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The map label for this gene is appC [H]

Identifier: 188586998

GI number: 188586998

Start: 2554189

End: 2555109

Strand: Direct

Name: appC [H]

Synonym: Nther_2390

Alternate gene names: 188586998

Gene position: 2554189-2555109 (Clockwise)

Preceding gene: 188586997

Following gene: 188586999

Centisome position: 80.69

GC content: 41.69

Gene sequence:

>921_bases
ATGAATAAAGAAATTGAATCTCAATTACAGGAACATGATGCTCCTAGTTTTAAAAGTAAAGTATCTTCATTGGCCTATTT
CATTAAAGAAATTTTCAGTCAGGACAAAATGGCCTTGATCGGGACCATTATTTTTATCCTGTTTATCATAGTCGCCCTCA
TGGCTCCAACTCTAGCACCCCATGACCCTATGGAAATACATCGCAGAGATGGGGAGATTGTACGGACTGAACCCCCATCT
AGCGAATTTCCCTTTGGGACAACTAATAGGGGACGCTGTGTCTTTAGCCAGGTGATTATGGGAAGCAGAGTTGCCCTATT
GGTAGGCGCCCTGGCAGCTCTACTAGTAACTATAATTGGCTCAAATATAGGATTGATTTCAGGTTATTATGGTGGTTGGA
TAGATAATCTATTCATGAGAATCGTCGACATCAGTTATGCCATACCTTTTATCCCTTTTACAATAATCCTGGTCACATTA
TTAAGACCTAGTATTTGGAATATAATTTTAGCCATTGTGGTCCTTACATGGAGGACAATAGCCAGGGTTTTAAGGGCTCA
AGTGTTGTCAGTAAAAGAACGTCCCTATGTGAAAGCGGCTAAAGTAGCTGGTGCAAGCAATGCCAGGATAATTTTCCTAT
ATATTCTTCCTAATGTCCTTCCTCTGGCTTTGCTGGAAATGTCACTAAGAATGGCTCAAGCCATTGTTGCAGAATCAACG
GTAAGCTTTTTGGGTTTCGGAGACCCGGATGTAATTAGCTGGGGTAGAATTTTACAGGAAGGCTTTATCGCTGGAGCTAT
GCGGGAAGCTTGGTGGTGGGTAATTCCACCAGGATTAGCTATTGCCATAGTAGTAGTATCGGTATTCTTTAGTTCCAGAG
CCCTGGAATTTGTAGCTAATCCTCAATTAAGGAGGCGATAG

Upstream 100 bases:

>100_bases
TGTTAGCAGCTAAAGTAATGGTACTGAATCTGTTAGTAGATATACTCTATGGCTATCTAGATCCCAGGATCACCTATGAA
TAAAGGGGGTTTCAAATTTA

Downstream 100 bases:

>100_bases
TTAGATGGCACTATTAGAAATTGAAAATCTGACCATCAGTTACCAGCTTAAAAATGGTGAATTACGTGCCGTCGATGACG
TTTCATTTAATATTCCCGAG

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNKEIESQLQEHDAPSFKSKVSSLAYFIKEIFSQDKMALIGTIIFILFIIVALMAPTLAPHDPMEIHRRDGEIVRTEPPS
SEFPFGTTNRGRCVFSQVIMGSRVALLVGALAALLVTIIGSNIGLISGYYGGWIDNLFMRIVDISYAIPFIPFTIILVTL
LRPSIWNIILAIVVLTWRTIARVLRAQVLSVKERPYVKAAKVAGASNARIIFLYILPNVLPLALLEMSLRMAQAIVAEST
VSFLGFGDPDVISWGRILQEGFIAGAMREAWWWVIPPGLAIAIVVVSVFFSSRALEFVANPQLRRR

Sequences:

>Translated_306_residues
MNKEIESQLQEHDAPSFKSKVSSLAYFIKEIFSQDKMALIGTIIFILFIIVALMAPTLAPHDPMEIHRRDGEIVRTEPPS
SEFPFGTTNRGRCVFSQVIMGSRVALLVGALAALLVTIIGSNIGLISGYYGGWIDNLFMRIVDISYAIPFIPFTIILVTL
LRPSIWNIILAIVVLTWRTIARVLRAQVLSVKERPYVKAAKVAGASNARIIFLYILPNVLPLALLEMSLRMAQAIVAEST
VSFLGFGDPDVISWGRILQEGFIAGAMREAWWWVIPPGLAIAIVVVSVFFSSRALEFVANPQLRRR
>Mature_306_residues
MNKEIESQLQEHDAPSFKSKVSSLAYFIKEIFSQDKMALIGTIIFILFIIVALMAPTLAPHDPMEIHRRDGEIVRTEPPS
SEFPFGTTNRGRCVFSQVIMGSRVALLVGALAALLVTIIGSNIGLISGYYGGWIDNLFMRIVDISYAIPFIPFTIILVTL
LRPSIWNIILAIVVLTWRTIARVLRAQVLSVKERPYVKAAKVAGASNARIIFLYILPNVLPLALLEMSLRMAQAIVAEST
VSFLGFGDPDVISWGRILQEGFIAGAMREAWWWVIPPGLAIAIVVVSVFFSSRALEFVANPQLRRR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787760, Length=262, Percent_Identity=33.969465648855, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787054, Length=274, Percent_Identity=30.6569343065693, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789964, Length=303, Percent_Identity=34.3234323432343, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787498, Length=306, Percent_Identity=30.3921568627451, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788505, Length=227, Percent_Identity=27.7533039647577, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789889, Length=247, Percent_Identity=28.3400809716599, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787549, Length=211, Percent_Identity=27.9620853080569, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33984; Mature: 33984

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEIESQLQEHDAPSFKSKVSSLAYFIKEIFSQDKMALIGTIIFILFIIVALMAPTLAP
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
HDPMEIHRRDGEIVRTEPPSSEFPFGTTNRGRCVFSQVIMGSRVALLVGALAALLVTIIG
CCCHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SNIGLISGYYGGWIDNLFMRIVDISYAIPFIPFTIILVTLLRPSIWNIILAIVVLTWRTI
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVLRAQVLSVKERPYVKAAKVAGASNARIIFLYILPNVLPLALLEMSLRMAQAIVAEST
HHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSFLGFGDPDVISWGRILQEGFIAGAMREAWWWVIPPGLAIAIVVVSVFFSSRALEFVAN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
PQLRRR
CHHCCC
>Mature Secondary Structure
MNKEIESQLQEHDAPSFKSKVSSLAYFIKEIFSQDKMALIGTIIFILFIIVALMAPTLAP
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
HDPMEIHRRDGEIVRTEPPSSEFPFGTTNRGRCVFSQVIMGSRVALLVGALAALLVTIIG
CCCHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SNIGLISGYYGGWIDNLFMRIVDISYAIPFIPFTIILVTLLRPSIWNIILAIVVLTWRTI
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARVLRAQVLSVKERPYVKAAKVAGASNARIIFLYILPNVLPLALLEMSLRMAQAIVAEST
HHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSFLGFGDPDVISWGRILQEGFIAGAMREAWWWVIPPGLAIAIVVVSVFFSSRALEFVAN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
PQLRRR
CHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]