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The map label for this gene is ziaA [H]

Identifier: 188587070

GI number: 188587070

Start: 2647880

End: 2650054

Strand: Direct

Name: ziaA [H]

Synonym: Nther_2462

Alternate gene names: 188587070

Gene position: 2647880-2650054 (Clockwise)

Preceding gene: 188587069

Following gene: 188587073

Centisome position: 83.65

GC content: 40.32

Gene sequence:

>2175_bases
ATGAAATATTATTTGCGAGGACTGGACTGTCCCAGCTGTGCAGCTAAAATAGAACGGAAATTAAATAACTTAAATCCAAA
TCCGAATCAAGAGATAAATATTAATCTTAACAATAATACTGTCGAATTGGACCCCGAATTATACGAGGAAGCTCAAAAAA
TAGTCGATGATATTGAACCTGGAGTGAAACTAATTCCCAAGGAAAATAACAAGGAACAACCCCATAATAACTATGAAGAT
GATCACAGTTCCAATTTAAAACAAGAATATTTAAAGATAATCATATCACTAGGATTACTAATATTTGGATTTATCTTTAG
GGAAGAGCTGCAAAACACTCCATGGGCGATAGCAGACTATTCTGTATTTTTAATCGCCTATTTCCTGGTCGGCGGTCACG
TTGTTATTTCTGCTGTTAAAAATTTAGTTCGCAGAGATATATTTAACGAAAAGTTCCTTATGACCATTGCTACCCTTGGT
GCTATTTTGATTCAAGAATTACCAGAAGCGGTAGCCGTTATGTTGTTTTATGCAGTAGGTGAGCTATTCCAAGACCTGGC
CGTTAATAAATCACGCCGCTCGATTTCTTCCCTATTAGATCTAAGGCCTGAGTTTGCCAACCTTATAACTGAAAAGGGTA
CCGAACAGGTCTCTCCGGAACAGGTGACACCTGGCGATGTAATTGAAATCTATCCAGGAGAACGCATCCCCTTAGATGGA
AAAGTTTTATCTGGTGAGTCATACATTAATGCCAGTGCCCTAACAGGTGAATCCGTTCCAGAAAGTGTAGGCCCCGGTGA
ACAAGTAATGGCTGGAACTATCAATGAAAATAACTTGCTTAGGGTACAAGTCACTAAAGAATTTAATAACTCATCTGTCG
CCAAGATTTTTGATTTGGTAGAAAAAGCAGCCGAACGAAAAGCTCCTACAGAAAAGTTCATCACTACCTTTGCGGCTTGG
TATACGCCTGTAGTTGTAGGAGGAGCTGCAGTGTTGGCCACTATACCACCGCTATTGATTCCGGGAGCAGAATTTAGTGA
GTGGATATACCGGGCATTGATACTTCTGGTGATATCTTGTCCCTGTGCTTTGGTACTATCCATACCTCTCGGCTATTTTG
GAGGTATAGGAGGAGCATCGAGAGGAGGAATATTAGTAAAAGGTGCCAACTTTCTAGATGCCTTGATTGATGCCGATACA
GTAGTCTTTGACAAAACAGGTACACTAACTGAGGGGACTTTTCAAGTTGTCAAAATTAATCCCAAAAACGGATTTTCAGA
CCAAGAATTATTGAACTATGCCTCTACAGCAGAAATTTACTCAAATCATCCCATCGCCAGATCCATATTACACGAAGCAA
AGCATAAGTTTAACTTTTCTAGGGAAGAACTCAAAGCTAAAGTTTTAAAACAGCGAGAAGACAAAGGTTTCGGTGTAAAA
ACAACATTGTCAGATGGTAGTGTGATTTTAGCCGGCAGCGAAAAATTGCTGACAAAGGAAAGTATCAACATGGACTTAAC
AGATGAAAAAGACAATGGTGAAACTATCGTTCATGTGGCTGTAGACGACAAATACGTTGGTTACCTGATTCTTGATGATG
AAATAAAAGCCGATGCGGCAGAGATTGTAGCCAAACTAAAAGCCAAAGGCGTTTCACACACAGTCATGCTCTCGGGAGAT
GAAGAACAAACTGCCAAGCGTGTAGCCAAACAACTGAATATAGATAAATATTATGCAGGTTTACTACCAGAAGAAAAAAT
TGAGATAATGGATGAACTAATCGCCAATAAGACTGGAGATGAGAAAATATTATATGTGGGTGATGGCATCAACGATGCTC
CCGTAATCACCAGGGCCGATGTTGGTATAGCCATGGGTGCGCTGGGAACGGATGCTGCCATTGAAGCTGCAGATATAGTC
CTAATGGATGATAATCTAGACAAAATTCCTTTGAGTTTAGATGTCGCCCGAAAAACCCGACGAATTGTATTACAAAATAT
CGTCTTCGCCTTGGGAGTAAAAGCAGCTTTTGTATCCCTGGGAGCTTTGGGAATGGCGACCATGTGGGGTGCAATTTTTG
CAGATGTAGGTGTAGCACTTTTGGCAGTATTTAATTCTACCAGGGCATTGAGAACACCGGGAAAGCTATCCCAATACAAT
TCTGATTCTGAATAA

Upstream 100 bases:

>100_bases
ATAACCGACATTACAGGATTCGGATTCAATAACTGCAGATACGCTTGTACTTGTTTTACTTTCTTAAACTTGTTGTGTTT
CTGTCAAGGGAGGGGAAATC

Downstream 100 bases:

>100_bases
ATATCTGTGATTATTTGATTATATTAACTAAAAACCAGCCAGGAAAAGTAAGCATTTAAAGTGAACTTCCCGGCTGGTTT
TAATTTGTCTCCAAGTATGA

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 724; Mature: 724

Protein sequence:

>724_residues
MKYYLRGLDCPSCAAKIERKLNNLNPNPNQEININLNNNTVELDPELYEEAQKIVDDIEPGVKLIPKENNKEQPHNNYED
DHSSNLKQEYLKIIISLGLLIFGFIFREELQNTPWAIADYSVFLIAYFLVGGHVVISAVKNLVRRDIFNEKFLMTIATLG
AILIQELPEAVAVMLFYAVGELFQDLAVNKSRRSISSLLDLRPEFANLITEKGTEQVSPEQVTPGDVIEIYPGERIPLDG
KVLSGESYINASALTGESVPESVGPGEQVMAGTINENNLLRVQVTKEFNNSSVAKIFDLVEKAAERKAPTEKFITTFAAW
YTPVVVGGAAVLATIPPLLIPGAEFSEWIYRALILLVISCPCALVLSIPLGYFGGIGGASRGGILVKGANFLDALIDADT
VVFDKTGTLTEGTFQVVKINPKNGFSDQELLNYASTAEIYSNHPIARSILHEAKHKFNFSREELKAKVLKQREDKGFGVK
TTLSDGSVILAGSEKLLTKESINMDLTDEKDNGETIVHVAVDDKYVGYLILDDEIKADAAEIVAKLKAKGVSHTVMLSGD
EEQTAKRVAKQLNIDKYYAGLLPEEKIEIMDELIANKTGDEKILYVGDGINDAPVITRADVGIAMGALGTDAAIEAADIV
LMDDNLDKIPLSLDVARKTRRIVLQNIVFALGVKAAFVSLGALGMATMWGAIFADVGVALLAVFNSTRALRTPGKLSQYN
SDSE

Sequences:

>Translated_724_residues
MKYYLRGLDCPSCAAKIERKLNNLNPNPNQEININLNNNTVELDPELYEEAQKIVDDIEPGVKLIPKENNKEQPHNNYED
DHSSNLKQEYLKIIISLGLLIFGFIFREELQNTPWAIADYSVFLIAYFLVGGHVVISAVKNLVRRDIFNEKFLMTIATLG
AILIQELPEAVAVMLFYAVGELFQDLAVNKSRRSISSLLDLRPEFANLITEKGTEQVSPEQVTPGDVIEIYPGERIPLDG
KVLSGESYINASALTGESVPESVGPGEQVMAGTINENNLLRVQVTKEFNNSSVAKIFDLVEKAAERKAPTEKFITTFAAW
YTPVVVGGAAVLATIPPLLIPGAEFSEWIYRALILLVISCPCALVLSIPLGYFGGIGGASRGGILVKGANFLDALIDADT
VVFDKTGTLTEGTFQVVKINPKNGFSDQELLNYASTAEIYSNHPIARSILHEAKHKFNFSREELKAKVLKQREDKGFGVK
TTLSDGSVILAGSEKLLTKESINMDLTDEKDNGETIVHVAVDDKYVGYLILDDEIKADAAEIVAKLKAKGVSHTVMLSGD
EEQTAKRVAKQLNIDKYYAGLLPEEKIEIMDELIANKTGDEKILYVGDGINDAPVITRADVGIAMGALGTDAAIEAADIV
LMDDNLDKIPLSLDVARKTRRIVLQNIVFALGVKAAFVSLGALGMATMWGAIFADVGVALLAVFNSTRALRTPGKLSQYN
SDSE
>Mature_724_residues
MKYYLRGLDCPSCAAKIERKLNNLNPNPNQEININLNNNTVELDPELYEEAQKIVDDIEPGVKLIPKENNKEQPHNNYED
DHSSNLKQEYLKIIISLGLLIFGFIFREELQNTPWAIADYSVFLIAYFLVGGHVVISAVKNLVRRDIFNEKFLMTIATLG
AILIQELPEAVAVMLFYAVGELFQDLAVNKSRRSISSLLDLRPEFANLITEKGTEQVSPEQVTPGDVIEIYPGERIPLDG
KVLSGESYINASALTGESVPESVGPGEQVMAGTINENNLLRVQVTKEFNNSSVAKIFDLVEKAAERKAPTEKFITTFAAW
YTPVVVGGAAVLATIPPLLIPGAEFSEWIYRALILLVISCPCALVLSIPLGYFGGIGGASRGGILVKGANFLDALIDADT
VVFDKTGTLTEGTFQVVKINPKNGFSDQELLNYASTAEIYSNHPIARSILHEAKHKFNFSREELKAKVLKQREDKGFGVK
TTLSDGSVILAGSEKLLTKESINMDLTDEKDNGETIVHVAVDDKYVGYLILDDEIKADAAEIVAKLKAKGVSHTVMLSGD
EEQTAKRVAKQLNIDKYYAGLLPEEKIEIMDELIANKTGDEKILYVGDGINDAPVITRADVGIAMGALGTDAAIEAADIV
LMDDNLDKIPLSLDVARKTRRIVLQNIVFALGVKAAFVSLGALGMATMWGAIFADVGVALLAVFNSTRALRTPGKLSQYN
SDSE

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=782, Percent_Identity=27.4936061381074, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI115529486, Length=814, Percent_Identity=27.5184275184275, Blast_Score=255, Evalue=1e-67,
Organism=Homo sapiens, GI55743073, Length=536, Percent_Identity=30.2238805970149, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI83700225, Length=183, Percent_Identity=28.4153005464481, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI297374799, Length=183, Percent_Identity=28.4153005464481, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1789879, Length=716, Percent_Identity=34.0782122905028, Blast_Score=351, Evalue=1e-97,
Organism=Escherichia coli, GI1786691, Length=702, Percent_Identity=29.3447293447293, Blast_Score=265, Evalue=1e-71,
Organism=Escherichia coli, GI1786914, Length=496, Percent_Identity=27.6209677419355, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17556548, Length=594, Percent_Identity=28.7878787878788, Blast_Score=209, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17557486, Length=183, Percent_Identity=27.8688524590164, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557770, Length=80, Percent_Identity=45, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32566766, Length=80, Percent_Identity=45, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17541776, Length=244, Percent_Identity=25.4098360655738, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=550, Percent_Identity=29.6363636363636, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6319772, Length=617, Percent_Identity=24.1491085899514, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6321271, Length=194, Percent_Identity=30.4123711340206, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221329854, Length=390, Percent_Identity=30.2564102564103, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281366676, Length=182, Percent_Identity=29.1208791208791, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668704, Length=621, Percent_Identity=20.450885668277, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24668696, Length=621, Percent_Identity=20.450885668277, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 79056; Mature: 79056

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYLRGLDCPSCAAKIERKLNNLNPNPNQEININLNNNTVELDPELYEEAQKIVDDIEP
CCCEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECHHHHHHHHHHHHHCCC
GVKLIPKENNKEQPHNNYEDDHSSNLKQEYLKIIISLGLLIFGFIFREELQNTPWAIADY
CCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHH
SVFLIAYFLVGGHVVISAVKNLVRRDIFNEKFLMTIATLGAILIQELPEAVAVMLFYAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELFQDLAVNKSRRSISSLLDLRPEFANLITEKGTEQVSPEQVTPGDVIEIYPGERIPLDG
HHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCC
KVLSGESYINASALTGESVPESVGPGEQVMAGTINENNLLRVQVTKEFNNSSVAKIFDLV
EEECCCCEECCHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHH
EKAAERKAPTEKFITTFAAWYTPVVVGGAAVLATIPPLLIPGAEFSEWIYRALILLVISC
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHH
PCALVLSIPLGYFGGIGGASRGGILVKGANFLDALIDADTVVFDKTGTLTEGTFQVVKIN
HHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCCCEECCCEEEEEEC
PKNGFSDQELLNYASTAEIYSNHPIARSILHEAKHKFNFSREELKAKVLKQREDKGFGVK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
TTLSDGSVILAGSEKLLTKESINMDLTDEKDNGETIVHVAVDDKYVGYLILDDEIKADAA
EEECCCCEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
EIVAKLKAKGVSHTVMLSGDEEQTAKRVAKQLNIDKYYAGLLPEEKIEIMDELIANKTGD
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
EKILYVGDGINDAPVITRADVGIAMGALGTDAAIEAADIVLMDDNLDKIPLSLDVARKTR
CEEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHCEEEEEEECCCCCCCCCCHHHHHHHH
RIVLQNIVFALGVKAAFVSLGALGMATMWGAIFADVGVALLAVFNSTRALRTPGKLSQYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SDSE
CCCC
>Mature Secondary Structure
MKYYLRGLDCPSCAAKIERKLNNLNPNPNQEININLNNNTVELDPELYEEAQKIVDDIEP
CCCEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECHHHHHHHHHHHHHCCC
GVKLIPKENNKEQPHNNYEDDHSSNLKQEYLKIIISLGLLIFGFIFREELQNTPWAIADY
CCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHH
SVFLIAYFLVGGHVVISAVKNLVRRDIFNEKFLMTIATLGAILIQELPEAVAVMLFYAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELFQDLAVNKSRRSISSLLDLRPEFANLITEKGTEQVSPEQVTPGDVIEIYPGERIPLDG
HHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCC
KVLSGESYINASALTGESVPESVGPGEQVMAGTINENNLLRVQVTKEFNNSSVAKIFDLV
EEECCCCEECCHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHH
EKAAERKAPTEKFITTFAAWYTPVVVGGAAVLATIPPLLIPGAEFSEWIYRALILLVISC
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHH
PCALVLSIPLGYFGGIGGASRGGILVKGANFLDALIDADTVVFDKTGTLTEGTFQVVKIN
HHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCCCEECCCEEEEEEC
PKNGFSDQELLNYASTAEIYSNHPIARSILHEAKHKFNFSREELKAKVLKQREDKGFGVK
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
TTLSDGSVILAGSEKLLTKESINMDLTDEKDNGETIVHVAVDDKYVGYLILDDEIKADAA
EEECCCCEEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
EIVAKLKAKGVSHTVMLSGDEEQTAKRVAKQLNIDKYYAGLLPEEKIEIMDELIANKTGD
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
EKILYVGDGINDAPVITRADVGIAMGALGTDAAIEAADIVLMDDNLDKIPLSLDVARKTR
CEEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHCEEEEEEECCCCCCCCCCHHHHHHHH
RIVLQNIVFALGVKAAFVSLGALGMATMWGAIFADVGVALLAVFNSTRALRTPGKLSQYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SDSE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]