| Definition | Treponema pallidum subsp. pallidum SS14, complete genome. |
|---|---|
| Accession | NC_010741 |
| Length | 1,139,457 |
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The map label for this gene is slt [H]
Identifier: 189025277
GI number: 189025277
Start: 50415
End: 52547
Strand: Direct
Name: slt [H]
Synonym: TPASS_0043
Alternate gene names: 189025277
Gene position: 50415-52547 (Clockwise)
Preceding gene: 189025276
Following gene: 189025278
Centisome position: 4.42
GC content: 51.62
Gene sequence:
>2133_bases TTGAAATTCCGTCACGGTAAGCATCTCGTGTGGGGAGGTGGCTTTTTCTCTCTCTTACGGGAGGGCAGGTTGTGCCTGCG CGTGTGGTGCGTGGTGTGTGTCCTTGTCTCGTGGGAGGGCACTGTGTGCGCGCGCGGCGCTAGGGAGGTTGATATCCCTC AGTTTTTGAGAGACAAAAACTACACTCCGTTTCTAAAGCCAACAGATGAGTTTCTCGAGCAGGTCGCCGCGCGGGAAGGT GCAAGTTACTTCATTGGGTTACACCTCAAGCGGGCCAAGTTTTCCGAAGAAGCTCACGAGTACTTCGTACGTGGCGCAGC GCAGGCCGCACCGTACCGCCAGTTATGTGCGCATGAGGCACACAATACAGGGAGTCCACTACAGCGTCTCGCCTTTATTG AAAAACAGCTGCATGTCCTTAATGCAGGCAGCGATGCGCGAACCAAAACGCAGCAACAGACACTTCGCCTTTTGCGTTCA AGGGTGCTCTTTGAACTCGAACGCTACTACAGTCTGAGAACGGTTGTTGAGTCTTGGTACAACGATAGGGCACTTGCGCC CCATACGAGTGCACAATTTGCTGCGCTTATTGCGGCACTGCCGGATCTGCCGCGTATCTTTAAGGAAGTACATGGTGCTC GTGTGGACGTCTTTCACAGGAATTACAAACGGGGGTGGGAGAGAGTGCGATTGTTGTTGCGCTCTTCTGCGTGGCACACG CGGTACGCTACAAATTCGGTTCTCTCCGATTTTGGGAAAGCAGCGCTTTACGGTAGTGAAAACAGTGTTAAAGCCGCGCA GGTTTTTCTTGACCATCTTGCACATCTATCGCGCTCAACGTTGTCCAATGCGGAATTAGAGGCACGACTGCGTTTTTATT GCTATTTTTATGCGGCGCGTCTTTACTCGCGGTCCGCTTCTCACAAGAAGCAAGCGCTTCCCCTTTTCAAAAAGGCAGAG AAAGTGGCCACAAGGCGGCAAGATGCTGATAATGCCCTGTGGTATTACTTGGACGTACTGCGTGCATTGGACTTTGATTC TTTCTTTAAGGTGCTTGTTGAAAGTGCACCACGTTGGCGTTCGGATTCTTGGTTTTCTGACCTTGTCGATTATGCAATTG TCCAGCTGACTACGCAGCAAGATTGGGGGCGTCTGGCTACACTGCAAGAGGTGCTGACGCATAGAGCATTACCCGAGCGC TCCGCGCGCGTTACGTATGTCCTTGCGCGTTCAGGTACGCTTTCAGAAGAGAGTGCGCGCCGCGCTTACCGTACCATCTT CGAAACTGCGCATTCTTCCCTTTACTATCGTGTTCTTGCTGCATGTGCATTGGGCATTCCTCTGGAAGAGGCTTTGTATA AGGTGCGGAGTAAGAGAACACCGCATCCTTTTCTTACCCCCGATGAGTCGCGTGCTATTCTCCAAGGTTATGTAGACTAT CACTTGGACGATATGTTCTACCAAGCTATGGTACAGTTCTATCCTGACATTCCTCTCCACCTTGCAGAGCATTTTGCGAA CGCACACATACAAAGATCACGATGGTCCGATGCCGTGCGCATTCAGTCGTACGCAATACGCTCTCACGGTGCGCGCTATT CTGTAGAACACTTGAAGATTGCGTACCCGCGTCCGTGGCTTGACGTCATACAAGGCTATGCAGGGAAGTATCATATTGAG GAGTATCTGCTGTTTGCGCTCATCCGGAGTGAAAGTCTGTTTCAGCCGCAGGTTATCTCTCGGGCGGGCGCTGTAGGTCT TGCTCAATTGATGAGGCCAACCGCTTCAGATATCGCTCGTAAGCTCAATATCGACACCTATGACTTAACTGACCCGGATA TCAATGTTAGATTCGGCAGTCTGTTCTTTTCCGATCTCATTCGTCGCTTTGATGGCTCCGTGTTCTGTGCCCTGTTCTCC TACAATGCGGGACCGTCGCGCGTCCGCAAATGGAAAAAACAGAGGGGAAGTCTGCCCGATGATCTGTTCCTCGAAACCCT GCCTCTTGCAGAACCTCGGGAGTACGGGAGGAAGATCCTATCCGCAGCGGTGATGTACGGGTACCTTTATTATCAGAAAC AGGCTTCAGATGTTGTGTGTGCGTTGCTTCCTGAATTCTGTCGTGCTTCCTGA
Upstream 100 bases:
>100_bases GATTTGGCGCGGAGTTATTACAAGACTCCGTGGCGCTACATGAGAATTGCTGAGTTTAACCGACTGAAAAACCCTGATCA TATCGTTGCAGGAACCTCAA
Downstream 100 bases:
>100_bases TTGAAGCCTTTTGCACCTTTCTTCTATAATCCGCTGCCCATGGGTTTCAGATTTTCTGACTATGACGTTATCGTCGTCGG TGGTGGACACGCAGGTGCCG
Product: soluble lytic transglycosylase
Products: 1,6-Anhydrobond [C]
Alternate protein names: Exomuramidase; Peptidoglycan lytic exotransglycosylase; Slt70 [H]
Number of amino acids: Translated: 710; Mature: 710
Protein sequence:
>710_residues MKFRHGKHLVWGGGFFSLLREGRLCLRVWCVVCVLVSWEGTVCARGAREVDIPQFLRDKNYTPFLKPTDEFLEQVAAREG ASYFIGLHLKRAKFSEEAHEYFVRGAAQAAPYRQLCAHEAHNTGSPLQRLAFIEKQLHVLNAGSDARTKTQQQTLRLLRS RVLFELERYYSLRTVVESWYNDRALAPHTSAQFAALIAALPDLPRIFKEVHGARVDVFHRNYKRGWERVRLLLRSSAWHT RYATNSVLSDFGKAALYGSENSVKAAQVFLDHLAHLSRSTLSNAELEARLRFYCYFYAARLYSRSASHKKQALPLFKKAE KVATRRQDADNALWYYLDVLRALDFDSFFKVLVESAPRWRSDSWFSDLVDYAIVQLTTQQDWGRLATLQEVLTHRALPER SARVTYVLARSGTLSEESARRAYRTIFETAHSSLYYRVLAACALGIPLEEALYKVRSKRTPHPFLTPDESRAILQGYVDY HLDDMFYQAMVQFYPDIPLHLAEHFANAHIQRSRWSDAVRIQSYAIRSHGARYSVEHLKIAYPRPWLDVIQGYAGKYHIE EYLLFALIRSESLFQPQVISRAGAVGLAQLMRPTASDIARKLNIDTYDLTDPDINVRFGSLFFSDLIRRFDGSVFCALFS YNAGPSRVRKWKKQRGSLPDDLFLETLPLAEPREYGRKILSAAVMYGYLYYQKQASDVVCALLPEFCRAS
Sequences:
>Translated_710_residues MKFRHGKHLVWGGGFFSLLREGRLCLRVWCVVCVLVSWEGTVCARGAREVDIPQFLRDKNYTPFLKPTDEFLEQVAAREG ASYFIGLHLKRAKFSEEAHEYFVRGAAQAAPYRQLCAHEAHNTGSPLQRLAFIEKQLHVLNAGSDARTKTQQQTLRLLRS RVLFELERYYSLRTVVESWYNDRALAPHTSAQFAALIAALPDLPRIFKEVHGARVDVFHRNYKRGWERVRLLLRSSAWHT RYATNSVLSDFGKAALYGSENSVKAAQVFLDHLAHLSRSTLSNAELEARLRFYCYFYAARLYSRSASHKKQALPLFKKAE KVATRRQDADNALWYYLDVLRALDFDSFFKVLVESAPRWRSDSWFSDLVDYAIVQLTTQQDWGRLATLQEVLTHRALPER SARVTYVLARSGTLSEESARRAYRTIFETAHSSLYYRVLAACALGIPLEEALYKVRSKRTPHPFLTPDESRAILQGYVDY HLDDMFYQAMVQFYPDIPLHLAEHFANAHIQRSRWSDAVRIQSYAIRSHGARYSVEHLKIAYPRPWLDVIQGYAGKYHIE EYLLFALIRSESLFQPQVISRAGAVGLAQLMRPTASDIARKLNIDTYDLTDPDINVRFGSLFFSDLIRRFDGSVFCALFS YNAGPSRVRKWKKQRGSLPDDLFLETLPLAEPREYGRKILSAAVMYGYLYYQKQASDVVCALLPEFCRAS >Mature_710_residues MKFRHGKHLVWGGGFFSLLREGRLCLRVWCVVCVLVSWEGTVCARGAREVDIPQFLRDKNYTPFLKPTDEFLEQVAAREG ASYFIGLHLKRAKFSEEAHEYFVRGAAQAAPYRQLCAHEAHNTGSPLQRLAFIEKQLHVLNAGSDARTKTQQQTLRLLRS RVLFELERYYSLRTVVESWYNDRALAPHTSAQFAALIAALPDLPRIFKEVHGARVDVFHRNYKRGWERVRLLLRSSAWHT RYATNSVLSDFGKAALYGSENSVKAAQVFLDHLAHLSRSTLSNAELEARLRFYCYFYAARLYSRSASHKKQALPLFKKAE KVATRRQDADNALWYYLDVLRALDFDSFFKVLVESAPRWRSDSWFSDLVDYAIVQLTTQQDWGRLATLQEVLTHRALPER SARVTYVLARSGTLSEESARRAYRTIFETAHSSLYYRVLAACALGIPLEEALYKVRSKRTPHPFLTPDESRAILQGYVDY HLDDMFYQAMVQFYPDIPLHLAEHFANAHIQRSRWSDAVRIQSYAIRSHGARYSVEHLKIAYPRPWLDVIQGYAGKYHIE EYLLFALIRSESLFQPQVISRAGAVGLAQLMRPTASDIARKLNIDTYDLTDPDINVRFGSLFFSDLIRRFDGSVFCALFS YNAGPSRVRKWKKQRGSLPDDLFLETLPLAEPREYGRKILSAAVMYGYLYYQKQASDVVCALLPEFCRAS
Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]
COG id: COG0741
COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
Gene ontology:
Cell location: Periplasm. Note=Tightly associated with the murein sacculus (By similarity) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transglycosylase slt family [H]
Homologues:
Organism=Escherichia coli, GI87082441, Length=208, Percent_Identity=27.4038461538462, Blast_Score=89, Evalue=1e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016026 - InterPro: IPR008258 - InterPro: IPR012289 - InterPro: IPR008939 - InterPro: IPR000189 [H]
Pfam domain/function: PF01464 SLT [H]
EC number: 3.2.1.- [C]
Molecular weight: Translated: 81751; Mature: 81751
Theoretical pI: Translated: 9.68; Mature: 9.68
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 0.7 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKFRHGKHLVWGGGFFSLLREGRLCLRVWCVVCVLVSWEGTVCARGAREVDIPQFLRDKN CCCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCC YTPFLKPTDEFLEQVAAREGASYFIGLHLKRAKFSEEAHEYFVRGAAQAAPYRQLCAHEA CCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC HNTGSPLQRLAFIEKQLHVLNAGSDARTKTQQQTLRLLRSRVLFELERYYSLRTVVESWY CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NDRALAPHTSAQFAALIAALPDLPRIFKEVHGARVDVFHRNYKRGWERVRLLLRSSAWHT CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCHH RYATNSVLSDFGKAALYGSENSVKAAQVFLDHLAHLSRSTLSNAELEARLRFYCYFYAAR HHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH LYSRSASHKKQALPLFKKAEKVATRRQDADNALWYYLDVLRALDFDSFFKVLVESAPRWR HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCC SDSWFSDLVDYAIVQLTTQQDWGRLATLQEVLTHRALPERSARVTYVLARSGTLSEESAR CCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHH RAYRTIFETAHSSLYYRVLAACALGIPLEEALYKVRSKRTPHPFLTPDESRAILQGYVDY HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH HLDDMFYQAMVQFYPDIPLHLAEHFANAHIQRSRWSDAVRIQSYAIRSHGARYSVEHLKI HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHEEE AYPRPWLDVIQGYAGKYHIEEYLLFALIRSESLFQPQVISRAGAVGLAQLMRPTASDIAR ECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH KLNIDTYDLTDPDINVRFGSLFFSDLIRRFDGSVFCALFSYNAGPSRVRKWKKQRGSLPD HCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCH DLFLETLPLAEPREYGRKILSAAVMYGYLYYQKQASDVVCALLPEFCRAS HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MKFRHGKHLVWGGGFFSLLREGRLCLRVWCVVCVLVSWEGTVCARGAREVDIPQFLRDKN CCCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCC YTPFLKPTDEFLEQVAAREGASYFIGLHLKRAKFSEEAHEYFVRGAAQAAPYRQLCAHEA CCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC HNTGSPLQRLAFIEKQLHVLNAGSDARTKTQQQTLRLLRSRVLFELERYYSLRTVVESWY CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH NDRALAPHTSAQFAALIAALPDLPRIFKEVHGARVDVFHRNYKRGWERVRLLLRSSAWHT CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCHH RYATNSVLSDFGKAALYGSENSVKAAQVFLDHLAHLSRSTLSNAELEARLRFYCYFYAAR HHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH LYSRSASHKKQALPLFKKAEKVATRRQDADNALWYYLDVLRALDFDSFFKVLVESAPRWR HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCC SDSWFSDLVDYAIVQLTTQQDWGRLATLQEVLTHRALPERSARVTYVLARSGTLSEESAR CCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHH RAYRTIFETAHSSLYYRVLAACALGIPLEEALYKVRSKRTPHPFLTPDESRAILQGYVDY HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH HLDDMFYQAMVQFYPDIPLHLAEHFANAHIQRSRWSDAVRIQSYAIRSHGARYSVEHLKI HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEHHHEEE AYPRPWLDVIQGYAGKYHIEEYLLFALIRSESLFQPQVISRAGAVGLAQLMRPTASDIAR ECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH KLNIDTYDLTDPDINVRFGSLFFSDLIRRFDGSVFCALFSYNAGPSRVRKWKKQRGSLPD HCCCCEEECCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCH DLFLETLPLAEPREYGRKILSAAVMYGYLYYQKQASDVVCALLPEFCRAS HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]
Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]
General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]