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The map label for this gene is dxs [C]

Identifier: 189352304

GI number: 189352304

Start: 352998

End: 353996

Strand: Reverse

Name: dxs [C]

Synonym: BMULJ_03523

Alternate gene names: 189352304

Gene position: 353996-352998 (Counterclockwise)

Preceding gene: 189352305

Following gene: 189352303

Centisome position: 14.31

GC content: 67.57

Gene sequence:

>999_bases
ATGAGTACCGCCGCCCAGAAGCCGCGCCTGAAAACCTCCGCGATGATCGCATCGATCGCGGCCGAAGGACAGCCGACGCG
CGCCGCACCGTTCGGTCACGCCCTCGTCGAGCTCGCGCGCACGAAGCCCGACGTGATCGGCATGACGGCGGATCTCGGCA
AGTACACGGACCTGCACGTATTCGCGAAGGCGTTTCCCGAGCGCTACTACCAGATGGGGATGGCCGAGCAGCTGTTGATG
GGAGCCGCGGCCGGCTTTGCGCACGAAGGTGCGCAGCCGTTCGTGACGACCTATGCGGTGTTCGCGACGCGCCGGGCGTA
CGACTTCATCCATCAGACGATCGCCGAGGACAATCTCGACGTGAAGATCGTCGCCGCGCTGCCGGGACTGACGACGGGCT
ACGGCCCGAGCCACCAGGCCGCGGAAGATCTCGCGCTGATGCGCGCGATGCCGAACATGACCGTGATCGATCCGTGCGAC
GCGCTCGACATCGAGCAGATGGTGCCCGCGATCGCGGCGCACGACGGCCCCGTGTATGCGCGGCTGCTGCGCGGCAACGT
GCCGGTCGTGCTCGACGAATACGACTACACGTTCGAGCTCGGCAAGGCGAAACGGCTGCGCGACGGCAACGACGTACTGC
TGATCTCGTCCGGCATCATGACAATGCGCGCGCTCGAAGTGGCGAACGCGCTGGAGGCCGATCGCGTCGGCGTCGCGGTG
CTGCACGTGCCGACGATCAAGCCGCTCGATACCGCGACGATCGTGCGCGAAGCGAAGCGCACGGGCCGCATGGTCGTCGT
CGCGGAAAACCACACGGTGATCGGCGGGCTCGGCGAAGCCGTCGCGCGCACACTGCTTGCCGAAGGCGTCGCGCCGACGT
TCCGGCAGATCGCGCTGCCCGATGCGTTCCTCGACGCGGGCGCGCTGCCGACGCTGCACGATCGCTACGGCATCTCGACC
GCCACGATGGTCGCGTCGATCAAGCGCTGGCTCGGCTGA

Upstream 100 bases:

>100_bases
GCGTGCCGTTCCTCGAACAACGCGAGAAGAACCATTTCATCCGCGTCGACGCGCACGAGTGGCAGCTCGCGCTCGACGCA
CTCGAAGCCGGGAGACAAGC

Downstream 100 bases:

>100_bases
TCGCGCACCGGGCCGCGGTGCGGCGACGGGCGGCCGTCCGCCTGGGCCGCAGCGCGCGCCCGACGCGCGGCTTACTCGTC
CAGGGGAATGAGGCGCGGCC

Product: putative transketolase

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSTAAQKPRLKTSAMIASIAAEGQPTRAAPFGHALVELARTKPDVIGMTADLGKYTDLHVFAKAFPERYYQMGMAEQLLM
GAAAGFAHEGAQPFVTTYAVFATRRAYDFIHQTIAEDNLDVKIVAALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCD
ALDIEQMVPAIAAHDGPVYARLLRGNVPVVLDEYDYTFELGKAKRLRDGNDVLLISSGIMTMRALEVANALEADRVGVAV
LHVPTIKPLDTATIVREAKRTGRMVVVAENHTVIGGLGEAVARTLLAEGVAPTFRQIALPDAFLDAGALPTLHDRYGIST
ATMVASIKRWLG

Sequences:

>Translated_332_residues
MSTAAQKPRLKTSAMIASIAAEGQPTRAAPFGHALVELARTKPDVIGMTADLGKYTDLHVFAKAFPERYYQMGMAEQLLM
GAAAGFAHEGAQPFVTTYAVFATRRAYDFIHQTIAEDNLDVKIVAALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCD
ALDIEQMVPAIAAHDGPVYARLLRGNVPVVLDEYDYTFELGKAKRLRDGNDVLLISSGIMTMRALEVANALEADRVGVAV
LHVPTIKPLDTATIVREAKRTGRMVVVAENHTVIGGLGEAVARTLLAEGVAPTFRQIALPDAFLDAGALPTLHDRYGIST
ATMVASIKRWLG
>Mature_331_residues
STAAQKPRLKTSAMIASIAAEGQPTRAAPFGHALVELARTKPDVIGMTADLGKYTDLHVFAKAFPERYYQMGMAEQLLMG
AAAGFAHEGAQPFVTTYAVFATRRAYDFIHQTIAEDNLDVKIVAALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDA
LDIEQMVPAIAAHDGPVYARLLRGNVPVVLDEYDYTFELGKAKRLRDGNDVLLISSGIMTMRALEVANALEADRVGVAVL
HVPTIKPLDTATIVREAKRTGRMVVVAENHTVIGGLGEAVARTLLAEGVAPTFRQIALPDAFLDAGALPTLHDRYGISTA
TMVASIKRWLG

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637463, Length=309, Percent_Identity=33.9805825242718, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI225637459, Length=312, Percent_Identity=33.974358974359, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI225637461, Length=312, Percent_Identity=33.974358974359, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI133778974, Length=303, Percent_Identity=33.6633663366337, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI205277463, Length=268, Percent_Identity=32.4626865671642, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4507521, Length=268, Percent_Identity=32.4626865671642, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1786622, Length=326, Percent_Identity=30.6748466257669, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17539652, Length=310, Percent_Identity=34.5161290322581, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45551847, Length=314, Percent_Identity=33.4394904458599, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI45550715, Length=314, Percent_Identity=33.4394904458599, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24645119, Length=314, Percent_Identity=33.4394904458599, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24666278, Length=300, Percent_Identity=32, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 35609; Mature: 35477

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAAQKPRLKTSAMIASIAAEGQPTRAAPFGHALVELARTKPDVIGMTADLGKYTDLHV
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
FAKAFPERYYQMGMAEQLLMGAAAGFAHEGAQPFVTTYAVFATRRAYDFIHQTIAEDNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VKIVAALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDALDIEQMVPAIAAHDGPVYA
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCHHHH
RLLRGNVPVVLDEYDYTFELGKAKRLRDGNDVLLISSGIMTMRALEVANALEADRVGVAV
HHHCCCCCEEECCCCCEEECCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
LHVPTIKPLDTATIVREAKRTGRMVVVAENHTVIGGLGEAVARTLLAEGVAPTFRQIALP
EEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCHHHHHHHCC
DAFLDAGALPTLHDRYGISTATMVASIKRWLG
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STAAQKPRLKTSAMIASIAAEGQPTRAAPFGHALVELARTKPDVIGMTADLGKYTDLHV
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
FAKAFPERYYQMGMAEQLLMGAAAGFAHEGAQPFVTTYAVFATRRAYDFIHQTIAEDNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VKIVAALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDALDIEQMVPAIAAHDGPVYA
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCHHHH
RLLRGNVPVVLDEYDYTFELGKAKRLRDGNDVLLISSGIMTMRALEVANALEADRVGVAV
HHHCCCCCEEECCCCCEEECCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
LHVPTIKPLDTATIVREAKRTGRMVVVAENHTVIGGLGEAVARTLLAEGVAPTFRQIALP
EEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCHHHHHHHCC
DAFLDAGALPTLHDRYGISTATMVASIKRWLG
HHHHCCCCCCCHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]