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The map label for this gene is tolC [H]

Identifier: 189182983

GI number: 189182983

Start: 79227

End: 80600

Strand: Direct

Name: tolC [H]

Synonym: OTT_0076

Alternate gene names: 189182983

Gene position: 79227-80600 (Clockwise)

Preceding gene: 189182980

Following gene: 189182984

Centisome position: 3.94

GC content: 28.31

Gene sequence:

>1374_bases
ATGTTAACTTTATTAAAAAAATATATTGTAGCAATATTATGCAGTATATTTCTAGCTTGTAGTTTTTCATGTAGCGCTAT
TGATATTAATACAGCATTAACAAATGCTTATAAAAATTCTGTAAAATTTAAACTATTGCAAGATGAATTTCTACAACAAG
CAAATCAGTACCAAAAAATTTATACAAGCTTCATACCTGAAGTACATGTATCAGTAGTATCTGGTGAAAGATATCATAAC
CCAAGCAATCGTTTTTTTAGCAATGACTGGTTTCCCGAAACTAATAATTTACATCGTTTGCAATCACTTAACGTGTTTAC
TCCTAAAGCAGAACTAACAATTTCACATAATTTATTTAATGGCGGACAGGACATAATCAAGCTTAAAACTATTAAGCAAA
AATCCTATGCTGCAAAGGAGAAATTTTATAATGATGAACAAGAATTAATATATGAAGGTATTGAAACCTACCTAAACTAT
TATTCTTTTCTTGAAACATCTAAACTATATGAAGCAAAGATGCATTATTTTCAAAAAATGCTTGAAATAGAAAAACAAAA
GCTAGACTTAGGAGAAAGTACAAGTGTTAGTGTAGCTAATGCACAAGTTCAATTATCAAAAGCTTTATCTGAACACATAG
CAAGCATTACTGCAGTACAAAACCTGGAAAAAAAATTCTACAATTTTTTTGGTATACTACCTAGTAATATAGAGTTACCA
AGGATATCTAATGATTTAGAAAACAGTGAAACTGCATTAATGAACTTAGCTCTAAATAACAGTTTTGTGCTTAACTACTA
TAAAAATCAAATATTAGAACAGCAACTAAAAGTCAAGTTTTGCAGAGCAGCTGTTTTACCTAAAATAAACGCACAATTTT
CAGTAATTAGCCCTTTACCTTTTCAGCCAGAACATAGCACTGCGACTTTTGCAATTGAAATGAGAATACCGATATTCAAT
CATAATACAGCATTTTTGGATTCTAGAACTGAAATAAGAGCTCTTAATATGCTGATAAGTCAGTATAAAGATAAATTAGA
ACAAATTAAGATGTCTGTAGCTTCAGAATGGAAACAATACAATTCCATAAAACAACAAATTGAATACTCCGACGACTATG
TTAAATTTGCTACTATTGCTTTATCAGCAACTCAACATGAATATGAGTTAGGCAATATACGTATTACAGATTTATTAAAA
GCCCAAAATAATTTCTATGATTCTAAAATTGAAAATATTAAAGTTAATGTTGCTCTTTTAAAGCACATGTATAAAATAAA
ACAGTTAACTAATAAATTAACTGCTAAATCATTAAATTTAAAGGTGAATTACTTTATTCCAGAGCAAAAGCAGAAATTTA
AAAAAACACTTTAA

Upstream 100 bases:

>100_bases
TTTTTAGACAATTACTCATAAATAAGTTTAGTAATTGCAGTATTTATAATAAAATAAGCATTAATAAAAATTCATAATAA
TATAAAAATTCTAACAATAA

Downstream 100 bases:

>100_bases
ACTACTCTTTAAGTTTAATAAAATTCTAAAGTAGCAAGAGGAGAATGTTTATGACTAAACTCCATAAAGAAAATGAAGAT
TATAATGAACATACTAATCA

Product: outer membrane protein TolC precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLTLLKKYIVAILCSIFLACSFSCSAIDINTALTNAYKNSVKFKLLQDEFLQQANQYQKIYTSFIPEVHVSVVSGERYHN
PSNRFFSNDWFPETNNLHRLQSLNVFTPKAELTISHNLFNGGQDIIKLKTIKQKSYAAKEKFYNDEQELIYEGIETYLNY
YSFLETSKLYEAKMHYFQKMLEIEKQKLDLGESTSVSVANAQVQLSKALSEHIASITAVQNLEKKFYNFFGILPSNIELP
RISNDLENSETALMNLALNNSFVLNYYKNQILEQQLKVKFCRAAVLPKINAQFSVISPLPFQPEHSTATFAIEMRIPIFN
HNTAFLDSRTEIRALNMLISQYKDKLEQIKMSVASEWKQYNSIKQQIEYSDDYVKFATIALSATQHEYELGNIRITDLLK
AQNNFYDSKIENIKVNVALLKHMYKIKQLTNKLTAKSLNLKVNYFIPEQKQKFKKTL

Sequences:

>Translated_457_residues
MLTLLKKYIVAILCSIFLACSFSCSAIDINTALTNAYKNSVKFKLLQDEFLQQANQYQKIYTSFIPEVHVSVVSGERYHN
PSNRFFSNDWFPETNNLHRLQSLNVFTPKAELTISHNLFNGGQDIIKLKTIKQKSYAAKEKFYNDEQELIYEGIETYLNY
YSFLETSKLYEAKMHYFQKMLEIEKQKLDLGESTSVSVANAQVQLSKALSEHIASITAVQNLEKKFYNFFGILPSNIELP
RISNDLENSETALMNLALNNSFVLNYYKNQILEQQLKVKFCRAAVLPKINAQFSVISPLPFQPEHSTATFAIEMRIPIFN
HNTAFLDSRTEIRALNMLISQYKDKLEQIKMSVASEWKQYNSIKQQIEYSDDYVKFATIALSATQHEYELGNIRITDLLK
AQNNFYDSKIENIKVNVALLKHMYKIKQLTNKLTAKSLNLKVNYFIPEQKQKFKKTL
>Mature_457_residues
MLTLLKKYIVAILCSIFLACSFSCSAIDINTALTNAYKNSVKFKLLQDEFLQQANQYQKIYTSFIPEVHVSVVSGERYHN
PSNRFFSNDWFPETNNLHRLQSLNVFTPKAELTISHNLFNGGQDIIKLKTIKQKSYAAKEKFYNDEQELIYEGIETYLNY
YSFLETSKLYEAKMHYFQKMLEIEKQKLDLGESTSVSVANAQVQLSKALSEHIASITAVQNLEKKFYNFFGILPSNIELP
RISNDLENSETALMNLALNNSFVLNYYKNQILEQQLKVKFCRAAVLPKINAQFSVISPLPFQPEHSTATFAIEMRIPIFN
HNTAFLDSRTEIRALNMLISQYKDKLEQIKMSVASEWKQYNSIKQQIEYSDDYVKFATIALSATQHEYELGNIRITDLLK
AQNNFYDSKIENIKVNVALLKHMYKIKQLTNKLTAKSLNLKVNYFIPEQKQKFKKTL

Specific function: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52967; Mature: 52967

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLLKKYIVAILCSIFLACSFSCSAIDINTALTNAYKNSVKFKLLQDEFLQQANQYQKI
CHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHH
YTSFIPEVHVSVVSGERYHNPSNRFFSNDWFPETNNLHRLQSLNVFTPKAELTISHNLFN
HHHHCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEECCCEEEEEEECCCC
GGQDIIKLKTIKQKSYAAKEKFYNDEQELIYEGIETYLNYYSFLETSKLYEAKMHYFQKM
CCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEIEKQKLDLGESTSVSVANAQVQLSKALSEHIASITAVQNLEKKFYNFFGILPSNIELP
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RISNDLENSETALMNLALNNSFVLNYYKNQILEQQLKVKFCRAAVLPKINAQFSVISPLP
CCCCCCCCCHHHEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
FQPEHSTATFAIEMRIPIFNHNTAFLDSRTEIRALNMLISQYKDKLEQIKMSVASEWKQY
CCCCCCCEEEEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSIKQQIEYSDDYVKFATIALSATQHEYELGNIRITDLLKAQNNFYDSKIENIKVNVALL
HHHHHHHHCCCCCEEEEHEEEECCCCCEEECCEEEHHHHHHHCCCCCCCHHHEEEHHHHH
KHMYKIKQLTNKLTAKSLNLKVNYFIPEQKQKFKKTL
HHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHHCC
>Mature Secondary Structure
MLTLLKKYIVAILCSIFLACSFSCSAIDINTALTNAYKNSVKFKLLQDEFLQQANQYQKI
CHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHH
YTSFIPEVHVSVVSGERYHNPSNRFFSNDWFPETNNLHRLQSLNVFTPKAELTISHNLFN
HHHHCCHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEECCCEEEEEEECCCC
GGQDIIKLKTIKQKSYAAKEKFYNDEQELIYEGIETYLNYYSFLETSKLYEAKMHYFQKM
CCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEIEKQKLDLGESTSVSVANAQVQLSKALSEHIASITAVQNLEKKFYNFFGILPSNIELP
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RISNDLENSETALMNLALNNSFVLNYYKNQILEQQLKVKFCRAAVLPKINAQFSVISPLP
CCCCCCCCCHHHEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
FQPEHSTATFAIEMRIPIFNHNTAFLDSRTEIRALNMLISQYKDKLEQIKMSVASEWKQY
CCCCCCCEEEEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSIKQQIEYSDDYVKFATIALSATQHEYELGNIRITDLLKAQNNFYDSKIENIKVNVALL
HHHHHHHHCCCCCEEEEHEEEECCCCCEEECCEEEHHHHHHHCCCCCCCHHHEEEHHHHH
KHMYKIKQLTNKLTAKSLNLKVNYFIPEQKQKFKKTL
HHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]