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The map label for this gene is hflC [H]

Identifier: 189184225

GI number: 189184225

Start: 1335904

End: 1336770

Strand: Direct

Name: hflC [H]

Synonym: OTT_1318

Alternate gene names: 189184225

Gene position: 1335904-1336770 (Clockwise)

Preceding gene: 189184224

Following gene: 189184226

Centisome position: 66.5

GC content: 31.14

Gene sequence:

>867_bases
ATGACGATAAAAAAAGTGTACTTAACAATTGTTATAGCTGTTGTAGCAGTACTAGCGATATTTAATTCTGTGTTTCAGGT
TATGCAGAATCAGTATGCAGTAGTTTTTCAATTTGGAGAAGCAGTAAAGGTTATTTCAGAGCCAGGATTAAGGTTTAAGG
TACCATTTGTTCAAAATGTATTATATTTTGATAAAAGGTTAGTTTCTGTTGAAGTATCAGCTAAAGAATTAACAGCAGCA
GATGGTAAGAGAGTAATTGTTAATGCATTTGCTAAATTTAAGATTATTGACCCTATTACTTTTTTTAAAACAGTATATAA
TCATAATGGAGTAAAAATTAGATTAAATAAAACTATTGAGTCTGCAATGCGCAAAGTTATTGGAAGAGCTACTTTTATTA
CTTTGTTGTCTAAGCAAAGATCAGAAATTATGTCTGATATTTATGATTTAGTAAATAAAGAGGGTAAATCATTTGGAGTA
GATGTAATTGACGTAAGGATTTCAAGAACTGATCTGCCAAAGGAGAATAGTGCTGCAATTTATCAAAGAATGCAGACAGA
GAGAGAAAAAGAAGCTAAGCAGATTAGAGCTGAAGGAAAGGAGGAGGCTGTGAGAATAATATCAAGAGCTGATAAAGAAT
GCGATATTATTTTAGCAGAAGCATATAAACAGGCCAAGATATTGGAAGGGGAAGGGGATGCTGAGGCTTCTCATATATAC
AATAGTGTATATAGTCAAGATCCAGAGTTTTATCGGTTTTACCAATCATTATTAACTTATTCTAAAGTGCTAAGAAAGGA
TGATACTTCTTTTGTATTATCTCCTAATAGTGAATTGTTTAAGTTTTTGAATTTAAGTAACAATTAA

Upstream 100 bases:

>100_bases
TATTACAAGGTAGCAAAAAAATTATTATAAGCGATGAGAGTAAATTATTGCCTCATATGGGTATATCGCTTAAATAAATA
TAAGTAGTAAGGTTTAAATC

Downstream 100 bases:

>100_bases
TATTAAAGGTTAAGTTTATGAAAAAGGCATTTTATTTACATTTGATAGTATTTGCATTACAAGGTATAAGTAATGTTCAT
TCTAAATCTCTACTAAATCA

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTIKKVYLTIVIAVVAVLAIFNSVFQVMQNQYAVVFQFGEAVKVISEPGLRFKVPFVQNVLYFDKRLVSVEVSAKELTAA
DGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKIRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGV
DVIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSELFKFLNLSNN

Sequences:

>Translated_288_residues
MTIKKVYLTIVIAVVAVLAIFNSVFQVMQNQYAVVFQFGEAVKVISEPGLRFKVPFVQNVLYFDKRLVSVEVSAKELTAA
DGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKIRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGV
DVIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSELFKFLNLSNN
>Mature_287_residues
TIKKVYLTIVIAVVAVLAIFNSVFQVMQNQYAVVFQFGEAVKVISEPGLRFKVPFVQNVLYFDKRLVSVEVSAKELTAAD
GKRVIVNAFAKFKIIDPITFFKTVYNHNGVKIRLNKTIESAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVD
VIDVRISRTDLPKENSAAIYQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIYN
SVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSELFKFLNLSNN

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=314, Percent_Identity=28.9808917197452, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786697, Length=228, Percent_Identity=26.3157894736842, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209764, Length=195, Percent_Identity=29.2307692307692, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17569493, Length=183, Percent_Identity=29.5081967213115, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32564147, Length=220, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32844; Mature: 32713

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKKVYLTIVIAVVAVLAIFNSVFQVMQNQYAVVFQFGEAVKVISEPGLRFKVPFVQNV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHCCCCCEEECHHHHHH
LYFDKRLVSVEVSAKELTAADGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKIRLNKTIE
HHHHHHHEEEEECHHHHHHCCCCEEEEEHHHHHEEECHHHHHHHHHCCCCEEEEECHHHH
SAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVDVIDVRISRTDLPKENSAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHH
YQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHHHHH
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSELFKFLNLSNN
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCC
>Mature Secondary Structure 
TIKKVYLTIVIAVVAVLAIFNSVFQVMQNQYAVVFQFGEAVKVISEPGLRFKVPFVQNV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHCCCCCEEECHHHHHH
LYFDKRLVSVEVSAKELTAADGKRVIVNAFAKFKIIDPITFFKTVYNHNGVKIRLNKTIE
HHHHHHHEEEEECHHHHHHCCCCEEEEEHHHHHEEECHHHHHHHHHCCCCEEEEECHHHH
SAMRKVIGRATFITLLSKQRSEIMSDIYDLVNKEGKSFGVDVIDVRISRTDLPKENSAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHH
YQRMQTEREKEAKQIRAEGKEEAVRIISRADKECDIILAEAYKQAKILEGEGDAEASHIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHHHHH
NSVYSQDPEFYRFYQSLLTYSKVLRKDDTSFVLSPNSELFKFLNLSNN
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]