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The map label for this gene is gcvPB [H]

Identifier: 188587342

GI number: 188587342

Start: 2967483

End: 2968949

Strand: Reverse

Name: gcvPB [H]

Synonym: Nther_2748

Alternate gene names: 188587342

Gene position: 2968949-2967483 (Counterclockwise)

Preceding gene: 188587343

Following gene: 188587341

Centisome position: 93.79

GC content: 40.29

Gene sequence:

>1467_bases
ATGAGTAAACAAAAAGCTCTTATCTTTGAACTAGGAGGCAGTGGGAGGAAGGGCTTCTCCCTGCCAGAAAGCGATGTCCC
CGAACAAGACCTAAAAGATTTGCTACCAGAAGAACAAATAAGGGAAGAGACCCCTGGTCTACCTGAGATTTCTGAAAATG
AAGCTATTAGGCATTTTATAGAATTATCTATTAAAAATCATCATGTTGATAGAGGGTTTTATCCTTTAGGTTCTTGTACT
ATGAAATACAACCCTAAGGTTAATGAAGATATTGCATCAATGCCAGGATTTACTCAGCTACATCCTTATCAGAGAGAAGA
CCATATTCAGGGAACTCTGGAGATGTTGTACAATACCGAACAGTTTATCAATGAAGTTACTGGTATGGATAGAGTAACCT
TCCAACCGGCAGCTGGAGCTCATGGCGAGCTAACTGGTCTGCTAGTAATGAAAGCTGCCCTAGAGGCTAAGGGAGAACAA
CGCACTAAGATTTTATGTCCGGACTCTGCCCATGGCACTAACCCTGCTAGTGCAGCCATGGCTGGTTTTAAGCTGGTGGA
GATCAAATCCAATGAAAAAGGTTTAGTTGATTTTGATGACTTGAAGGCCAATTTAGATGAAGATGTAGCGGGTATAATGT
TAACAAACCCAAATACATTGGGATTGTTTGAAGAAGAAATTATGGATATAGCAGAAGCGGTTCATGAAGTCGGAGGTCTC
TTGTATTACGATGGTGCAAACTTGAACGCCATCATGGGTTATGCCAGACCAGGGGATATGGGCTTTGATGTGGTTCATCT
CAATTTGCATAAAACATTTTCTGCACCCCACGGTGGCGGTGGCCCTGGCAGTGGCCCCATAGCTGTTAAAAAAGAACTAG
AACCATATTTACCAGTACCGGATATAAAAAAACAAGGTGATAAATTTGTCTTGGATTATGATGTTCCCAACACTATTGGT
AAAGTTCATGGTTATTACGGTAATATAAATGTGATTATAAAATCTTACAGCTACATGCGTTATATGGGAATGGAAGGCCT
GAAACAAGTAAGTAGTGACGCGGTATTAAATGCAAACTATCTGCGGGAACAATTAAAAGGCATTTATCAACTTGACCATG
ATCAATTACCATGTAAACACGAATTCGTAATCAGTGGTAATAAACAGAAGAAAAACTACGGTGTTTCAACTATGGATATA
GCCAAGCGGCATCTAGATTACGGTGTTCATCCTTCCATGGTATATTTCCCACTAATTGTGGATGAAGCTATGATGGTAGA
ACCTACTGAAACTGAATCCAAAGAATCCTTAGATGAATTTATCGATGTTATGAAACAAATATCCCAAGAAGCTGAATCTG
ATCCTGAAACAGTTCAAAATGCTCCCTATACTACACCTGTCAAGAGATTGGATGAGGTTACGGCTGCTAGGAAACCTGTG
GTTAGGTGGTATCCAGCAGAAGAATAG

Upstream 100 bases:

>100_bases
GCTTTTATTCTGGTTTAGAAAATCACATGTTGATCTGTGTGACTGAGAAAAGAACCAAAGAAGAAATTGACAATTTGGTT
CTTGGATTGGAGGGTATTAA

Downstream 100 bases:

>100_bases
TCGAAATAACACGAATAAATACGACAAGATAACTTAATAAGTTGTTTTTAGAAGTAATTGTGCCCACTGTTTATGTGGGC
ACAATTTACGCTTATTATTG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSKQKALIFELGGSGRKGFSLPESDVPEQDLKDLLPEEQIREETPGLPEISENEAIRHFIELSIKNHHVDRGFYPLGSCT
MKYNPKVNEDIASMPGFTQLHPYQREDHIQGTLEMLYNTEQFINEVTGMDRVTFQPAAGAHGELTGLLVMKAALEAKGEQ
RTKILCPDSAHGTNPASAAMAGFKLVEIKSNEKGLVDFDDLKANLDEDVAGIMLTNPNTLGLFEEEIMDIAEAVHEVGGL
LYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSAPHGGGGPGSGPIAVKKELEPYLPVPDIKKQGDKFVLDYDVPNTIG
KVHGYYGNINVIIKSYSYMRYMGMEGLKQVSSDAVLNANYLREQLKGIYQLDHDQLPCKHEFVISGNKQKKNYGVSTMDI
AKRHLDYGVHPSMVYFPLIVDEAMMVEPTETESKESLDEFIDVMKQISQEAESDPETVQNAPYTTPVKRLDEVTAARKPV
VRWYPAEE

Sequences:

>Translated_488_residues
MSKQKALIFELGGSGRKGFSLPESDVPEQDLKDLLPEEQIREETPGLPEISENEAIRHFIELSIKNHHVDRGFYPLGSCT
MKYNPKVNEDIASMPGFTQLHPYQREDHIQGTLEMLYNTEQFINEVTGMDRVTFQPAAGAHGELTGLLVMKAALEAKGEQ
RTKILCPDSAHGTNPASAAMAGFKLVEIKSNEKGLVDFDDLKANLDEDVAGIMLTNPNTLGLFEEEIMDIAEAVHEVGGL
LYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSAPHGGGGPGSGPIAVKKELEPYLPVPDIKKQGDKFVLDYDVPNTIG
KVHGYYGNINVIIKSYSYMRYMGMEGLKQVSSDAVLNANYLREQLKGIYQLDHDQLPCKHEFVISGNKQKKNYGVSTMDI
AKRHLDYGVHPSMVYFPLIVDEAMMVEPTETESKESLDEFIDVMKQISQEAESDPETVQNAPYTTPVKRLDEVTAARKPV
VRWYPAEE
>Mature_487_residues
SKQKALIFELGGSGRKGFSLPESDVPEQDLKDLLPEEQIREETPGLPEISENEAIRHFIELSIKNHHVDRGFYPLGSCTM
KYNPKVNEDIASMPGFTQLHPYQREDHIQGTLEMLYNTEQFINEVTGMDRVTFQPAAGAHGELTGLLVMKAALEAKGEQR
TKILCPDSAHGTNPASAAMAGFKLVEIKSNEKGLVDFDDLKANLDEDVAGIMLTNPNTLGLFEEEIMDIAEAVHEVGGLL
YYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSAPHGGGGPGSGPIAVKKELEPYLPVPDIKKQGDKFVLDYDVPNTIGK
VHGYYGNINVIIKSYSYMRYMGMEGLKQVSSDAVLNANYLREQLKGIYQLDHDQLPCKHEFVISGNKQKKNYGVSTMDIA
KRHLDYGVHPSMVYFPLIVDEAMMVEPTETESKESLDEFIDVMKQISQEAESDPETVQNAPYTTPVKRLDEVTAARKPVV
RWYPAEE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=506, Percent_Identity=39.3280632411067, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1789269, Length=407, Percent_Identity=40.7862407862408, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17535605, Length=410, Percent_Identity=40.2439024390244, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI32564013, Length=364, Percent_Identity=40.9340659340659, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=454, Percent_Identity=40.0881057268723, Blast_Score=292, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=41.0194174757282, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54284; Mature: 54153

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKALIFELGGSGRKGFSLPESDVPEQDLKDLLPEEQIREETPGLPEISENEAIRHFI
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
ELSIKNHHVDRGFYPLGSCTMKYNPKVNEDIASMPGFTQLHPYQREDHIQGTLEMLYNTE
HHHHHCCCCCCCCEECCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHH
QFINEVTGMDRVTFQPAAGAHGELTGLLVMKAALEAKGEQRTKILCPDSAHGTNPASAAM
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHH
AGFKLVEIKSNEKGLVDFDDLKANLDEDVAGIMLTNPNTLGLFEEEIMDIAEAVHEVGGL
HCEEEEEEECCCCCCEEHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCE
LYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSAPHGGGGPGSGPIAVKKELEPYLPVP
EEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCC
DIKKQGDKFVLDYDVPNTIGKVHGYYGNINVIIKSYSYMRYMGMEGLKQVSSDAVLNANY
CHHCCCCEEEEEECCCHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEECHHH
LREQLKGIYQLDHDQLPCKHEFVISGNKQKKNYGVSTMDIAKRHLDYGVHPSMVYFPLIV
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHH
DEAMMVEPTETESKESLDEFIDVMKQISQEAESDPETVQNAPYTTPVKRLDEVTAARKPV
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCE
VRWYPAEE
EEECCCCC
>Mature Secondary Structure 
SKQKALIFELGGSGRKGFSLPESDVPEQDLKDLLPEEQIREETPGLPEISENEAIRHFI
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
ELSIKNHHVDRGFYPLGSCTMKYNPKVNEDIASMPGFTQLHPYQREDHIQGTLEMLYNTE
HHHHHCCCCCCCCEECCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHH
QFINEVTGMDRVTFQPAAGAHGELTGLLVMKAALEAKGEQRTKILCPDSAHGTNPASAAM
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHH
AGFKLVEIKSNEKGLVDFDDLKANLDEDVAGIMLTNPNTLGLFEEEIMDIAEAVHEVGGL
HCEEEEEEECCCCCCEEHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCE
LYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSAPHGGGGPGSGPIAVKKELEPYLPVP
EEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCC
DIKKQGDKFVLDYDVPNTIGKVHGYYGNINVIIKSYSYMRYMGMEGLKQVSSDAVLNANY
CHHCCCCEEEEEECCCHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEECHHH
LREQLKGIYQLDHDQLPCKHEFVISGNKQKKNYGVSTMDIAKRHLDYGVHPSMVYFPLIV
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHH
DEAMMVEPTETESKESLDEFIDVMKQISQEAESDPETVQNAPYTTPVKRLDEVTAARKPV
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCE
VRWYPAEE
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA