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The map label for this gene is pgl

Identifier: 189025708

GI number: 189025708

Start: 507930

End: 508655

Strand: Reverse

Name: pgl

Synonym: TPASS_0477

Alternate gene names: 189025708

Gene position: 508655-507930 (Counterclockwise)

Preceding gene: 189025709

Following gene: 189025707

Centisome position: 44.64

GC content: 56.34

Gene sequence:

>726_bases
ATGAAGAAGCATATTTTTGAGGATGCGCGTGCCATCGCGGCGTTCCTCGTTTCGGTGTTTGATTCTCGGCTCAAAACACA
AGAGATTCTCTGGTTGGCCCTGTCGGGGGGTTCCACTCCAAGGGAGATTTTCAGAACTTGGGCGCACGAGTTTCGACACC
ACCTTGATTGGAAGCGCCTCCGCTTCTTCTGGAGCGATGAGCGTTGCGTACCCCCCACGGATGCGCAGAGTAACTTCAAC
ATGACCCATAGTGCGCTCCTTGAGCCTCTGGAAATAAATCCTGACGCGGTGTTTCGCGTCAGGGGAGAAGACGCCCCGGA
GAGCGCCTGCGCCGCATACTCACAGGAAATTGAAGCACGGCTCCCAAGACAGCGTGGCGTGCCGTGCTTTGATATTATAC
TCCTGGGTATGGGGGCGGATGGACACACCGCGTCTATTTTCCCTCATGAAATAGAGCTGTGGGACCACAGCGGCTGTTGC
GTCGTGGCAACTCACCCAGACACCGGTCAGAAACGTGTGAGTTTCACTGGGCACCTTATCAATAATGCACACGAAATCTA
CGTCGTAGTTACCGGGCGTGAAAAGCAGGACATGCTCGCGTCAGTCGCGTCAGATCCCCACGCGTCCGTGCCCTTGCACG
CGTGGACACTGCCAAAGCGCAGTGGCTGCTGGATACCGCTGCTGCGGGGGCTATATCCGCGTAAGCAGTGTAAGCCAACG
GTGTAG

Upstream 100 bases:

>100_bases
TTCTACGCTGCTCAGCGATGATTTTGCCTGCCGACTCTAGCGGTAATGCCGAGCCTTGAACGACACTAGAACGTAGCGGG
AGAGAGGAGGATGTTCGCCC

Downstream 100 bases:

>100_bases
GAAAGTGGCGCATTTTGCGTGTATGCTACGGTGTCCGAGAAATTACCAAAACGGTGGAGGTGTATTATGATTATCCTCAC
GCTAAACTGCGGCAGTTCAT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: 6PGL

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRLRFFWSDERCVPPTDAQSNFN
MTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEARLPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCC
VVATHPDTGQKRVSFTGHLINNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPT
V

Sequences:

>Translated_241_residues
MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRLRFFWSDERCVPPTDAQSNFN
MTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEARLPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCC
VVATHPDTGQKRVSFTGHLINNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPT
V
>Mature_241_residues
MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRLRFFWSDERCVPPTDAQSNFN
MTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEARLPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCC
VVATHPDTGQKRVSFTGHLINNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPT
V

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily

Homologues:

Organism=Homo sapiens, GI52145310, Length=182, Percent_Identity=36.2637362637363, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI6912586, Length=198, Percent_Identity=28.2828282828283, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533060, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533058, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321957, Length=207, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324362, Length=189, Percent_Identity=24.8677248677249, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641119, Length=192, Percent_Identity=30.7291666666667, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGL_TREPA (O83490)

Other databases:

- EMBL:   AE000520
- PIR:   C71319
- RefSeq:   NP_218918.1
- ProteinModelPortal:   O83490
- SMR:   O83490
- GeneID:   2611121
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0477
- NMPDR:   fig|243276.1.peg.477
- TIGR:   TP_0477
- HOGENOM:   HBG725991
- OMA:   PRLTFTF
- ProtClustDB:   CLSK2300224
- BioCyc:   TPAL243276:TP_0477-MONOMER
- BRENDA:   3.1.1.31
- InterPro:   IPR005900
- PANTHER:   PTHR11054
- TIGRFAMs:   TIGR01198

Pfam domain/function: NA

EC number: =3.1.1.31

Molecular weight: Translated: 27272; Mature: 27272

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHH
RFFWSDERCVPPTDAQSNFNMTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEAR
HEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCCVVATHPDTGQKRVSFTGHLI
CCHHCCCCHHHEEEEECCCCCCEEEECCCEEEEECCCCCEEEEECCCCCCEEEEEEEHEE
NNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPT
CCCEEEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCC
V
C
>Mature Secondary Structure
MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHH
RFFWSDERCVPPTDAQSNFNMTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEAR
HEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCCVVATHPDTGQKRVSFTGHLI
CCHHCCCCHHHEEEEECCCCCCEEEECCCEEEEECCCCCEEEEECCCCCCEEEEEEEHEE
NNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPT
CCCEEEEEEEECCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876