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The map label for this gene is tdh [H]

Identifier: 189351984

GI number: 189351984

Start: 4945

End: 5973

Strand: Direct

Name: tdh [H]

Synonym: BMULJ_03201

Alternate gene names: 189351984

Gene position: 4945-5973 (Clockwise)

Preceding gene: 189351983

Following gene: 189351985

Centisome position: 0.2

GC content: 63.65

Gene sequence:

>1029_bases
ATGAAAGCACTGGCAAAGCTCGAACGTGCGCCCGGCCTCACGCTCACGCGCGTGAAGCGCCCGGAGGTCGGTCACAACGA
CGTGCTGATCAAGATCCGGCGTACCGCGATCTGCGGCACCGATATCCATATCTGGAAGTGGGACGACTGGGCGCAGAAGA
CGATTCCGGTGCCGATGCATGTCGGCCACGAATATGTCGGCGAGATCGTCGAAATGGGTCAGGAGGTGCGCGGCTTCGCG
ATCGGCGATCGCGTGTCCGGCGAAGGCCACATCACCTGCGGTTTCTGTCGCAACTGCCGCGCCGGGCGCCGTCACCTGTG
CCGCAATACGGTCGGCGTCGGCGTGAACCGCGAAGGCGCGTTCGCGGAGTATCTGGCGATTCCGGCGTTCAACGCATTCA
AGATTCCGCCCGAAATCTCCGACGATCTCGCATCGATCTTCGATCCGTTCGGCAACGCGACGCATACCGCGCTGTCGTTC
AATCTCGTCGGCGAGGACGTGCTGATCACCGGCGCGGGGCCGATCGGAATCATGGCCGTCGCGATCGCGAAGCATGTCGG
CGCGCGCAACGTCGTGATCACCGACATCAACGACTATCGCCTCGAACTCGCGCGCAAGATGGGCGCGACGCGTGCCGTCA
ACGTCGCGCGCGAGTCGCTGCGCGACGTGATGGCCGATCTGCGGATGACCGAAGGCTTCGACGTCGGGCTCGAGATGTCG
GGCGTGCCGAGCGCCTTCACGAGCCTGCTCGAGGCGATGAACCACGGCGGGAAGGTCGCGCTGCTCGGCATTCCGCCCGC
GCAGACGGCGATCGACTGGAACCAGGTGATCTTCAAGGGGCTCGAGATCAAGGGCATCTACGGCCGCGAGATGTTCGAGA
CCTGGTACAAGATGGTCGCGATGCTGCAAAGCGGCCTCGATTTGTCGCCGATCATCACGCACCGCTTTGCCGCCGACGAT
TACGAGAAAGGCTTCGCCGCGATGCTGTCCGGCGAAAGCGGCAAGGTGATTCTCGACTGGACCGTGTGA

Upstream 100 bases:

>100_bases
CAGATGAGCGCCGCACACACGCCGGAACAGATCGACCAGGCCGTCGCCGCGTTCGTGCGCGTCGGCAAGTCGCTCGGCAT
CGTCTGACGGAGGCGCGGCG

Downstream 100 bases:

>100_bases
TCGTCGGACGACACGGAGCGGTATGCGCATCGCTCCGTGTCGCTTGCATCGATCGCCGTTCGGATACGTTGGGCCTGCGT
CCGATTTCGCGCTTAAGGTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKALAKLERAPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLRMTEGFDVGLEMS
GVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAADD
YEKGFAAMLSGESGKVILDWTV

Sequences:

>Translated_342_residues
MKALAKLERAPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLRMTEGFDVGLEMS
GVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAADD
YEKGFAAMLSGESGKVILDWTV
>Mature_342_residues
MKALAKLERAPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFA
IGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSF
NLVGEDVLITGAGPIGIMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLRMTEGFDVGLEMS
GVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAADD
YEKGFAAMLSGESGKVILDWTV

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=341, Percent_Identity=26.6862170087977, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4501929, Length=351, Percent_Identity=25.3561253561254, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI34577061, Length=346, Percent_Identity=26.0115606936416, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI262073058, Length=349, Percent_Identity=26.0744985673352, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71743840, Length=349, Percent_Identity=26.0744985673352, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=25.8522727272727, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=25.7225433526012, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=24.2744063324538, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=77.3529411764706, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI1788075, Length=370, Percent_Identity=30.2702702702703, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788073, Length=332, Percent_Identity=26.8072289156627, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=31.728045325779, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1787863, Length=325, Percent_Identity=28.9230769230769, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI226510992, Length=315, Percent_Identity=28.8888888888889, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=27.6276276276276, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=31.0861423220974, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786825, Length=355, Percent_Identity=27.3239436619718, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790718, Length=309, Percent_Identity=25.5663430420712, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=27.6315789473684, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=29.6407185628743, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=341, Percent_Identity=29.9120234604106, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=287, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=209, Percent_Identity=31.5789473684211, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=277, Percent_Identity=25.6317689530686, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=372, Percent_Identity=26.3440860215054, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=24.9299719887955, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=327, Percent_Identity=29.3577981651376, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=322, Percent_Identity=27.0186335403727, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=307, Percent_Identity=26.7100977198697, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=25.2688172043011, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=294, Percent_Identity=26.8707482993197, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=28.2352941176471, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=26.4204545454545, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=309, Percent_Identity=30.42071197411, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=320, Percent_Identity=29.375, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=301, Percent_Identity=28.2392026578073, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=342, Percent_Identity=26.0233918128655, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=269, Percent_Identity=28.2527881040892, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=25.4545454545455, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=25.776397515528, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=28.328611898017, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221457811, Length=182, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=182, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=182, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37420; Mature: 37420

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLERAPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCEEECCEECCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAV
HHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLRMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
GVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPIITHRFAADDYEKGFAAMLSGESGKVILDWTV
HHHCCCCCCHHHHHHHCCCCHHCCHHEEECCCCCCEEEEEEC
>Mature Secondary Structure
MKALAKLERAPGLTLTRVKRPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMH
CCHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCHHHCCCCCCHH
VGHEYVGEIVEMGQEVRGFAIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGA
CCHHHHHHHHHHHHHHCCEEECCEECCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCC
FAEYLAIPAFNAFKIPPEISDDLASIFDPFGNATHTALSFNLVGEDVLITGAGPIGIMAV
HHHHHHCCCCCCEECCCCCHHHHHHHHCCCCCCEEEEEEEEEECCEEEEECCCHHHHHHH
AIAKHVGARNVVITDINDYRLELARKMGATRAVNVARESLRDVMADLRMTEGFDVGLEMS
HHHHHCCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
GVPSAFTSLLEAMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVA
CCCHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHH
MLQSGLDLSPIITHRFAADDYEKGFAAMLSGESGKVILDWTV
HHHCCCCCCHHHHHHHCCCCHHCCHHEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA