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The map label for this gene is mutL [H]

Identifier: 189183683

GI number: 189183683

Start: 815544

End: 817586

Strand: Direct

Name: mutL [H]

Synonym: OTT_0776

Alternate gene names: 189183683

Gene position: 815544-817586 (Clockwise)

Preceding gene: 189183682

Following gene: 189183684

Centisome position: 40.59

GC content: 30.79

Gene sequence:

>2043_bases
ATGGGTGTAATAAAATATTTGTCTGATACTACTATAAACCGTATAGCTGCTGGAGAGGTAGTAGAGCGTCCTGCTTCTGT
TGTTAAAGAACTAGTTGAGAATTCAATTGACTCAGGAGCAATGAAAGTTGATATTACACTGGAAAAATCTGGCAAGAATT
TAATTATAGTTTCAGATAATGGCTGCGGTATGTCTGCAGAAGATTTAGAAACTGCAATTGAACGTCATACTACTTCGAAG
TTAAATGAAAATGATATTATGAATATTAATACTTTTGGATTTCGAGGTGAAGCTTTGCCTTCAATTGCTTCTGTTAGTAG
AATGCGCATTGTAACTAAATCTAAACTTCATGATCAAGCTTATGAAATTAATGTTCATGGTGGTGTTAAAACTAAAATAA
ATTCGTTACCTCAATTGCAGCTAACAGGAACTAAAATAGAAGTAAGAGACCTTTTTTTTGCTACTCCAGCTAGATTAAAA
TTTTTACGGTCTGATCGTACTGAATATATAGTGTGTTATGATGTAGTAAAAAGATTAGCAATTTCTTATCCTCATATTGC
ATTTTCATTAGTACATGATGATAAGACTATTTTAAAACTTAAAGCAAGTTCTCAATTATCTTTTGATGATGCTAGAAAAT
CTAGAATATCTGAGATATTATCAAAAAATTTTATTGATAATGCAATATCAATAGGCATAGAAAGAGATGAATTATCTATT
ACTGGCTTTGTTAGTGTTCCAACATATAATAAGGCTTCAGCTGAAGATCAATTATTATTTGTTAATAATCGTCCAGTAAA
AGATAAGCTGTTAATGACAGCAATCAGATTAGCATATCAAGGAGTATTAGCTCGTGAAAGATATCCAGTAGTTGTAATTT
TTATTAGCGTTGCTCCTCATTTTGTTGATGTTAATGTTCATCCTACTAAAAGTGAAGTGAGGTTTCATGACTCTAGTTTA
GTTAGAGGCATTATAATTAGTGCTATTAAACAAGCATTATTGAATACATCTCAGTTGGTTTCATCGATAGCTGCAAGTGA
TGCAAATAAATATATGAAACCTCAATATGATACTGATATATCTGAAAAACTAGAATTAAGTAAAGATATAAAAAATATTC
AGCAGTTTCCATTACAAGAACTAGTAAATAATTTTAGCAAGGATTTTAATGTAAATTTGAAATCTGAATTTCAAGATATT
CAAGCAAACAATTTAGTCAGTGATAACGAGCAGCAGAAAATAGAGTCAACAACAGAGAATATAAAATCTTTTTCTGCATT
TAATCAATTAGGTGGTAATACAGAGTCAAATCAGCATATGAGTATTTTGGATGATGATAAGACCAAAGATGATATAATTG
CTCGTAACATAGCTACTAATGAGAAAGTAGATGTTAATAAGCAGGAAAATATACAGAAATTAAATGATAGTTTCTGTAAT
AATTTTGGAGATAGTTATCAACTGCCTTTAGGATTAGCTTGTGCTCAATTTCATGGTAATTATATTCTTGCTCAAACTGT
AGATAGCTTAATAATTGTAGATCAGCATGCAGCTCATGAAAGGATAACTTATGAGAATTTACGTTCTCAATTTCAGGCAG
GACAAATTATCAGACAGCGATTGTTGATGCCGCAAGTTGTTATTTTGCCTGATATTGTTAGAGTAGAAAAATTATGTGAT
AAAATGCAAGAAATTCTAGCATTAGGTATGGGGTTTGAACGTTGTGGTGATGTACAAGTAAAAGTTTTTGAAATGCCAGC
AATATTGCAATCTGTTGATATTGAAGCAGTTGTGAATGATGTTGCTGATTATTTACTTACTACTGATGATCATATATTAT
TAGCTGATATGGTGGAAAAAATATTACAATCTTATTCATGTTATCATTCTATAAGATCAGGTAGAATATTAACTATTGCA
GAGATGAATAGTTTATTACGTCAAATTGAAACAACTCCATTTTCTGGACAATGTAATCATGGTCGCCCAACTTATGTTAG
ATTTGAGCTAAAAGATATAGAGAAGCTATTTGGCAGGAGATGA

Upstream 100 bases:

>100_bases
AATCGTTATTATGATTACAGTAATTTATTTGCTTGATTATTGTAGCAAAAATCAGCAAAATCTAAGTTTCTAATCTAAAT
ATGTGATGTGGTAAAGTTGT

Downstream 100 bases:

>100_bases
TTTTTTTCAGTCTACTACTTTATTTTCCTTATATCAAACGCATGGTAGAAAGCAGTACATATAATCAATTCTTTTCTTGC
CAATTCTAAGTTAAATCAGT

Product: DNA mismatch repair protein MutL1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSK
LNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAYEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLK
FLRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKASSQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPVVVIFISVAPHFVDVNVHPTKSEVRFHDSSL
VRGIIISAIKQALLNTSQLVSSIAASDANKYMKPQYDTDISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSEFQDI
QANNLVSDNEQQKIESTTENIKSFSAFNQLGGNTESNQHMSILDDDKTKDDIIARNIATNEKVDVNKQENIQKLNDSFCN
NFGDSYQLPLGLACAQFHGNYILAQTVDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCD
KMQEILALGMGFERCGDVQVKVFEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIA
EMNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR

Sequences:

>Translated_680_residues
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSK
LNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAYEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLK
FLRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKASSQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPVVVIFISVAPHFVDVNVHPTKSEVRFHDSSL
VRGIIISAIKQALLNTSQLVSSIAASDANKYMKPQYDTDISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSEFQDI
QANNLVSDNEQQKIESTTENIKSFSAFNQLGGNTESNQHMSILDDDKTKDDIIARNIATNEKVDVNKQENIQKLNDSFCN
NFGDSYQLPLGLACAQFHGNYILAQTVDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCD
KMQEILALGMGFERCGDVQVKVFEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIA
EMNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR
>Mature_679_residues
GVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSKL
NENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAYEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKF
LRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKASSQLSFDDARKSRISEILSKNFIDNAISIGIERDELSIT
GFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPVVVIFISVAPHFVDVNVHPTKSEVRFHDSSLV
RGIIISAIKQALLNTSQLVSSIAASDANKYMKPQYDTDISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSEFQDIQ
ANNLVSDNEQQKIESTTENIKSFSAFNQLGGNTESNQHMSILDDDKTKDDIIARNIATNEKVDVNKQENIQKLNDSFCNN
FGDSYQLPLGLACAQFHGNYILAQTVDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCDK
MQEILALGMGFERCGDVQVKVFEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAE
MNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=327, Percent_Identity=36.085626911315, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI310128478, Length=359, Percent_Identity=28.9693593314763, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4505913, Length=415, Percent_Identity=27.9518072289157, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4505911, Length=335, Percent_Identity=29.2537313432836, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458898, Length=335, Percent_Identity=29.2537313432836, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=29.595015576324, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI263191589, Length=231, Percent_Identity=31.6017316017316, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310128480, Length=315, Percent_Identity=27.3015873015873, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992162, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI91992160, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1790612, Length=328, Percent_Identity=39.6341463414634, Blast_Score=249, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=32.6219512195122, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=362, Percent_Identity=28.7292817679558, Blast_Score=128, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=448, Percent_Identity=33.7053571428571, Blast_Score=184, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=25.414364640884, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=215, Percent_Identity=26.9767441860465, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136968, Length=364, Percent_Identity=33.2417582417582, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=28.8951841359773, Blast_Score=109, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76462; Mature: 76331

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDN
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
GCGMSAEDLETAIERHTTSKLNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQA
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
YEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKFLRSDRTEYIVCYDVVKRLA
EEEEECCCCHHHHCCCCCEEEECCEEEEHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHH
ISYPHIAFSLVHDDKTILKLKASSQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
HCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEE
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPVVVIFISVAPH
EEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCE
FVDVNVHPTKSEVRFHDSSLVRGIIISAIKQALLNTSQLVSSIAASDANKYMKPQYDTDI
EEEEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCH
SEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSEFQDIQANNLVSDNEQQKIESTTEN
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IKSFSAFNQLGGNTESNQHMSILDDDKTKDDIIARNIATNEKVDVNKQENIQKLNDSFCN
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
NFGDSYQLPLGLACAQFHGNYILAQTVDSLIIVDQHAAHERITYENLRSQFQAGQIIRQR
CCCCCCCCCHHHHHHHHCCCEEEEEHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LLMPQVVILPDIVRVEKLCDKMQEILALGMGFERCGDVQVKVFEMPAILQSVDIEAVVND
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHH
VADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAEMNSLLRQIETTPFSGQCNH
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCC
GRPTYVRFELKDIEKLFGRR
CCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
GVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDN
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
GCGMSAEDLETAIERHTTSKLNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQA
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
YEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKFLRSDRTEYIVCYDVVKRLA
EEEEECCCCHHHHCCCCCEEEECCEEEEHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHH
ISYPHIAFSLVHDDKTILKLKASSQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
HCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEE
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPVVVIFISVAPH
EEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCE
FVDVNVHPTKSEVRFHDSSLVRGIIISAIKQALLNTSQLVSSIAASDANKYMKPQYDTDI
EEEEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCH
SEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSEFQDIQANNLVSDNEQQKIESTTEN
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
IKSFSAFNQLGGNTESNQHMSILDDDKTKDDIIARNIATNEKVDVNKQENIQKLNDSFCN
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
NFGDSYQLPLGLACAQFHGNYILAQTVDSLIIVDQHAAHERITYENLRSQFQAGQIIRQR
CCCCCCCCCHHHHHHHHCCCEEEEEHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LLMPQVVILPDIVRVEKLCDKMQEILALGMGFERCGDVQVKVFEMPAILQSVDIEAVVND
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHH
VADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAEMNSLLRQIETTPFSGQCNH
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCC
GRPTYVRFELKDIEKLFGRR
CCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA