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The map label for this gene is thiD [H]

Identifier: 188587090

GI number: 188587090

Start: 2671554

End: 2672381

Strand: Reverse

Name: thiD [H]

Synonym: Nther_2484

Alternate gene names: 188587090

Gene position: 2672381-2671554 (Counterclockwise)

Preceding gene: 188587091

Following gene: 188587089

Centisome position: 84.42

GC content: 39.61

Gene sequence:

>828_bases
ATGTCTAAAACAAAAGTAGTTATGACCATTGCAGGTTCTGATTCTGGGGGTGGTGCTGGAATACAAGCTGACCTAAAAAC
ATTTCAGTCTATAGGAGTATTCGGAACTACCGTGCTAACAGGTGTGACTGCCCAGAACACTGCAGGGGTACAAAACGCTG
TTCATCTTGAATCTAGTTTGGTGGCAGAGCAATTTAAGTCAGTGGCGGAGGATATGGAAATTTCTGCAGTAAAGACGGGG
ATGCTTTCAAATGCTCAAATAATTGAAACCGTTTCCGATAATCTTGCTTCTTTTTCAACGAAACCTTGGATTGTAATTGA
CCCTGTTTTGGCAGCTACAAGCGGTGATTTACTACTAGAAAGACAAGCAGTATCAACTTTGCTAGAGAAGCTTATTCCCA
TCTCTGATATCATCACTCCTAATATTCCCGAAGCAGAGATATTGACTGGCATAAACATTGACCATTCAAAAGACTTACAA
AAAGCAGCTCATAAGTTGAAGGAAGCGGGAGCAAAATCCGTATTAATCAAGGGTGGACATACAAGTGGAAACGCTACTGA
TCATTTCTTTTGGGAAGATGAATATCACACATTTTCAGCTGAAAGAGTGGGCGTTGGCAGTCTTCACGGAACGGGTTGTA
CCCTGGGATCAGCTATATGTGCATATTTGAGTAAAACAGATGATCTATTAACTAGCATAAAATTAGCTAAAAAATACGTT
ACACAAGCCATTAATAATAGTTTTACAATCGGTGAAGGTTCAAAAGTACTCTTGCATTCATCAATAGGAGATGAAGAAGT
GCAAGAAAAGGAGGAATTAAATGCATGA

Upstream 100 bases:

>100_bases
CAGTTAAAGCAGTGGGGCTTTAGTGGGGTTTTAGCGGGACTTTAGCGGGGCTTTCTCTTTCTGTTTCTCATAAACAACTA
TAACAAAAAAGGGTGATTAT

Downstream 100 bases:

>100_bases
GTACATTCAATTCTAATTTTAAGTTGGGAACTTATTTGACACAAGTTAGGCAAGAAAATCCTTTAGTCCATGCTATTACT
AATTATGTCACAATGAATGA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSKTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVAEQFKSVAEDMEISAVKTG
MLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQAVSTLLEKLIPISDIITPNIPEAEILTGINIDHSKDLQ
KAAHKLKEAGAKSVLIKGGHTSGNATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYV
TQAINNSFTIGEGSKVLLHSSIGDEEVQEKEELNA

Sequences:

>Translated_275_residues
MSKTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVAEQFKSVAEDMEISAVKTG
MLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQAVSTLLEKLIPISDIITPNIPEAEILTGINIDHSKDLQ
KAAHKLKEAGAKSVLIKGGHTSGNATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYV
TQAINNSFTIGEGSKVLLHSSIGDEEVQEKEELNA
>Mature_274_residues
SKTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSLVAEQFKSVAEDMEISAVKTGM
LSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLERQAVSTLLEKLIPISDIITPNIPEAEILTGINIDHSKDLQK
AAHKLKEAGAKSVLIKGGHTSGNATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYVT
QAINNSFTIGEGSKVLLHSSIGDEEVQEKEELNA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=250, Percent_Identity=38, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325378, Length=254, Percent_Identity=35.4330708661417, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324517, Length=254, Percent_Identity=35.8267716535433, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324997, Length=254, Percent_Identity=35.4330708661417, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29015; Mature: 28884

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSL
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VAEQFKSVAEDMEISAVKTGMLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCHHHH
RQAVSTLLEKLIPISDIITPNIPEAEILTGINIDHSKDLQKAAHKLKEAGAKSVLIKGGH
HHHHHHHHHHHCCHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
TSGNATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYV
CCCCCCCCEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQAINNSFTIGEGSKVLLHSSIGDEEVQEKEELNA
HHHHCCCEEECCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SKTKVVMTIAGSDSGGGAGIQADLKTFQSIGVFGTTVLTGVTAQNTAGVQNAVHLESSL
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VAEQFKSVAEDMEISAVKTGMLSNAQIIETVSDNLASFSTKPWIVIDPVLAATSGDLLLE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCHHHH
RQAVSTLLEKLIPISDIITPNIPEAEILTGINIDHSKDLQKAAHKLKEAGAKSVLIKGGH
HHHHHHHHHHHCCHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
TSGNATDHFFWEDEYHTFSAERVGVGSLHGTGCTLGSAICAYLSKTDDLLTSIKLAKKYV
CCCCCCCCEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQAINNSFTIGEGSKVLLHSSIGDEEVQEKEELNA
HHHHCCCEEECCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]