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The map label for this gene is nadB [H]

Identifier: 188587022

GI number: 188587022

Start: 2586843

End: 2588657

Strand: Direct

Name: nadB [H]

Synonym: Nther_2414

Alternate gene names: 188587022

Gene position: 2586843-2588657 (Clockwise)

Preceding gene: 188587021

Following gene: 188587023

Centisome position: 81.72

GC content: 39.5

Gene sequence:

>1815_bases
ATGTCTGCAATAATTTCAATACACCATTTTCCCGTTATTGTTCTAGGTTCAGGCATTTCCGGCATGTGTGCCGCTTTAAA
GGCAGGGCTAAAAAAAGGGCAAGAATGTGAAACAGCTACAGCTTTGATTTCTCAAGGAGATGAATCCCTGACCAATACTT
ACCTAGCCCAGGGCGGCATAGCTGCCGCCCTTAAAGATATAGACAGCCCGTACCAACATTATAAAGATACTTTACAGGCA
TCTTCGGGTCTCACCAACCCGGATATTGTTCATATGCTTGCAGAAGGTGGACCAGAAACAATTGATCAACTTGAACAGTT
GGGTGTTGAATTTGATAAAGACCAGCGTGGGGATTACAAACTGGCCAAAGAAGGAGCACATTCTTACCGTAGGATATTAC
GATGCGGAGGTGATCGTAGCGGTCAGCAAATAGCAGTGAAATTAGCGGACAAAATTATAAATTGCCCATATATTGCCAGA
TTTAACTGCCACAAACTACTAAAACTTTTAGTAATACAAGGTACCTGCATGGGAGCTATTACTCTTGATGATGAAGGTGA
ATTCCATCTATTTTTCTCTGATAGTACTATTTTGGCAACTGGGGGTTATGGAGGTTTATTTGAAAAGACTTCCAATCAAC
CAGGGGCCCTAGGTGATGCCATTGGTGAAGCATTATTACAAGGAGCTACAGTGGCAGATTTAGAATTTGTTCAATTCCAT
CCCACTGGGCTAGAAATTAAAGATATACCTTCCCAGGGAAAAGAAACAAACCATTATCCTGCAAGCAATTATTATTATCC
TGCTTTTACAAATCAATATCCGTTAATTTCAGAGGCAGTCAGAGGTGAAAAGGCCCTATTAATTAACGATACAGGCCGAA
GAATCATGGATGGAGTACATCCTTTAGAAGAACTGGCGCCTCGTGATGTAGTATCAGCAACCATTTATCAGTATCAACAA
GCTGGATCAAGGGTGTATCTAGACGCTACACATCTAAATACCGGCTATGTTGAACAAAGATTCCCGGGAATTTCATCTAT
GCTAAAAAAATATGGATTAGACTTGGCCAGGGATCGGATTCCCGTCACTCCGGCAGCTCATTACACCATAGGAGGTATTT
TAACCCCTTTTGGTATTTCGACCGGCATCAAGGGATTATTTGCCGCTGGAGAGGCAACGTCCTCGGGAGTACATGGCGCC
AATAGACTTGCCAGTAACTCTCTTCTGGAAGGTGCTTTCTTTGGATTCATGGCTGGGAAACGAGCTTTAGAGTTACATCT
TCACTATAAAGAAAAATCCAGATCAAATAGTTCAGAGAGAACTTTATTTAATAATCATGAAAAAAATAAATTTATAAAAC
AAATTCAAAAAAACTTTTCCCAGGCTGTCGAACATCTCACGGACAATGATAAAGATGTCTTTTTTCATGATAGTGATTTT
AACCAAAAATTTATCGCTCAAATTCAAAACATTATGTGGACAAAGGCAGGAGTAATCAGAGATGAAAGCAAGTTACAAGA
AGGTTTAATTCAGCTAAAAACCTTGGAGCAAGAATATTTTAAGTCACTGCCAAAAAACTTACAAAAACTGCAACAGCATA
ATTTGCAGTTATCTCCCCTTCCCAAAGTAATCCTGTTGGCAAAAAAAATTATAGAAGCCTCGCTGAGACGCAGAGAAAAT
AGGGGTGTACACAAAAGAAGGGAGTATCTTCAAATACCCGAACAAAACCCTGATAAATTTTTGTTTAGACAAGCTTACAA
TATTTCGAAAGGATGGTTTAAATATGACAATGGTTCGTATAGACTGGTTAGATAA

Upstream 100 bases:

>100_bases
TTTAGGATTAGTTTTATACTAATTTCAGAAGTAGGATTAGGAATAAGATTAGGAAAAAGATTAGTATTAGTAGAAGTTTA
GGAGTAATTGGAGTGATTTT

Downstream 100 bases:

>100_bases
AGTGATTGACAGGGCCTTAGAAGAAGATTTGGGAAGCAGCTCAGACCTGACCACTTCGGCTGTTGTGAACTATAATAATG
ATCTCTCAAGCGACAATCAA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSAIISIHHFPVIVLGSGISGMCAALKAGLKKGQECETATALISQGDESLTNTYLAQGGIAAALKDIDSPYQHYKDTLQA
SSGLTNPDIVHMLAEGGPETIDQLEQLGVEFDKDQRGDYKLAKEGAHSYRRILRCGGDRSGQQIAVKLADKIINCPYIAR
FNCHKLLKLLVIQGTCMGAITLDDEGEFHLFFSDSTILATGGYGGLFEKTSNQPGALGDAIGEALLQGATVADLEFVQFH
PTGLEIKDIPSQGKETNHYPASNYYYPAFTNQYPLISEAVRGEKALLINDTGRRIMDGVHPLEELAPRDVVSATIYQYQQ
AGSRVYLDATHLNTGYVEQRFPGISSMLKKYGLDLARDRIPVTPAAHYTIGGILTPFGISTGIKGLFAAGEATSSGVHGA
NRLASNSLLEGAFFGFMAGKRALELHLHYKEKSRSNSSERTLFNNHEKNKFIKQIQKNFSQAVEHLTDNDKDVFFHDSDF
NQKFIAQIQNIMWTKAGVIRDESKLQEGLIQLKTLEQEYFKSLPKNLQKLQQHNLQLSPLPKVILLAKKIIEASLRRREN
RGVHKRREYLQIPEQNPDKFLFRQAYNISKGWFKYDNGSYRLVR

Sequences:

>Translated_604_residues
MSAIISIHHFPVIVLGSGISGMCAALKAGLKKGQECETATALISQGDESLTNTYLAQGGIAAALKDIDSPYQHYKDTLQA
SSGLTNPDIVHMLAEGGPETIDQLEQLGVEFDKDQRGDYKLAKEGAHSYRRILRCGGDRSGQQIAVKLADKIINCPYIAR
FNCHKLLKLLVIQGTCMGAITLDDEGEFHLFFSDSTILATGGYGGLFEKTSNQPGALGDAIGEALLQGATVADLEFVQFH
PTGLEIKDIPSQGKETNHYPASNYYYPAFTNQYPLISEAVRGEKALLINDTGRRIMDGVHPLEELAPRDVVSATIYQYQQ
AGSRVYLDATHLNTGYVEQRFPGISSMLKKYGLDLARDRIPVTPAAHYTIGGILTPFGISTGIKGLFAAGEATSSGVHGA
NRLASNSLLEGAFFGFMAGKRALELHLHYKEKSRSNSSERTLFNNHEKNKFIKQIQKNFSQAVEHLTDNDKDVFFHDSDF
NQKFIAQIQNIMWTKAGVIRDESKLQEGLIQLKTLEQEYFKSLPKNLQKLQQHNLQLSPLPKVILLAKKIIEASLRRREN
RGVHKRREYLQIPEQNPDKFLFRQAYNISKGWFKYDNGSYRLVR
>Mature_603_residues
SAIISIHHFPVIVLGSGISGMCAALKAGLKKGQECETATALISQGDESLTNTYLAQGGIAAALKDIDSPYQHYKDTLQAS
SGLTNPDIVHMLAEGGPETIDQLEQLGVEFDKDQRGDYKLAKEGAHSYRRILRCGGDRSGQQIAVKLADKIINCPYIARF
NCHKLLKLLVIQGTCMGAITLDDEGEFHLFFSDSTILATGGYGGLFEKTSNQPGALGDAIGEALLQGATVADLEFVQFHP
TGLEIKDIPSQGKETNHYPASNYYYPAFTNQYPLISEAVRGEKALLINDTGRRIMDGVHPLEELAPRDVVSATIYQYQQA
GSRVYLDATHLNTGYVEQRFPGISSMLKKYGLDLARDRIPVTPAAHYTIGGILTPFGISTGIKGLFAAGEATSSGVHGAN
RLASNSLLEGAFFGFMAGKRALELHLHYKEKSRSNSSERTLFNNHEKNKFIKQIQKNFSQAVEHLTDNDKDVFFHDSDFN
QKFIAQIQNIMWTKAGVIRDESKLQEGLIQLKTLEQEYFKSLPKNLQKLQQHNLQLSPLPKVILLAKKIIEASLRRRENR
GVHKRREYLQIPEQNPDKFLFRQAYNISKGWFKYDNGSYRLVR

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=564, Percent_Identity=29.6099290780142, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1788928, Length=582, Percent_Identity=29.2096219931272, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1790597, Length=550, Percent_Identity=29.4545454545455, Blast_Score=202, Evalue=7e-53,
Organism=Escherichia coli, GI1786942, Length=591, Percent_Identity=27.072758037225, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17505833, Length=566, Percent_Identity=28.9752650176678, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17550100, Length=569, Percent_Identity=29.1739894551845, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322701, Length=581, Percent_Identity=28.2271944922547, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=584, Percent_Identity=28.2534246575343, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320788, Length=498, Percent_Identity=25.9036144578313, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322511, Length=503, Percent_Identity=25.2485089463221, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137288, Length=567, Percent_Identity=30.1587301587302, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24655642, Length=567, Percent_Identity=30.1587301587302, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24655647, Length=567, Percent_Identity=30.1587301587302, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24663005, Length=566, Percent_Identity=27.7385159010601, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 67160; Mature: 67029

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIISIHHFPVIVLGSGISGMCAALKAGLKKGQECETATALISQGDESLTNTYLAQGGI
CCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCH
AAALKDIDSPYQHYKDTLQASSGLTNPDIVHMLAEGGPETIDQLEQLGVEFDKDQRGDYK
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHH
LAKEGAHSYRRILRCGGDRSGQQIAVKLADKIINCPYIARFNCHKLLKLLVIQGTCMGAI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCEEEEE
TLDDEGEFHLFFSDSTILATGGYGGLFEKTSNQPGALGDAIGEALLQGATVADLEFVQFH
EECCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECEEEEEEC
PTGLEIKDIPSQGKETNHYPASNYYYPAFTNQYPLISEAVRGEKALLINDTGRRIMDGVH
CCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEECCCHHHHHCCC
PLEELAPRDVVSATIYQYQQAGSRVYLDATHLNTGYVEQRFPGISSMLKKYGLDLARDRI
CHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCHHHHHHHHCCHHHHCCC
PVTPAAHYTIGGILTPFGISTGIKGLFAAGEATSSGVHGANRLASNSLLEGAFFGFMAGK
CCCCCCCHHHCCHHCCCCHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
RALELHLHYKEKSRSNSSERTLFNNHEKNKFIKQIQKNFSQAVEHLTDNDKDVFFHDSDF
EEEEEEEEEHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
NQKFIAQIQNIMWTKAGVIRDESKLQEGLIQLKTLEQEYFKSLPKNLQKLQQHNLQLSPL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PKVILLAKKIIEASLRRRENRGVHKRREYLQIPEQNPDKFLFRQAYNISKGWFKYDNGSY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCE
RLVR
EEEC
>Mature Secondary Structure 
SAIISIHHFPVIVLGSGISGMCAALKAGLKKGQECETATALISQGDESLTNTYLAQGGI
CCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCH
AAALKDIDSPYQHYKDTLQASSGLTNPDIVHMLAEGGPETIDQLEQLGVEFDKDQRGDYK
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHH
LAKEGAHSYRRILRCGGDRSGQQIAVKLADKIINCPYIARFNCHKLLKLLVIQGTCMGAI
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCEEEEE
TLDDEGEFHLFFSDSTILATGGYGGLFEKTSNQPGALGDAIGEALLQGATVADLEFVQFH
EECCCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECEEEEEEC
PTGLEIKDIPSQGKETNHYPASNYYYPAFTNQYPLISEAVRGEKALLINDTGRRIMDGVH
CCCCEEECCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHCCCCEEEEECCCHHHHHCCC
PLEELAPRDVVSATIYQYQQAGSRVYLDATHLNTGYVEQRFPGISSMLKKYGLDLARDRI
CHHHHCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHCCCHHHHHHHHCCHHHHCCC
PVTPAAHYTIGGILTPFGISTGIKGLFAAGEATSSGVHGANRLASNSLLEGAFFGFMAGK
CCCCCCCHHHCCHHCCCCHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
RALELHLHYKEKSRSNSSERTLFNNHEKNKFIKQIQKNFSQAVEHLTDNDKDVFFHDSDF
EEEEEEEEEHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
NQKFIAQIQNIMWTKAGVIRDESKLQEGLIQLKTLEQEYFKSLPKNLQKLQQHNLQLSPL
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PKVILLAKKIIEASLRRRENRGVHKRREYLQIPEQNPDKFLFRQAYNISKGWFKYDNGSY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCE
RLVR
EEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]