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The map label for this gene is ziaR [H]

Identifier: 188587069

GI number: 188587069

Start: 2647427

End: 2647783

Strand: Direct

Name: ziaR [H]

Synonym: Nther_2461

Alternate gene names: 188587069

Gene position: 2647427-2647783 (Clockwise)

Preceding gene: 188587068

Following gene: 188587070

Centisome position: 83.63

GC content: 36.69

Gene sequence:

>357_bases
GTGACCAAAAAAGATACATGTCAAGAGTTCTGTTTTGATAGTGAAGCAGTGGAGCATGTTCAAAAACATATGTTGAATGA
ACAGGATATTGATAAAATGGCTGAAACCTTTAAAATACTGGCAGATCCTACCCGGGTAAAAATTTTACATGCCCTGGCTC
ATAAAGAACTGTGTGTATGTGATATCGCAGTCACCCTGGATATGAAAGTATCGGCAGTTTCTCATCAATTGAGATTATTA
AAAAGCGCCCGATTAGTTAAACAAAGGCGAGAAGGCAAGAATGTTTATTATCAATTGGATGATCACCATGTAGAGCAACT
CTTTGAAAAAACACTAGAACACATCAAGCATCAATAA

Upstream 100 bases:

>100_bases
GACAACCCCTTCCCCTTTTACAGGACTTTATGTTAGAATTCAATATAACAGTTGAACAGTTGTGCAAATGTTAACATCAA
AAATAATTGGAGGGTTATCA

Downstream 100 bases:

>100_bases
CCGACATTACAGGATTCGGATTCAATAACTGCAGATACGCTTGTACTTGTTTTACTTTCTTAAACTTGTTGTGTTTCTGT
CAAGGGAGGGGAAATCATGA

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 118; Mature: 117

Protein sequence:

>118_residues
MTKKDTCQEFCFDSEAVEHVQKHMLNEQDIDKMAETFKILADPTRVKILHALAHKELCVCDIAVTLDMKVSAVSHQLRLL
KSARLVKQRREGKNVYYQLDDHHVEQLFEKTLEHIKHQ

Sequences:

>Translated_118_residues
MTKKDTCQEFCFDSEAVEHVQKHMLNEQDIDKMAETFKILADPTRVKILHALAHKELCVCDIAVTLDMKVSAVSHQLRLL
KSARLVKQRREGKNVYYQLDDHHVEQLFEKTLEHIKHQ
>Mature_117_residues
TKKDTCQEFCFDSEAVEHVQKHMLNEQDIDKMAETFKILADPTRVKILHALAHKELCVCDIAVTLDMKVSAVSHQLRLLK
SARLVKQRREGKNVYYQLDDHHVEQLFEKTLEHIKHQ

Specific function: Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ziaA-mediated efflux of excess zinc into the periplasm [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13838; Mature: 13707

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKDTCQEFCFDSEAVEHVQKHMLNEQDIDKMAETFKILADPTRVKILHALAHKELCVC
CCCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHH
DIAVTLDMKVSAVSHQLRLLKSARLVKQRREGKNVYYQLDDHHVEQLFEKTLEHIKHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKKDTCQEFCFDSEAVEHVQKHMLNEQDIDKMAETFKILADPTRVKILHALAHKELCVC
CCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHH
DIAVTLDMKVSAVSHQLRLLKSARLVKQRREGKNVYYQLDDHHVEQLFEKTLEHIKHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]