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The map label for this gene is hutC [H]

Identifier: 189352289

GI number: 189352289

Start: 337878

End: 338573

Strand: Reverse

Name: hutC [H]

Synonym: BMULJ_03508

Alternate gene names: 189352289

Gene position: 338573-337878 (Counterclockwise)

Preceding gene: 189352299

Following gene: 189352287

Centisome position: 13.69

GC content: 68.39

Gene sequence:

>696_bases
ATGACCACACCGATCTATCAGGAAATCAAGGACTTCATCCTCGCGCGCATCCATGCCGGCGAATGGGCGGAGGGCGACCA
GGTGCCGTCGGAGAACGAGCTCGCGCGCGAGTTCAACGTCGCGCGCATGACCGTGAACCGCGCGCTGCGCGAGCTGACGG
CCGAGCAGGTGCTCACGCGCACGCGCGGTTCCGGCACGTATGTCGCGTCGCCGAAATACGAGTCGACGCTCGTCGCGATC
CGCAGCATCTCCGACGAAATCGCCGCGCGCGGCCACGCGTATCGCGCCGAGGTGCTCGAAGTCGGCGCGGCCGTCGCCGA
CGCCAAGCTCGCCGACGAACTGCAGCTCGACGCGGGCAGCCCGATCTTCCACTCGCGCGTGCTGCACTTCGAGAACGACA
CGCCCGTGCAGCTCGAGGAGCGCTGGGTCAATCCAGCCTGCGCGCCCGAGTACGCGCTACAGGACTTCACGACGACCACG
CCGAACCAGTACCTGACGCGCGTCGCGCCGCTGCAGCGCGTCGAATACCGGATCGAGGCCGCCATGCCCGGCGCGGAAAC
GCGCCGCCGGCTCGCGATGGACGACCGCGAGCCGTGCCTGATGCTGCATCGGCGCACGTGGTCGCAGGGGATGGTCGCGT
CGGTCGCGAATCTCTGGCATCCGGGCAGCCGCTACCGGTTCACCGGACATTTCTGA

Upstream 100 bases:

>100_bases
GCCGCTATGTCCCTTTCAGGTACGCAAGGCGATTCGAAGCTTGTCTATACTTGACGGCGCGGCGCGCAGCGCCTTCCGCC
GCCTCTTGAACAACGACGCA

Downstream 100 bases:

>100_bases
TCGGGCGCGCGGCGCCCGCCGGGCATCAACGCCTGCGCGCGCGCGTCCAGCGTTCGATCGCCTCGACCGCGCCGGTGAGC
CCGTCCTCGCTGGCGATGCG

Product: GntR family histidine utilization transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTTPIYQEIKDFILARIHAGEWAEGDQVPSENELAREFNVARMTVNRALRELTAEQVLTRTRGSGTYVASPKYESTLVAI
RSISDEIAARGHAYRAEVLEVGAAVADAKLADELQLDAGSPIFHSRVLHFENDTPVQLEERWVNPACAPEYALQDFTTTT
PNQYLTRVAPLQRVEYRIEAAMPGAETRRRLAMDDREPCLMLHRRTWSQGMVASVANLWHPGSRYRFTGHF

Sequences:

>Translated_231_residues
MTTPIYQEIKDFILARIHAGEWAEGDQVPSENELAREFNVARMTVNRALRELTAEQVLTRTRGSGTYVASPKYESTLVAI
RSISDEIAARGHAYRAEVLEVGAAVADAKLADELQLDAGSPIFHSRVLHFENDTPVQLEERWVNPACAPEYALQDFTTTT
PNQYLTRVAPLQRVEYRIEAAMPGAETRRRLAMDDREPCLMLHRRTWSQGMVASVANLWHPGSRYRFTGHF
>Mature_230_residues
TTPIYQEIKDFILARIHAGEWAEGDQVPSENELAREFNVARMTVNRALRELTAEQVLTRTRGSGTYVASPKYESTLVAIR
SISDEIAARGHAYRAEVLEVGAAVADAKLADELQLDAGSPIFHSRVLHFENDTPVQLEERWVNPACAPEYALQDFTTTTP
NQYLTRVAPLQRVEYRIEAAMPGAETRRRLAMDDREPCLMLHRRTWSQGMVASVANLWHPGSRYRFTGHF

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=30.6532663316583, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI87082252, Length=148, Percent_Identity=30.4054054054054, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788418, Length=214, Percent_Identity=27.1028037383178, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790118, Length=150, Percent_Identity=25.3333333333333, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26129; Mature: 25998

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPIYQEIKDFILARIHAGEWAEGDQVPSENELAREFNVARMTVNRALRELTAEQVLTR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRGSGTYVASPKYESTLVAIRSISDEIAARGHAYRAEVLEVGAAVADAKLADELQLDAGS
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIFHSRVLHFENDTPVQLEERWVNPACAPEYALQDFTTTTPNQYLTRVAPLQRVEYRIEA
CHHHHEEEEECCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AMPGAETRRRLAMDDREPCLMLHRRTWSQGMVASVANLWHPGSRYRFTGHF
CCCCHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
TTPIYQEIKDFILARIHAGEWAEGDQVPSENELAREFNVARMTVNRALRELTAEQVLTR
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRGSGTYVASPKYESTLVAIRSISDEIAARGHAYRAEVLEVGAAVADAKLADELQLDAGS
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIFHSRVLHFENDTPVQLEERWVNPACAPEYALQDFTTTTPNQYLTRVAPLQRVEYRIEA
CHHHHEEEEECCCCCCCHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
AMPGAETRRRLAMDDREPCLMLHRRTWSQGMVASVANLWHPGSRYRFTGHF
CCCCHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]