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The map label for this gene is degP [H]

Identifier: 189184226

GI number: 189184226

Start: 1336788

End: 1338188

Strand: Direct

Name: degP [H]

Synonym: OTT_1319

Alternate gene names: 189184226

Gene position: 1336788-1338188 (Clockwise)

Preceding gene: 189184225

Following gene: 189184227

Centisome position: 66.54

GC content: 30.55

Gene sequence:

>1401_bases
ATGAAAAAGGCATTTTATTTACATTTGATAGTATTTGCATTACAAGGTATAAGTAATGTTCATTCTAAATCTCTACTAAA
TCAAAAGGCAGTATTACCTCAACAAAAATCTGATATGCATATTAATGTAAATAGTTTATCCGATATAGTTGAGCCATTAA
TATCTACAGTAGTAAGTATTTATGCTGTAGATACTAACATTGGAATTAGTTTAAATAATAAGGTATCTAAGTATCAACAA
GAAGTGTTCTTAGGTTCTGGGGTTATCATTGATAGTTCTGGATATATTGTTACTAATGAGAATGTTATAGCGGGAGCTGA
AAATATAAAAGTAAAGTTGCATGATGGTTCAGAACTGATAGCAGAATTAGTTGGCAGTGACAATAAAATTAATATAGCTT
TATTAAAAATTAATTCTTCAGCAGCATTATCTTATGCTACTTTTGGCGATTCAAATCAGTCTAGAGTAGGAGATCAGGTT
ATTGCAATAGGTAGTCCTTTCGGTTTAAGAGGAACAGTAACAAATGGCATTATTTCTTCTAAAGGACGAGATATGGGTAA
CGGCATAGTAACTGATTTTATTCAAACTAATGCTGCTATTCATATGGGTAGCTTTGGTGGACCGATGTTTAATCTTGAAG
GAAAAATTATTGGAATTAATTCTATTCATGTATCTTACTCAGGCATAAGTTTTGCTATTCCATCTAATACTGTACTTGAA
GCAGTTGAATGCTTAAAAAAAGGAGAAAAAATTCGTCGTGGTATGTTAAATGTTATGCTTAATGAATTAACTCCAGAATT
AAATGAGAATTTAGGACTTAAAAAAGATCAAAATGGAGTTCTAATAACTGAAGTTATAAAAGAAGGATCTGCAGCACAAT
GTGGAATTGCTCCTGGAGATGTAATTACTAAATTTCATGATAAAGAGATCAAAACAGGAAGAGATTTACAGGTAGCTGTA
TCTTCAACTATGCTTAATTCTGAAAGAGAAGTTGAGCTTTTACGTAATGGTAAGTCTATGACTCTAAAATGTAAAATTAT
TGCCAACAAAGGTGAGGATAGTGAGCAACAAAGTAATGATCAAAGCCTTGTGGTTAATGGTGTAAAATTTATTGATCTTA
CACCTGATTTAGTGAAGAAATATAATATTACTTCAGCTAATAATAATGGGTTATTTGTCCTTGAAGTTTCGCCTAACTCT
TCTTGGGGAAGATATGGTTTAAAAATGGGGCTAAGACCTAGAGATATAATTTTATCAGTTAAACGTGATGATAATAAAAA
AGATATTTCTGTTAAAACACTAAGAGAAATAGTGACAAATATAAAGCATAATGAAATTTTCTTTACAGTGCAAAGAGGAG
ATAGAATGCTTTACATTGCTTTACCTAATATTAATAAGTAA

Upstream 100 bases:

>100_bases
AAGTGCTAAGAAAGGATGATACTTCTTTTGTATTATCTCCTAATAGTGAATTGTTTAAGTTTTTGAATTTAAGTAACAAT
TAATATTAAAGGTTAAGTTT

Downstream 100 bases:

>100_bases
ATCTAGTTTAAAGGCGATTTTAAAAAAAATTGCCTTTAAATATCAATTGTTAATTTAAAAGTTAAATATTAAGTTTAGAA
GTAATTAGCTTAGTATTTAG

Product: 47 kDa protein (periplasmic serine protease)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKKAFYLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHINVNSLSDIVEPLISTVVSIYAVDTNIGISLNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDNKINIALLKINSSAALSYATFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAIHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVELLRNGKSMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFIDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLRPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK

Sequences:

>Translated_466_residues
MKKAFYLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHINVNSLSDIVEPLISTVVSIYAVDTNIGISLNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDNKINIALLKINSSAALSYATFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAIHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVELLRNGKSMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFIDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLRPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
>Mature_466_residues
MKKAFYLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHINVNSLSDIVEPLISTVVSIYAVDTNIGISLNNKVSKYQQ
EVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELIAELVGSDNKINIALLKINSSAALSYATFGDSNQSRVGDQV
IAIGSPFGLRGTVTNGIISSKGRDMGNGIVTDFIQTNAAIHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGDVITKFHDKEIKTGRDLQVAV
SSTMLNSEREVELLRNGKSMTLKCKIIANKGEDSEQQSNDQSLVVNGVKFIDLTPDLVKKYNITSANNNGLFVLEVSPNS
SWGRYGLKMGLRPRDIILSVKRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=317, Percent_Identity=34.0694006309148, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=31.9488817891374, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=34.5890410958904, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI24308541, Length=261, Percent_Identity=36.7816091954023, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1786356, Length=387, Percent_Identity=35.1421188630491, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789629, Length=453, Percent_Identity=30.242825607064, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI1789630, Length=300, Percent_Identity=34.6666666666667, Blast_Score=141, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646839, Length=279, Percent_Identity=36.5591397849462, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50759; Mature: 50759

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAFYLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHINVNSLSDIVEPLISTVVSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEE
YAVDTNIGISLNNKVSKYQQEVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELI
EEEECCCCEEECCHHHHHHHHHHCCCCEEECCCCEEEECCCEEECCCEEEEEEECCHHHH
AELVGSDNKINIALLKINSSAALSYATFGDSNQSRVGDQVIAIGSPFGLRGTVTNGIISS
HHHHCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCEEECCCEECC
KGRDMGNGIVTDFIQTNAAIHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEEEECCEEEECCCHHHHH
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGD
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCH
VITKFHDKEIKTGRDLQVAVSSTMLNSEREVELLRNGKSMTLKCKIIANKGEDSEQQSND
HHHHCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCC
QSLVVNGVKFIDLTPDLVKKYNITSANNNGLFVLEVSPNSSWGRYGLKMGLRPRDIILSV
CEEEEECEEEEECCHHHHHHEECCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHEEEEE
KRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
ECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MKKAFYLHLIVFALQGISNVHSKSLLNQKAVLPQQKSDMHINVNSLSDIVEPLISTVVSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHEE
YAVDTNIGISLNNKVSKYQQEVFLGSGVIIDSSGYIVTNENVIAGAENIKVKLHDGSELI
EEEECCCCEEECCHHHHHHHHHHCCCCEEECCCCEEEECCCEEECCCEEEEEEECCHHHH
AELVGSDNKINIALLKINSSAALSYATFGDSNQSRVGDQVIAIGSPFGLRGTVTNGIISS
HHHHCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCEEECCCEECC
KGRDMGNGIVTDFIQTNAAIHMGSFGGPMFNLEGKIIGINSIHVSYSGISFAIPSNTVLE
CCCCCCCCHHHHHHHCCCEEEECCCCCCEEECCCEEEEEEEEEEEECCEEEECCCHHHHH
AVECLKKGEKIRRGMLNVMLNELTPELNENLGLKKDQNGVLITEVIKEGSAAQCGIAPGD
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCH
VITKFHDKEIKTGRDLQVAVSSTMLNSEREVELLRNGKSMTLKCKIIANKGEDSEQQSND
HHHHCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCC
QSLVVNGVKFIDLTPDLVKKYNITSANNNGLFVLEVSPNSSWGRYGLKMGLRPRDIILSV
CEEEEECEEEEECCHHHHHHEECCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHEEEEE
KRDDNKKDISVKTLREIVTNIKHNEIFFTVQRGDRMLYIALPNINK
ECCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893; 9274032 [H]