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The map label for this gene is trxA [H]

Identifier: 189182938

GI number: 189182938

Start: 39171

End: 39497

Strand: Direct

Name: trxA [H]

Synonym: OTT_0031

Alternate gene names: 189182938

Gene position: 39171-39497 (Clockwise)

Preceding gene: 189182937

Following gene: 189182939

Centisome position: 1.95

GC content: 28.75

Gene sequence:

>327_bases
ATGACTAAAAATATTACAGAGATTAATGATGAAGAAAATTTTAAGCAAGAAGTGTTTTTATCACCTAAGTTGGTGTTAGT
AGATTTTTATGCTGACTGGTGTGGTCCATGCCGTCAGCTTTCACCAATTTTAGAGCAAATATCTGAAGAATTATCTGATA
AGGTAAAGATTGTTAAAGTTAACATAGAAAAAAATATTCAGGTAGCTACTGATTTTAAAATACAAAGTATTCCAACACTA
ATATTATTTAATAATGGAGAAGCAGTTTCTAGAGAGATAGGAGGTAAGAGCAAGCAAGATATTATAGATTGGATTAATAA
TTATTAA

Upstream 100 bases:

>100_bases
TTTTTCTATGCTGTGCCTATTAAGCGTGAGAAGTACGATGAAGTTGAAAAATTGGGTTTTACACTAGGATTTATATAGCT
AATTAATATATGGAGTTATT

Downstream 100 bases:

>100_bases
AGCTAATAATTATTAATTTAACTTTGCAAAGGAGTATACAAAGAGAAAATGTTGAGTTATAAAGACAAATTTAAATAAAA
ATGAAATAACTCAATATGAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MTKNITEINDEENFKQEVFLSPKLVLVDFYADWCGPCRQLSPILEQISEELSDKVKIVKVNIEKNIQVATDFKIQSIPTL
ILFNNGEAVSREIGGKSKQDIIDWINNY

Sequences:

>Translated_108_residues
MTKNITEINDEENFKQEVFLSPKLVLVDFYADWCGPCRQLSPILEQISEELSDKVKIVKVNIEKNIQVATDFKIQSIPTL
ILFNNGEAVSREIGGKSKQDIIDWINNY
>Mature_107_residues
TKNITEINDEENFKQEVFLSPKLVLVDFYADWCGPCRQLSPILEQISEELSDKVKIVKVNIEKNIQVATDFKIQSIPTLI
LFNNGEAVSREIGGKSKQDIIDWINNY

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=35.632183908046, Blast_Score=72, Evalue=6e-14,
Organism=Homo sapiens, GI5031973, Length=104, Percent_Identity=31.7307692307692, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=36.7924528301887, Blast_Score=93, Evalue=4e-21,
Organism=Escherichia coli, GI1788936, Length=82, Percent_Identity=43.9024390243902, Blast_Score=85, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=104, Percent_Identity=33.6538461538462, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115532252, Length=100, Percent_Identity=38, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=99, Percent_Identity=34.3434343434343, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532254, Length=100, Percent_Identity=38, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=84, Percent_Identity=39.2857142857143, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=84, Percent_Identity=39.2857142857143, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=84, Percent_Identity=39.2857142857143, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=103, Percent_Identity=33.9805825242718, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=95, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=91, Percent_Identity=32.967032967033, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=39.7260273972603, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573567, Length=102, Percent_Identity=32.3529411764706, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24639826, Length=93, Percent_Identity=32.258064516129, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=37.9746835443038, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=37.9746835443038, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647799, Length=98, Percent_Identity=34.6938775510204, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358065, Length=103, Percent_Identity=33.0097087378641, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=73, Percent_Identity=32.8767123287671, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639068, Length=87, Percent_Identity=32.183908045977, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921434, Length=101, Percent_Identity=29.7029702970297, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12403; Mature: 12272

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNITEINDEENFKQEVFLSPKLVLVDFYADWCGPCRQLSPILEQISEELSDKVKIVKV
CCCCCCCCCCCCCHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEE
NIEKNIQVATDFKIQSIPTLILFNNGEAVSREIGGKSKQDIIDWINNY
ECCCCEEEEECCEECCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TKNITEINDEENFKQEVFLSPKLVLVDFYADWCGPCRQLSPILEQISEELSDKVKIVKV
CCCCCCCCCCCCHHHHHHCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEE
NIEKNIQVATDFKIQSIPTLILFNNGEAVSREIGGKSKQDIIDWINNY
ECCCCEEEEECCEECCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA