Click here to switch to the map view.

The map label for this gene is mleN [H]

Identifier: 188586851

GI number: 188586851

Start: 2378608

End: 2379993

Strand: Reverse

Name: mleN [H]

Synonym: Nther_2242

Alternate gene names: 188586851

Gene position: 2379993-2378608 (Counterclockwise)

Preceding gene: 188586853

Following gene: 188586850

Centisome position: 75.18

GC content: 38.1

Gene sequence:

>1386_bases
ATGAAAAATGAAATTGACAAGGCTCAAGAAATTCAAGAAGGACCAAAGGCAAATCCGATAGCACTATTACCTTTTATTTT
GTTTCTGGGTTTATACCTGGGTATAGGGATTTATTTACAGGTCACCGGTGTGGAAGATCCTTTCTACCAATTTCCGATGC
CCGTAGCCGTTTCAATCGGTGTGGTCCTGGCGTTTATAATCTTAAAAGGTACTGTTGCAGAAAAAACGGAAACATTTTTA
GCTGGTATGGGTGAGAAAAACATATTAACCATGTGTACCATCTATCTATTAGCTGGAGCTTTCTCCGCAGTATCTGAAGC
CATGGGCGGTGTTGATTCTGTCGTTAATTTTGGATTGTCTTTAGCTCCAGTTAACCTTTTAACCATTGGATTATTTTTGA
TTACAGGTTTTATTTCAATTTCAACTGGTACATCTATGGGAGCCTTAGGTGCAGTTGCCCCCATTGCCTTGGGTTTTGCT
CAAGAAACTGGTTTGAGTTTACCTTTGATTATGGCGGTTATAATAGGTGGTGCCATGTTTGGGGATAACCTTTCAGTAAT
ATCTGATACCACCATTGCAGCTACAACTTCTCAAGGTGTAAAAATGCGTGATAAGTTTAAAATTAACTTATTTATTGCTG
TACCAGCAGCCCTTGTAACTATTGTCCTTCTATTTTTCTTTTCAGGAACTCCAGATGAATTACAAACGGGTGGTTATGAT
TATAATCTGATTAAAATAATTCCGTATATTTTTGTCTTAATTTTTGCAATAGCAGGTGGGAATGTATTTTTAGTTCTAAC
TAGTGGGATTGTAATGGCTGGTTTGATAGGAATGCTTTACGGGGAACTGAACTTTCTTACTTTCGGCCAAGAGATTTATG
ATGGTTTCTTATCAATGATGAATGTATTCTTGGTCTCGTTAATTACCGGTGGATTGGCTAAAATGGTAACAGATGCCGGT
GGACTGCAATACCTTGTAGATTCCATCAATAAGAGAATTACGAGTAAAAATTCTGCAGAACTTGGTATAGCTGGACTAGT
TGCTTTAACAGATGCTGCAATTGCTAATAATACTATTGCAATCATAATTAATGGTCCAATAGCTAAAAAGATATCTAGGA
CTTTTAAAGTCGATCCGAGAAGAAGTGCCGCACTAATGGATATTGCTGCATGTGTAATGCAAGGGGCTCTCCCATATGGT
GCTCAAATACTTATGGTAATGGGGCTTACAGGCGGAGCCGTTGGTCCTTTAGATGTTATTCCATTATTATGGTATCAGGG
GCTATTAGCCATCTTTGGAATCATGTCTATCTTTATTCCATTTGCCAACAAACTCATTAAAGATGAACCTTGGGACTGGG
AACAAGAAGAATCTATTGAAGGGTAA

Upstream 100 bases:

>100_bases
GTTTTGATTTCTGTCTAAAACTATCTTAACTCCGGGACGGAGACTGATTCAAATATCATATAACTTAACAGAACTTAAAA
GTTTTAGAGGAGGATTTGAA

Downstream 100 bases:

>100_bases
CTTTTACGCTGGATTGTGAAAATTAATATGTTGGAAATTTAGAATAAATTAGTAGGGTGTACTGTCTATTTTGAATGTTG
AATGGTCTTTTATATGGGCA

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKNEIDKAQEIQEGPKANPIALLPFILFLGLYLGIGIYLQVTGVEDPFYQFPMPVAVSIGVVLAFIILKGTVAEKTETFL
AGMGEKNILTMCTIYLLAGAFSAVSEAMGGVDSVVNFGLSLAPVNLLTIGLFLITGFISISTGTSMGALGAVAPIALGFA
QETGLSLPLIMAVIIGGAMFGDNLSVISDTTIAATTSQGVKMRDKFKINLFIAVPAALVTIVLLFFFSGTPDELQTGGYD
YNLIKIIPYIFVLIFAIAGGNVFLVLTSGIVMAGLIGMLYGELNFLTFGQEIYDGFLSMMNVFLVSLITGGLAKMVTDAG
GLQYLVDSINKRITSKNSAELGIAGLVALTDAAIANNTIAIIINGPIAKKISRTFKVDPRRSAALMDIAACVMQGALPYG
AQILMVMGLTGGAVGPLDVIPLLWYQGLLAIFGIMSIFIPFANKLIKDEPWDWEQEESIEG

Sequences:

>Translated_461_residues
MKNEIDKAQEIQEGPKANPIALLPFILFLGLYLGIGIYLQVTGVEDPFYQFPMPVAVSIGVVLAFIILKGTVAEKTETFL
AGMGEKNILTMCTIYLLAGAFSAVSEAMGGVDSVVNFGLSLAPVNLLTIGLFLITGFISISTGTSMGALGAVAPIALGFA
QETGLSLPLIMAVIIGGAMFGDNLSVISDTTIAATTSQGVKMRDKFKINLFIAVPAALVTIVLLFFFSGTPDELQTGGYD
YNLIKIIPYIFVLIFAIAGGNVFLVLTSGIVMAGLIGMLYGELNFLTFGQEIYDGFLSMMNVFLVSLITGGLAKMVTDAG
GLQYLVDSINKRITSKNSAELGIAGLVALTDAAIANNTIAIIINGPIAKKISRTFKVDPRRSAALMDIAACVMQGALPYG
AQILMVMGLTGGAVGPLDVIPLLWYQGLLAIFGIMSIFIPFANKLIKDEPWDWEQEESIEG
>Mature_461_residues
MKNEIDKAQEIQEGPKANPIALLPFILFLGLYLGIGIYLQVTGVEDPFYQFPMPVAVSIGVVLAFIILKGTVAEKTETFL
AGMGEKNILTMCTIYLLAGAFSAVSEAMGGVDSVVNFGLSLAPVNLLTIGLFLITGFISISTGTSMGALGAVAPIALGFA
QETGLSLPLIMAVIIGGAMFGDNLSVISDTTIAATTSQGVKMRDKFKINLFIAVPAALVTIVLLFFFSGTPDELQTGGYD
YNLIKIIPYIFVLIFAIAGGNVFLVLTSGIVMAGLIGMLYGELNFLTFGQEIYDGFLSMMNVFLVSLITGGLAKMVTDAG
GLQYLVDSINKRITSKNSAELGIAGLVALTDAAIANNTIAIIINGPIAKKISRTFKVDPRRSAALMDIAACVMQGALPYG
AQILMVMGLTGGAVGPLDVIPLLWYQGLLAIFGIMSIFIPFANKLIKDEPWDWEQEESIEG

Specific function: Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48806; Mature: 48806

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEIDKAQEIQEGPKANPIALLPFILFLGLYLGIGIYLQVTGVEDPFYQFPMPVAVSIG
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHCCCHHHHHHH
VVLAFIILKGTVAEKTETFLAGMGEKNILTMCTIYLLAGAFSAVSEAMGGVDSVVNFGLS
HHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH
LAPVNLLTIGLFLITGFISISTGTSMGALGAVAPIALGFAQETGLSLPLIMAVIIGGAMF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHC
GDNLSVISDTTIAATTSQGVKMRDKFKINLFIAVPAALVTIVLLFFFSGTPDELQTGGYD
CCCCEEEECCEEEEECCCCCEEECEEEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCCCC
YNLIKIIPYIFVLIFAIAGGNVFLVLTSGIVMAGLIGMLYGELNFLTFGQEIYDGFLSMM
CHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFLVSLITGGLAKMVTDAGGLQYLVDSINKRITSKNSAELGIAGLVALTDAAIANNTIA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEE
IIINGPIAKKISRTFKVDPRRSAALMDIAACVMQGALPYGAQILMVMGLTGGAVGPLDVI
EEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCHHHHH
PLLWYQGLLAIFGIMSIFIPFANKLIKDEPWDWEQEESIEG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNEIDKAQEIQEGPKANPIALLPFILFLGLYLGIGIYLQVTGVEDPFYQFPMPVAVSIG
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHCCCHHHHHHH
VVLAFIILKGTVAEKTETFLAGMGEKNILTMCTIYLLAGAFSAVSEAMGGVDSVVNFGLS
HHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH
LAPVNLLTIGLFLITGFISISTGTSMGALGAVAPIALGFAQETGLSLPLIMAVIIGGAMF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHC
GDNLSVISDTTIAATTSQGVKMRDKFKINLFIAVPAALVTIVLLFFFSGTPDELQTGGYD
CCCCEEEECCEEEEECCCCCEEECEEEEEEEEECHHHHHHHHHHHHHCCCCHHHHCCCCC
YNLIKIIPYIFVLIFAIAGGNVFLVLTSGIVMAGLIGMLYGELNFLTFGQEIYDGFLSMM
CHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFLVSLITGGLAKMVTDAGGLQYLVDSINKRITSKNSAELGIAGLVALTDAAIANNTIA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEE
IIINGPIAKKISRTFKVDPRRSAALMDIAACVMQGALPYGAQILMVMGLTGGAVGPLDVI
EEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCHHHHH
PLLWYQGLLAIFGIMSIFIPFANKLIKDEPWDWEQEESIEG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10903309 [H]