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The map label for this gene is tktA [C]

Identifier: 188586823

GI number: 188586823

Start: 2350523

End: 2351377

Strand: Reverse

Name: tktA [C]

Synonym: Nther_2214

Alternate gene names: 188586823

Gene position: 2351377-2350523 (Counterclockwise)

Preceding gene: 188586824

Following gene: 188586822

Centisome position: 74.28

GC content: 44.68

Gene sequence:

>855_bases
ATGGCCATCACGGCTAAAGAAAAAAGTTATCTCAGTGAAATGGCGTATAAAATCAGGGTAGAAACTTTAAAGATGCTTAA
TAAAGCAGAATCAGGCCATCCGGGCGGTTCCCTGTCCATGGCTGATATATTATCTTCCCTTTATTTTAAGCATATGAATA
TAGACCCTGAAAACGGAGAAGATCCCGATAGAGACAGATTGGTACTGAGTAAGGGCCATGGAGTGCCCGGCCTTTATTCT
GTATTGGCTTTAAAGGGTTTCTTTCCCTTAGATGAATTACAAACCTTGAGAGACATTAATTCCAGGCTGCAAGGTCATCC
CGATAGAAAAGGTACACCGGGTATCGAGATGACAACTGGATCTTTGGGTCAAGGCCTGTCAGCAGCTAATGGTATGGCCC
TGGCTGCCAAGATGGACGGTCGAGACTACAATGTTTACTGCATTTTGGGTGATGGTGAGATCCAGGAAGGTCAAATTTGG
GAAGCGGCCATGACAGCTTCTCATTACAAGATCGATAATTTGATTGGCATTTTGGATTACAATGGCCTGCAAATCGACGG
TAAAGTTGAAGACATTATGGATCCTGGCCCGGTTTCCGATAAATGGCGAGCCTTTGGCTGGTATGTTATTGAGACCGATG
GTCATGATCTGGAAAAGTTTAATGCAGCTATCGAAGAAGCCAAGGGAGTTAAAGATCAACCTGTAATGATCGTGGCAGAT
ACTGTTAAAGGCAAAGGAGTTTCATACATGGAAAATGTAGTTGACTGGCACGGTAAGGCGCCAGGAGACGAGGAACTAGA
GCAGGCATTAGAAGAACTTGAACAAGGCCTAGCAGGCACAAGGGGGGAAGAGTAA

Upstream 100 bases:

>100_bases
GCATTTAATTTTCTTTTTGCAGGAATCGAGAATAAATCTAACTAAATAAAGAAAAATTAGGCATTAGTGCCAACATCGAC
ACCATGGAGGTGAAAGAAAT

Downstream 100 bases:

>100_bases
TGGCAAATATCGGCGAAAAAATACCTACCAGAAAGGCCTATGGTGAGACGCTAATCGAACTAGGTCAAGAGCGTTCAGAT
ATAGTGGTTTTAGATGCCGA

Product: transketolase subunit A

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAITAKEKSYLSEMAYKIRVETLKMLNKAESGHPGGSLSMADILSSLYFKHMNIDPENGEDPDRDRLVLSKGHGVPGLYS
VLALKGFFPLDELQTLRDINSRLQGHPDRKGTPGIEMTTGSLGQGLSAANGMALAAKMDGRDYNVYCILGDGEIQEGQIW
EAAMTASHYKIDNLIGILDYNGLQIDGKVEDIMDPGPVSDKWRAFGWYVIETDGHDLEKFNAAIEEAKGVKDQPVMIVAD
TVKGKGVSYMENVVDWHGKAPGDEELEQALEELEQGLAGTRGEE

Sequences:

>Translated_284_residues
MAITAKEKSYLSEMAYKIRVETLKMLNKAESGHPGGSLSMADILSSLYFKHMNIDPENGEDPDRDRLVLSKGHGVPGLYS
VLALKGFFPLDELQTLRDINSRLQGHPDRKGTPGIEMTTGSLGQGLSAANGMALAAKMDGRDYNVYCILGDGEIQEGQIW
EAAMTASHYKIDNLIGILDYNGLQIDGKVEDIMDPGPVSDKWRAFGWYVIETDGHDLEKFNAAIEEAKGVKDQPVMIVAD
TVKGKGVSYMENVVDWHGKAPGDEELEQALEELEQGLAGTRGEE
>Mature_283_residues
AITAKEKSYLSEMAYKIRVETLKMLNKAESGHPGGSLSMADILSSLYFKHMNIDPENGEDPDRDRLVLSKGHGVPGLYSV
LALKGFFPLDELQTLRDINSRLQGHPDRKGTPGIEMTTGSLGQGLSAANGMALAAKMDGRDYNVYCILGDGEIQEGQIWE
AAMTASHYKIDNLIGILDYNGLQIDGKVEDIMDPGPVSDKWRAFGWYVIETDGHDLEKFNAAIEEAKGVKDQPVMIVADT
VKGKGVSYMENVVDWHGKAPGDEELEQALEELEQGLAGTRGEE

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=271, Percent_Identity=42.0664206642066, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI4507521, Length=271, Percent_Identity=42.0664206642066, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI133778974, Length=276, Percent_Identity=36.9565217391304, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI225637459, Length=272, Percent_Identity=30.8823529411765, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI225637461, Length=272, Percent_Identity=30.1470588235294, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI225637463, Length=239, Percent_Identity=30.9623430962343, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI48994911, Length=273, Percent_Identity=38.4615384615385, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788808, Length=273, Percent_Identity=37.7289377289377, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539652, Length=263, Percent_Identity=39.9239543726236, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6319593, Length=270, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=242, Percent_Identity=40.495867768595, Blast_Score=155, Evalue=6e-39,
Organism=Drosophila melanogaster, GI45551847, Length=267, Percent_Identity=39.3258426966292, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI45550715, Length=267, Percent_Identity=39.3258426966292, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24666278, Length=273, Percent_Identity=37.7289377289377, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24645119, Length=228, Percent_Identity=40.3508771929825, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 31076; Mature: 30945

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITAKEKSYLSEMAYKIRVETLKMLNKAESGHPGGSLSMADILSSLYFKHMNIDPENGE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DPDRDRLVLSKGHGVPGLYSVLALKGFFPLDELQTLRDINSRLQGHPDRKGTPGIEMTTG
CCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
SLGQGLSAANGMALAAKMDGRDYNVYCILGDGEIQEGQIWEAAMTASHYKIDNLIGILDY
CCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEHHHEEEEEEC
NGLQIDGKVEDIMDPGPVSDKWRAFGWYVIETDGHDLEKFNAAIEEAKGVKDQPVMIVAD
CCEEECCCHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEE
TVKGKGVSYMENVVDWHGKAPGDEELEQALEELEQGLAGTRGEE
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AITAKEKSYLSEMAYKIRVETLKMLNKAESGHPGGSLSMADILSSLYFKHMNIDPENGE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DPDRDRLVLSKGHGVPGLYSVLALKGFFPLDELQTLRDINSRLQGHPDRKGTPGIEMTTG
CCCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
SLGQGLSAANGMALAAKMDGRDYNVYCILGDGEIQEGQIWEAAMTASHYKIDNLIGILDY
CCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEHHHEEEEEEC
NGLQIDGKVEDIMDPGPVSDKWRAFGWYVIETDGHDLEKFNAAIEEAKGVKDQPVMIVAD
CCEEECCCHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEE
TVKGKGVSYMENVVDWHGKAPGDEELEQALEELEQGLAGTRGEE
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]