIAGSFVEMGVSRILPFVKRLITPLVTGIVVLLIGLTLIKVGLI
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMGGGYGAMAKGTFASAQNLTLSCLVLGTIILLNRVPVVWVRSTALVIALAIGYAAAAFL
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
GRLDFTGMHQAAVFQVPTPLHFGIGFSWSLFVPMLIIYLVTSLEAIGDVTATSKISKEPV
HHCCCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGPVWMQRIKGGVLVNGANSLLAGVFNTFPSSVFAQNNGVIQITGVASRYVGIWIAAMLV
CCHHHHHHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPVVAGALQAVPEPVLGGAAMVMFGAVAASGINILAGIQLDRRALLIIAVSLALGL
HHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
GVSQVPDILNSLPHALKNVLESGVATGGICALVMNWFLPEKK
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]