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The map label for this gene is murB

Identifier: 189025324

GI number: 189025324

Start: 98740

End: 99804

Strand: Reverse

Name: murB

Synonym: TPASS_0090

Alternate gene names: 189025324

Gene position: 99804-98740 (Counterclockwise)

Preceding gene: 189025330

Following gene: 189025323

Centisome position: 8.76

GC content: 57.75

Gene sequence:

>1065_bases
ATGTCCGCGCACCGGATACGCGCGCGTCGGATCACGCGCCGTAACGTCCCACTTGCAGAGCGATGTTCTTTCCGCATTGG
TGGCGCTGCGCAGTTTTGGGCGGAGCCGCGCTCCTGCACACAGCTGCGCGCGCTTATTGAGGAAGCGCAGCGCGCACGCA
TTCCGCTGTCCCTTATTGGGGGAGGCTCTAACGTGTTAATCGCAGACGAGGGCGTACCGGGTCTGATGTTGAGCCTTCGT
CGCTTTCGCAGTCTACACACCCAAACACAGCGCGATGGCTCAGTGCTCGTACATGCAGGCGCGGGGTTACCTGTGGCCGC
CCTCCTGGCCTTTTGTGCCCATCACGCTCTACGCGGGCTTGAGACCTTTGCAGGGCTGCCTGGTAGTGTCGGTGGTGCCG
CGTACATGAACGCCCGATGTTATGGGCGTGCAATCGCAGATTGCTTTCACTCTGCGCGCACGCTCGTACTTCACCCCGTG
CGTTCGCGCGCAAAAGAACTGCCAGAGGTGAGAAAAAACGCACAAGACAAAAGAGGGGAATGTCTTGGCCTCGACGGCGG
ACCGTTTACCTGCAGCAGTTTTCAGACCGTCTTCGCGCGCGCGGGGGATTGGGGCTACAAGCGCTCTCCTTTCCAGAGTC
CTCACGGTGTTGAACTCCATGCAGGAAGGCGTCTTATCCTCTCGCTGTGTGTACGTCTCACTCCCGGCAATCCGGCGCAG
ATTAGGAAGCACATGCAGGAGAAGATTGCCGATCGTATTTCAAAGGGGCAGTTTCGCTTTCCGTCAGCAGGCAGCGCGTT
TAAAAACAACCCAGCTTTTGGTAAACCGTCTGGCATTCTCATAGAAGAGGCAGGTTTACGGGGCACCTCCTGTGGGGCTG
CGCAGGTAGCACCCTGGCATGGAAATCTCATTATCAATACGGGGAATGCCACCGCACATCAGGTGCGCACACTCTTGCGC
GTCGTTCGGCAACGCGTGTTTGAAACACACGGAGTGTGGCTCGAACGGGAAATCATTTTTTCTGGAGAATCTGTGAGGAT
GACTTCCAGTTCGCGAGACTCATGA

Upstream 100 bases:

>100_bases
TGCCCGCCTGCGCTTCAGTCTACCCTCCCTCGAAACGCAAAGAAGGCCAAGACCGCGCCATTGTAGCATAAGCGCGTGAA
ATCGTATATGTTTTCTGTCC

Downstream 100 bases:

>100_bases
GGCGGGCACCTGTGCACTGCAAGACGTACGGGTTGTCTTGTAAACAGAGCATAGAGCGACGATTAGGAAGGAGTGGGATA
CTTTGTTACAGCTGACGTTT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLR
RFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPV
RSRAKELPEVRKNAQDKRGECLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQ
IRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLR
VVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS

Sequences:

>Translated_354_residues
MSAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLR
RFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPV
RSRAKELPEVRKNAQDKRGECLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQ
IRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLR
VVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS
>Mature_353_residues
SAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLRR
FRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVR
SRAKELPEVRKNAQDKRGECLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQI
RKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRV
VRQRVFETHGVWLEREIIFSGESVRMTSSSRDS

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_TREPA (O83128)

Other databases:

- EMBL:   AE000520
- PIR:   C71368
- RefSeq:   NP_218530.1
- ProteinModelPortal:   O83128
- SMR:   O83128
- GeneID:   2611262
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0090
- NMPDR:   fig|243276.1.peg.89
- TIGR:   TP_0090
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK14648
- BioCyc:   TPAL243276:TP_0090-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 38596; Mature: 38465

Theoretical pI: Translated: 11.50; Mature: 11.50

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 265-265 ACT_SITE 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIG
CCCHHHHHHHHHHCCCCHHHHCCCEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEC
GGSNVLIADEGVPGLMLSLRRFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGL
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
ETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVRSRAKELPEVRKNAQDKRGE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCC
CLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQ
EEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHH
IRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWH
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCC
GNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCCCCCC
>Mature Secondary Structure 
SAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIG
CCHHHHHHHHHHCCCCHHHHCCCEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEC
GGSNVLIADEGVPGLMLSLRRFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGL
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
ETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVRSRAKELPEVRKNAQDKRGE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCC
CLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQ
EEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHH
IRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWH
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCC
GNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876