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The map label for this gene is lysR [H]

Identifier: 189352196

GI number: 189352196

Start: 233340

End: 234332

Strand: Reverse

Name: lysR [H]

Synonym: BMULJ_03414

Alternate gene names: 189352196

Gene position: 234332-233340 (Counterclockwise)

Preceding gene: 189352201

Following gene: 189352195

Centisome position: 9.47

GC content: 72.41

Gene sequence:

>993_bases
ATGGAGCTGCATCAACTCGAGGCTTTTTCCGCCGTCATGTCGGCCGGCAGCGTGACCGGCGCGGGCGAACTGCTCGGCCG
CTCGCAACCGGCCGTCACGCGGCAGATCCAGGAACTCGAGGCCGACCTCGGCTATGCGCTGTTCGATCGTCACGGCCCGC
GTGTCACGCCGACGCGGCGCGCGTTCCTGCTTTACGAGGAAGTCGAGCGTTCGCTGATCGGGCTGCGCGCGATCGACGCG
CGCGCCCGTGCAATCGGCAGCGAAATCGCTCAACCCGTGCGCATCGCCGCGACGCCCGCGCTCGCGGCCACGATCGTGCC
GGCCGCGCTCGCGGCGCTGCCCGACGACGCGCACGCGCCGCACTACCAGTTGCGCAGCGAATCGGCCGAGCACGTCGTGC
ACGAAGTGCTGGCCGGCACCGCGGACGTCGGCGTCGTCACGCTGCCGATGGCGCATGCGGGGCTCGACGTGCACTGGATC
GCGCAGACGCCCTGCGTCGCGGTGCTGGCCGCCGGCGATCCGCTCGCGGCGAAGCCGCGCATCGCGCTGCGCGATCTCGC
GCGCCGCCGCATCGTCACCGTCGCGAACCGCCATCGACTGCGCCAGCGCATCGACGCGGCATTCGCCGCCGCGCGCGTCG
AGCCGCGCGTCTTCATCGAGACCAATGCGTCGCTCAACGCGGTGATGGCCGCGCGCGCCGGCGTCGGGATCGGCATCGTC
GATCCGGCGACGGGTGTCGCGCTGCCGGTGGACGGCGTCGTCGCGCGGCCGCTCGACGTCGACATTCCGTTCGCGTTCGG
CGTCGCGACGCCGGCCGGCAAGACACGCACGGCGGCCGTCGATGCGCTGCTTGACGCGTTGCATCGCACGACGCGCGCGT
TGTTCGACGATGCGATCTTTCACGACGCGTCCGCACACGATGCGCTGCTGCGCGGCGACCGCCCGCGCACGCGTGCGCGG
GTGCGCAGGCTGCGCCCGGAGGTTTCCGCATGA

Upstream 100 bases:

>100_bases
CGCCCTTCGCATTTTTAGCGCTGTCGATAGCAAAAATCATTATAAGAATTGCGCATGCTCACGCTCCTACAATGCGCAAA
TCGCATCATCGGAACGCGTC

Downstream 100 bases:

>100_bases
CGGCTTTCCGCACCCTTTCGAATAACGAAACGATGGACGAACAATTCGCATGACGACCTCACTCGACGCACTCGAATCGC
GGCTCGCCGAGGATCTGCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MELHQLEAFSAVMSAGSVTGAGELLGRSQPAVTRQIQELEADLGYALFDRHGPRVTPTRRAFLLYEEVERSLIGLRAIDA
RARAIGSEIAQPVRIAATPALAATIVPAALAALPDDAHAPHYQLRSESAEHVVHEVLAGTADVGVVTLPMAHAGLDVHWI
AQTPCVAVLAAGDPLAAKPRIALRDLARRRIVTVANRHRLRQRIDAAFAAARVEPRVFIETNASLNAVMAARAGVGIGIV
DPATGVALPVDGVVARPLDVDIPFAFGVATPAGKTRTAAVDALLDALHRTTRALFDDAIFHDASAHDALLRGDRPRTRAR
VRRLRPEVSA

Sequences:

>Translated_330_residues
MELHQLEAFSAVMSAGSVTGAGELLGRSQPAVTRQIQELEADLGYALFDRHGPRVTPTRRAFLLYEEVERSLIGLRAIDA
RARAIGSEIAQPVRIAATPALAATIVPAALAALPDDAHAPHYQLRSESAEHVVHEVLAGTADVGVVTLPMAHAGLDVHWI
AQTPCVAVLAAGDPLAAKPRIALRDLARRRIVTVANRHRLRQRIDAAFAAARVEPRVFIETNASLNAVMAARAGVGIGIV
DPATGVALPVDGVVARPLDVDIPFAFGVATPAGKTRTAAVDALLDALHRTTRALFDDAIFHDASAHDALLRGDRPRTRAR
VRRLRPEVSA
>Mature_330_residues
MELHQLEAFSAVMSAGSVTGAGELLGRSQPAVTRQIQELEADLGYALFDRHGPRVTPTRRAFLLYEEVERSLIGLRAIDA
RARAIGSEIAQPVRIAATPALAATIVPAALAALPDDAHAPHYQLRSESAEHVVHEVLAGTADVGVVTLPMAHAGLDVHWI
AQTPCVAVLAAGDPLAAKPRIALRDLARRRIVTVANRHRLRQRIDAAFAAARVEPRVFIETNASLNAVMAARAGVGIGIV
DPATGVALPVDGVVARPLDVDIPFAFGVATPAGKTRTAAVDALLDALHRTTRALFDDAIFHDASAHDALLRGDRPRTRAR
VRRLRPEVSA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=285, Percent_Identity=30.5263157894737, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693105, Length=257, Percent_Identity=23.7354085603113, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI157672245, Length=254, Percent_Identity=27.9527559055118, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788481, Length=245, Percent_Identity=27.3469387755102, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=26.7206477732794, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787601, Length=151, Percent_Identity=29.1390728476821, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35091; Mature: 35091

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHQLEAFSAVMSAGSVTGAGELLGRSQPAVTRQIQELEADLGYALFDRHGPRVTPTRR
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCHH
AFLLYEEVERSLIGLRAIDARARAIGSEIAQPVRIAATPALAATIVPAALAALPDDAHAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCC
HYQLRSESAEHVVHEVLAGTADVGVVTLPMAHAGLDVHWIAQTPCVAVLAAGDPLAAKPR
CHHHHCCHHHHHHHHHHHCCCCCCEEEEEHHHCCCCEEEECCCCEEEEEECCCCCCCCCC
IALRDLARRRIVTVANRHRLRQRIDAAFAAARVEPRVFIETNASLNAVMAARAGVGIGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEE
DPATGVALPVDGVVARPLDVDIPFAFGVATPAGKTRTAAVDALLDALHRTTRALFDDAIF
CCCCCCEECCCCEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HDASAHDALLRGDRPRTRARVRRLRPEVSA
CCCCHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MELHQLEAFSAVMSAGSVTGAGELLGRSQPAVTRQIQELEADLGYALFDRHGPRVTPTRR
CCCHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCHH
AFLLYEEVERSLIGLRAIDARARAIGSEIAQPVRIAATPALAATIVPAALAALPDDAHAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCC
HYQLRSESAEHVVHEVLAGTADVGVVTLPMAHAGLDVHWIAQTPCVAVLAAGDPLAAKPR
CHHHHCCHHHHHHHHHHHCCCCCCEEEEEHHHCCCCEEEECCCCEEEEEECCCCCCCCCC
IALRDLARRRIVTVANRHRLRQRIDAAFAAARVEPRVFIETNASLNAVMAARAGVGIGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEE
DPATGVALPVDGVVARPLDVDIPFAFGVATPAGKTRTAAVDALLDALHRTTRALFDDAIF
CCCCCCEECCCCEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HDASAHDALLRGDRPRTRARVRRLRPEVSA
CCCCHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]