BacMap

Definition	Treponema pallidum subsp. pallidum SS14, complete genome.
Accession	NC_010741
Length	1,139,457

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The map label for this gene is znuC [C]

Identifier: 189025269

GI number: 189025269

Start: 42934

End: 43650

Strand: Direct

Name: znuC [C]

Synonym: TPASS_0035

Alternate gene names: 189025269

Gene position: 42934-43650 (Clockwise)

Preceding gene: 189025265

Following gene: 189025270

Centisome position: 3.77

GC content: 47.84

Gene sequence:

>717_bases
ATGCGCATCATGGCTAGTCCCTTCGCGGTGCTTTTACAAAACGTTAGTTTCAGGTACACCGCAGACGCGCGCTTTATACT
GCACGAGGTGGATCTTGCAATACCAAAAGGCGCGTACCTTTCCGTTGTAGGAGAAAATGGTAGTGGGAAAAGCACGCTTG
TGAAGCTTGTCCTCAAATTACTTAAGCCGAGCACCGGTACGATCGCTCACTTTGTACAGCGTGTTGGTTCTGTTCCACAG
ACAAAGATGCACACGCTCTATTTTCCGCTTACGGTATATGAAATGCTTAACTCGTATCGCAGACTTCTGCGCATATCGCA
CAAGTGGGTTGTCGATGCTGTGCTGGAGGAGGTGGGTATGCGGGGTGCGAAAAAAAAGCTTGTGTATACCCTCTCTGGAG
GAGAATTACAGAAGGTGTACATTGCGCGGAGCCTGATCGGAGATCCTGATTTGCTGGTGCTCGATGAGCTGTCAACAGGT
ATTGATTCTCGAGGACAGAAAGATATTTACGCTCTGCTGAAGGGATTGAACACATCACGTAACGTAACGGTTATATCGGT
GGAGCATAATCTTGATGCAGCGATTACAAACTCTACGCAAATTTTTCATCTCAGCGAAGGACATGGCCATTTGTGTAATC
CTCAGCAGTACGTCAGTGAGTTTTTGGATATGCAGAAAAAAGATGCGCTTGCCTGTGCGCAGTGTCGGAGTCGGTGA

Upstream 100 bases:

>100_bases
TCTTCGAAAACCATGGTAGAGAGACAATTTGCATTGTGCAGCTGTGGTCTCTTTTTTCTCAGAGACAGTAGTGTTGCATT
CATAAAAATAGAGTATAACC

Downstream 100 bases:

>100_bases
TGTTGCAGTACGCATTTATGCGCAACGCTTTTGTTGCTTCTTTTCTCATAGCCTTGTTGTGTCCTCTTGTGGGGATGCAC
TTAGTGCTCCGCCGTTACGC

Product: ABC transporter, ATP-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKLLKPSTGTIAHFVQRVGSVPQ
TKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGMRGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTG
IDSRGQKDIYALLKGLNTSRNVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR

Sequences:

>Translated_238_residues
MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKLLKPSTGTIAHFVQRVGSVPQ
TKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGMRGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTG
IDSRGQKDIYALLKGLNTSRNVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR
>Mature_238_residues
MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKLLKPSTGTIAHFVQRVGSVPQ
TKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGMRGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTG
IDSRGQKDIYALLKGLNTSRNVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR

Specific function: Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Probably responsible for energy coupling to the transport system

COG id: COG1121

COG function: function code P; ABC-type Mn/Zn transport systems, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI42490749, Length=267, Percent_Identity=28.8389513108614, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI9955963, Length=223, Percent_Identity=30.0448430493274, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI45446740, Length=220, Percent_Identity=25.4545454545455, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI47078218, Length=220, Percent_Identity=25.4545454545455, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI255708477, Length=227, Percent_Identity=29.9559471365639, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI27881501, Length=218, Percent_Identity=30.7339449541284, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI30795238, Length=218, Percent_Identity=30.7339449541284, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI21536376, Length=220, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI105990541, Length=200, Percent_Identity=26, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI27477115, Length=210, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI153792144, Length=191, Percent_Identity=25.130890052356, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI9955970, Length=181, Percent_Identity=30.939226519337, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI6005701, Length=163, Percent_Identity=28.8343558282209, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI116734710, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI27436953, Length=235, Percent_Identity=24.2553191489362, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI150417984, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788165, Length=204, Percent_Identity=35.7843137254902, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786345, Length=206, Percent_Identity=32.0388349514563, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788506, Length=207, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787370, Length=213, Percent_Identity=27.6995305164319, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787758, Length=169, Percent_Identity=34.3195266272189, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786563, Length=213, Percent_Identity=27.6995305164319, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI87081709, Length=210, Percent_Identity=27.6190476190476, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87081834, Length=213, Percent_Identity=27.6995305164319, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787164, Length=213, Percent_Identity=29.5774647887324, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786803, Length=193, Percent_Identity=29.0155440414508, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787712, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789586, Length=239, Percent_Identity=26.3598326359833, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790544, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790739, Length=221, Percent_Identity=26.6968325791855, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787112, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789873, Length=217, Percent_Identity=30.4147465437788, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787089, Length=204, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1786319, Length=186, Percent_Identity=26.3440860215054, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI87081782, Length=180, Percent_Identity=28.8888888888889, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=200, Percent_Identity=27.5, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI48994943, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789864, Length=215, Percent_Identity=23.7209302325581, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081791, Length=208, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788225, Length=205, Percent_Identity=25.3658536585366, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787500, Length=201, Percent_Identity=25.8706467661692, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789593, Length=201, Percent_Identity=23.3830845771144, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788450, Length=200, Percent_Identity=22.5, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=192, Percent_Identity=30.7291666666667, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996550, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=222, Percent_Identity=26.5765765765766, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17510237, Length=194, Percent_Identity=26.8041237113402, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=235, Percent_Identity=27.2340425531915, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323959, Length=232, Percent_Identity=27.1551724137931, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357907, Length=224, Percent_Identity=29.0178571428571, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85726357, Length=234, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24650855, Length=187, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24650853, Length=187, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281362751, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552805, Length=173, Percent_Identity=29.4797687861272, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007184, Length=179, Percent_Identity=27.9329608938547, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647219, Length=173, Percent_Identity=29.4797687861272, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y035_TREPA (O83078)

Other databases:

- EMBL:   AE000520
- PIR:   E71375
- RefSeq:   NP_218475.1
- ProteinModelPortal:   O83078
- IntAct:   O83078
- GeneID:   2611285
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0035
- NMPDR:   fig|243276.1.peg.34
- TIGR:   TP_0035
- HOGENOM:   HBG758042
- ProtClustDB:   CLSK793388
- BioCyc:   TPAL243276:TP_0035-MONOMER
- GO:   GO:0006810
- InterPro:   IPR003439
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 26460; Mature: 26460

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKL
CCCCCCHHHHHHHCCCEEEECCCEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
LKPSTGTIAHFVQRVGSVPQTKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGM
HCCCCCHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTGIDSRGQKDIYALLKGLNTSR
CCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECHHCCCCCCCHHHHHHHHHCCCCCC
NVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR
CEEEEEEECCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKL
CCCCCCHHHHHHHCCCEEEECCCEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
LKPSTGTIAHFVQRVGSVPQTKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGM
HCCCCCHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTGIDSRGQKDIYALLKGLNTSR
CCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECHHCCCCCCCHHHHHHHHHCCCCCC
NVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR
CEEEEEEECCCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9665876