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The map label for this gene is comEB [H]

Identifier: 188587446

GI number: 188587446

Start: 3087950

End: 3088414

Strand: Reverse

Name: comEB [H]

Synonym: Nther_2856

Alternate gene names: 188587446

Gene position: 3088414-3087950 (Counterclockwise)

Preceding gene: 188587447

Following gene: 188587445

Centisome position: 97.56

GC content: 44.95

Gene sequence:

>465_bases
ATGAGACAAAGACCCGATTGGGATAGCTATTTTATGGAAATTGCCGGAACTGTCAAAAAAAGATCTACATGCCTGAGACG
TCAGGTTGGAGCTGTCATGGTTAGTGAAAGAAGAATATTGGCTACGGGCTATAATGGTGCCCCTCAAGATCTACCTCATT
GCAGTGAAACAGGTTGCCTTAGAGAGGAATTAAACGTTCCCTCGGGGGAACGCCATGAAATCTGTAGAGGCCTTCATGCA
GAGCAAAATGCCATTATTCAATCGGCACTTCATGGTGTAACCACTCGGGGGAGCACCCTTTATACTACTGACTTTCCTTG
CTCTTTATGTGCCAAAATGCTGGTAAATGCCGGCGTGAGTGAAATAGTAGCTGAACGGAGCTATCCAGATGAACTTTCAA
AAGAAGTACTTGCCGAAGCAGGTATTAAAGTCAGGAGGTATGGTAATGAAACACCGGGTTGTTAG

Upstream 100 bases:

>100_bases
GTGCAGTAGACGAAAAACTCAATGAGAAGGCTTATATAGTACCTGGTCTTGGAGATGCTGGAGACCGACTATTTGGAACT
AAGTAACGGAAGTGATAACT

Downstream 100 bases:

>100_bases
CGTCTTTGGAACAAGGCCAGAAGCTATCAAAATGGCCCCCCTGGTTTCCGCCATTGAATCTTCTCCTAATCTGACATCTT
CAGTGGTGGTAACAGCCCAG

Product: CMP/dCMP deaminase zinc-binding

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MRQRPDWDSYFMEIAGTVKKRSTCLRRQVGAVMVSERRILATGYNGAPQDLPHCSETGCLREELNVPSGERHEICRGLHA
EQNAIIQSALHGVTTRGSTLYTTDFPCSLCAKMLVNAGVSEIVAERSYPDELSKEVLAEAGIKVRRYGNETPGC

Sequences:

>Translated_154_residues
MRQRPDWDSYFMEIAGTVKKRSTCLRRQVGAVMVSERRILATGYNGAPQDLPHCSETGCLREELNVPSGERHEICRGLHA
EQNAIIQSALHGVTTRGSTLYTTDFPCSLCAKMLVNAGVSEIVAERSYPDELSKEVLAEAGIKVRRYGNETPGC
>Mature_154_residues
MRQRPDWDSYFMEIAGTVKKRSTCLRRQVGAVMVSERRILATGYNGAPQDLPHCSETGCLREELNVPSGERHEICRGLHA
EQNAIIQSALHGVTTRGSTLYTTDFPCSLCAKMLVNAGVSEIVAERSYPDELSKEVLAEAGIKVRRYGNETPGC

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=162, Percent_Identity=30.2469135802469, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI61742821, Length=150, Percent_Identity=31.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321938, Length=146, Percent_Identity=43.1506849315069, Blast_Score=116, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24667298, Length=151, Percent_Identity=35.0993377483444, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667302, Length=151, Percent_Identity=35.0993377483444, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 17016; Mature: 17016

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQRPDWDSYFMEIAGTVKKRSTCLRRQVGAVMVSERRILATGYNGAPQDLPHCSETGCL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHH
REELNVPSGERHEICRGLHAEQNAIIQSALHGVTTRGSTLYTTDFPCSLCAKMLVNAGVS
HHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCHH
EIVAERSYPDELSKEVLAEAGIKVRRYGNETPGC
HHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCC
>Mature Secondary Structure
MRQRPDWDSYFMEIAGTVKKRSTCLRRQVGAVMVSERRILATGYNGAPQDLPHCSETGCL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHH
REELNVPSGERHEICRGLHAEQNAIIQSALHGVTTRGSTLYTTDFPCSLCAKMLVNAGVS
HHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCHH
EIVAERSYPDELSKEVLAEAGIKVRRYGNETPGC
HHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]