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The map label for this gene is lytC [H]

Identifier: 188586935

GI number: 188586935

Start: 2472633

End: 2473553

Strand: Direct

Name: lytC [H]

Synonym: Nther_2327

Alternate gene names: 188586935

Gene position: 2472633-2473553 (Clockwise)

Preceding gene: 188586919

Following gene: 188586939

Centisome position: 78.11

GC content: 36.81

Gene sequence:

>921_bases
ATGAACTGTGATCAAAGGAAAAACTGGATTACTAATCTATGGACAAAAATTGAAGAAAAAGATGGAGATTTTTTTTCTCT
CATAGGAGTGGATTGTTATCCCTTTTCAGCTACTCCTGAAATAGAATCCTTGGATTCTCTAAGATATCTCTGTACTTTCT
CAGATATCCATCTTAATATGCCTCCTACAACTTTGGCACCTAGAGATGGCCTAATTAAAGAAGTCCACCTGAAACAAGAG
TGGGAAGGTAAGATTTCCTTAAAAATTATTCTAGAACATCAAACTCCTATCAAGGTGAATATTAACAAAGCTTGTCCTAA
TCAAATAATTTTAACTTTAGATAGGAATCCTTTAAGGAAAATTATACAAGACAAATTGATTGTAATAGACCCAGCTCATG
GTGGGAATGACAGTGGCAGTATCAGCCCTACATCTCTACAGGAAAAAGAAGTTACTCTAGACCTGGCCAGAAGAGCTAAG
ACACTACTCGAAGCATATCAGGGGCAAGTTGTCCTCCTACGCAACCAGGATAAGCAAGTACCCCTTCAAAGAAAAATAAA
TCAGGTGAAAAGTATCTCACCTGATTTGCTAATCTCATTACATACGGGAGAGGATCCCATGGGGAGAATAATTGGGCCAA
GGACAGGATTTACAGGTATAAGTAGTAACAGACAACAAAGGGCTGAACTCATGCAAAGAGCCCTGTTTCAAAAATTAATT
TTTCCTAATGGTGGAGTTTTCAAAACCACAGACCCACTAATGCAAATTCATCCCGATAAAAGTCTCATGGTAGAAATTAG
TAACATTACAAGTAGATTAGAAGAAGGGTGGATGAGAGATGATGGTTTTAAAACTATTATGGCTCAAGGAATTTTTAATG
GTATAAAAACCATCCTTAAGAACCAAGACCGATTTTCTTAA

Upstream 100 bases:

>100_bases
TTGAACTAAAATTTTTCCAAAAATTTAACAATACCTCTTGTTTTAACATAATATATCTATTACCCCCTGTTAACCCGGAA
GGGCATATTGAGGTGATTTT

Downstream 100 bases:

>100_bases
TAAAACCTGCTATTCCTGGACCAATCTTAGGGATACTCTCCAAGTCATCAGTGGAAATACCGCCACATGTGATTAAAATT
ATCCCATAACTCACAGCACC

Product: cell wall hydrolase/autolysin

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNCDQRKNWITNLWTKIEEKDGDFFSLIGVDCYPFSATPEIESLDSLRYLCTFSDIHLNMPPTTLAPRDGLIKEVHLKQE
WEGKISLKIILEHQTPIKVNINKACPNQIILTLDRNPLRKIIQDKLIVIDPAHGGNDSGSISPTSLQEKEVTLDLARRAK
TLLEAYQGQVVLLRNQDKQVPLQRKINQVKSISPDLLISLHTGEDPMGRIIGPRTGFTGISSNRQQRAELMQRALFQKLI
FPNGGVFKTTDPLMQIHPDKSLMVEISNITSRLEEGWMRDDGFKTIMAQGIFNGIKTILKNQDRFS

Sequences:

>Translated_306_residues
MNCDQRKNWITNLWTKIEEKDGDFFSLIGVDCYPFSATPEIESLDSLRYLCTFSDIHLNMPPTTLAPRDGLIKEVHLKQE
WEGKISLKIILEHQTPIKVNINKACPNQIILTLDRNPLRKIIQDKLIVIDPAHGGNDSGSISPTSLQEKEVTLDLARRAK
TLLEAYQGQVVLLRNQDKQVPLQRKINQVKSISPDLLISLHTGEDPMGRIIGPRTGFTGISSNRQQRAELMQRALFQKLI
FPNGGVFKTTDPLMQIHPDKSLMVEISNITSRLEEGWMRDDGFKTIMAQGIFNGIKTILKNQDRFS
>Mature_306_residues
MNCDQRKNWITNLWTKIEEKDGDFFSLIGVDCYPFSATPEIESLDSLRYLCTFSDIHLNMPPTTLAPRDGLIKEVHLKQE
WEGKISLKIILEHQTPIKVNINKACPNQIILTLDRNPLRKIIQDKLIVIDPAHGGNDSGSISPTSLQEKEVTLDLARRAK
TLLEAYQGQVVLLRNQDKQVPLQRKINQVKSISPDLLISLHTGEDPMGRIIGPRTGFTGISSNRQQRAELMQRALFQKLI
FPNGGVFKTTDPLMQIHPDKSLMVEISNITSRLEEGWMRDDGFKTIMAQGIFNGIKTILKNQDRFS

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI87082163, Length=88, Percent_Identity=36.3636363636364, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 34727; Mature: 34727

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCDQRKNWITNLWTKIEEKDGDFFSLIGVDCYPFSATPEIESLDSLRYLCTFSDIHLNM
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECEEECCCCCCCHHHHHHHHEEEEEEEEEECC
PPTTLAPRDGLIKEVHLKQEWEGKISLKIILEHQTPIKVNINKACPNQIILTLDRNPLRK
CCCCCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCHHHH
IIQDKLIVIDPAHGGNDSGSISPTSLQEKEVTLDLARRAKTLLEAYQGQVVLLRNQDKQV
HHHCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
PLQRKINQVKSISPDLLISLHTGEDPMGRIIGPRTGFTGISSNRQQRAELMQRALFQKLI
CHHHHHHHHHCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FPNGGVFKTTDPLMQIHPDKSLMVEISNITSRLEEGWMRDDGFKTIMAQGIFNGIKTILK
CCCCCEEECCCCCEEECCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
NQDRFS
CCCCCC
>Mature Secondary Structure
MNCDQRKNWITNLWTKIEEKDGDFFSLIGVDCYPFSATPEIESLDSLRYLCTFSDIHLNM
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECEEECCCCCCCHHHHHHHHEEEEEEEEEECC
PPTTLAPRDGLIKEVHLKQEWEGKISLKIILEHQTPIKVNINKACPNQIILTLDRNPLRK
CCCCCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCHHHH
IIQDKLIVIDPAHGGNDSGSISPTSLQEKEVTLDLARRAKTLLEAYQGQVVLLRNQDKQV
HHHCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
PLQRKINQVKSISPDLLISLHTGEDPMGRIIGPRTGFTGISSNRQQRAELMQRALFQKLI
CHHHHHHHHHCCCCCEEEEEECCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
FPNGGVFKTTDPLMQIHPDKSLMVEISNITSRLEEGWMRDDGFKTIMAQGIFNGIKTILK
CCCCCEEECCCCCEEECCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
NQDRFS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]