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The map label for this gene is uppS [H]

Identifier: 189184298

GI number: 189184298

Start: 1418449

End: 1419144

Strand: Reverse

Name: uppS [H]

Synonym: OTT_1391

Alternate gene names: 189184298

Gene position: 1419144-1418449 (Counterclockwise)

Preceding gene: 189184300

Following gene: 189184297

Centisome position: 70.64

GC content: 30.46

Gene sequence:

>696_bases
ATGTCAATTAAACATCTAGCCATAATAATGGATGGTAACCTTAGGTGGGCTATGGCTAATCAGTTGACAATGTTTGATGG
ATACAATAAAGGAGTGGAAGTAGCTAAAAAAGTAGTCGATTGCGCTATAAAGAAAAAAATTCAACATTTAACTTTATTTG
CATTTTCTATGGAAAATTGGAACCGATCGCAGTTAGAGATTAATTATTTACAAGCATTAATGCAATCATATTTGGAATCA
GATGCTAGAAATTACTGCGAATATGGCGTCAAATTTACTGTAATAGGGGATACAACAAAATTAAATTTTGAGTTACAAAA
GGTTATTAAAGAAGTGGAAGAGTTAACTATTAACAATTCTGTCTTAAATTTATACATAGCTTTTAGTTATAGTGGACGTT
CTGAAATCATTGATGCTTATAAAAGGATTGTAAGTTCTAACATTAAGGCTGAAGAGTTAACTGAACAAGAATTTAGAAAG
TATCTATATTCTCCAACTATGCCTGATATTGATTTACTAATTCGTACCAGTGGAGAGCAAAGAATTAGCAATTTCTTATT
GTGGCATTTAGCATATAGTGAGTTATACTTTATTGATAAATATTGGCCTGATTTTGATGAAGCTGATTTTAATATAGCTT
TGGAAGATTATTTAAGACGTAAGCGTACCTTTGGACTATCAAGAAAAGTGAATTAA

Upstream 100 bases:

>100_bases
TTAAAAAAATAATATGAATATTTGCAATAAAATTAAAATTCTTATTAATTGTTTGGTATATGAATGTTGACTATTAATAA
AAGTTGTTTAGGAGTTTAAA

Downstream 100 bases:

>100_bases
ATATGAGTACAACACAAAATCAACTAAGGCTTTTATCAGGTATAGTAATTGCTATGTTATTCTTATCAAGCCTATTATAT
ATTAGATTTTTATTTTATAT

Product: UPP synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSIKHLAIIMDGNLRWAMANQLTMFDGYNKGVEVAKKVVDCAIKKKIQHLTLFAFSMENWNRSQLEINYLQALMQSYLES
DARNYCEYGVKFTVIGDTTKLNFELQKVIKEVEELTINNSVLNLYIAFSYSGRSEIIDAYKRIVSSNIKAEELTEQEFRK
YLYSPTMPDIDLLIRTSGEQRISNFLLWHLAYSELYFIDKYWPDFDEADFNIALEDYLRRKRTFGLSRKVN

Sequences:

>Translated_231_residues
MSIKHLAIIMDGNLRWAMANQLTMFDGYNKGVEVAKKVVDCAIKKKIQHLTLFAFSMENWNRSQLEINYLQALMQSYLES
DARNYCEYGVKFTVIGDTTKLNFELQKVIKEVEELTINNSVLNLYIAFSYSGRSEIIDAYKRIVSSNIKAEELTEQEFRK
YLYSPTMPDIDLLIRTSGEQRISNFLLWHLAYSELYFIDKYWPDFDEADFNIALEDYLRRKRTFGLSRKVN
>Mature_230_residues
SIKHLAIIMDGNLRWAMANQLTMFDGYNKGVEVAKKVVDCAIKKKIQHLTLFAFSMENWNRSQLEINYLQALMQSYLESD
ARNYCEYGVKFTVIGDTTKLNFELQKVIKEVEELTINNSVLNLYIAFSYSGRSEIIDAYKRIVSSNIKAEELTEQEFRKY
LYSPTMPDIDLLIRTSGEQRISNFLLWHLAYSELYFIDKYWPDFDEADFNIALEDYLRRKRTFGLSRKVN

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=209, Percent_Identity=33.0143540669856, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI45580742, Length=209, Percent_Identity=33.0143540669856, Blast_Score=117, Evalue=7e-27,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=39.9122807017544, Blast_Score=187, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=31.924882629108, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319474, Length=207, Percent_Identity=32.3671497584541, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=211, Percent_Identity=29.8578199052133, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27176; Mature: 27045

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKHLAIIMDGNLRWAMANQLTMFDGYNKGVEVAKKVVDCAIKKKIQHLTLFAFSMENW
CCCEEEEEEEECCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
NRSQLEINYLQALMQSYLESDARNYCEYGVKFTVIGDTTKLNFELQKVIKEVEELTINNS
CCHHEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHHHHHHCCCC
VLNLYIAFSYSGRSEIIDAYKRIVSSNIKAEELTEQEFRKYLYSPTMPDIDLLIRTSGEQ
EEEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
RISNFLLWHLAYSELYFIDKYWPDFDEADFNIALEDYLRRKRTFGLSRKVN
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIKHLAIIMDGNLRWAMANQLTMFDGYNKGVEVAKKVVDCAIKKKIQHLTLFAFSMENW
CCEEEEEEEECCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
NRSQLEINYLQALMQSYLESDARNYCEYGVKFTVIGDTTKLNFELQKVIKEVEELTINNS
CCHHEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEECHHHHHHHHHHHHHHCCCC
VLNLYIAFSYSGRSEIIDAYKRIVSSNIKAEELTEQEFRKYLYSPTMPDIDLLIRTSGEQ
EEEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
RISNFLLWHLAYSELYFIDKYWPDFDEADFNIALEDYLRRKRTFGLSRKVN
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]