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The map label for this gene is dxs

Identifier: 189026048

GI number: 189026048

Start: 893001

End: 894893

Strand: Direct

Name: dxs

Synonym: TPASS_0824

Alternate gene names: 189026048

Gene position: 893001-894893 (Clockwise)

Preceding gene: 189026039

Following gene: 189026049

Centisome position: 78.37

GC content: 56.05

Gene sequence:

>1893_bases
ATGGATTTGTCGCTGCTTCGCTCCCTCACTGGGCCCCACGATCTTAAGAGTCTCTCCCCCGAGCAGGTGCGCGCGCTCGC
GCAGGAGGTACGCCAGGAGATCTTGCGCGTTGTCAGTGCCAATGGTGGTCATCTTGCCAGTAACCTCGGTGTCGTCGAGC
TCACCATCGCACTCCACCGCGTCTTTTCCTGTCCCCACGACGTTGTCGTTTGGGATGTCGGTCATCAGTGCTACGCGCAC
AAGCTCCTCACTGGACGCGCAGGGCGCTTCCATACCCTCCGCCAGAAGGATGGTATTTCGGGGTTCCCGCGGCGCGATGA
AAGCCCGTACGACGCTTTTGGTACCGGTCACTCTTCCACGGCACTTTCTGCCGCAAGTGGTATCCTCAGCGCCCTACGAT
ACCGGGGTAAATCAGGTAAGGTAGTCGCTGTCGTAGGAGACGGCGCACTCACCGCGGGCCTCGCCTTCGAGGCCCTCCTG
AATGTGGGCCGTTCCTGCAGTGATCTCATCGTCATCCTCAACGACAACAAAATGTCCATTAGCCCCAATACGGGGTCCTT
TTCCCGCTACCTGAGTACCCTCACGGTAAAAGGTCCATACCAGAAGCTCAAAACGCGGCTTCGCCGCGCGCTCCAGACTG
TCCCACTCGTCGGTCGCCCCGCCTGCCGCGCCCTCAGCCGCCTGAAACGAAGTGCAAGAACGCTTTTGTACCAGTCAAAT
ATTTTCGCAGACTTTGGATTCGAGTACGTCGGTCCCTTAAATGGACACCATATCGAAGATCTTGAGCGCGTACTCAACGA
CGCTAAAAAACTCACCCGTCCCACTCTCCTCCACGTGCAGACTGTAAAGGGAAAAGGCTACCCCTTTGCGGAGCAGAATC
CTACCGATTTCCACGGCGTAGGACCGTTTAACCTTGCAGAAGGAATAGTAGAAAAAAAGGATGCGCTCACCTTTACCGAA
GCCTTCTCCCATACCCTCCTAAATGCAGCGCGTACTGATGACCGTGTTGTCGCTATCACCGCTGCTATGACTGGCGGCAC
CGGGCTTGGATTGTTTTCCCATATATACCCTGAACGCTTCTTCGATGTTGGCATTGCTGAGCAACATGCGGTCACGTTCG
CCGCAGGGCTTGCATGCGCCGGCGTAAAACCTGTCGTTGCCGTCTACAGTACGTTTTTGCAGCGCGCCGTTGATCAGGTT
ATTCACGATGTTGCTGTGCAGAATCTGCCGGTCATTTTTGCGCTTGACCGCGCAGGTGCCGTACCCCACGATGGGGAAAC
ACACCAGGGCCTGTTTGATCTCAGCATTCTTCGCGCTGTTCCGAACATAAACATCCTGTGCCCTGCGTCGGCGCACGAGC
TTTCGTTGCTCTTTGGCTGGGCGCTTGCACAGGACACCCCCGTAGCTATCCGCTATCCTAAGGCGTTATGTCCACCTGAA
GAAGACGGATTCAGTACACCTGTACATACCGGACGCGGCGTCCTTATCACCCGAGAGAATGAGTGCAATGTACTGTTAGT
GTGCACAGGGGGCGTTTTTCCCGAGGTAACCGCTGCGGCCAACACTCTTGCGCGAAAGGGCATATTTGCAGATATCTACA
ACGTGCGCTTCGTAAAGCCGGTAGACGAAGATTACTTTTTAGATCTTGTAGGTCGCTACCGTTCCGTTCTTTTTGTCGAA
GACGGCGTAAAAATCGGAGGAATTGCAGAAGCGCTCCAGGCACTCTTGAACACCAGGCACCCGGCTCCGTGCAGCGACGT
GCTTGCTTTTCAGGACATGTTCTACCCGCATGGTTCGCGCGCGCAGGTACTCGCCGCAGCAGGCCTTTCTGCACCGCATA
TTGCCGCACGCGCAGAATGGCTGTTAGCCCATTCAGTTGGGCAGATTCGGTGA

Upstream 100 bases:

>100_bases
ATAGCAACCCACAAGCGCAAGAAGAAGCTTCGCAAGAATCGGCACAAGAACAGGTAGTCTCGGCCCGTGCGCCTTCTGTT
CGACATGAGGCGTTTTCGTC

Downstream 100 bases:

>100_bases
ACAGTATGCATCTGCACGCCGTTCGTTACATCCGCGTGCGCTTGCAGCGCATGCGGCAGATGGCCGCCATACAGCGGAAG
GAACGGGGAGGCCCCGCCTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MDLSLLRSLTGPHDLKSLSPEQVRALAQEVRQEILRVVSANGGHLASNLGVVELTIALHRVFSCPHDVVVWDVGHQCYAH
KLLTGRAGRFHTLRQKDGISGFPRRDESPYDAFGTGHSSTALSAASGILSALRYRGKSGKVVAVVGDGALTAGLAFEALL
NVGRSCSDLIVILNDNKMSISPNTGSFSRYLSTLTVKGPYQKLKTRLRRALQTVPLVGRPACRALSRLKRSARTLLYQSN
IFADFGFEYVGPLNGHHIEDLERVLNDAKKLTRPTLLHVQTVKGKGYPFAEQNPTDFHGVGPFNLAEGIVEKKDALTFTE
AFSHTLLNAARTDDRVVAITAAMTGGTGLGLFSHIYPERFFDVGIAEQHAVTFAAGLACAGVKPVVAVYSTFLQRAVDQV
IHDVAVQNLPVIFALDRAGAVPHDGETHQGLFDLSILRAVPNINILCPASAHELSLLFGWALAQDTPVAIRYPKALCPPE
EDGFSTPVHTGRGVLITRENECNVLLVCTGGVFPEVTAAANTLARKGIFADIYNVRFVKPVDEDYFLDLVGRYRSVLFVE
DGVKIGGIAEALQALLNTRHPAPCSDVLAFQDMFYPHGSRAQVLAAAGLSAPHIAARAEWLLAHSVGQIR

Sequences:

>Translated_630_residues
MDLSLLRSLTGPHDLKSLSPEQVRALAQEVRQEILRVVSANGGHLASNLGVVELTIALHRVFSCPHDVVVWDVGHQCYAH
KLLTGRAGRFHTLRQKDGISGFPRRDESPYDAFGTGHSSTALSAASGILSALRYRGKSGKVVAVVGDGALTAGLAFEALL
NVGRSCSDLIVILNDNKMSISPNTGSFSRYLSTLTVKGPYQKLKTRLRRALQTVPLVGRPACRALSRLKRSARTLLYQSN
IFADFGFEYVGPLNGHHIEDLERVLNDAKKLTRPTLLHVQTVKGKGYPFAEQNPTDFHGVGPFNLAEGIVEKKDALTFTE
AFSHTLLNAARTDDRVVAITAAMTGGTGLGLFSHIYPERFFDVGIAEQHAVTFAAGLACAGVKPVVAVYSTFLQRAVDQV
IHDVAVQNLPVIFALDRAGAVPHDGETHQGLFDLSILRAVPNINILCPASAHELSLLFGWALAQDTPVAIRYPKALCPPE
EDGFSTPVHTGRGVLITRENECNVLLVCTGGVFPEVTAAANTLARKGIFADIYNVRFVKPVDEDYFLDLVGRYRSVLFVE
DGVKIGGIAEALQALLNTRHPAPCSDVLAFQDMFYPHGSRAQVLAAAGLSAPHIAARAEWLLAHSVGQIR
>Mature_630_residues
MDLSLLRSLTGPHDLKSLSPEQVRALAQEVRQEILRVVSANGGHLASNLGVVELTIALHRVFSCPHDVVVWDVGHQCYAH
KLLTGRAGRFHTLRQKDGISGFPRRDESPYDAFGTGHSSTALSAASGILSALRYRGKSGKVVAVVGDGALTAGLAFEALL
NVGRSCSDLIVILNDNKMSISPNTGSFSRYLSTLTVKGPYQKLKTRLRRALQTVPLVGRPACRALSRLKRSARTLLYQSN
IFADFGFEYVGPLNGHHIEDLERVLNDAKKLTRPTLLHVQTVKGKGYPFAEQNPTDFHGVGPFNLAEGIVEKKDALTFTE
AFSHTLLNAARTDDRVVAITAAMTGGTGLGLFSHIYPERFFDVGIAEQHAVTFAAGLACAGVKPVVAVYSTFLQRAVDQV
IHDVAVQNLPVIFALDRAGAVPHDGETHQGLFDLSILRAVPNINILCPASAHELSLLFGWALAQDTPVAIRYPKALCPPE
EDGFSTPVHTGRGVLITRENECNVLLVCTGGVFPEVTAAANTLARKGIFADIYNVRFVKPVDEDYFLDLVGRYRSVLFVE
DGVKIGGIAEALQALLNTRHPAPCSDVLAFQDMFYPHGSRAQVLAAAGLSAPHIAARAEWLLAHSVGQIR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=516, Percent_Identity=23.062015503876, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4507521, Length=516, Percent_Identity=23.062015503876, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI225637459, Length=443, Percent_Identity=24.8306997742664, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI225637461, Length=443, Percent_Identity=24.8306997742664, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI225637463, Length=443, Percent_Identity=24.8306997742664, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI133778974, Length=438, Percent_Identity=23.7442922374429, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=40.6451612903226, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17539652, Length=406, Percent_Identity=25.8620689655172, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551847, Length=410, Percent_Identity=25.609756097561, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550715, Length=410, Percent_Identity=25.609756097561, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645119, Length=456, Percent_Identity=24.5614035087719, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666278, Length=606, Percent_Identity=24.5874587458746, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_TREPA (O83796)

Other databases:

- EMBL:   AE000520
- PIR:   B71276
- RefSeq:   NP_219260.1
- ProteinModelPortal:   O83796
- SMR:   O83796
- IntAct:   O83796
- GeneID:   2610932
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0824
- NMPDR:   fig|243276.1.peg.819
- TIGR:   TP_0824
- HOGENOM:   HBG571647
- OMA:   HATPDES
- ProtClustDB:   PRK05444
- BioCyc:   TPAL243276:TP_0824-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68104; Mature: 68104

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSLLRSLTGPHDLKSLSPEQVRALAQEVRQEILRVVSANGGHLASNLGVVELTIALHR
CCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
VFSCPHDVVVWDVGHQCYAHKLLTGRAGRFHTLRQKDGISGFPRRDESPYDAFGTGHSST
HHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHH
ALSAASGILSALRYRGKSGKVVAVVGDGALTAGLAFEALLNVGRSCSDLIVILNDNKMSI
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEE
SPNTGSFSRYLSTLTVKGPYQKLKTRLRRALQTVPLVGRPACRALSRLKRSARTLLYQSN
CCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
IFADFGFEYVGPLNGHHIEDLERVLNDAKKLTRPTLLHVQTVKGKGYPFAEQNPTDFHGV
CHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCC
GPFNLAEGIVEKKDALTFTEAFSHTLLNAARTDDRVVAITAAMTGGTGLGLFSHIYPERF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHH
FDVGIAEQHAVTFAAGLACAGVKPVVAVYSTFLQRAVDQVIHDVAVQNLPVIFALDRAGA
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
VPHDGETHQGLFDLSILRAVPNINILCPASAHELSLLFGWALAQDTPVAIRYPKALCPPE
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCC
EDGFSTPVHTGRGVLITRENECNVLLVCTGGVFPEVTAAANTLARKGIFADIYNVRFVKP
CCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCEEEECC
VDEDYFLDLVGRYRSVLFVEDGVKIGGIAEALQALLNTRHPAPCSDVLAFQDMFYPHGSR
CCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
AQVLAAAGLSAPHIAARAEWLLAHSVGQIR
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLSLLRSLTGPHDLKSLSPEQVRALAQEVRQEILRVVSANGGHLASNLGVVELTIALHR
CCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
VFSCPHDVVVWDVGHQCYAHKLLTGRAGRFHTLRQKDGISGFPRRDESPYDAFGTGHSST
HHCCCCCEEEEECCCHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCHH
ALSAASGILSALRYRGKSGKVVAVVGDGALTAGLAFEALLNVGRSCSDLIVILNDNKMSI
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEE
SPNTGSFSRYLSTLTVKGPYQKLKTRLRRALQTVPLVGRPACRALSRLKRSARTLLYQSN
CCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
IFADFGFEYVGPLNGHHIEDLERVLNDAKKLTRPTLLHVQTVKGKGYPFAEQNPTDFHGV
CHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCC
GPFNLAEGIVEKKDALTFTEAFSHTLLNAARTDDRVVAITAAMTGGTGLGLFSHIYPERF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHH
FDVGIAEQHAVTFAAGLACAGVKPVVAVYSTFLQRAVDQVIHDVAVQNLPVIFALDRAGA
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
VPHDGETHQGLFDLSILRAVPNINILCPASAHELSLLFGWALAQDTPVAIRYPKALCPPE
CCCCCCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCC
EDGFSTPVHTGRGVLITRENECNVLLVCTGGVFPEVTAAANTLARKGIFADIYNVRFVKP
CCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCEEEECC
VDEDYFLDLVGRYRSVLFVEDGVKIGGIAEALQALLNTRHPAPCSDVLAFQDMFYPHGSR
CCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
AQVLAAAGLSAPHIAARAEWLLAHSVGQIR
CCEEEECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876