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The map label for this gene is dinB [H]

Identifier: 188586939

GI number: 188586939

Start: 2477367

End: 2478593

Strand: Direct

Name: dinB [H]

Synonym: Nther_2331

Alternate gene names: 188586939

Gene position: 2477367-2478593 (Clockwise)

Preceding gene: 188586935

Following gene: 188586945

Centisome position: 78.26

GC content: 41.89

Gene sequence:

>1227_bases
ATGACTACCAGTAAATACGACCGTAACAAAAATAATTACAGACAGATCCTACATATTGATATGGACGCTTTTTACGCTTC
AGTGGAAAAGAGAGACAACCCAGAGCTAGAAGACAAACCCGTTATTATCGGTGGTAGCCGAAGAGGTGTTGTCTCCACAT
GCTGTTATAAAGCTAGAAAATACGGCCTTCACTCAGCTATGCCTATGTATCGGGCTCAAAGATTATGCCCCCATGGTGTA
TATCTGAGACCTGATATGGATAAATATCGACGGGTCTCCCAGGAAATAAAAAAAATTTTTCTTGAATTTACTCCACTAGT
TGAGCCCTTATCACTAGATGAGGCCTTTCTTGACGTAACAGGTTCTCTCAATTTATTTGGTGATGCTGTAAACATTGCAG
AGAAAATCCAAACACAGATTAGCGACCAACTTCAACTCACCTGTTCCATTGGAGTAGCTACAAATAAATTCATCGCAAAA
GTCGCTTCTGATCTTAAAAAACCGGCAGGACTCACTCATGTTCCAACAGGTAAGGAACAGGACTTTCTAGCACCCCTGCC
AGTAGATAAACTTTGGGGAGTGGGTGAAAAAACCACTGCTCGGATAAAAAGCCGGGGCTATCATACAATAGGTGAACTAC
AGCAAATGCTTGCAAAGGCTCAAAATATAAACAGCCTGGCCAAATCCTTTAATATCACTGAAGACACCCTGCTTTTAGCC
AAGGGATATGACGACCGGGAGGTAGTACCAGAAGAACCTCCTAAATCCATCGGGCAGGAAAAAACCTTTGCCCAGGACCT
GACTGCGGGGAGTCAGTATAATCAGTTAATTCCCCATCTACTGAAGTTCTCTGAACAAGTAGGAGCTCGCCTGCGAAAAG
CAGGTTACAAAGGGAAAACTGTTACAGTTAAAATTAGGGATTCCAGATTTAAAACTTGGACCAAACAGAAAACAGTTCCG
GAAACAGATCAAGATAAAGAGATATATGCCCATGCCCAGGAACTGCTTCAAAATATGAATTTAAAACCTAGTGATGAAAT
CAGACTATTAGGAGTAACTGTCAGCAACCTGGTTTCATCTACTCAGCAACAGCTTTCCCTTGATATGTCTAATGAACAGT
ACGAAAAAGAACAGCAGCTACAATGGACCCTTGATGAAATGCGAGAAAAATTTGGTGACGATGCTATTCGCCGAGCCCGT
CTTATTTTTCCACAAGAGCAAAAGTGA

Upstream 100 bases:

>100_bases
GACCTAAAATGAGAAGGAAATCAATTAATTATGGTGAATAATATCCAAATACAAGTAATAAATACAGATACTAAAACAAT
TAGTCTTAGGAGGATAATGC

Downstream 100 bases:

>100_bases
GCTGACCTTGGGCCGCTAGTTCATCTCCTACATATACCTTTCCTTCACCTTTTCCGATACTACCTTTAACCCGGGTTAGC
TCAACCTCTATACTGAGCAC

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTTSKYDRNKNNYRQILHIDMDAFYASVEKRDNPELEDKPVIIGGSRRGVVSTCCYKARKYGLHSAMPMYRAQRLCPHGV
YLRPDMDKYRRVSQEIKKIFLEFTPLVEPLSLDEAFLDVTGSLNLFGDAVNIAEKIQTQISDQLQLTCSIGVATNKFIAK
VASDLKKPAGLTHVPTGKEQDFLAPLPVDKLWGVGEKTTARIKSRGYHTIGELQQMLAKAQNINSLAKSFNITEDTLLLA
KGYDDREVVPEEPPKSIGQEKTFAQDLTAGSQYNQLIPHLLKFSEQVGARLRKAGYKGKTVTVKIRDSRFKTWTKQKTVP
ETDQDKEIYAHAQELLQNMNLKPSDEIRLLGVTVSNLVSSTQQQLSLDMSNEQYEKEQQLQWTLDEMREKFGDDAIRRAR
LIFPQEQK

Sequences:

>Translated_408_residues
MTTSKYDRNKNNYRQILHIDMDAFYASVEKRDNPELEDKPVIIGGSRRGVVSTCCYKARKYGLHSAMPMYRAQRLCPHGV
YLRPDMDKYRRVSQEIKKIFLEFTPLVEPLSLDEAFLDVTGSLNLFGDAVNIAEKIQTQISDQLQLTCSIGVATNKFIAK
VASDLKKPAGLTHVPTGKEQDFLAPLPVDKLWGVGEKTTARIKSRGYHTIGELQQMLAKAQNINSLAKSFNITEDTLLLA
KGYDDREVVPEEPPKSIGQEKTFAQDLTAGSQYNQLIPHLLKFSEQVGARLRKAGYKGKTVTVKIRDSRFKTWTKQKTVP
ETDQDKEIYAHAQELLQNMNLKPSDEIRLLGVTVSNLVSSTQQQLSLDMSNEQYEKEQQLQWTLDEMREKFGDDAIRRAR
LIFPQEQK
>Mature_407_residues
TTSKYDRNKNNYRQILHIDMDAFYASVEKRDNPELEDKPVIIGGSRRGVVSTCCYKARKYGLHSAMPMYRAQRLCPHGVY
LRPDMDKYRRVSQEIKKIFLEFTPLVEPLSLDEAFLDVTGSLNLFGDAVNIAEKIQTQISDQLQLTCSIGVATNKFIAKV
ASDLKKPAGLTHVPTGKEQDFLAPLPVDKLWGVGEKTTARIKSRGYHTIGELQQMLAKAQNINSLAKSFNITEDTLLLAK
GYDDREVVPEEPPKSIGQEKTFAQDLTAGSQYNQLIPHLLKFSEQVGARLRKAGYKGKTVTVKIRDSRFKTWTKQKTVPE
TDQDKEIYAHAQELLQNMNLKPSDEIRLLGVTVSNLVSSTQQQLSLDMSNEQYEKEQQLQWTLDEMREKFGDDAIRRARL
IFPQEQK

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=423, Percent_Identity=26.9503546099291, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI154350220, Length=401, Percent_Identity=28.428927680798, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI7705344, Length=117, Percent_Identity=47.8632478632479, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI7706681, Length=338, Percent_Identity=29.2899408284024, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786425, Length=359, Percent_Identity=37.6044568245125, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1787432, Length=391, Percent_Identity=23.2736572890026, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193205700, Length=414, Percent_Identity=29.4685990338164, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193205702, Length=352, Percent_Identity=27.8409090909091, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17537959, Length=197, Percent_Identity=27.9187817258883, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI115534089, Length=126, Percent_Identity=37.3015873015873, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324921, Length=288, Percent_Identity=23.9583333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355641, Length=296, Percent_Identity=30.0675675675676, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24644984, Length=296, Percent_Identity=30.0675675675676, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI19923006, Length=344, Percent_Identity=24.7093023255814, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24668444, Length=126, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 46420; Mature: 46288

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSKYDRNKNNYRQILHIDMDAFYASVEKRDNPELEDKPVIIGGSRRGVVSTCCYKARK
CCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
YGLHSAMPMYRAQRLCPHGVYLRPDMDKYRRVSQEIKKIFLEFTPLVEPLSLDEAFLDVT
HCCHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
GSLNLFGDAVNIAEKIQTQISDQLQLTCSIGVATNKFIAKVASDLKKPAGLTHVPTGKEQ
CCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DFLAPLPVDKLWGVGEKTTARIKSRGYHTIGELQQMLAKAQNINSLAKSFNITEDTLLLA
CCCCCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
KGYDDREVVPEEPPKSIGQEKTFAQDLTAGSQYNQLIPHLLKFSEQVGARLRKAGYKGKT
CCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTVKIRDSRFKTWTKQKTVPETDQDKEIYAHAQELLQNMNLKPSDEIRLLGVTVSNLVSS
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
TQQQLSLDMSNEQYEKEQQLQWTLDEMREKFGDDAIRRARLIFPQEQK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTSKYDRNKNNYRQILHIDMDAFYASVEKRDNPELEDKPVIIGGSRRGVVSTCCYKARK
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
YGLHSAMPMYRAQRLCPHGVYLRPDMDKYRRVSQEIKKIFLEFTPLVEPLSLDEAFLDVT
HCCHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
GSLNLFGDAVNIAEKIQTQISDQLQLTCSIGVATNKFIAKVASDLKKPAGLTHVPTGKEQ
CCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DFLAPLPVDKLWGVGEKTTARIKSRGYHTIGELQQMLAKAQNINSLAKSFNITEDTLLLA
CCCCCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEE
KGYDDREVVPEEPPKSIGQEKTFAQDLTAGSQYNQLIPHLLKFSEQVGARLRKAGYKGKT
CCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTVKIRDSRFKTWTKQKTVPETDQDKEIYAHAQELLQNMNLKPSDEIRLLGVTVSNLVSS
EEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
TQQQLSLDMSNEQYEKEQQLQWTLDEMREKFGDDAIRRARLIFPQEQK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA