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The map label for this gene is lysP [H]

Identifier: 189352644

GI number: 189352644

Start: 731279

End: 732808

Strand: Direct

Name: lysP [H]

Synonym: BMULJ_03875

Alternate gene names: 189352644

Gene position: 731279-732808 (Clockwise)

Preceding gene: 189352643

Following gene: 189352646

Centisome position: 29.57

GC content: 66.21

Gene sequence:

>1530_bases
ATGGATGCGATACAAGCGGCGACGAAGGCGGCCGCGCCGGCCGCAGCGGGGCTCAAGCGCCGGTTGCAAAGCCGCCACAT
CGCGATGATCGCGATCGGCGGCTCGATCGGCACGGGGCTGTTCGTTGCATCGGGGGCGTCGGTGGCGCAGGCGGGGCCGG
GCGGCGCGATCGCCGCGTATGTCGCGATCGGGATGATGGTGTATTTCGTCGTGACCGGCCTCGGCGAGATGGCCGCATTG
ATGCCGGTGTCGGGCTCGTTCGCGATCTACGGCGAGAAATACGTCGACAAGGGTTTCGGCATCGCGCTCGGCTGGACCTA
CTGGTATAGCTGGGCAGTGACGATCGCGATCGAGCTCGTCGCCGCGCAGATCGTGATGCGCTACTGGTTTCCGGCGGTAC
CGGGCGTGTGGTGGGGCGCCGGCTTTCTCGTGCTGATCTTCCTGCTCAACACGTTGTCGGTGCGCGGTTTCGGCGAATCC
GAATACTGGTTCTCGCTGATCAAGGTCGTTACCGTCGTCGCGTTCATCGCGGCAGGGCTGCTGATCGCGGCCGGCGTGAT
CGGCAGCGGGCATCCGGTCGGCTGGCGCAATTTCACGACGGGCGATGCGCCGTTCGTCGGCGGCTCGCATGCGATGATGA
GCGTCGCGCTGATCGCGGGATTCTCGTTTCTCGGCACCGAACTCGTCGGCATCACGGCCGGCGAATCGGCGAACCCGCGC
CAGACGATCCCGCGCGCGGTGAAGCAGATCTTCTGGCGCATCATGCTGTTCTATGTGCTCGCGATCTTCGTGATCGGGCT
GCTGGTGCCGTACACCGATCCGAACCTGCTCAAGAGCGACGTGACCGACATCGGCGTGAGCCCGTTCACGCTCGTGTTCA
GCCATGCGGGCTTTCGGCTCGCCGCCGGCGCGATGAACCTCGTGATCCTCACGGCGGTGCTGTCGGCCGGCAACTCCGGC
ACCTACGCGGCGACGCGGATGCTCTACAACCTCGCTGCCGAGGGCCGCGCGCCCGCGATGTTCGCGACGCTGTCGCCGGG
CGGCGTGCCGCGCAATGCACTCTACGCGACGATGGCGGTCGGCGGACTCTGTTTCCTGACGTCGCTGGCCAGCAACCAGA
GCATCTATCTCTGGCTGCTCAATACGGTCGGCATTACCGGCTTCATCGCGTGGCTCGGCATCGCCGTCTGTCATTACCGG
TTCCGCAAGGGCTTCGTGAAGCAGGGGCACCGGCTCGACGAACTGCCGTACCGCGCGAAGTGGTTCCCGTTCGGGCCGCT
GTTCGCGATCGCGGTCTGCATCGTGATCTCGCTCGGGCAGGACTACCAGGCGTTCTTCGCGGCGCGCATCGACTGGATGG
AAGTGCTGTCGATCTATGTGTGGATTCCGCTGTTCGTCGCGATCTGGTTCGCGTATCGCCGCGCGCACAAGAGCCGGCTC
GTGCGCTACGACGAGATGGAGATCGGCCCGTGGCTGACGCGCGCGGTGGACGAGCGCGCGGCAACGCAGGCGCGCGCGGA
CGGCGCGTAA

Upstream 100 bases:

>100_bases
GGGATGGAAGCGCGCCGGGTTCGATTCGACCAACCGGCATGATCATCGATCTGCATTCCGAATCGAATCGATCGGGCCGA
ATTCAGTCAGGGTGAATACG

Downstream 100 bases:

>100_bases
CGTGCGGCCGCCCGCCGGCAGCGCTACGCGTCCAGCTCGGGGTAGTGCCGGAAGATTCCCATGTCGTTGAACGGGATGCG
ACGTTCCGACGCGAGATAGC

Product: putative lysine permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDAIQAATKAAAPAAAGLKRRLQSRHIAMIAIGGSIGTGLFVASGASVAQAGPGGAIAAYVAIGMMVYFVVTGLGEMAAL
MPVSGSFAIYGEKYVDKGFGIALGWTYWYSWAVTIAIELVAAQIVMRYWFPAVPGVWWGAGFLVLIFLLNTLSVRGFGES
EYWFSLIKVVTVVAFIAAGLLIAAGVIGSGHPVGWRNFTTGDAPFVGGSHAMMSVALIAGFSFLGTELVGITAGESANPR
QTIPRAVKQIFWRIMLFYVLAIFVIGLLVPYTDPNLLKSDVTDIGVSPFTLVFSHAGFRLAAGAMNLVILTAVLSAGNSG
TYAATRMLYNLAAEGRAPAMFATLSPGGVPRNALYATMAVGGLCFLTSLASNQSIYLWLLNTVGITGFIAWLGIAVCHYR
FRKGFVKQGHRLDELPYRAKWFPFGPLFAIAVCIVISLGQDYQAFFAARIDWMEVLSIYVWIPLFVAIWFAYRRAHKSRL
VRYDEMEIGPWLTRAVDERAATQARADGA

Sequences:

>Translated_509_residues
MDAIQAATKAAAPAAAGLKRRLQSRHIAMIAIGGSIGTGLFVASGASVAQAGPGGAIAAYVAIGMMVYFVVTGLGEMAAL
MPVSGSFAIYGEKYVDKGFGIALGWTYWYSWAVTIAIELVAAQIVMRYWFPAVPGVWWGAGFLVLIFLLNTLSVRGFGES
EYWFSLIKVVTVVAFIAAGLLIAAGVIGSGHPVGWRNFTTGDAPFVGGSHAMMSVALIAGFSFLGTELVGITAGESANPR
QTIPRAVKQIFWRIMLFYVLAIFVIGLLVPYTDPNLLKSDVTDIGVSPFTLVFSHAGFRLAAGAMNLVILTAVLSAGNSG
TYAATRMLYNLAAEGRAPAMFATLSPGGVPRNALYATMAVGGLCFLTSLASNQSIYLWLLNTVGITGFIAWLGIAVCHYR
FRKGFVKQGHRLDELPYRAKWFPFGPLFAIAVCIVISLGQDYQAFFAARIDWMEVLSIYVWIPLFVAIWFAYRRAHKSRL
VRYDEMEIGPWLTRAVDERAATQARADGA
>Mature_509_residues
MDAIQAATKAAAPAAAGLKRRLQSRHIAMIAIGGSIGTGLFVASGASVAQAGPGGAIAAYVAIGMMVYFVVTGLGEMAAL
MPVSGSFAIYGEKYVDKGFGIALGWTYWYSWAVTIAIELVAAQIVMRYWFPAVPGVWWGAGFLVLIFLLNTLSVRGFGES
EYWFSLIKVVTVVAFIAAGLLIAAGVIGSGHPVGWRNFTTGDAPFVGGSHAMMSVALIAGFSFLGTELVGITAGESANPR
QTIPRAVKQIFWRIMLFYVLAIFVIGLLVPYTDPNLLKSDVTDIGVSPFTLVFSHAGFRLAAGAMNLVILTAVLSAGNSG
TYAATRMLYNLAAEGRAPAMFATLSPGGVPRNALYATMAVGGLCFLTSLASNQSIYLWLLNTVGITGFIAWLGIAVCHYR
FRKGFVKQGHRLDELPYRAKWFPFGPLFAIAVCIVISLGQDYQAFFAARIDWMEVLSIYVWIPLFVAIWFAYRRAHKSRL
VRYDEMEIGPWLTRAVDERAATQARADGA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=480, Percent_Identity=63.5416666666667, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=431, Percent_Identity=38.2830626450116, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1786789, Length=433, Percent_Identity=37.4133949191686, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI48994972, Length=454, Percent_Identity=34.8017621145374, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786302, Length=396, Percent_Identity=38.3838383838384, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1790653, Length=463, Percent_Identity=33.2613390928726, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=33.2512315270936, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789017, Length=394, Percent_Identity=32.994923857868, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786602, Length=388, Percent_Identity=34.5360824742268, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87081869, Length=242, Percent_Identity=24.3801652892562, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=481, Percent_Identity=37.2141372141372, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=499, Percent_Identity=36.2725450901804, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6324059, Length=511, Percent_Identity=36.5949119373777, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6322892, Length=528, Percent_Identity=34.280303030303, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6324990, Length=503, Percent_Identity=31.610337972167, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=31.9105691056911, Blast_Score=259, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324924, Length=494, Percent_Identity=32.1862348178138, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6324553, Length=428, Percent_Identity=34.5794392523364, Blast_Score=252, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6319824, Length=502, Percent_Identity=29.0836653386454, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6320717, Length=525, Percent_Identity=28, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=505, Percent_Identity=31.4851485148515, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6320251, Length=534, Percent_Identity=28.8389513108614, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6319542, Length=523, Percent_Identity=27.7246653919694, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6324981, Length=519, Percent_Identity=30.4431599229287, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319543, Length=513, Percent_Identity=27.2904483430799, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319608, Length=504, Percent_Identity=26.1904761904762, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6321053, Length=457, Percent_Identity=30.6345733041575, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=560, Percent_Identity=24.4642857142857, Blast_Score=158, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54761; Mature: 54761

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00435 PEROXIDASE_1 ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAIQAATKAAAPAAAGLKRRLQSRHIAMIAIGGSIGTGLFVASGASVAQAGPGGAIAAY
CCHHHHHHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCHHCCCCCHHHHHH
VAIGMMVYFVVTGLGEMAALMPVSGSFAIYGEKYVDKGFGIALGWTYWYSWAVTIAIELV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
AAQIVMRYWFPAVPGVWWGAGFLVLIFLLNTLSVRGFGESEYWFSLIKVVTVVAFIAAGL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIAAGVIGSGHPVGWRNFTTGDAPFVGGSHAMMSVALIAGFSFLGTELVGITAGESANPR
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCH
QTIPRAVKQIFWRIMLFYVLAIFVIGLLVPYTDPNLLKSDVTDIGVSPFTLVFSHAGFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHH
AAGAMNLVILTAVLSAGNSGTYAATRMLYNLAAEGRAPAMFATLSPGGVPRNALYATMAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHH
GGLCFLTSLASNQSIYLWLLNTVGITGFIAWLGIAVCHYRFRKGFVKQGHRLDELPYRAK
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
WFPFGPLFAIAVCIVISLGQDYQAFFAARIDWMEVLSIYVWIPLFVAIWFAYRRAHKSRL
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VRYDEMEIGPWLTRAVDERAATQARADGA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDAIQAATKAAAPAAAGLKRRLQSRHIAMIAIGGSIGTGLFVASGASVAQAGPGGAIAAY
CCHHHHHHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCHHCCCCCHHHHHH
VAIGMMVYFVVTGLGEMAALMPVSGSFAIYGEKYVDKGFGIALGWTYWYSWAVTIAIELV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
AAQIVMRYWFPAVPGVWWGAGFLVLIFLLNTLSVRGFGESEYWFSLIKVVTVVAFIAAGL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIAAGVIGSGHPVGWRNFTTGDAPFVGGSHAMMSVALIAGFSFLGTELVGITAGESANPR
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCH
QTIPRAVKQIFWRIMLFYVLAIFVIGLLVPYTDPNLLKSDVTDIGVSPFTLVFSHAGFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHH
AAGAMNLVILTAVLSAGNSGTYAATRMLYNLAAEGRAPAMFATLSPGGVPRNALYATMAV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHH
GGLCFLTSLASNQSIYLWLLNTVGITGFIAWLGIAVCHYRFRKGFVKQGHRLDELPYRAK
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
WFPFGPLFAIAVCIVISLGQDYQAFFAARIDWMEVLSIYVWIPLFVAIWFAYRRAHKSRL
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VRYDEMEIGPWLTRAVDERAATQARADGA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]