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The map label for this gene is tdpX1 [C]

Identifier: 189183182

GI number: 189183182

Start: 276859

End: 277461

Strand: Direct

Name: tdpX1 [C]

Synonym: OTT_0275

Alternate gene names: 189183182

Gene position: 276859-277461 (Clockwise)

Preceding gene: 189183180

Following gene: 189183183

Centisome position: 13.78

GC content: 33.33

Gene sequence:

>603_bases
ATGGAAATTTTTGTAGGTAAGTCAGCTTGTGATTTTACAGCTCCAGCAGTTTTGCCAAAGAACAATATTAATGAAAAATT
TAACTTAAAACATGAACTGGACGGTAGAAAGGCAGTTTTATTTTTTTATCCTTTAAACTTTACTTTTGTTTGTCCAACGG
AAATTATTGCTTTTAATAATAGATATGGTGAGTTCTTAAAAAGAAATACCGAAGTGATTGGAATTAGTGTAGACTCACAT
TTTTGCCATAAGGCTTGGAAACTTACTCCTTATAATAAGGGAGGAATAGGTGACATACAATTTCCATTAGTGTCAGACAT
AAATAAAGATATTTCCAAGACGTATAATGTGCTCAACCAGGATGGAGTAGCTGTTCGAGCAACATTTATTATTGATCAAG
AGTTTGTACTACGCCATGTTACTATTAATGATTTAAGTATAGGACGAAATGTTGAAGAAAGTTTAAGAATAATTGATGCA
ATAGATTTTCATAAAAAGTACGGTGATGTATGCCCAGCTGGTTGGACTCCAGGAACTGAAGGAATGGAAGCAACATCAGA
TGGTGTATGTCACTACTTAACATCAAATGCTGAGAAGTTGTAA

Upstream 100 bases:

>100_bases
TCTAGTTGCAGTATTTTTAATTTAGAATATTATGGGTACATGGATATATTTTATTAGTATAATTTATTCAAATAATTTAT
TTAGTTAGAGAGTAGTAGCT

Downstream 100 bases:

>100_bases
TTTTAAGTTCCTTTTTGCAGTTTATAAATTGCTACAGACTGTATGCTAAAAGTGCCAGTTAGTGATAATATTTCTACTGA
GTATGATGATGAAACAATTT

Product: thioredoxin peroxidase 1

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MEIFVGKSACDFTAPAVLPKNNINEKFNLKHELDGRKAVLFFYPLNFTFVCPTEIIAFNNRYGEFLKRNTEVIGISVDSH
FCHKAWKLTPYNKGGIGDIQFPLVSDINKDISKTYNVLNQDGVAVRATFIIDQEFVLRHVTINDLSIGRNVEESLRIIDA
IDFHKKYGDVCPAGWTPGTEGMEATSDGVCHYLTSNAEKL

Sequences:

>Translated_200_residues
MEIFVGKSACDFTAPAVLPKNNINEKFNLKHELDGRKAVLFFYPLNFTFVCPTEIIAFNNRYGEFLKRNTEVIGISVDSH
FCHKAWKLTPYNKGGIGDIQFPLVSDINKDISKTYNVLNQDGVAVRATFIIDQEFVLRHVTINDLSIGRNVEESLRIIDA
IDFHKKYGDVCPAGWTPGTEGMEATSDGVCHYLTSNAEKL
>Mature_200_residues
MEIFVGKSACDFTAPAVLPKNNINEKFNLKHELDGRKAVLFFYPLNFTFVCPTEIIAFNNRYGEFLKRNTEVIGISVDSH
FCHKAWKLTPYNKGGIGDIQFPLVSDINKDISKTYNVLNQDGVAVRATFIIDQEFVLRHVTINDLSIGRNVEESLRIIDA
IDFHKKYGDVCPAGWTPGTEGMEATSDGVCHYLTSNAEKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=193, Percent_Identity=47.1502590673575, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32455266, Length=193, Percent_Identity=47.1502590673575, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32455264, Length=193, Percent_Identity=47.1502590673575, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=46.1139896373057, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI5453549, Length=160, Percent_Identity=51.25, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI5802974, Length=163, Percent_Identity=46.6257668711656, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI32483377, Length=163, Percent_Identity=46.6257668711656, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI33188454, Length=134, Percent_Identity=38.8059701492537, Blast_Score=87, Evalue=9e-18,
Organism=Escherichia coli, GI1786822, Length=162, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=181, Percent_Identity=47.5138121546961, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32565831, Length=181, Percent_Identity=47.5138121546961, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17554494, Length=166, Percent_Identity=45.7831325301205, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=24.8648648648649, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323613, Length=192, Percent_Identity=41.1458333333333, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320661, Length=176, Percent_Identity=42.0454545454545, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=162, Percent_Identity=32.0987654320988, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656348, Length=193, Percent_Identity=48.7046632124352, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17864676, Length=193, Percent_Identity=48.7046632124352, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17738015, Length=178, Percent_Identity=47.752808988764, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17157991, Length=192, Percent_Identity=44.7916666666667, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24641739, Length=192, Percent_Identity=44.7916666666667, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=43.1578947368421, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24652436, Length=176, Percent_Identity=34.6590909090909, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24652434, Length=176, Percent_Identity=34.6590909090909, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17975518, Length=176, Percent_Identity=34.0909090909091, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581278, Length=152, Percent_Identity=29.6052631578947, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22481; Mature: 22481

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFVGKSACDFTAPAVLPKNNINEKFNLKHELDGRKAVLFFYPLNFTFVCPTEIIAFNN
CEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEEECCEEEECCCEEEEECC
RYGEFLKRNTEVIGISVDSHFCHKAWKLTPYNKGGIGDIQFPLVSDINKDISKTYNVLNQ
HHHHHHHCCCEEEEEEECCHHHHHHEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
DGVAVRATFIIDQEFVLRHVTINDLSIGRNVEESLRIIDAIDFHKKYGDVCPAGWTPGTE
CCEEEEEEEEECHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMEATSDGVCHYLTSNAEKL
CCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MEIFVGKSACDFTAPAVLPKNNINEKFNLKHELDGRKAVLFFYPLNFTFVCPTEIIAFNN
CEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEEECCEEEECCCEEEEECC
RYGEFLKRNTEVIGISVDSHFCHKAWKLTPYNKGGIGDIQFPLVSDINKDISKTYNVLNQ
HHHHHHHCCCEEEEEEECCHHHHHHEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCC
DGVAVRATFIIDQEFVLRHVTINDLSIGRNVEESLRIIDAIDFHKKYGDVCPAGWTPGTE
CCEEEEEEEEECHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMEATSDGVCHYLTSNAEKL
CCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]