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The map label for this gene is uvrC

Identifier: 189025703

GI number: 189025703

Start: 501109

End: 503184

Strand: Reverse

Name: uvrC

Synonym: TPASS_0472

Alternate gene names: 189025703

Gene position: 503184-501109 (Counterclockwise)

Preceding gene: 189025704

Following gene: 189025701

Centisome position: 44.16

GC content: 50.72

Gene sequence:

>2076_bases
GTGCGTCCTTCTGAATCTCTCGTGGAGACGTTGCGCATTCAGGCACTCAGTGCCCCGTCTACAAGCGGTGTATATCTGTG
GAAAGACGTACACGGCGTTGTCATCTATGTCGGTAAAGCAAAATCACTCAGGACAAGACTCACTTCTTACTTTCGCTGCA
GGCACGACCCAAAGACACGCGTGCTGATGTCGCGCGCCGCTGCACTTGAATATCTACAAACACAACACGAATACGAGGCG
CTGCTCCTTGAGAACACACTCATAAAAAAACATACTCCGCGCTACAATATCTGCCTCAAAGACGGGAAAACCTATCCTTT
GCTCAAGCTAACCTGCGAGCCATTTCCGCGTATTTTTCGCACACGCCAATTCTGTCAAGACGGTGCACGGTACTTTGGTC
CCTTCCCTGACGTGCAAATCCTCGATTCTTTTCTTAAACTCATTTTACGCACCTATAAAATCCGTACGTGCACCACCTTG
CGGAAGAGAAAAAATCCTTGCCTCTACTATCACCTGAAGCGCTGCGATGCCCCGTGTTGTGGATGGGTCTCTCCACGCAC
ATATCAAAAGGACATACATGAGATTACCCTGCTGCTCGAGGGGAATATTGACGCGACTGTAGCGCGTCTAGAAAAGCGCA
TGAAACGAGCAGTCCGCCAAGAAGCATTCGAAGCTGCCGCGCGCATACGCGATGATATCCAGGCAATCCGCTGTATTACA
CACAAAAGTCTTGTTCAAGACATGGACGAACGTGCACGCGATTACATCGCCTGGTCGAGCACGGGAGCAATCGTCACCTT
CGCCGTTCTACGCATGCGGGGAGGAAAATTAAACGGTAGAGAACTTTTTCGCACACGTTCATTAAAAAATGAAGAGGAAA
TCCTTTCAGAATTTCTCATCACTTACTACTCTGACCATACCATACCCCCACATCTATTTGTACACTCGTCTGCAGGGTTA
GCAGAACACTGGCTCAGCCATAAAGCAGGTACACAATGTACCGTCACGCTCATCCCTTTGCATACCTTTCCTACGCCGCA
GACCCCTTCTTCCACTGTCACCACAAACGCTCCTACCCTTGCAGCTTCGCAAAATAGCAATGCAGTACAAGATTCAGGGT
TACGTTCTTGCAGCGAAACGTCCACCATGCATACGCTTCAAAAAGCACACGACGCCTGCACTGCAAGCGAAGGCACACGA
GAAAACACACCGCACGAGAGCGCGCACACTCCTCATCACCGCGCCATTTTAGCCATGGCGCAGTTAAACGCTCATGAAGA
TATTACTCGGTATCTGAAAAATCGCGGCGCTGACGATGCACTCAAGGAATTGCAAAAGCAACTGCATCTTGCACGCATTC
CAACGCTCATTGAAGGATTTGACATTTCCCATTTGGGTGGAAAGTACACTGTCGCAAGTCTCATTTGCTTCAAAAATGGG
GCCCCCGACACAAAGAACTACCGATTGTTTAATTTACGTGCGCACGACACCCGTATTGACGATTTTGCATCGATGCGCGA
AGCAATTGCCCGCCGTTATACCCACACACCAGAGGGCTACACTCTGCCCGATCTTATCCTTGTCGATGGGGGAATCGGTC
ACGTTTCTGCTGCACAGCACGTCCTCGACGCTCTTGGTCTTAGTATCCCGCTTGTAGGTCTTGCAAAACGCGCAGAAGAG
CTATTTATCCCCAATTCTCCTACACCACTAGTTCTGGATCGTCGCAACCCTGCACTGCATATGCTGCAACGCATCCGAGA
TGAAGCACACCGCTTTGCAATCACACGGAATCGGCATCTACGCACAAAGAAAGAGCTAGTCTTAAGCTTTGAGCGTCTCC
CCCATGTGGGCAAAGTGCGCGCACACAGACTGCTTGCTCACTTCGGTTCGTTCCGCAGCCTGCAGAGCGCAACTCCCCAG
GACATAGCGACAGCCATTCATATACCGCTCACCCAAGCACACACCATCCTGCACGCGGCAACCCGCTCAACAACCGCCCC
TGTACGAGAAGAATATAAAGAACACGAGCACGACCCCCAGGGAGAATCACCTGGACCAGGTCGGAAAACAGACTAA

Upstream 100 bases:

>100_bases
TTGCCGTGCGTATGAATGTTCGTTAGAACCAAAATAAGCCGGCATGCTTCTGCGCGTGACAGGAAAAACAGTTTCACGAT
TCTTGGTGGGGGCATGACCC

Downstream 100 bases:

>100_bases
CGCGCACCCGGCCTACGACGACGCATCCAGGAGTCGCTCAAGCTCATTCTTTCCCAGAAGCTCGAGCGGACGATTTTCTG
CAAACGAAAGCGCAGCGCGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTRVLMSRAAALEYLQTQHEYEA
LLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFRTRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTL
RKRKNPCLYYHLKRCDAPCCGWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCIT
HKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLITYYSDHTIPPHLFVHSSAGL
AEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTLAASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTR
ENTPHESAHTPHHRAILAMAQLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNG
APDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQHVLDALGLSIPLVGLAKRAEE
LFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHLRTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQ
DIATAIHIPLTQAHTILHAATRSTTAPVREEYKEHEHDPQGESPGPGRKTD

Sequences:

>Translated_691_residues
MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTRVLMSRAAALEYLQTQHEYEA
LLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFRTRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTL
RKRKNPCLYYHLKRCDAPCCGWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCIT
HKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLITYYSDHTIPPHLFVHSSAGL
AEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTLAASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTR
ENTPHESAHTPHHRAILAMAQLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNG
APDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQHVLDALGLSIPLVGLAKRAEE
LFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHLRTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQ
DIATAIHIPLTQAHTILHAATRSTTAPVREEYKEHEHDPQGESPGPGRKTD
>Mature_691_residues
MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTRVLMSRAAALEYLQTQHEYEA
LLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFRTRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTL
RKRKNPCLYYHLKRCDAPCCGWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCIT
HKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLITYYSDHTIPPHLFVHSSAGL
AEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTLAASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTR
ENTPHESAHTPHHRAILAMAQLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNG
APDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQHVLDALGLSIPLVGLAKRAEE
LFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHLRTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQ
DIATAIHIPLTQAHTILHAATRSTTAPVREEYKEHEHDPQGESPGPGRKTD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=333, Percent_Identity=35.4354354354354, Blast_Score=182, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_TREPA (O83485)

Other databases:

- EMBL:   AE000520
- PIR:   B71322
- RefSeq:   NP_218913.1
- ProteinModelPortal:   O83485
- IntAct:   O83485
- GeneID:   2611102
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0472
- NMPDR:   fig|243276.1.peg.472
- TIGR:   TP_0472
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK14672
- BioCyc:   TPAL243276:TP_0472-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 78211; Mature: 78211

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTR
CCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCHHH
VLMSRAAALEYLQTQHEYEALLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCHHHHHHH
TRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTLRKRKNPCLYYHLKRCDAPCC
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCC
GWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCIT
CCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLI
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TYYSDHTIPPHLFVHSSAGLAEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTL
HHHCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCEECCCCCE
AASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTRENTPHESAHTPHHRAILAMA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
QLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNG
HHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCC
APDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQH
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHH
VLDALGLSIPLVGLAKRAEELFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHL
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
RTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQDIATAIHIPLTQAHTILHAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHHHHHHHH
TRSTTAPVREEYKEHEHDPQGESPGPGRKTD
HCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTR
CCCHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCHHH
VLMSRAAALEYLQTQHEYEALLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCHHHHHHH
TRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTLRKRKNPCLYYHLKRCDAPCC
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCC
GWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCIT
CCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLI
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHH
TYYSDHTIPPHLFVHSSAGLAEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTL
HHHCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCEECCCCCE
AASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTRENTPHESAHTPHHRAILAMA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
QLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNG
HHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCC
APDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQH
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHH
VLDALGLSIPLVGLAKRAEELFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHL
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
RTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQDIATAIHIPLTQAHTILHAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHHHHHHHH
TRSTTAPVREEYKEHEHDPQGESPGPGRKTD
HCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876