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The map label for this gene is comEC [H]

Identifier: 188587040

GI number: 188587040

Start: 2607444

End: 2608808

Strand: Direct

Name: comEC [H]

Synonym: Nther_2432

Alternate gene names: 188587040

Gene position: 2607444-2608808 (Clockwise)

Preceding gene: 188587038

Following gene: 188587052

Centisome position: 82.37

GC content: 36.56

Gene sequence:

>1365_bases
ATGAAAAAATTAATTTACGTTTTAACAGTTATAGCAATTATTTTTTATCTTGTTCATATAGCGAGAGAACCCCCTAAACA
AGTAGATTTCAAAATAGATGGACAAGACTTAAATATAACAGTTAATCCAATTAAACCAGCTGACGAAGTCTTGATTCCAG
CAAGATTTATATTTGAACCCCTTGGTGGAGAATTGAATTGGAATGGCGAAAAACAAATTACTTCAATTTCTTTTGAAGAC
AAATACATAGAGTTTCCCATCGATAGTAAAGAAATCACTGTAAACAATTCTAAAAGAAAACTGGCAGATCCAATAATATT
ACAAGAAAACAGGACCTACATTCCTTTGGAGTTTGCCCAGGAAGTGCTCACAGCTGAAGCCAGGTGGAACAGTGCTACAA
ATACAGTAGTTTTGGATATACCAGAAAAAGCATTTAACCGTGACTTTGCAGAAGTCAAAGAAAAGGTACAATCATACCAA
AAGGCACGGGAAAAAAGCCAGGATTATACTACCGATCCAAAGGAAACTGCAAAAGAAGCTACAAATAACAAGAAAAATAA
ACAAGAAAATTCTGATCCTGTTAAATCTGAAGAACTAATTGCACATTTTATAGACGTGGGACAAGGAGATGCGATTTTTA
TTGAAACTCCTTGTGACAGCCATATATTAGTTGATGCCGGTCAAAACTGGGAAGGGGAAACTGTAGTCACCTATCTTGAA
GAATTAGAGATTAATGAAATAGCCAAAGTAGTTGCAACTCATCCTCACGCCGATCACATAGGAGGATTAACTGATATATA
CAAAAACTTTGAAGTTGATGTGACTTATGACAGTGGATACGAACATGACACCCAAACTTATCAAGAATACTATGACCTGG
CCAACAAAAATTCGGACTTTCAGATAGCTAGAACAGGGGATACTCTAGATTTAAGTTGTCTAGAAGCAGAGTTCATTTAT
CCGCCCGAGGGGAAAGGAGAGGCAGAGGAAGTGGAAGTTCATGATCTAAACCTAATTCTAAATATCAACTACGGTAAGCA
ATCTATCTTACTAACCGGTGATGCAGAAATCCCTGCAGAAAAAGAAATAATCGCTAATCACTCAGAATTATTACCAAGTG
ATATTTTAAAGGTTGGACACCATGGTTCAGAGACCAGTACCAGTGAAGATTTCTTAGAAATAGTAGATCCAGAAGCTGCT
GTGATTCAAGTAGGAGAAGATAATAGATACGATCACCCCCATGATGAAGTCCTAAGTCGTCTTGAAGATAATGGTGCCAA
AATTTATAGAAATGATTATCACGGAAATATAGTAATCACCATCGAAGACAGTAATTGGGAAGCCAATGTTGAGCCATGGA
ATTAG

Upstream 100 bases:

>100_bases
ACTTTAGTCATAAGAGGTTCACAAAGAAATTATAACATGGTAAATTAATAATATTGTGCAAGGCTATCAGGCAATTAGGC
AATGACTGGGGTGAGTGGCT

Downstream 100 bases:

>100_bases
AGCTCGAGTTCATGAACAACGATCTCTCCATAAACAGAGAAACGTCAAAATAAAAAACACCCTGCTTTTGTCGGCAACAA
GTCAACAAGCCGAAAGGCGA

Product: copper amine oxidase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKKLIYVLTVIAIIFYLVHIAREPPKQVDFKIDGQDLNITVNPIKPADEVLIPARFIFEPLGGELNWNGEKQITSISFED
KYIEFPIDSKEITVNNSKRKLADPIILQENRTYIPLEFAQEVLTAEARWNSATNTVVLDIPEKAFNRDFAEVKEKVQSYQ
KAREKSQDYTTDPKETAKEATNNKKNKQENSDPVKSEELIAHFIDVGQGDAIFIETPCDSHILVDAGQNWEGETVVTYLE
ELEINEIAKVVATHPHADHIGGLTDIYKNFEVDVTYDSGYEHDTQTYQEYYDLANKNSDFQIARTGDTLDLSCLEAEFIY
PPEGKGEAEEVEVHDLNLILNINYGKQSILLTGDAEIPAEKEIIANHSELLPSDILKVGHHGSETSTSEDFLEIVDPEAA
VIQVGEDNRYDHPHDEVLSRLEDNGAKIYRNDYHGNIVITIEDSNWEANVEPWN

Sequences:

>Translated_454_residues
MKKLIYVLTVIAIIFYLVHIAREPPKQVDFKIDGQDLNITVNPIKPADEVLIPARFIFEPLGGELNWNGEKQITSISFED
KYIEFPIDSKEITVNNSKRKLADPIILQENRTYIPLEFAQEVLTAEARWNSATNTVVLDIPEKAFNRDFAEVKEKVQSYQ
KAREKSQDYTTDPKETAKEATNNKKNKQENSDPVKSEELIAHFIDVGQGDAIFIETPCDSHILVDAGQNWEGETVVTYLE
ELEINEIAKVVATHPHADHIGGLTDIYKNFEVDVTYDSGYEHDTQTYQEYYDLANKNSDFQIARTGDTLDLSCLEAEFIY
PPEGKGEAEEVEVHDLNLILNINYGKQSILLTGDAEIPAEKEIIANHSELLPSDILKVGHHGSETSTSEDFLEIVDPEAA
VIQVGEDNRYDHPHDEVLSRLEDNGAKIYRNDYHGNIVITIEDSNWEANVEPWN
>Mature_454_residues
MKKLIYVLTVIAIIFYLVHIAREPPKQVDFKIDGQDLNITVNPIKPADEVLIPARFIFEPLGGELNWNGEKQITSISFED
KYIEFPIDSKEITVNNSKRKLADPIILQENRTYIPLEFAQEVLTAEARWNSATNTVVLDIPEKAFNRDFAEVKEKVQSYQ
KAREKSQDYTTDPKETAKEATNNKKNKQENSDPVKSEELIAHFIDVGQGDAIFIETPCDSHILVDAGQNWEGETVVTYLE
ELEINEIAKVVATHPHADHIGGLTDIYKNFEVDVTYDSGYEHDTQTYQEYYDLANKNSDFQIARTGDTLDLSCLEAEFIY
PPEGKGEAEEVEVHDLNLILNINYGKQSILLTGDAEIPAEKEIIANHSELLPSDILKVGHHGSETSTSEDFLEIVDPEAA
VIQVGEDNRYDHPHDEVLSRLEDNGAKIYRNDYHGNIVITIEDSNWEANVEPWN

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=259, Percent_Identity=24.3243243243243, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 51477; Mature: 51477

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLIYVLTVIAIIFYLVHIAREPPKQVDFKIDGQDLNITVNPIKPADEVLIPARFIFEP
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCHHEEECHHHHHHH
LGGELNWNGEKQITSISFEDKYIEFPIDSKEITVNNSKRKLADPIILQENRTYIPLEFAQ
CCCCCCCCCCCEEEEEEECCCEEECCCCCCEEEECCCCHHHCCCEEEECCCCEECHHHHH
EVLTAEARWNSATNTVVLDIPEKAFNRDFAEVKEKVQSYQKAREKSQDYTTDPKETAKEA
HHHHHHHCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TNNKKNKQENSDPVKSEELIAHFIDVGQGDAIFIETPCDSHILVDAGQNWEGETVVTYLE
HCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHHH
ELEINEIAKVVATHPHADHIGGLTDIYKNFEVDVTYDSGYEHDTQTYQEYYDLANKNSDF
HHCHHHHHHHHHCCCCHHHCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
QIARTGDTLDLSCLEAEFIYPPEGKGEAEEVEVHDLNLILNINYGKQSILLTGDAEIPAE
EEEECCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCEEEEEECCCCCCCC
KEIIANHSELLPSDILKVGHHGSETSTSEDFLEIVDPEAAVIQVGEDNRYDHPHDEVLSR
HHHHHCCHHHCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHH
LEDNGAKIYRNDYHGNIVITIEDSNWEANVEPWN
HHCCCCEEEEECCCCEEEEEEECCCCEECCCCCC
>Mature Secondary Structure
MKKLIYVLTVIAIIFYLVHIAREPPKQVDFKIDGQDLNITVNPIKPADEVLIPARFIFEP
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEECCCCCCHHEEECHHHHHHH
LGGELNWNGEKQITSISFEDKYIEFPIDSKEITVNNSKRKLADPIILQENRTYIPLEFAQ
CCCCCCCCCCCEEEEEEECCCEEECCCCCCEEEECCCCHHHCCCEEEECCCCEECHHHHH
EVLTAEARWNSATNTVVLDIPEKAFNRDFAEVKEKVQSYQKAREKSQDYTTDPKETAKEA
HHHHHHHCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TNNKKNKQENSDPVKSEELIAHFIDVGQGDAIFIETPCDSHILVDAGQNWEGETVVTYLE
HCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHHH
ELEINEIAKVVATHPHADHIGGLTDIYKNFEVDVTYDSGYEHDTQTYQEYYDLANKNSDF
HHCHHHHHHHHHCCCCHHHCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
QIARTGDTLDLSCLEAEFIYPPEGKGEAEEVEVHDLNLILNINYGKQSILLTGDAEIPAE
EEEECCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCEEEEEECCCCCCCC
KEIIANHSELLPSDILKVGHHGSETSTSEDFLEIVDPEAAVIQVGEDNRYDHPHDEVLSR
HHHHHCCHHHCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHH
LEDNGAKIYRNDYHGNIVITIEDSNWEANVEPWN
HHCCCCEEEEECCCCEEEEEEECCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]