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The map label for this gene is fadH [C]

Identifier: 188587037

GI number: 188587037

Start: 2603907

End: 2605847

Strand: Direct

Name: fadH [C]

Synonym: Nther_2429

Alternate gene names: 188587037

Gene position: 2603907-2605847 (Clockwise)

Preceding gene: 188587033

Following gene: 188587038

Centisome position: 82.26

GC content: 41.58

Gene sequence:

>1941_bases
ATGGTTTATAATGAATTATTTCAAAGAGGAAGAATTGGAAAGTTAACTATCAAAAATCGAACAGTCATGCCTGCCATGGG
AACTTCCCTGGCGGAACCAACAGGTGAGCCTTCAGAAGAGATGATTAAGTATTATGAAGAACGGGCAAAAAATGGCTGTG
GTTTAATAATCACCGAGATTACTAGAGTAGATGAAGATTACGGAGTCGGGACTGCCAATCAGCTATCAGCTACAAGTCCA
CAGCACATTCCGGGTCTGGAAAAACTGGCAAGAAGGGTACAAATCCACGATTCCAAATTATTTGTACAGCTTCATCATCC
TGGTCGCCAGGGGCATGCTAGATTAATTGGCGACAAACAGATAATCGCTCCCAGTGAATTAGAATGTCAGGTCACCAAAG
AAAAACCTCGAGCCATGACTACAGAAGAAGCGGAAGGTCTGGTTAAAAAATTCGTTAAAGGAGCTGTCATATCTCAAAAG
GCAGGAGTAGATGGAGTGGAAATCCACGGGGCTCACGGGTATCTGATCAATCAATTCTTAAGCCCTTATACCAACAGGCG
AACAGATAAGTATGGAGGCAACTTCGAAAATAGAATGCGCTTCCTCACGGAAATTATTGTTGGTATTAAGTATATGTGCG
GAAATGACTTTCCCATCAGTGTGCGTTTAAGTGCCGATGAATTCAATCCCAAAGGTATCGATTTGCAAGAAGGTACTAAA
ATCGCTAAATACCTGGAAAGTATCGGAGTTGACGCCATTAATGTCAGCTGTGGAAGCTATGAAACTGGTACTACAATAAT
TGAACCAAATGCCTTCCAACAGGGCTGGAAAAAACATTTGGCTGCTAAAATCAGGCTCAAACTAAATATACCTGTTATAG
CTGTCAATAACATCAAAGAACCACAAATTGCAGAACAAATGCTGTCAGATCAAGTTTGTGATTTTGTCGGCCTGGGAAGA
TCCCAGCTTGCTGATCCCCAGTGGATCTATAAGGCATATCAAGGTAAAGATGAGATGATAAGACCTTGTATTTCGTGCCT
ATATTGCATTGAACAACTTATGGGAGGGAGAAAATTCAAGTGTTCCGTTAACCCCTATCTGGGAAGAGAACAAGAGTTTA
GCCAGTTAACAGTTGATGGCCAAGGAGATACGGTAGCTATAATAGGAGGAGGACCCGCCGGAATGGTGGCAGCAGAAACC
CTGGCTTTGAGAGGATTTACACCGGTCATTTTCGAAAAGGAACAAGAACTTGGAGGTACCTTACTGACTGCAGACAAAAC
ACCACACAAAGAACAAATCACCCGATACGTCAAGTATATGGAAAAAAGACTGACAGAACTTAATGTAAAGTTGAATCTAG
GTCAGGAAGCTACAGTAGATACTATCAAAGCACTGTCACCAAAAGCCGTCTTTGTCGCTGCCGGAGCTAATCCCATTGTA
CCAAAGGATATATCCGGTATAGATAAGGATCATGTTTACACTGTCTTTGATGTATTGAAAGGTGAAGTAGAATTAACAAA
TCAGCATGTTGCCGTTATTGGTTCTGGACTCACCGGACTTGAAACTGCCGAACTCCTCGGACAACAGGGCAATAAAATTT
CCGTCGTTGAAATGGCCAAAGAAATTGGACCAAGTGTATATCGCAATATTTTAGCAGATATAACCGGTAGATTGAAACAC
TATGATGTAAACTACATGCCCCTACAGCAATTGAAAAAAGTCACCGATAATAGCATCATTACCTTGGACAGACAGAAATC
TACTTTGGCAGAACTCGAAGTCGATGCCGTAGTCCTGGCTTTAGGAGTTACTCCAAACACAAAACTTGCCGAAGAGTTTT
ATCAATCCTTTGAAAACTGTTATTACATTGGTGACATTGTAGAAGCTGCTAGAATTCCAGAAGCTGTGAGAGACGGCTTG
GAAAAAGGAAGTATCTTATAA

Upstream 100 bases:

>100_bases
TGCACATTTTATCCACCAATTCTTGTTTGTTTGTACATGTGAAAACCTGCACTAATTTGCTAATATTAGTTTAAAAGCTA
GTAAGAAGGAGTGAATAAGA

Downstream 100 bases:

>100_bases
ACTGTTGGTATCACCGGTATCAATACAAGTTTGAAAATTTGTGAATTTGAAACTGATTTTTTTGACTTTGACTAACTGAT
TAGGGAGGGTTAGAAATGAA

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MVYNELFQRGRIGKLTIKNRTVMPAMGTSLAEPTGEPSEEMIKYYEERAKNGCGLIITEITRVDEDYGVGTANQLSATSP
QHIPGLEKLARRVQIHDSKLFVQLHHPGRQGHARLIGDKQIIAPSELECQVTKEKPRAMTTEEAEGLVKKFVKGAVISQK
AGVDGVEIHGAHGYLINQFLSPYTNRRTDKYGGNFENRMRFLTEIIVGIKYMCGNDFPISVRLSADEFNPKGIDLQEGTK
IAKYLESIGVDAINVSCGSYETGTTIIEPNAFQQGWKKHLAAKIRLKLNIPVIAVNNIKEPQIAEQMLSDQVCDFVGLGR
SQLADPQWIYKAYQGKDEMIRPCISCLYCIEQLMGGRKFKCSVNPYLGREQEFSQLTVDGQGDTVAIIGGGPAGMVAAET
LALRGFTPVIFEKEQELGGTLLTADKTPHKEQITRYVKYMEKRLTELNVKLNLGQEATVDTIKALSPKAVFVAAGANPIV
PKDISGIDKDHVYTVFDVLKGEVELTNQHVAVIGSGLTGLETAELLGQQGNKISVVEMAKEIGPSVYRNILADITGRLKH
YDVNYMPLQQLKKVTDNSIITLDRQKSTLAELEVDAVVLALGVTPNTKLAEEFYQSFENCYYIGDIVEAARIPEAVRDGL
EKGSIL

Sequences:

>Translated_646_residues
MVYNELFQRGRIGKLTIKNRTVMPAMGTSLAEPTGEPSEEMIKYYEERAKNGCGLIITEITRVDEDYGVGTANQLSATSP
QHIPGLEKLARRVQIHDSKLFVQLHHPGRQGHARLIGDKQIIAPSELECQVTKEKPRAMTTEEAEGLVKKFVKGAVISQK
AGVDGVEIHGAHGYLINQFLSPYTNRRTDKYGGNFENRMRFLTEIIVGIKYMCGNDFPISVRLSADEFNPKGIDLQEGTK
IAKYLESIGVDAINVSCGSYETGTTIIEPNAFQQGWKKHLAAKIRLKLNIPVIAVNNIKEPQIAEQMLSDQVCDFVGLGR
SQLADPQWIYKAYQGKDEMIRPCISCLYCIEQLMGGRKFKCSVNPYLGREQEFSQLTVDGQGDTVAIIGGGPAGMVAAET
LALRGFTPVIFEKEQELGGTLLTADKTPHKEQITRYVKYMEKRLTELNVKLNLGQEATVDTIKALSPKAVFVAAGANPIV
PKDISGIDKDHVYTVFDVLKGEVELTNQHVAVIGSGLTGLETAELLGQQGNKISVVEMAKEIGPSVYRNILADITGRLKH
YDVNYMPLQQLKKVTDNSIITLDRQKSTLAELEVDAVVLALGVTPNTKLAEEFYQSFENCYYIGDIVEAARIPEAVRDGL
EKGSIL
>Mature_646_residues
MVYNELFQRGRIGKLTIKNRTVMPAMGTSLAEPTGEPSEEMIKYYEERAKNGCGLIITEITRVDEDYGVGTANQLSATSP
QHIPGLEKLARRVQIHDSKLFVQLHHPGRQGHARLIGDKQIIAPSELECQVTKEKPRAMTTEEAEGLVKKFVKGAVISQK
AGVDGVEIHGAHGYLINQFLSPYTNRRTDKYGGNFENRMRFLTEIIVGIKYMCGNDFPISVRLSADEFNPKGIDLQEGTK
IAKYLESIGVDAINVSCGSYETGTTIIEPNAFQQGWKKHLAAKIRLKLNIPVIAVNNIKEPQIAEQMLSDQVCDFVGLGR
SQLADPQWIYKAYQGKDEMIRPCISCLYCIEQLMGGRKFKCSVNPYLGREQEFSQLTVDGQGDTVAIIGGGPAGMVAAET
LALRGFTPVIFEKEQELGGTLLTADKTPHKEQITRYVKYMEKRLTELNVKLNLGQEATVDTIKALSPKAVFVAAGANPIV
PKDISGIDKDHVYTVFDVLKGEVELTNQHVAVIGSGLTGLETAELLGQQGNKISVVEMAKEIGPSVYRNILADITGRLKH
YDVNYMPLQQLKKVTDNSIITLDRQKSTLAELEVDAVVLALGVTPNTKLAEEFYQSFENCYYIGDIVEAARIPEAVRDGL
EKGSIL

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=666, Percent_Identity=30.3303303303303, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1787939, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17564188, Length=317, Percent_Identity=28.391167192429, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17559804, Length=317, Percent_Identity=27.7602523659306, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17565138, Length=351, Percent_Identity=27.6353276353276, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17540738, Length=371, Percent_Identity=27.4932614555256, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17566914, Length=247, Percent_Identity=29.5546558704453, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI72001454, Length=317, Percent_Identity=28.0757097791798, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17559802, Length=322, Percent_Identity=25.1552795031056, Blast_Score=100, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321973, Length=343, Percent_Identity=29.1545189504373, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325086, Length=354, Percent_Identity=27.9661016949153, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 71298; Mature: 71298

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYNELFQRGRIGKLTIKNRTVMPAMGTSLAEPTGEPSEEMIKYYEERAKNGCGLIITEI
CCCHHHHHCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEH
TRVDEDYGVGTANQLSATSPQHIPGLEKLARRVQIHDSKLFVQLHHPGRQGHARLIGDKQ
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCEEEEEEECCCCCCCEEEECCCE
IIAPSELECQVTKEKPRAMTTEEAEGLVKKFVKGAVISQKAGVDGVEIHGAHGYLINQFL
EECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
SPYTNRRTDKYGGNFENRMRFLTEIIVGIKYMCGNDFPISVRLSADEFNPKGIDLQEGTK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHCHH
IAKYLESIGVDAINVSCGSYETGTTIIEPNAFQQGWKKHLAAKIRLKLNIPVIAVNNIKE
HHHHHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHCEEEEEEEEECCEEEECCCCC
PQIAEQMLSDQVCDFVGLGRSQLADPQWIYKAYQGKDEMIRPCISCLYCIEQLMGGRKFK
HHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEE
CSVNPYLGREQEFSQLTVDGQGDTVAIIGGGPAGMVAAETLALRGFTPVIFEKEQELGGT
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHEEECCHHHCCE
LLTADKTPHKEQITRYVKYMEKRLTELNVKLNLGQEATVDTIKALSPKAVFVAAGANPIV
EEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCC
PKDISGIDKDHVYTVFDVLKGEVELTNQHVAVIGSGLTGLETAELLGQQGNKISVVEMAK
CCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEECCCCCHHHHHHHHCCCCEEHHHHHHH
EIGPSVYRNILADITGRLKHYDVNYMPLQQLKKVTDNSIITLDRQKSTLAELEVDAVVLA
HHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEE
LGVTPNTKLAEEFYQSFENCYYIGDIVEAARIPEAVRDGLEKGSIL
ECCCCCHHHHHHHHHHHHCEEEHHHHHHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MVYNELFQRGRIGKLTIKNRTVMPAMGTSLAEPTGEPSEEMIKYYEERAKNGCGLIITEI
CCCHHHHHCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEH
TRVDEDYGVGTANQLSATSPQHIPGLEKLARRVQIHDSKLFVQLHHPGRQGHARLIGDKQ
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCEEEEEEECCCCCCCEEEECCCE
IIAPSELECQVTKEKPRAMTTEEAEGLVKKFVKGAVISQKAGVDGVEIHGAHGYLINQFL
EECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
SPYTNRRTDKYGGNFENRMRFLTEIIVGIKYMCGNDFPISVRLSADEFNPKGIDLQEGTK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHCHH
IAKYLESIGVDAINVSCGSYETGTTIIEPNAFQQGWKKHLAAKIRLKLNIPVIAVNNIKE
HHHHHHHCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHCEEEEEEEEECCEEEECCCCC
PQIAEQMLSDQVCDFVGLGRSQLADPQWIYKAYQGKDEMIRPCISCLYCIEQLMGGRKFK
HHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEE
CSVNPYLGREQEFSQLTVDGQGDTVAIIGGGPAGMVAAETLALRGFTPVIFEKEQELGGT
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHEEECCHHHCCE
LLTADKTPHKEQITRYVKYMEKRLTELNVKLNLGQEATVDTIKALSPKAVFVAAGANPIV
EEECCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCC
PKDISGIDKDHVYTVFDVLKGEVELTNQHVAVIGSGLTGLETAELLGQQGNKISVVEMAK
CCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEECCCCCHHHHHHHHCCCCEEHHHHHHH
EIGPSVYRNILADITGRLKHYDVNYMPLQQLKKVTDNSIITLDRQKSTLAELEVDAVVLA
HHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEE
LGVTPNTKLAEEFYQSFENCYYIGDIVEAARIPEAVRDGLEKGSIL
ECCCCCHHHHHHHHHHHHCEEEHHHHHHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]