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The map label for this gene is rpiA

Identifier: 189025842

GI number: 189025842

Start: 670123

End: 670887

Strand: Direct

Name: rpiA

Synonym: TPASS_0616

Alternate gene names: 189025842

Gene position: 670123-670887 (Clockwise)

Preceding gene: 189025841

Following gene: 189025849

Centisome position: 58.81

GC content: 55.16

Gene sequence:

>765_bases
ATGCACGAGAGGAACACGACGACGAACACCCCATTAGACGTTACCGCGCAGAAATTGCTGGTTGCCCAGCGCAGCGTGGA
CACCCTCGTTCAAGAGGGGGTGCTGCACGCGCACATGAGTATTGGCCTTGGGACGGGCTCTACGGCAATGCCTGCGGTAA
AACGCATCGCAGATCACCTTGCACGCGGCACTCTCTCTGACATAGCGGCAGTGCCCACTAGTTTTCAAACAGCGCTCATA
TGTGAGCGGTACAACATCCCCCTTTTTTCTCTCAGTTCAAAACGGATTGGGGGCAAACTGGATGTGACTATCGACGGCGC
GGATGAAATTGACACCCAAAATTTTGTCATCAAAGGCGGTGGAGCTGCGCTTTTGCAAGAAAAGATCGCTGCATACAACA
GCGCGCACTTTGTTATCATCGTAGACGAAACAAAGGTGGTAGAAACCTTAGGTACGCGCGCAGCGCTCCCTATCGAAGTG
GTGCCTGAGGCCCGCATGAGCGTGATGCGCACGCTTCAGGATTGGGGGTTGTCCGTGCACATACGCGAAGCGGTAAGAAA
AAAAGGACCGGTAGTGACTGACCACGGAAATTTTATTTTAGACGCGCGGTGGCAATCGCTCCCGACGCGCACCCCGCAAG
ACATGGAACGCGCGCTCAATGCACTGCCGGGGGTCATTGAAAATGGCTTGTTCACCGAGCGAACCGTACGCGTCTTTGTT
GCGCACGCAGACGGTTCGGTAGAGGAGCGCTCGGCCTCCTTCTAA

Upstream 100 bases:

>100_bases
CTGCGCGCATTAAGTGCGCAACCCTCAGCTGGCACAATGCAGATATTCTTTTGCACCACAAAAAGGATACAGACGCGTGA
GTGCACTTGTGGAAAAAGCT

Downstream 100 bases:

>100_bases
ACGGGGCACGCTGAGCGCGCACCCGCTCAGGTGCGGAAGACCGGGCCAACGCGCAACGTATACGGGATGCGGAACTTAGC
CAGCTTGGTGTCAACGCCAA

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHLARGTLSDIAAVPTSFQTALI
CERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGGGAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEV
VPEARMSVMRTLQDWGLSVHIREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFV
AHADGSVEERSASF

Sequences:

>Translated_254_residues
MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHLARGTLSDIAAVPTSFQTALI
CERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGGGAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEV
VPEARMSVMRTLQDWGLSVHIREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFV
AHADGSVEERSASF
>Mature_254_residues
MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHLARGTLSDIAAVPTSFQTALI
CERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGGGAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEV
VPEARMSVMRTLQDWGLSVHIREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFV
AHADGSVEERSASF

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=253, Percent_Identity=36.3636363636364, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1789280, Length=206, Percent_Identity=37.378640776699, Blast_Score=104, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17551758, Length=223, Percent_Identity=39.9103139013453, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324669, Length=241, Percent_Identity=34.0248962655602, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281364072, Length=214, Percent_Identity=38.785046728972, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_TREPA (O83625)

Other databases:

- EMBL:   AE000520
- PIR:   E71303
- RefSeq:   NP_219054.1
- ProteinModelPortal:   O83625
- GeneID:   2611225
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0616
- NMPDR:   fig|243276.1.peg.613
- TIGR:   TP_0616
- HOGENOM:   HBG515603
- OMA:   MVVIADA
- ProtClustDB:   PRK00702
- BioCyc:   TPAL243276:TP_0616-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 27573; Mature: 27573

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHEEEECCCCCHHHHHHHHHHHHH
ARGTLSDIAAVPTSFQTALICERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGG
HHCCHHHHHHCCCCHHHHEEEHCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCEEEECC
GAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEVVPEARMSVMRTLQDWGLSVH
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCEEE
IREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFV
HHHHHHHCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCEEEEEEE
AHADGSVEERSASF
EECCCCCCCCCCCC
>Mature Secondary Structure
MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHEEEECCCCCHHHHHHHHHHHHH
ARGTLSDIAAVPTSFQTALICERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGG
HHCCHHHHHHCCCCHHHHEEEHCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCEEEECC
GAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEVVPEARMSVMRTLQDWGLSVH
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCEEE
IREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFV
HHHHHHHCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCEEEEEEE
AHADGSVEERSASF
EECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876