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The map label for this gene is nadC [H]

Identifier: 188587023

GI number: 188587023

Start: 2588626

End: 2589543

Strand: Direct

Name: nadC [H]

Synonym: Nther_2415

Alternate gene names: 188587023

Gene position: 2588626-2589543 (Clockwise)

Preceding gene: 188587022

Following gene: 188587030

Centisome position: 81.77

GC content: 40.31

Gene sequence:

>918_bases
ATGACAATGGTTCGTATAGACTGGTTAGATAAAGTGATTGACAGGGCCTTAGAAGAAGATTTGGGAAGCAGCTCAGACCT
GACCACTTCGGCTGTTGTGAACTATAATAATGATCTCTCAAGCGACAATCAAGGTGATCATTTAAATTCTTCCACATTCA
ACCAAGGGGAACAAGGGAAGCAAGGGACAGGAATGATCACTGCCAAGGAAGAAGGAATCTTAGCTGGTAGCTTTGTTGTA
ACAAGAGTTTTTCAAAAGTTATCTGATCAGATTAACTGCCAAATACTTATACCGGACGGTCAAAGAGTCTTATCAGGCCA
GGATATTATGCAAGTGACAGGGCCTTTAGCGCCCATTTTAACAGCTGAACGGTTGGCCCTGAATTTTTATCAACGCCTTT
CCGGCATTGCCACAGAAACCAGGAAGTTAGTAGATCTAATCACACCCTATTCTTGTGAACTTTTAGATACTCGTAAAACC
ACCCCAGGACTTAGGCCACTAGAAAAGTATGCTGTTAGAATGGGCGGTGGTACAAATCATAGAATGGGGCTTTATGATGG
TGTTATGATCAAAGACAATCACAAAAAAGCTTCCGGATCTATCACGGAAGCGATTAGAAGAGTTAAAAACACAGTAGGCC
CTATGGTCAAAATATCGGTGGAAGCTACCAACCAAAAGGAAGCAGAAGAAGCTTATCAACACGGGGCAGATATCATCCTT
TTAGATAATATGTCAACAAATCAATTAGTTCAAATTACAAAAAAGCTCTCTGGTAAAGTACTTCTGGAGGCCTCGGGAAA
TATCAGTAGTGACAATATTTCAGAAATAGCCAGAACAGGTGTTGATTATATTTCTTCAGGGAGTATTACTCATTCCGCTG
AATCCCTGGATTTGAGCTTTAATTTAGTTGAATTTTAA

Upstream 100 bases:

>100_bases
GGTGTACACAAAAGAAGGGAGTATCTTCAAATACCCGAACAAAACCCTGATAAATTTTTGTTTAGACAAGCTTACAATAT
TTCGAAAGGATGGTTTAAAT

Downstream 100 bases:

>100_bases
CAATAGATATGTTAATTTTTTATCTTTTATTATTTAATAATTTGTATTAGGAACAAATTTTGATAACTATAAATTACAAT
TTCACTTAAAATGCTAGTTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTMVRIDWLDKVIDRALEEDLGSSSDLTTSAVVNYNNDLSSDNQGDHLNSSTFNQGEQGKQGTGMITAKEEGILAGSFVV
TRVFQKLSDQINCQILIPDGQRVLSGQDIMQVTGPLAPILTAERLALNFYQRLSGIATETRKLVDLITPYSCELLDTRKT
TPGLRPLEKYAVRMGGGTNHRMGLYDGVMIKDNHKKASGSITEAIRRVKNTVGPMVKISVEATNQKEAEEAYQHGADIIL
LDNMSTNQLVQITKKLSGKVLLEASGNISSDNISEIARTGVDYISSGSITHSAESLDLSFNLVEF

Sequences:

>Translated_305_residues
MTMVRIDWLDKVIDRALEEDLGSSSDLTTSAVVNYNNDLSSDNQGDHLNSSTFNQGEQGKQGTGMITAKEEGILAGSFVV
TRVFQKLSDQINCQILIPDGQRVLSGQDIMQVTGPLAPILTAERLALNFYQRLSGIATETRKLVDLITPYSCELLDTRKT
TPGLRPLEKYAVRMGGGTNHRMGLYDGVMIKDNHKKASGSITEAIRRVKNTVGPMVKISVEATNQKEAEEAYQHGADIIL
LDNMSTNQLVQITKKLSGKVLLEASGNISSDNISEIARTGVDYISSGSITHSAESLDLSFNLVEF
>Mature_304_residues
TMVRIDWLDKVIDRALEEDLGSSSDLTTSAVVNYNNDLSSDNQGDHLNSSTFNQGEQGKQGTGMITAKEEGILAGSFVVT
RVFQKLSDQINCQILIPDGQRVLSGQDIMQVTGPLAPILTAERLALNFYQRLSGIATETRKLVDLITPYSCELLDTRKTT
PGLRPLEKYAVRMGGGTNHRMGLYDGVMIKDNHKKASGSITEAIRRVKNTVGPMVKISVEATNQKEAEEAYQHGADIILL
DNMSTNQLVQITKKLSGKVLLEASGNISSDNISEIARTGVDYISSGSITHSAESLDLSFNLVEF

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=34.2756183745583, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786299, Length=295, Percent_Identity=38.6440677966102, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321162, Length=253, Percent_Identity=37.5494071146245, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33270; Mature: 33139

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMVRIDWLDKVIDRALEEDLGSSSDLTTSAVVNYNNDLSSDNQGDHLNSSTFNQGEQGK
CCEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
QGTGMITAKEEGILAGSFVVTRVFQKLSDQINCQILIPDGQRVLSGQDIMQVTGPLAPIL
CCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHCCHHHHH
TAERLALNFYQRLSGIATETRKLVDLITPYSCELLDTRKTTPGLRPLEKYAVRMGGGTNH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCC
RMGLYDGVMIKDNHKKASGSITEAIRRVKNTVGPMVKISVEATNQKEAEEAYQHGADIIL
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEE
LDNMSTNQLVQITKKLSGKVLLEASGNISSDNISEIARTGVDYISSGSITHSAESLDLSF
ECCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCHHHHCCCCCCCCCCCEEEEE
NLVEF
EEECC
>Mature Secondary Structure 
TMVRIDWLDKVIDRALEEDLGSSSDLTTSAVVNYNNDLSSDNQGDHLNSSTFNQGEQGK
CEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
QGTGMITAKEEGILAGSFVVTRVFQKLSDQINCQILIPDGQRVLSGQDIMQVTGPLAPIL
CCCCEEEECCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCHHHHHHCCHHHHH
TAERLALNFYQRLSGIATETRKLVDLITPYSCELLDTRKTTPGLRPLEKYAVRMGGGTNH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCC
RMGLYDGVMIKDNHKKASGSITEAIRRVKNTVGPMVKISVEATNQKEAEEAYQHGADIIL
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEE
LDNMSTNQLVQITKKLSGKVLLEASGNISSDNISEIARTGVDYISSGSITHSAESLDLSF
ECCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHCHHHHCCCCCCCCCCCEEEEE
NLVEF
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]