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Identifier: 188587447

GI number: 188587447

Start: 3088429

End: 3089058

Strand: Reverse

Name: upp

Synonym: Nther_2857

Alternate gene names: 188587447

Gene position: 3089058-3088429 (Counterclockwise)

Preceding gene: 188587448

Following gene: 188587446

Centisome position: 97.58

GC content: 42.22

Gene sequence:

>630_bases
ATGAGCAAATTACATGTAGTGGATCATCCATTGATTCAGCACAAGTTAGCTTTTATTAGAGACAAGGAGACGGGTTCTAA
GACTTTTCGGGAACTTGTTAATGAGGTTTCAATGTTGATGGCCTATGAAGTGACAAGGGAATTACAAACAGAAGAGTATG
AAGTGGAAACACCAATTAGTACGGCAAAGACACGCATTTTGTCCGGAAAAAAGCTGGGATTAGTACCTATTTTGCGAGCA
GGTCTTGGAATGGTAGAGAGTGTTCGAAATTTAATTCCTGCGGCTCGGGTTGGTCATATAGGGGTGTATAGGGATCCAGA
AACCCTTCAACCAGTAGAGTATTACTGTAAACTACCCCAGGATATTCACGAGCGCGAATTGATAGTTTTAGATCCCATGC
TTGCTACAGGAGGATCGGCTAAAGCTAGCATTCAATTCATTAAGGATCGGGGCGGTACTAATATTAGATTTATGTGCATT
AATGCAGCCCCCGAAGGGGTTGAGGAACTTCAAAAAGCTCATCCAGATGTGGATATCTGGACTTGTGCAGTAGACGAAAA
ACTCAATGAGAAGGCTTATATAGTACCTGGTCTTGGAGATGCTGGAGACCGACTATTTGGAACTAAGTAA

Upstream 100 bases:

>100_bases
GTATCGTCAATAATCTAGTTTTATCCCCTTTAAATTTGTGTTATTATAGATGTGATTTAAGATTGGATAAAATTAATTGG
ACTAAATAGGGGGTTATAGT

Downstream 100 bases:

>100_bases
CGGAAGTGATAACTATGAGACAAAGACCCGATTGGGATAGCTATTTTATGGAAATTGCCGGAACTGTCAAAAAAAGATCT
ACATGCCTGAGACGTCAGGT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKLHVVDHPLIQHKLAFIRDKETGSKTFRELVNEVSMLMAYEVTRELQTEEYEVETPISTAKTRILSGKKLGLVPILRA
GLGMVESVRNLIPAARVGHIGVYRDPETLQPVEYYCKLPQDIHERELIVLDPMLATGGSAKASIQFIKDRGGTNIRFMCI
NAAPEGVEELQKAHPDVDIWTCAVDEKLNEKAYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MSKLHVVDHPLIQHKLAFIRDKETGSKTFRELVNEVSMLMAYEVTRELQTEEYEVETPISTAKTRILSGKKLGLVPILRA
GLGMVESVRNLIPAARVGHIGVYRDPETLQPVEYYCKLPQDIHERELIVLDPMLATGGSAKASIQFIKDRGGTNIRFMCI
NAAPEGVEELQKAHPDVDIWTCAVDEKLNEKAYIVPGLGDAGDRLFGTK
>Mature_208_residues
SKLHVVDHPLIQHKLAFIRDKETGSKTFRELVNEVSMLMAYEVTRELQTEEYEVETPISTAKTRILSGKKLGLVPILRAG
LGMVESVRNLIPAARVGHIGVYRDPETLQPVEYYCKLPQDIHERELIVLDPMLATGGSAKASIQFIKDRGGTNIRFMCIN
AAPEGVEELQKAHPDVDIWTCAVDEKLNEKAYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.6930693069307, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.6930693069307, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI21450816, Length=169, Percent_Identity=26.0355029585799, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=48.7684729064039, Blast_Score=216, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=190, Percent_Identity=37.8947368421053, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45550449, Length=211, Percent_Identity=32.2274881516588, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573516, Length=211, Percent_Identity=32.2274881516588, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573514, Length=211, Percent_Identity=32.2274881516588, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573512, Length=211, Percent_Identity=32.2274881516588, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_NATTJ (B2A3H5)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918992.1
- ProteinModelPortal:   B2A3H5
- SMR:   B2A3H5
- GeneID:   6316947
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_2857
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23282; Mature: 23151

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLHVVDHPLIQHKLAFIRDKETGSKTFRELVNEVSMLMAYEVTRELQTEEYEVETPIS
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHH
TAKTRILSGKKLGLVPILRAGLGMVESVRNLIPAARVGHIGVYRDPETLQPVEYYCKLPQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCEECCCCCCCHHHHHHCCCC
DIHERELIVLDPMLATGGSAKASIQFIKDRGGTNIRFMCINAAPEGVEELQKAHPDVDIW
HHCCCCEEEECCHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCEEE
TCAVDEKLNEKAYIVPGLGDAGDRLFGTK
EEEECCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKLHVVDHPLIQHKLAFIRDKETGSKTFRELVNEVSMLMAYEVTRELQTEEYEVETPIS
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHH
TAKTRILSGKKLGLVPILRAGLGMVESVRNLIPAARVGHIGVYRDPETLQPVEYYCKLPQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCEECCCCCCCHHHHHHCCCC
DIHERELIVLDPMLATGGSAKASIQFIKDRGGTNIRFMCINAAPEGVEELQKAHPDVDIW
HHCCCCEEEECCHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCEEE
TCAVDEKLNEKAYIVPGLGDAGDRLFGTK
EEEECCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA