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The map label for this gene is thrS

Identifier: 189026061

GI number: 189026061

Start: 907634

End: 909412

Strand: Direct

Name: thrS

Synonym: TPASS_0837

Alternate gene names: 189026061

Gene position: 907634-909412 (Clockwise)

Preceding gene: 189026057

Following gene: 189026064

Centisome position: 79.65

GC content: 57.9

Gene sequence:

>1779_bases
TTGGGCCTCTGTGTAGAAGAGAATATCACCATGCTGCAAAAACGCTCAGATACCCTCGACCGTCTGCGTCACAGTCTGGC
GCACGTTATGGCAGAGGCCGTTCAAGCTCTCTTCCCCGGCACCAAGCTCGCGGTGGGGCCGCCTATCGATTACGGGTTTT
ACTATGACTTCTCACCTCCCCGTCCCCTGTGCGATGCAGACCTAGCCCCCATTGAAGAGAAAATGCGCGCCATCTTGCGT
GCGGGGTGTCCCTTTGTCAAAGAGGTGGTTTCGCGTCCTGACGCGCTTGCTCGTTTTAAAGACGAGCCATTCAAGCAAGA
GCTCATCGAACGCATCAGCGCAGACGACACGCTCAGTCTCTACCACTCCGGCGCGTTCACTGACCTGTGCCGGGGTCCTC
ACGTGCAGTCTATGCGAGACATTAATCCGCACGCCTTTAAACTCACGAGCATCGCTGGGGCCTATTGGCGCGGTAATGAG
CGCGGCCCCCAGCTGACGCGCATCTACGGCACTGCCTGGGAATCTGAAGAAGATTTGCACACATACCTTCGCATGCAGGA
TGAAGCAAAACGCCGAGATCACCGTAAGCTCGGTCCTGCACTCGGTCTCTTTCACTTGGACGAAGAAAATCCTGGCCAGG
TCTTTTGGCACCCTGAGGGGTGGACCCTCTACGTGGCCATCCAGCAGTACTTGCGCCGCGTCATGCACGAAGACGGGTAC
GCAGAGGTGCATACTCCCTTTGTCATGCCCCAAAGCCTTTGGGAACGCTCGGGGCACTGGGACAAATACCGCGCCAACAT
GTACCTGACCGAAGGCGAGAAGCGTTCTTTTGCGCTCAAGCCCATGAATTGTCCCGGACATGTCGAAATCTTCAAGCAAA
AAACACGCAGTTACCGTGATCTCCCGCTCCGTCTTTCGGAGTTTGGCTCGTGCACCCGCAATGAACCGTCAGGCTCCCTG
CATGGAGTTATGCGCGTACGTGGCTTTGTACAAGACGATGCCCATATCTTTTGTACTGAGGCGCAAATCGCATCGGAGGT
CACCCGTTTCTGTCGCCTCCTTGCGCGGGTATATGCTGACTTTGGCTTTGCACAGGAGCAGATCCGCGTCAAGTTTTCTA
CGCGCCCAGAGCAGCGCATCGGAGACGACGCCACCTGGGACCGGGCCGAACGCGCATTGGCAGAAGCATGTGAAGCAGCA
GGCCTTTCGTACGAGCACGCACCGGGAGAAGGAGCGTTCTATGGACCAAAGTTGGAGTTTGCACTTATAGATACACTCGA
ACGCGAGTGGCAGTGCGGCACCATTCAGGTAGACTATCAGTTGCCCTCGTGCGAGCGCTTGAACGCAGAGTATGTGGGGG
AGGACAACCAACGGCACATGCCAGTGATACTCCACCGCACGGTGATTGGGTCTCTAGAACGGTTCATCGGTATTCTCATT
GAACACTACGGGGGTGCATTCCCCCCATGGCTCGCACCGGTGCAGGCAGTGGTGATTCCGGTTGCCCCTGCCTTCCTCGA
ATATGCGCAGCACGTTGCACGGGAGCTGTGCGCCCGTTCGCTCCGCGTGCAGGCAGACGTGAGCGCAGAGCGCATGAACG
CAAAGATCCGCACTGCCCAAACGCAGAAAGTGCCCTATCTGCTCATAGTTGGCGAGCGGGAGCTGCGCGCGCAGCAGGTA
GCGGTGCGTCCGCGCACAGGGCCCCAGCACTCAATGGGGCTCTCAGCCTTTTCCACCTTTTTGCTCGCGAAGCTAGAGAC
GCGCGCGCTGCACGCCTAG

Upstream 100 bases:

>100_bases
CACGTCCCTTCCTACAGACTGCAGTGACGGCGCAGGCGCACTGGCTCAGTGCTTCCTCCAAAACGGCGCCCATTGACAAA
CCACCCATAAGGTCTCACGA

Downstream 100 bases:

>100_bases
CCCATGAGTCCCCTGTGCCTTTTCCCCAAACCTTCAGGGGAAGGGACGCTATATCCGTAGCTGCTGTACGCTACCGCCGT
AGAGCTGCGCGCGCGTGGCG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MGLCVEENITMLQKRSDTLDRLRHSLAHVMAEAVQALFPGTKLAVGPPIDYGFYYDFSPPRPLCDADLAPIEEKMRAILR
AGCPFVKEVVSRPDALARFKDEPFKQELIERISADDTLSLYHSGAFTDLCRGPHVQSMRDINPHAFKLTSIAGAYWRGNE
RGPQLTRIYGTAWESEEDLHTYLRMQDEAKRRDHRKLGPALGLFHLDEENPGQVFWHPEGWTLYVAIQQYLRRVMHEDGY
AEVHTPFVMPQSLWERSGHWDKYRANMYLTEGEKRSFALKPMNCPGHVEIFKQKTRSYRDLPLRLSEFGSCTRNEPSGSL
HGVMRVRGFVQDDAHIFCTEAQIASEVTRFCRLLARVYADFGFAQEQIRVKFSTRPEQRIGDDATWDRAERALAEACEAA
GLSYEHAPGEGAFYGPKLEFALIDTLEREWQCGTIQVDYQLPSCERLNAEYVGEDNQRHMPVILHRTVIGSLERFIGILI
EHYGGAFPPWLAPVQAVVIPVAPAFLEYAQHVARELCARSLRVQADVSAERMNAKIRTAQTQKVPYLLIVGERELRAQQV
AVRPRTGPQHSMGLSAFSTFLLAKLETRALHA

Sequences:

>Translated_592_residues
MGLCVEENITMLQKRSDTLDRLRHSLAHVMAEAVQALFPGTKLAVGPPIDYGFYYDFSPPRPLCDADLAPIEEKMRAILR
AGCPFVKEVVSRPDALARFKDEPFKQELIERISADDTLSLYHSGAFTDLCRGPHVQSMRDINPHAFKLTSIAGAYWRGNE
RGPQLTRIYGTAWESEEDLHTYLRMQDEAKRRDHRKLGPALGLFHLDEENPGQVFWHPEGWTLYVAIQQYLRRVMHEDGY
AEVHTPFVMPQSLWERSGHWDKYRANMYLTEGEKRSFALKPMNCPGHVEIFKQKTRSYRDLPLRLSEFGSCTRNEPSGSL
HGVMRVRGFVQDDAHIFCTEAQIASEVTRFCRLLARVYADFGFAQEQIRVKFSTRPEQRIGDDATWDRAERALAEACEAA
GLSYEHAPGEGAFYGPKLEFALIDTLEREWQCGTIQVDYQLPSCERLNAEYVGEDNQRHMPVILHRTVIGSLERFIGILI
EHYGGAFPPWLAPVQAVVIPVAPAFLEYAQHVARELCARSLRVQADVSAERMNAKIRTAQTQKVPYLLIVGERELRAQQV
AVRPRTGPQHSMGLSAFSTFLLAKLETRALHA
>Mature_591_residues
GLCVEENITMLQKRSDTLDRLRHSLAHVMAEAVQALFPGTKLAVGPPIDYGFYYDFSPPRPLCDADLAPIEEKMRAILRA
GCPFVKEVVSRPDALARFKDEPFKQELIERISADDTLSLYHSGAFTDLCRGPHVQSMRDINPHAFKLTSIAGAYWRGNER
GPQLTRIYGTAWESEEDLHTYLRMQDEAKRRDHRKLGPALGLFHLDEENPGQVFWHPEGWTLYVAIQQYLRRVMHEDGYA
EVHTPFVMPQSLWERSGHWDKYRANMYLTEGEKRSFALKPMNCPGHVEIFKQKTRSYRDLPLRLSEFGSCTRNEPSGSLH
GVMRVRGFVQDDAHIFCTEAQIASEVTRFCRLLARVYADFGFAQEQIRVKFSTRPEQRIGDDATWDRAERALAEACEAAG
LSYEHAPGEGAFYGPKLEFALIDTLEREWQCGTIQVDYQLPSCERLNAEYVGEDNQRHMPVILHRTVIGSLERFIGILIE
HYGGAFPPWLAPVQAVVIPVAPAFLEYAQHVARELCARSLRVQADVSAERMNAKIRTAQTQKVPYLLIVGERELRAQQVA
VRPRTGPQHSMGLSAFSTFLLAKLETRALHA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=573, Percent_Identity=39.7905759162304, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI38202255, Length=552, Percent_Identity=40.5797101449275, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI20070344, Length=562, Percent_Identity=37.5444839857651, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1788013, Length=581, Percent_Identity=48.881239242685, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984184, Length=546, Percent_Identity=38.4615384615385, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71984192, Length=546, Percent_Identity=38.4615384615385, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322112, Length=555, Percent_Identity=38.1981981981982, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322654, Length=391, Percent_Identity=38.3631713554987, Blast_Score=287, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24583842, Length=549, Percent_Identity=40.2550091074681, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28574141, Length=549, Percent_Identity=40.2550091074681, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583839, Length=549, Percent_Identity=40.2550091074681, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_TREPA (O83809)

Other databases:

- EMBL:   AE000520
- PIR:   B71275
- RefSeq:   NP_219273.1
- ProteinModelPortal:   O83809
- SMR:   O83809
- GeneID:   2610983
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0837
- NMPDR:   fig|243276.1.peg.832
- TIGR:   TP_0837
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK12305
- BioCyc:   TPAL243276:TP_0837-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 67400; Mature: 67268

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLCVEENITMLQKRSDTLDRLRHSLAHVMAEAVQALFPGTKLAVGPPIDYGFYYDFSPP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCC
RPLCDADLAPIEEKMRAILRAGCPFVKEVVSRPDALARFKDEPFKQELIERISADDTLSL
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCCCHH
YHSGAFTDLCRGPHVQSMRDINPHAFKLTSIAGAYWRGNERGPQLTRIYGTAWESEEDLH
HHCCCHHHHHCCCCCCHHHCCCCCEEEHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHH
TYLRMQDEAKRRDHRKLGPALGLFHLDEENPGQVFWHPEGWTLYVAIQQYLRRVMHEDGY
HHHHHHHHHHHHHHHHCCCHHCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCC
AEVHTPFVMPQSLWERSGHWDKYRANMYLTEGEKRSFALKPMNCPGHVEIFKQKTRSYRD
CEECCCCCCCHHHHHCCCCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCC
LPLRLSEFGSCTRNEPSGSLHGVMRVRGFVQDDAHIFCTEAQIASEVTRFCRLLARVYAD
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
FGFAQEQIRVKFSTRPEQRIGDDATWDRAERALAEACEAAGLSYEHAPGEGAFYGPKLEF
CCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHH
ALIDTLEREWQCGTIQVDYQLPSCERLNAEYVGEDNQRHMPVILHRTVIGSLERFIGILI
HHHHHHHHCCCCCEEEEEEECCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EHYGGAFPPWLAPVQAVVIPVAPAFLEYAQHVARELCARSLRVQADVSAERMNAKIRTAQ
HHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEECCCCHHHHCCHHEECC
TQKVPYLLIVGERELRAQQVAVRPRTGPQHSMGLSAFSTFLLAKLETRALHA
CCCCCEEEEECCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLCVEENITMLQKRSDTLDRLRHSLAHVMAEAVQALFPGTKLAVGPPIDYGFYYDFSPP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCC
RPLCDADLAPIEEKMRAILRAGCPFVKEVVSRPDALARFKDEPFKQELIERISADDTLSL
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCCCHH
YHSGAFTDLCRGPHVQSMRDINPHAFKLTSIAGAYWRGNERGPQLTRIYGTAWESEEDLH
HHCCCHHHHHCCCCCCHHHCCCCCEEEHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHH
TYLRMQDEAKRRDHRKLGPALGLFHLDEENPGQVFWHPEGWTLYVAIQQYLRRVMHEDGY
HHHHHHHHHHHHHHHHCCCHHCEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCC
AEVHTPFVMPQSLWERSGHWDKYRANMYLTEGEKRSFALKPMNCPGHVEIFKQKTRSYRD
CEECCCCCCCHHHHHCCCCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCC
LPLRLSEFGSCTRNEPSGSLHGVMRVRGFVQDDAHIFCTEAQIASEVTRFCRLLARVYAD
CCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
FGFAQEQIRVKFSTRPEQRIGDDATWDRAERALAEACEAAGLSYEHAPGEGAFYGPKLEF
CCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHH
ALIDTLEREWQCGTIQVDYQLPSCERLNAEYVGEDNQRHMPVILHRTVIGSLERFIGILI
HHHHHHHHCCCCCEEEEEEECCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EHYGGAFPPWLAPVQAVVIPVAPAFLEYAQHVARELCARSLRVQADVSAERMNAKIRTAQ
HHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEECCCCHHHHCCHHEECC
TQKVPYLLIVGERELRAQQVAVRPRTGPQHSMGLSAFSTFLLAKLETRALHA
CCCCCEEEEECCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876