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The map label for this gene is adhC [H]

Identifier: 189352593

GI number: 189352593

Start: 675031

End: 676200

Strand: Reverse

Name: adhC [H]

Synonym: BMULJ_03824

Alternate gene names: 189352593

Gene position: 676200-675031 (Counterclockwise)

Preceding gene: 189352594

Following gene: 189352592

Centisome position: 27.34

GC content: 62.99

Gene sequence:

>1170_bases
ATGAGAGCACTCCGCTGGCATGGCAAGCACGACGTGCGCTGCGATACCGTTCCCGACCCGATCATCGAAAGCGGCCGCGA
TGCGATCGTCAAGGTGTCCGCATGCGCGATCTGCGGATCCGATCTTCACCTGTTCGATGGCCTGATGCCGTCGATGAAGC
ACGGCGACATTCTCGGCCACGAGTTCATGGGCGAAGTCGTCGAGGTCGGCAAGGACAACGCATCGCTGAAGATCGGCGAT
CGCGTGGTCGTGCCGTTCACGATTTTCTGCGGCGAATGCGATCAGTGTCGCCGCGGCAATTTCTCGGTTTGCGAACGCAC
GAATCGCAACCGAAACGATGCCGATCGCGTGTTCGGCCACACGACGGCCGGGCTGTTCGGGTATTCGCATTTGACCGGCG
GCTATCCCGGCGGCCAGGCCGAATACGTGCGCGTGCCGTTTGCCGATCGCACGCACATCCGGATACCGGACGGCCTGACG
GACGAACAAGTCCTGTTCCTCGGCGACATTCTGCCGACCGGCTGGCAGGCGGCGGTCAATTGCGAGATCGAGCCGACCGA
CACGGTCGCCGTGTGGGGCGCCGGTCCGGTCGGCCAGATGGCGATCCGCAGCGCGCTGCTGTTGGGAGCCAGGCAAGTGG
TGGTAATCGATCGCGTTGCCGAACGGCTCGAGATGGCAGAGCGAAGCGGCGCGATTCCGATTCATTTCGAGCAGGAAAGC
GTGCTCGACCGGCTCGGCGAGCTGACACACGGCAAGGGCCCCGAAAAATGCATCGACGCGGTCGGAATGGAGTCGCATGC
GACGCGGTCCGCAGACGCGATCTACGACCGCGTCAAGCAGGCGATGATGCTCGAAACCGACCGGCCGCACGTGCTGCGCG
AGATGATCTACGTGTGCCGCCCGGCGGGCATTCTGTCGATACCGGGCGTTTATGCGGGCGTGCTCGACAAGATTCCGTTC
GGCGCCGCGATGAACAAGGGACTGACGTTCCGCATGGGACAGACGCACGTCAACCGCTGGACCGACGATCTGCTCGCGCG
CATACGATCGGGTCAGTTCGATCCGTCGTTCGTCATCACGCATACCGTCCCGCTCGAGAAAGGGCCGGACATGTACAAGG
TGTTTCGCGACAAGCTCGACGGCTGCATCAAGGTGGTCATGAAGCCGTAG

Upstream 100 bases:

>100_bases
GCGCTTGGCGTGAAATCCATCGGGCATCGCACAGGGAACGATCGTTGCTGAGTGCGCATCCGAGGCGGCGCGCTTTCGCG
CCGCCGTCACTGGAGACAAC

Downstream 100 bases:

>100_bases
GCGCAGGGAACGGCGTTCGCCGCGCGCTCGACGCCGACGCCGTGGGGCCGCTTCGATCGCATCGAGACGGCCGGCCGGCG
CGGGCGCATGCTTGCGCCGT

Product: S-(hydroxymethyl)glutathione dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MRALRWHGKHDVRCDTVPDPIIESGRDAIVKVSACAICGSDLHLFDGLMPSMKHGDILGHEFMGEVVEVGKDNASLKIGD
RVVVPFTIFCGECDQCRRGNFSVCERTNRNRNDADRVFGHTTAGLFGYSHLTGGYPGGQAEYVRVPFADRTHIRIPDGLT
DEQVLFLGDILPTGWQAAVNCEIEPTDTVAVWGAGPVGQMAIRSALLLGARQVVVIDRVAERLEMAERSGAIPIHFEQES
VLDRLGELTHGKGPEKCIDAVGMESHATRSADAIYDRVKQAMMLETDRPHVLREMIYVCRPAGILSIPGVYAGVLDKIPF
GAAMNKGLTFRMGQTHVNRWTDDLLARIRSGQFDPSFVITHTVPLEKGPDMYKVFRDKLDGCIKVVMKP

Sequences:

>Translated_389_residues
MRALRWHGKHDVRCDTVPDPIIESGRDAIVKVSACAICGSDLHLFDGLMPSMKHGDILGHEFMGEVVEVGKDNASLKIGD
RVVVPFTIFCGECDQCRRGNFSVCERTNRNRNDADRVFGHTTAGLFGYSHLTGGYPGGQAEYVRVPFADRTHIRIPDGLT
DEQVLFLGDILPTGWQAAVNCEIEPTDTVAVWGAGPVGQMAIRSALLLGARQVVVIDRVAERLEMAERSGAIPIHFEQES
VLDRLGELTHGKGPEKCIDAVGMESHATRSADAIYDRVKQAMMLETDRPHVLREMIYVCRPAGILSIPGVYAGVLDKIPF
GAAMNKGLTFRMGQTHVNRWTDDLLARIRSGQFDPSFVITHTVPLEKGPDMYKVFRDKLDGCIKVVMKP
>Mature_389_residues
MRALRWHGKHDVRCDTVPDPIIESGRDAIVKVSACAICGSDLHLFDGLMPSMKHGDILGHEFMGEVVEVGKDNASLKIGD
RVVVPFTIFCGECDQCRRGNFSVCERTNRNRNDADRVFGHTTAGLFGYSHLTGGYPGGQAEYVRVPFADRTHIRIPDGLT
DEQVLFLGDILPTGWQAAVNCEIEPTDTVAVWGAGPVGQMAIRSALLLGARQVVVIDRVAERLEMAERSGAIPIHFEQES
VLDRLGELTHGKGPEKCIDAVGMESHATRSADAIYDRVKQAMMLETDRPHVLREMIYVCRPAGILSIPGVYAGVLDKIPF
GAAMNKGLTFRMGQTHVNRWTDDLLARIRSGQFDPSFVITHTVPLEKGPDMYKVFRDKLDGCIKVVMKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=23.4501347708895, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=351, Percent_Identity=23.9316239316239, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI71743840, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262073058, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565154, Length=227, Percent_Identity=29.0748898678414, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI34577061, Length=232, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI71565152, Length=210, Percent_Identity=27.1428571428571, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4501929, Length=235, Percent_Identity=28.0851063829787, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501933, Length=232, Percent_Identity=25.8620689655172, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=47.0737913486005, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1787863, Length=377, Percent_Identity=28.3819628647215, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790045, Length=379, Percent_Identity=27.4406332453826, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082125, Length=262, Percent_Identity=30.5343511450382, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788073, Length=371, Percent_Identity=25.6064690026954, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI226510992, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788075, Length=401, Percent_Identity=26.4339152119701, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081918, Length=227, Percent_Identity=32.5991189427313, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786552, Length=211, Percent_Identity=29.8578199052133, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788407, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=256, Percent_Identity=29.296875, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=223, Percent_Identity=30.9417040358744, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=295, Percent_Identity=28.135593220339, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=234, Percent_Identity=29.4871794871795, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=142, Percent_Identity=33.8028169014084, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=348, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=143, Percent_Identity=36.3636363636364, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17137530, Length=396, Percent_Identity=26.2626262626263, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17737897, Length=393, Percent_Identity=24.9363867684478, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17737895, Length=204, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45550770, Length=227, Percent_Identity=26.8722466960352, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551930, Length=227, Percent_Identity=26.8722466960352, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221457811, Length=227, Percent_Identity=26.8722466960352, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42880; Mature: 42880

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALRWHGKHDVRCDTVPDPIIESGRDAIVKVSACAICGSDLHLFDGLMPSMKHGDILGH
CCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHEECCCCHHHHHCCCCCCCCCCCHHH
EFMGEVVEVGKDNASLKIGDRVVVPFTIFCGECDQCRRGNFSVCERTNRNRNDADRVFGH
HHHHHHHHHCCCCCEEEECCEEEEEEEEECCCCCHHCCCCCHHHHHCCCCCCHHHHHHCC
TTAGLFGYSHLTGGYPGGQAEYVRVPFADRTHIRIPDGLTDEQVLFLGDILPTGWQAAVN
HHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEE
CEIEPTDTVAVWGAGPVGQMAIRSALLLGARQVVVIDRVAERLEMAERSGAIPIHFEQES
EEECCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECHHH
VLDRLGELTHGKGPEKCIDAVGMESHATRSADAIYDRVKQAMMLETDRPHVLREMIYVCR
HHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
PAGILSIPGVYAGVLDKIPFGAAMNKGLTFRMGQTHVNRWTDDLLARIRSGQFDPSFVIT
CCCCEECCHHHHHHHHHCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEE
HTVPLEKGPDMYKVFRDKLDGCIKVVMKP
EEECCCCCCHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MRALRWHGKHDVRCDTVPDPIIESGRDAIVKVSACAICGSDLHLFDGLMPSMKHGDILGH
CCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHEECCCCHHHHHCCCCCCCCCCCHHH
EFMGEVVEVGKDNASLKIGDRVVVPFTIFCGECDQCRRGNFSVCERTNRNRNDADRVFGH
HHHHHHHHHCCCCCEEEECCEEEEEEEEECCCCCHHCCCCCHHHHHCCCCCCHHHHHHCC
TTAGLFGYSHLTGGYPGGQAEYVRVPFADRTHIRIPDGLTDEQVLFLGDILPTGWQAAVN
HHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEE
CEIEPTDTVAVWGAGPVGQMAIRSALLLGARQVVVIDRVAERLEMAERSGAIPIHFEQES
EEECCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECHHH
VLDRLGELTHGKGPEKCIDAVGMESHATRSADAIYDRVKQAMMLETDRPHVLREMIYVCR
HHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
PAGILSIPGVYAGVLDKIPFGAAMNKGLTFRMGQTHVNRWTDDLLARIRSGQFDPSFVIT
CCCCEECCHHHHHHHHHCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEE
HTVPLEKGPDMYKVFRDKLDGCIKVVMKP
EEECCCCCCHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]