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The map label for this gene is hemA [H]

Identifier: 189183979

GI number: 189183979

Start: 1100020

End: 1101231

Strand: Direct

Name: hemA [H]

Synonym: OTT_1072

Alternate gene names: 189183979

Gene position: 1100020-1101231 (Clockwise)

Preceding gene: 189183978

Following gene: 189183981

Centisome position: 54.75

GC content: 30.28

Gene sequence:

>1212_bases
ATGGTAAGTTATAATAATTTTTTTGATAATCACTTACATAGCATAAAATTAGAAGGAAGATATAGAAAATTTACTTGTAT
TAAAAAATCTGCTAAGTGTTTTCCTTATAATATTTGTGCACAAACAGGGAAAAAAGTTCTAATATGGTGTACTAATGATT
ATTTAGGAATGAGTTTTCATCCTGAAGTTTTATCATCAGCAGTTTTAGCAGTAAAACAAATGGGAGTAGGGGCTGGTGGA
ACTAGAAATATTGGTGGTAATAATAGTGCTATAGTTGAGCTTGAAGAGTTATTAGCGATATTACATAAAAAACAGAAAGC
TTTAGTATTTACTTCTGGGTATGTTGCAAACGATACAACTTTACAAACTCTAGCTAAAATTATTCCTGGTTTGGTATTTA
TTTCTGATGAATATAATCATGCATCCATAATTGCAGGTATTAGAAATTCAAGAGCAGAAAAACATATTTATTTCCATAAT
AATATGCAATCTTTACAACAAATTTTATCATCTATACCAATAAATCAGCCAAAAATTATTGTATTTGAAGCAATTTATTC
TATGAGTGGGACTATTGCCGACGTAAAAGGGATTTGTAATTTAGCTAAGATGTATAATGCATTAACATATATTGATGAAG
TGCATAGCGTTGGATTGTATGGAGATGATGGCTCTGGGATATGTACATTAACTGGTTTATTTAACCAAGTTGATATTATA
CAAGGTAATTTGGCTAAAGCTTATGGAGCAATTGGAGGATATATTGCGGCCAATAGTAATATCATTGATGCTATTAGGTC
AACAGCATCAGGGTTTATTTTTACAACTGCTTTACCTCCAGTAATTAGTTGTGCAGCTATGACTAGTATAAGATATTTAA
TGAAGTCTAATAAAGAAAGGCTTAAACTTCACGAAACTGTATCTAAGTTAAAGGATAGTTTATCAAATGCTGGAATAAGA
TATTTGACTAATAATAGTCATATTATAGCTATAGTTATTGGTGAGCCAGTATTAACGCAGAGACTTGCTCAAATCTTATT
AGAGGAGTATAATATATACATTCAAGCTATTAACTTTCCAACAGTGCCAAGAGGTACAGAAAGATTGAGAATTACTCCTA
CTCCATTTCATACTGATGAAATGATACATAATTTAACAGTAGCTTTAAAACAGGTATTATTAAATCTTAATATATCTGCA
GCATTGGGCTAA

Upstream 100 bases:

>100_bases
TCCTAGTGATCGTTTTGCTTATTTAAAAGAACAAGCTCAAGATTATTGCTTTATTTTAAGTTTGCTAGCAGATTAGAAGA
TGCAATTTATTTAATATAAG

Downstream 100 bases:

>100_bases
TATGGCTTTTTATTTATAATTGAAGTTATTTAACTTATAAGTATCTATTATTGTTTGACATACAATTTTGATTATAATAG
CCAGCGGAATAGCCAAAAAT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MVSYNNFFDNHLHSIKLEGRYRKFTCIKKSAKCFPYNICAQTGKKVLIWCTNDYLGMSFHPEVLSSAVLAVKQMGVGAGG
TRNIGGNNSAIVELEELLAILHKKQKALVFTSGYVANDTTLQTLAKIIPGLVFISDEYNHASIIAGIRNSRAEKHIYFHN
NMQSLQQILSSIPINQPKIIVFEAIYSMSGTIADVKGICNLAKMYNALTYIDEVHSVGLYGDDGSGICTLTGLFNQVDII
QGNLAKAYGAIGGYIAANSNIIDAIRSTASGFIFTTALPPVISCAAMTSIRYLMKSNKERLKLHETVSKLKDSLSNAGIR
YLTNNSHIIAIVIGEPVLTQRLAQILLEEYNIYIQAINFPTVPRGTERLRITPTPFHTDEMIHNLTVALKQVLLNLNISA
ALG

Sequences:

>Translated_403_residues
MVSYNNFFDNHLHSIKLEGRYRKFTCIKKSAKCFPYNICAQTGKKVLIWCTNDYLGMSFHPEVLSSAVLAVKQMGVGAGG
TRNIGGNNSAIVELEELLAILHKKQKALVFTSGYVANDTTLQTLAKIIPGLVFISDEYNHASIIAGIRNSRAEKHIYFHN
NMQSLQQILSSIPINQPKIIVFEAIYSMSGTIADVKGICNLAKMYNALTYIDEVHSVGLYGDDGSGICTLTGLFNQVDII
QGNLAKAYGAIGGYIAANSNIIDAIRSTASGFIFTTALPPVISCAAMTSIRYLMKSNKERLKLHETVSKLKDSLSNAGIR
YLTNNSHIIAIVIGEPVLTQRLAQILLEEYNIYIQAINFPTVPRGTERLRITPTPFHTDEMIHNLTVALKQVLLNLNISA
ALG
>Mature_403_residues
MVSYNNFFDNHLHSIKLEGRYRKFTCIKKSAKCFPYNICAQTGKKVLIWCTNDYLGMSFHPEVLSSAVLAVKQMGVGAGG
TRNIGGNNSAIVELEELLAILHKKQKALVFTSGYVANDTTLQTLAKIIPGLVFISDEYNHASIIAGIRNSRAEKHIYFHN
NMQSLQQILSSIPINQPKIIVFEAIYSMSGTIADVKGICNLAKMYNALTYIDEVHSVGLYGDDGSGICTLTGLFNQVDII
QGNLAKAYGAIGGYIAANSNIIDAIRSTASGFIFTTALPPVISCAAMTSIRYLMKSNKERLKLHETVSKLKDSLSNAGIR
YLTNNSHIIAIVIGEPVLTQRLAQILLEEYNIYIQAINFPTVPRGTERLRITPTPFHTDEMIHNLTVALKQVLLNLNISA
ALG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=393, Percent_Identity=43.2569974554707, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI83977444, Length=393, Percent_Identity=43.2569974554707, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI83977440, Length=393, Percent_Identity=43.2569974554707, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI4502025, Length=404, Percent_Identity=44.3069306930693, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI40316939, Length=404, Percent_Identity=44.3069306930693, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=29.7709923664122, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=32.183908045977, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=30.7901907356948, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI119220554, Length=386, Percent_Identity=28.7564766839378, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5454084, Length=254, Percent_Identity=27.9527559055118, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=30.4568527918782, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=26.7441860465116, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71994529, Length=358, Percent_Identity=31.8435754189944, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=372, Percent_Identity=30.1075268817204, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=372, Percent_Identity=30.1075268817204, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=28.1420765027322, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=293, Percent_Identity=24.9146757679181, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=293, Percent_Identity=24.9146757679181, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=43.3014354066986, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320267, Length=369, Percent_Identity=28.7262872628726, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=26.6903914590747, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=45.273631840796, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=29.3296089385475, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17136286, Length=336, Percent_Identity=29.7619047619048, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653280, Length=272, Percent_Identity=26.8382352941176, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653276, Length=272, Percent_Identity=26.8382352941176, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24653278, Length=272, Percent_Identity=26.8382352941176, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44261; Mature: 44261

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSYNNFFDNHLHSIKLEGRYRKFTCIKKSAKCFPYNICAQTGKKVLIWCTNDYLGMSFH
CCCCCCHHHCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHCCCEEEEEEECCCCCCEEC
PEVLSSAVLAVKQMGVGAGGTRNIGGNNSAIVELEELLAILHKKQKALVFTSGYVANDTT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCEECCCHH
LQTLAKIIPGLVFISDEYNHASIIAGIRNSRAEKHIYFHNNMQSLQQILSSIPINQPKII
HHHHHHHHCCEEEEECCCCCHHHEEEHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCEE
VFEAIYSMSGTIADVKGICNLAKMYNALTYIDEVHSVGLYGDDGSGICTLTGLFNQVDII
EEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEHHHCHHHHH
QGNLAKAYGAIGGYIAANSNIIDAIRSTASGFIFTTALPPVISCAAMTSIRYLMKSNKER
CCCHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHH
LKLHETVSKLKDSLSNAGIRYLTNNSHIIAIVIGEPVLTQRLAQILLEEYNIYIQAINFP
HHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCC
TVPRGTERLRITPTPFHTDEMIHNLTVALKQVLLNLNISAALG
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MVSYNNFFDNHLHSIKLEGRYRKFTCIKKSAKCFPYNICAQTGKKVLIWCTNDYLGMSFH
CCCCCCHHHCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHCCCEEEEEEECCCCCCEEC
PEVLSSAVLAVKQMGVGAGGTRNIGGNNSAIVELEELLAILHKKQKALVFTSGYVANDTT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCEECCCHH
LQTLAKIIPGLVFISDEYNHASIIAGIRNSRAEKHIYFHNNMQSLQQILSSIPINQPKII
HHHHHHHHCCEEEEECCCCCHHHEEEHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCEE
VFEAIYSMSGTIADVKGICNLAKMYNALTYIDEVHSVGLYGDDGSGICTLTGLFNQVDII
EEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEHHHCHHHHH
QGNLAKAYGAIGGYIAANSNIIDAIRSTASGFIFTTALPPVISCAAMTSIRYLMKSNKER
CCCHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCHHH
LKLHETVSKLKDSLSNAGIRYLTNNSHIIAIVIGEPVLTQRLAQILLEEYNIYIQAINFP
HHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCC
TVPRGTERLRITPTPFHTDEMIHNLTVALKQVLLNLNISAALG
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA