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The map label for this gene is kbl [C]

Identifier: 189351983

GI number: 189351983

Start: 3732

End: 4931

Strand: Direct

Name: kbl [C]

Synonym: BMULJ_03200

Alternate gene names: 189351983

Gene position: 3732-4931 (Clockwise)

Preceding gene: 189351979

Following gene: 189351984

Centisome position: 0.15

GC content: 66.08

Gene sequence:

>1200_bases
ATGCGTGATGCCTTTCTCGCCCAGGTGCGCGGGACACTCGACCAGATCCGCGCGGACGGCTTTTACAAGACCGAGCGCGA
GATCGCGAGTCCCCAAGCGGCCGCCGTGCGGCTCGCCGGCGGCGCCGGTGTGCTGAATTTCTGCGCGAACAACTACCTCG
GTCTCGCGAACGATCCGCGGCTGATCGAGGCAGCGAAGGCGGGGCTCGACCAGGACGGGTTCGGCATGGCGTCGGTGCGC
TTCATCTGCGGTACGCAAACCGTGCACAAGCAGCTCGAAAGCGCACTCGCCGCGTTTCTCGGCACCGAGGACAGCATTCT
CTATTCGAGCTGCTTCGACGCGAACGGCGGCCTGTTCGAGACGCTGCTCGACGAGAACGACGCGGTGATCAGCGACGAGC
TGAACCACGCGAGCATCATCGACGGCATCCGTTTGTGCAAGGCGAAGCGCTACCGCTACCGGAACAACGATCTGGCCGAT
CTCGAGGCGAAGCTGAAGGAAGCCGATGCAGCCGGCGCGCGCCACAAGCTGATCGCGACCGACGGCGTATTCTCGATGGA
CGGCATCATCGCCGATCTGAAAGGCATCTGCGATCTCGCCGATCGCTACGGCGCGCTCGTGATGGTCGACGATTCGCATG
CGGTCGGCTTCATCGGCGCGCACGGCCGCGGCACGCCCGAGCATTGCGGCGTCGAAGGCCGCGTCGACATCATCACCGGT
ACGCTCGGCAAGGCGCTCGGCGGCGCATCGGGCGGCTACGTCGCGGCACGCCCCGAGATCGTCGATTTGCTGCGCCAACG
CTCGCGTCCGTATTTGTTCTCGAATACGCTGACGCCGAGCATTGCCGCTGCGTCGCTGAAAGTGCTCGAACTGCTCGGCA
GCGACGAAGGCGCGCAACTGCGCGAACGCGTGCGCGAGAACGGCGTGCGCTTCCGCGAGCAAATGACCGAGGCCGGCTTC
ACGCTCGTGCCGGGTGCGCATCCGATCATCCCGGTCATGCTCGGCGATGCGCAGCTTGCGTCGAACATGGCCGACAAGCT
GCTCGGCGAAGGCGTCTACGTGATCGGCTTTTCGTTCCCCGTCGTGCCGCGCGGCCGCGCGCGCATCCGCACGCAGATGA
GCGCCGCACACACGCCGGAACAGATCGACCAGGCCGTCGCCGCGTTCGTGCGCGTCGGCAAGTCGCTCGGCATCGTCTGA

Upstream 100 bases:

>100_bases
GGTCAACCGAACGACCGACTATAACAGTAGCAGGCTGTTGCGCGGCGGCCACGAGCCGTTTCTCGCGCTGCGTGCTGCGA
ACCCTGTCAGGAGCTTTGTG

Downstream 100 bases:

>100_bases
CGGAGGCGCGGCGATGAAAGCACTGGCAAAGCTCGAACGTGCGCCCGGCCTCACGCTCACGCGCGTGAAGCGCCCGGAGG
TCGGTCACAACGACGTGCTG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MRDAFLAQVRGTLDQIRADGFYKTEREIASPQAAAVRLAGGAGVLNFCANNYLGLANDPRLIEAAKAGLDQDGFGMASVR
FICGTQTVHKQLESALAAFLGTEDSILYSSCFDANGGLFETLLDENDAVISDELNHASIIDGIRLCKAKRYRYRNNDLAD
LEAKLKEADAAGARHKLIATDGVFSMDGIIADLKGICDLADRYGALVMVDDSHAVGFIGAHGRGTPEHCGVEGRVDIITG
TLGKALGGASGGYVAARPEIVDLLRQRSRPYLFSNTLTPSIAAASLKVLELLGSDEGAQLRERVRENGVRFREQMTEAGF
TLVPGAHPIIPVMLGDAQLASNMADKLLGEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDQAVAAFVRVGKSLGIV

Sequences:

>Translated_399_residues
MRDAFLAQVRGTLDQIRADGFYKTEREIASPQAAAVRLAGGAGVLNFCANNYLGLANDPRLIEAAKAGLDQDGFGMASVR
FICGTQTVHKQLESALAAFLGTEDSILYSSCFDANGGLFETLLDENDAVISDELNHASIIDGIRLCKAKRYRYRNNDLAD
LEAKLKEADAAGARHKLIATDGVFSMDGIIADLKGICDLADRYGALVMVDDSHAVGFIGAHGRGTPEHCGVEGRVDIITG
TLGKALGGASGGYVAARPEIVDLLRQRSRPYLFSNTLTPSIAAASLKVLELLGSDEGAQLRERVRENGVRFREQMTEAGF
TLVPGAHPIIPVMLGDAQLASNMADKLLGEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDQAVAAFVRVGKSLGIV
>Mature_399_residues
MRDAFLAQVRGTLDQIRADGFYKTEREIASPQAAAVRLAGGAGVLNFCANNYLGLANDPRLIEAAKAGLDQDGFGMASVR
FICGTQTVHKQLESALAAFLGTEDSILYSSCFDANGGLFETLLDENDAVISDELNHASIIDGIRLCKAKRYRYRNNDLAD
LEAKLKEADAAGARHKLIATDGVFSMDGIIADLKGICDLADRYGALVMVDDSHAVGFIGAHGRGTPEHCGVEGRVDIITG
TLGKALGGASGGYVAARPEIVDLLRQRSRPYLFSNTLTPSIAAASLKVLELLGSDEGAQLRERVRENGVRFREQMTEAGF
TLVPGAHPIIPVMLGDAQLASNMADKLLGEGVYVIGFSFPVVPRGRARIRTQMSAAHTPEQIDQAVAAFVRVGKSLGIV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=57.9746835443038, Blast_Score=440, Evalue=1e-124,
Organism=Homo sapiens, GI284448556, Length=421, Percent_Identity=54.3942992874109, Blast_Score=430, Evalue=1e-121,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=35.2112676056338, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=35.2112676056338, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=35.2112676056338, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=35.4929577464789, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=35.4929577464789, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=32.0652173913043, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=32.2493224932249, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI5454084, Length=277, Percent_Identity=31.0469314079422, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=69.4235588972431, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=34.0175953079179, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=54.75, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=30.8943089430894, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=360, Percent_Identity=32.5, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=360, Percent_Identity=32.5, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=26.8292682926829, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=26.8292682926829, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=35.4223433242507, Blast_Score=220, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.1630434782609, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=30.2238805970149, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662918, Length=398, Percent_Identity=59.0452261306533, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137420, Length=351, Percent_Identity=34.1880341880342, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=31.1653116531165, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24653280, Length=382, Percent_Identity=26.1780104712042, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653276, Length=382, Percent_Identity=26.1780104712042, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653278, Length=382, Percent_Identity=26.1780104712042, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42549; Mature: 42549

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAFLAQVRGTLDQIRADGFYKTEREIASPQAAAVRLAGGAGVLNFCANNYLGLANDPR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHEEEECCCCHHHHHHHCCCCCCCCCCH
LIEAAKAGLDQDGFGMASVRFICGTQTVHKQLESALAAFLGTEDSILYSSCFDANGGLFE
HHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCHHH
TLLDENDAVISDELNHASIIDGIRLCKAKRYRYRNNDLADLEAKLKEADAAGARHKLIAT
HHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGIIADLKGICDLADRYGALVMVDDSHAVGFIGAHGRGTPEHCGVEGRVDIITG
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHHCCCCCEEEEEEC
TLGKALGGASGGYVAARPEIVDLLRQRSRPYLFSNTLTPSIAAASLKVLELLGSDEGAQL
HHHHHHCCCCCCEEEECHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHH
RERVRENGVRFREQMTEAGFTLVPGAHPIIPVMLGDAQLASNMADKLLGEGVYVIGFSFP
HHHHHHCCHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTPEQIDQAVAAFVRVGKSLGIV
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDAFLAQVRGTLDQIRADGFYKTEREIASPQAAAVRLAGGAGVLNFCANNYLGLANDPR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHEEEECCCCHHHHHHHCCCCCCCCCCH
LIEAAKAGLDQDGFGMASVRFICGTQTVHKQLESALAAFLGTEDSILYSSCFDANGGLFE
HHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCHHH
TLLDENDAVISDELNHASIIDGIRLCKAKRYRYRNNDLADLEAKLKEADAAGARHKLIAT
HHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGIIADLKGICDLADRYGALVMVDDSHAVGFIGAHGRGTPEHCGVEGRVDIITG
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHHCCCCCEEEEEEC
TLGKALGGASGGYVAARPEIVDLLRQRSRPYLFSNTLTPSIAAASLKVLELLGSDEGAQL
HHHHHHCCCCCCEEEECHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHH
RERVRENGVRFREQMTEAGFTLVPGAHPIIPVMLGDAQLASNMADKLLGEGVYVIGFSFP
HHHHHHCCHHHHHHHHHCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGRARIRTQMSAAHTPEQIDQAVAAFVRVGKSLGIV
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]