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The map label for this gene is gltT [H]

Identifier: 188587008

GI number: 188587008

Start: 2564309

End: 2565628

Strand: Reverse

Name: gltT [H]

Synonym: Nther_2400

Alternate gene names: 188587008

Gene position: 2565628-2564309 (Counterclockwise)

Preceding gene: 188587009

Following gene: 188587007

Centisome position: 81.05

GC content: 39.7

Gene sequence:

>1320_bases
ATGGCTGAAGGTAAAGGAATCTTACGCAAGTATTTTGAAATCCCCTTCATCCAGAGAATGGGGGTAGCCTTTGTACTTGG
TATTATCGTAGGCCTAATAGTTGGAGAACCCATAAAAGTAATTGAACCTCTAGGAGATCTATTTCTCAGATTATTGATGA
TGGTTGTTATTCCAATTATTGTTTTTACTTTAATTACAGCAATGAAGAAATTGACACCATCGCAATTGGGGCGAGTGGGT
GGTCAAACTGTCGGAATTTATATTTTAACTACTATTGTAGCAATTATTATCGGTTTAACAATGGCTAATTTGTTCAACCC
TGGACTAGGTTTAGAGTTGCCCGGTGAGTACGATATGGATCCAGAAGAAGCACCGAGTATGATTGATGTATTTCTGAATT
TATTCCCAGAAAACGTGGTTGAGGCTATGGCCGAGGCCGAAGTTCTTCAGGTATTGATATTTGCAATTATCTTCGGTATA
GCTTTGGCTTTTGTCAGGGAATCCAGTGATAATGAAGAAGTAAAAAATGGTGTAGACATAATTTTTAACATTACAGAAAC
AGCTTCTGAAGCCATGTTCAAAATTGTCAGGGGTGTAATGGAATACGGTGTTATTGGTGTATTTGCATTATTAGCAGTTA
CTTTTGGGGAAGCTGGCCCCGAAGCCCTGGTGGAATTTGGCCTGGTAATATTAACTTTCGTGTTGGCTGTGGGAATCCAC
ATGTTGATAATTTATGGTGTTATTTTAAATGGAGTTATATTGAGAAAATCGCCTTTGAGATTTATTAAAGGTACTAAAGA
AATACTGTTAACAGCTTTTGCAACCAGGTCCAGTGCTGGTGTACTACCTATTTCCATGCGAACTGCCAATGAAAACTTGA
AAATCGATGAGAAAATATATTCATTTACTCTTCCTTTAGGAGCCACAATTAATATGGATGGAACTGCCATGTATCAGGGT
GTTGCCGCTATTTTTGCAGCTAACCTGGTTGGGGAATCACTGACTCTGGTGGAACAGATTACTATTGTTACTACTACGGT
ACTGGCCAGTATTGGTACAGCAGGAGTACCTGGTTCAGGTATGATAATGTTGTCTATGGTATTGACTCAGTTGGGCTTAC
CCCTGGGAGTAGTCGCCTTTGTAGCGGGTGTTGATCCAATATTAGATGCTTTCAGAACCATGAACAATGTCGCCGGTGAC
TTGTCAGTAACCAGTGTTGTTGCTAAGTACAATGATGGTATTGACCTGAATTCAGGAGCGTGGGTTGACTTTCAAGATGA
AGGTGAAAGTACAGACTCTGGAACAAGTTCTGATAGTTAA

Upstream 100 bases:

>100_bases
ATGGCTTAATGACAAATTTATCTTGACTCCCTTCATATTTATAATAAAATAATAGTAAATATAGTAATGTTTTAATACTT
TAACTGAGAGGAGGAAAATG

Downstream 100 bases:

>100_bases
GAACTAAATAATAATAAAATCAAATATTTAATTAGAAATAAATACTTTAGTAATTACTTGGGGATGCCTTTGGTGTCCCC
TTTTTTTGATTTGGTATTTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAEGKGILRKYFEIPFIQRMGVAFVLGIIVGLIVGEPIKVIEPLGDLFLRLLMMVVIPIIVFTLITAMKKLTPSQLGRVG
GQTVGIYILTTIVAIIIGLTMANLFNPGLGLELPGEYDMDPEEAPSMIDVFLNLFPENVVEAMAEAEVLQVLIFAIIFGI
ALAFVRESSDNEEVKNGVDIIFNITETASEAMFKIVRGVMEYGVIGVFALLAVTFGEAGPEALVEFGLVILTFVLAVGIH
MLIIYGVILNGVILRKSPLRFIKGTKEILLTAFATRSSAGVLPISMRTANENLKIDEKIYSFTLPLGATINMDGTAMYQG
VAAIFAANLVGESLTLVEQITIVTTTVLASIGTAGVPGSGMIMLSMVLTQLGLPLGVVAFVAGVDPILDAFRTMNNVAGD
LSVTSVVAKYNDGIDLNSGAWVDFQDEGESTDSGTSSDS

Sequences:

>Translated_439_residues
MAEGKGILRKYFEIPFIQRMGVAFVLGIIVGLIVGEPIKVIEPLGDLFLRLLMMVVIPIIVFTLITAMKKLTPSQLGRVG
GQTVGIYILTTIVAIIIGLTMANLFNPGLGLELPGEYDMDPEEAPSMIDVFLNLFPENVVEAMAEAEVLQVLIFAIIFGI
ALAFVRESSDNEEVKNGVDIIFNITETASEAMFKIVRGVMEYGVIGVFALLAVTFGEAGPEALVEFGLVILTFVLAVGIH
MLIIYGVILNGVILRKSPLRFIKGTKEILLTAFATRSSAGVLPISMRTANENLKIDEKIYSFTLPLGATINMDGTAMYQG
VAAIFAANLVGESLTLVEQITIVTTTVLASIGTAGVPGSGMIMLSMVLTQLGLPLGVVAFVAGVDPILDAFRTMNNVAGD
LSVTSVVAKYNDGIDLNSGAWVDFQDEGESTDSGTSSDS
>Mature_438_residues
AEGKGILRKYFEIPFIQRMGVAFVLGIIVGLIVGEPIKVIEPLGDLFLRLLMMVVIPIIVFTLITAMKKLTPSQLGRVGG
QTVGIYILTTIVAIIIGLTMANLFNPGLGLELPGEYDMDPEEAPSMIDVFLNLFPENVVEAMAEAEVLQVLIFAIIFGIA
LAFVRESSDNEEVKNGVDIIFNITETASEAMFKIVRGVMEYGVIGVFALLAVTFGEAGPEALVEFGLVILTFVLAVGIHM
LIIYGVILNGVILRKSPLRFIKGTKEILLTAFATRSSAGVLPISMRTANENLKIDEKIYSFTLPLGATINMDGTAMYQGV
AAIFAANLVGESLTLVEQITIVTTTVLASIGTAGVPGSGMIMLSMVLTQLGLPLGVVAFVAGVDPILDAFRTMNNVAGDL
SVTSVVAKYNDGIDLNSGAWVDFQDEGESTDSGTSSDS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=449, Percent_Identity=31.6258351893096, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI40254478, Length=446, Percent_Identity=29.8206278026906, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI194239697, Length=468, Percent_Identity=30.3418803418803, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4827012, Length=433, Percent_Identity=30.9468822170901, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI169790839, Length=444, Percent_Identity=31.3063063063063, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI21314632, Length=406, Percent_Identity=31.7733990147783, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI5032093, Length=398, Percent_Identity=30.4020100502513, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI223468564, Length=274, Percent_Identity=33.9416058394161, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI223468566, Length=273, Percent_Identity=34.0659340659341, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI262359914, Length=405, Percent_Identity=29.6296296296296, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI301601644, Length=175, Percent_Identity=34.8571428571429, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=33.7349397590361, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789947, Length=403, Percent_Identity=31.0173697270471, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1788024, Length=445, Percent_Identity=25.1685393258427, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789473, Length=392, Percent_Identity=27.5510204081633, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996953, Length=478, Percent_Identity=30.9623430962343, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17537407, Length=420, Percent_Identity=30.4761904761905, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71983106, Length=466, Percent_Identity=29.1845493562232, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71983099, Length=466, Percent_Identity=29.1845493562232, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=27.4678111587983, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=30.3482587064677, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193206654, Length=412, Percent_Identity=27.9126213592233, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=27.6887871853547, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=27.6887871853547, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=27.6887871853547, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281360481, Length=475, Percent_Identity=26.9473684210526, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281360483, Length=475, Percent_Identity=26.9473684210526, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137666, Length=475, Percent_Identity=26.9473684210526, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46754; Mature: 46623

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGKGILRKYFEIPFIQRMGVAFVLGIIVGLIVGEPIKVIEPLGDLFLRLLMMVVIPII
CCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VFTLITAMKKLTPSQLGRVGGQTVGIYILTTIVAIIIGLTMANLFNPGLGLELPGEYDMD
HHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PEEAPSMIDVFLNLFPENVVEAMAEAEVLQVLIFAIIFGIALAFVRESSDNEEVKNGVDI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEE
IFNITETASEAMFKIVRGVMEYGVIGVFALLAVTFGEAGPEALVEFGLVILTFVLAVGIH
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MLIIYGVILNGVILRKSPLRFIKGTKEILLTAFATRSSAGVLPISMRTANENLKIDEKIY
HHHHHHHHHCCCHHCCCCHHHHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHH
SFTLPLGATINMDGTAMYQGVAAIFAANLVGESLTLVEQITIVTTTVLASIGTAGVPGSG
HEECCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
MIMLSMVLTQLGLPLGVVAFVAGVDPILDAFRTMNNVAGDLSVTSVVAKYNDGIDLNSGA
HHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
WVDFQDEGESTDSGTSSDS
EEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEGKGILRKYFEIPFIQRMGVAFVLGIIVGLIVGEPIKVIEPLGDLFLRLLMMVVIPII
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VFTLITAMKKLTPSQLGRVGGQTVGIYILTTIVAIIIGLTMANLFNPGLGLELPGEYDMD
HHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PEEAPSMIDVFLNLFPENVVEAMAEAEVLQVLIFAIIFGIALAFVRESSDNEEVKNGVDI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEE
IFNITETASEAMFKIVRGVMEYGVIGVFALLAVTFGEAGPEALVEFGLVILTFVLAVGIH
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MLIIYGVILNGVILRKSPLRFIKGTKEILLTAFATRSSAGVLPISMRTANENLKIDEKIY
HHHHHHHHHCCCHHCCCCHHHHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHH
SFTLPLGATINMDGTAMYQGVAAIFAANLVGESLTLVEQITIVTTTVLASIGTAGVPGSG
HEECCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCH
MIMLSMVLTQLGLPLGVVAFVAGVDPILDAFRTMNNVAGDLSVTSVVAKYNDGIDLNSGA
HHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
WVDFQDEGESTDSGTSSDS
EEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]