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The map label for this gene is groEL [H]

Identifier: 189352050

GI number: 189352050

Start: 67744

End: 69366

Strand: Direct

Name: groEL [H]

Synonym: BMULJ_03267

Alternate gene names: 189352050

Gene position: 67744-69366 (Clockwise)

Preceding gene: 189352049

Following gene: 189352053

Centisome position: 2.74

GC content: 67.22

Gene sequence:

>1623_bases
ATGGCAGCAAAAGACGTGAAGTTCCACGACGGCGCGCGTAGCCGGATCGTGAAGGGCGTGAACGTACTCGCCGATGCGGT
GAAGGTGACGCTGGGCCCGAAGGGCCGCAACGTACTGATCGAGCGCAGCTTCGGCGCGCCGACGATCACGAAGGACGGCG
TGTCGGTCGCGAAGGAAATCGAGCTGAAGGACCGCTTCGAGAACATGGGCGCGCAAGTGGTCAAGCAGGTCGCGTCGAAG
ACGGCCGACGTCGCCGGCGACGGTACGACGACCGCGACCGTGCTCGCGCAGGCGATCGTGCAGGAAGGGATGAAGCACGT
CGCGGCCGGCATCAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCGGTCGGTGCGGTGCTCGACGAGTTGCGCAAGC
TGTCGCGTCCGATCGCGACGAACAAGGAAATCGCGCAGGTCGGCGCGATCTCGGCGAACTCGGACGAGGCGATCGGCAAG
ATCATCGCGGACGCGATGGAGCGCGTCGGCAAGGAAGGCGTGATCACCGTCGAGGACGGCAAGTCGCTCGAGAACGAGCT
CGAAGTCGTCGAAGGGATGCAGTTCGATCGCGGCTACGTGAGCCCGTACTTCATCAACGATCCGGAGAAGCAGGCCGCCT
ATCTCGACGACCCGCTGATCCTGCTGCATGACAAGAAGATCTCGAGCATCCGCGATCTGCTGCCGATCCTCGAGGCCGCC
TCGAAGGCCGGCAAGCCGCTGCTGATCGTCGCCGAGGACGTCGACGGCGAAGCGCTCGCGACGCTCGTCGTCAACGCGAT
GCGCGGCATCCTGAAGGTCGCCGCGGTGAAGGCGCCGGGCTTCGGCGATCGCCGCAAGGCGATGCTCGAGGACATCGCGA
TCCTCACCGGCGCGACCGTCATCTCCGAGGAAACCGGCAAGCAGCTCGAGAAGGCCACGCTCGAGGATCTCGGCCGCGCG
AAGCGCGTCGAGGTGCGCAAGGACGACACGATCATCATCGACGGCGCGGGCGATCCGGCGCGCATCGACGCGCGCGTGAA
GGCAATCCGCGTGCAGATCGACGAAGCGACGAGCGACTACGATCGCGAGAAGCTGCAGGAGCGCGTCGCGAAGCTCGCGG
GCGGCGTCGCGGTGATCAAGGTCGGCGCGGCCACCGAAGTCGAAATGAAGGAGAAGAAGGATCGCGTCGACGATGCGCTG
CATGCGACGCGCGCGGCCGTCGAGGAAGGGATCGTGCCGGGCGGCGGCGTCGCGCTGCTGCGCGCACGCGCGGCGCTCGC
CGACATCAAGGGCGCGAATGCCGACCAGGACGCCGGCATCCGGATCGTGCTGCGCGCGCTCGAAGCGCCGCTGCGCGTGA
TCGTGTCGAACGCCGGCGAAGAGCCGTCGGTCGTGATCGCGAAGGTGCTCGAAGGCAAAGGCAACTTCGGCTACAACGCG
GCGACCGGCGAGTATGGCGATCTCGTCGAAGCGGGTGTCGTCGATCCGACCAAGGTCACGCGCACCGCGCTGCAGAACGC
CGCGTCGATCGCCGGCCTAATCCTGACGACGGACGCGACCGTCGCCGACGCGCCGAAGGACGAAAGCGCGGCGCCGGCGC
CGTCGCCCGCCCTCGACTACTGA

Upstream 100 bases:

>100_bases
CCGCACGCAAGGCGGCCTGATCCCCCGATTCGACCGCGGCGCACGGCGCGCAGTCGGAGCGCGCGGCATTTCGTACAACG
ACATTATCCGGAGCAACAAC

Downstream 100 bases:

>100_bases
GCGGCGGTCTTACCGCCCGGTCTTGACCCGCCGGCCTGTCGCCGGCCGGCGCGGTTCCCGTTCGGCGCACGCGGCGTCAC
ACCCGCGTTGCGCCGTTTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAAKDVKFHDGARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGINPMDLKRGIDKAVGAVLDELRKLSRPIATNKEIAQVGAISANSDEAIGK
IIADAMERVGKEGVITVEDGKSLENELEVVEGMQFDRGYVSPYFINDPEKQAAYLDDPLILLHDKKISSIRDLLPILEAA
SKAGKPLLIVAEDVDGEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAILTGATVISEETGKQLEKATLEDLGRA
KRVEVRKDDTIIIDGAGDPARIDARVKAIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARAALADIKGANADQDAGIRIVLRALEAPLRVIVSNAGEEPSVVIAKVLEGKGNFGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASIAGLILTTDATVADAPKDESAAPAPSPALDY

Sequences:

>Translated_540_residues
MAAKDVKFHDGARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQAIVQEGMKHVAAGINPMDLKRGIDKAVGAVLDELRKLSRPIATNKEIAQVGAISANSDEAIGK
IIADAMERVGKEGVITVEDGKSLENELEVVEGMQFDRGYVSPYFINDPEKQAAYLDDPLILLHDKKISSIRDLLPILEAA
SKAGKPLLIVAEDVDGEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAILTGATVISEETGKQLEKATLEDLGRA
KRVEVRKDDTIIIDGAGDPARIDARVKAIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARAALADIKGANADQDAGIRIVLRALEAPLRVIVSNAGEEPSVVIAKVLEGKGNFGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASIAGLILTTDATVADAPKDESAAPAPSPALDY
>Mature_539_residues
AAKDVKFHDGARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASKT
ADVAGDGTTTATVLAQAIVQEGMKHVAAGINPMDLKRGIDKAVGAVLDELRKLSRPIATNKEIAQVGAISANSDEAIGKI
IADAMERVGKEGVITVEDGKSLENELEVVEGMQFDRGYVSPYFINDPEKQAAYLDDPLILLHDKKISSIRDLLPILEAAS
KAGKPLLIVAEDVDGEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAILTGATVISEETGKQLEKATLEDLGRAK
RVEVRKDDTIIIDGAGDPARIDARVKAIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRARAALADIKGANADQDAGIRIVLRALEAPLRVIVSNAGEEPSVVIAKVLEGKGNFGYNAA
TGEYGDLVEAGVVDPTKVTRTALQNAASIAGLILTTDATVADAPKDESAAPAPSPALDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=54.0796963946869, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=54.0796963946869, Blast_Score=558, Evalue=1e-159,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=73.3962264150943, Blast_Score=777, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=53.5849056603774, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=54.2452830188679, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=560, Percent_Identity=23.0357142857143, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.3726235741445, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322524, Length=566, Percent_Identity=22.6148409893993, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=54.0796963946869, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=54.0796963946869, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=53.1309297912713, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=53.1309297912713, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=53.1309297912713, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=44.7169811320755, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=39.8481973434535, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=39.8481973434535, Blast_Score=358, Evalue=3e-99,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56822; Mature: 56690

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFHDGARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGINPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DKAVGAVLDELRKLSRPIATNKEIAQVGAISANSDEAIGKIIADAMERVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLENELEVVEGMQFDRGYVSPYFINDPEKQAAYLDDPLILLHDKKISSIRDLLPILEAA
CCHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
SKAGKPLLIVAEDVDGEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAILTGATV
HHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLEKATLEDLGRAKRVEVRKDDTIIIDGAGDPARIDARVKAIRVQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHEEEEEEEEECCCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARAALADIKGANADQDAGIRIVLRALEAPLRVIVSNAGEEPSVVIAKVLEGKGNFGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASIAGLILTTDATVADAPKDESAAPAPSPALDY
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKDVKFHDGARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQAIVQEGMKHVAAGINPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DKAVGAVLDELRKLSRPIATNKEIAQVGAISANSDEAIGKIIADAMERVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KSLENELEVVEGMQFDRGYVSPYFINDPEKQAAYLDDPLILLHDKKISSIRDLLPILEAA
CCHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
SKAGKPLLIVAEDVDGEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAILTGATV
HHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLEKATLEDLGRAKRVEVRKDDTIIIDGAGDPARIDARVKAIRVQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHEEEEEEEEECCCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARAALADIKGANADQDAGIRIVLRALEAPLRVIVSNAGEEPSVVIAKVLEGKGNFGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASIAGLILTTDATVADAPKDESAAPAPSPALDY
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA