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The map label for this gene is pyrE [H]

Identifier: 188587353

GI number: 188587353

Start: 2981223

End: 2981810

Strand: Reverse

Name: pyrE [H]

Synonym: Nther_2760

Alternate gene names: 188587353

Gene position: 2981810-2981223 (Counterclockwise)

Preceding gene: 188587354

Following gene: 188587351

Centisome position: 94.2

GC content: 39.46

Gene sequence:

>588_bases
ATGACTAAAGATAATCGTATTATGGAAATTTTTGAACAAACAGGTGCAATAACTCATGGACATTTCTTATTAACATCAGG
CAGACACAGTGATTGTTATGTTCAATGTGCCCAGGTTCTTCAATATCCGTATTATACTGAACAGTTAGTTCAGGAACTGG
GTAAAAAGTTGCCAGGGGACTATGATATGATCGTAGGACCAGCCATGGGAGGTGTGATTCTCTCCTATGAAATGGCAAGA
TACTACAATGTGAAAGCAGTATTTTCCGAACGGCAGAAAGGGAAAATGACTTTTCGTAGGGGCTTTGAAATATCTCCCGG
ACAAAAAGTTTTAGTTGTCGAGGATGTGGTTACAACTGGAGGTTCTGTTCAAGAAGTTATTGATCTTGTTAATGAAAAAG
GTGCAATAGTCAGCAATGTGGCTGCCCTTGTGGATAGAAGTGGTGGGAATATAAGTTTTTCAGGGGTTGAAAATGGATTT
GTTTCCCTAATAGAAATGAATATCAAATCCTATGAAGAACAGGATTGTCCCCTGTGTGAACAGGGGAGCACACCTGTTAA
GCCTGGGAGTCGTAATATTGATAGTTAA

Upstream 100 bases:

>100_bases
ACCCATATAGTGGTAGGACGATCAATTACTGGCAAAGAAGGGCCAGGGCAAAAGAAAACAGCGGTTCAAGAGATATATAA
CTGTATGAGGAGTGAGCAAA

Downstream 100 bases:

>100_bases
AAGAACCGGTTTGTTTTAAGGAAAACTGATTTAAGATGGAGTCACCCTTTTTATCTTTTGGTGCCATGTATCCCATCATT
TCGAAAATAATTTTTTGAGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MTKDNRIMEIFEQTGAITHGHFLLTSGRHSDCYVQCAQVLQYPYYTEQLVQELGKKLPGDYDMIVGPAMGGVILSYEMAR
YYNVKAVFSERQKGKMTFRRGFEISPGQKVLVVEDVVTTGGSVQEVIDLVNEKGAIVSNVAALVDRSGGNISFSGVENGF
VSLIEMNIKSYEEQDCPLCEQGSTPVKPGSRNIDS

Sequences:

>Translated_195_residues
MTKDNRIMEIFEQTGAITHGHFLLTSGRHSDCYVQCAQVLQYPYYTEQLVQELGKKLPGDYDMIVGPAMGGVILSYEMAR
YYNVKAVFSERQKGKMTFRRGFEISPGQKVLVVEDVVTTGGSVQEVIDLVNEKGAIVSNVAALVDRSGGNISFSGVENGF
VSLIEMNIKSYEEQDCPLCEQGSTPVKPGSRNIDS
>Mature_194_residues
TKDNRIMEIFEQTGAITHGHFLLTSGRHSDCYVQCAQVLQYPYYTEQLVQELGKKLPGDYDMIVGPAMGGVILSYEMARY
YNVKAVFSERQKGKMTFRRGFEISPGQKVLVVEDVVTTGGSVQEVIDLVNEKGAIVSNVAALVDRSGGNISFSGVENGFV
SLIEMNIKSYEEQDCPLCEQGSTPVKPGSRNIDS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21489; Mature: 21358

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDNRIMEIFEQTGAITHGHFLLTSGRHSDCYVQCAQVLQYPYYTEQLVQELGKKLPGD
CCCCHHHHHHHHHHCCEECCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
YDMIVGPAMGGVILSYEMARYYNVKAVFSERQKGKMTFRRGFEISPGQKVLVVEDVVTTG
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEHHHCC
GSVQEVIDLVNEKGAIVSNVAALVDRSGGNISFSGVENGFVSLIEMNIKSYEEQDCPLCE
CCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCC
QGSTPVKPGSRNIDS
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKDNRIMEIFEQTGAITHGHFLLTSGRHSDCYVQCAQVLQYPYYTEQLVQELGKKLPGD
CCCHHHHHHHHHHCCEECCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
YDMIVGPAMGGVILSYEMARYYNVKAVFSERQKGKMTFRRGFEISPGQKVLVVEDVVTTG
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEHHHCC
GSVQEVIDLVNEKGAIVSNVAALVDRSGGNISFSGVENGFVSLIEMNIKSYEEQDCPLCE
CCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCC
QGSTPVKPGSRNIDS
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]