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The map label for this gene is dxs [C]

Identifier: 188586822

GI number: 188586822

Start: 2349570

End: 2350523

Strand: Reverse

Name: dxs [C]

Synonym: Nther_2213

Alternate gene names: 188586822

Gene position: 2350523-2349570 (Counterclockwise)

Preceding gene: 188586823

Following gene: 188586821

Centisome position: 74.25

GC content: 43.71

Gene sequence:

>954_bases
ATGGCAAATATCGGCGAAAAAATACCTACCAGAAAGGCCTATGGTGAGACGCTAATCGAACTAGGTCAAGAGCGTTCAGA
TATAGTGGTTTTAGATGCCGACCTGTCTAAATCAACTAAGACTGCAGGTTTTCAAAAGGAATTCCCAGAGCGATTTTTCA
ATGTGGGAATTTCGGAAGCTGATCTCATGGGGACTGCAGCTGGTTTTGCTACTACAGGTAAAACGGTGTTTGCTAGTACC
TTTGCTATATTTGCTACTGGTAGAGCTTATGATCAGGTGCGAAACTCCATCTGTTATCCCAAATTAAATGTAAAAATTGC
CGCCACCCATTGTGGCTTAACTGTAGGAGAAGACGGGGCTTCCCATCAAATGCTAGAAGATATGGCCTTGATGCGAGCTC
TTCCCAATATGAAAGTCATGGTGCCTGCTGATGCTACTTCTGCCAGAGCTTTGGTGAAAGAAGCGGCCAGCTTTAAAGGC
CCTTGTTATATCAGATTGGGAAGACCGGGAGTACCTGTGATTTACGAAGAAGGAGAACAGTTTACCATTGGCCAAGGAAA
GCTGTTGAAAAAGGGTGAAGATGTCACTATAGTTGCCTGTGGTCACATGGTAGAACGAGCTAATAAAGCTGCTGAGGAAC
TGAAAGAACAGGGGATTTCGGCAGAGGTTCTGGATATGTACTCTGTCAAGCCAATTGATAAACAGTTGATCATTGATAGT
GCCAAGAAAACAGGAGCCGTAGTAACTGCTGAAGAACATAATATGTTTGGTGGCCTGGGTGAGGCCGTGGCATCTGTCTT
AACTGAAAAGTGTCCTGTTCCCCTGCGAAAAGTAGCTGTGAACGATACCTTTGGTGAAAGCGGAAAAGCCGAAGATCTAA
TGGATAAATACGGATTGACTTCTCAAGATATTGTGGAACAGTCCAAAAACGTGATTAAATTTAAGCAAAGCTAA

Upstream 100 bases:

>100_bases
ATGTAGTTGACTGGCACGGTAAGGCGCCAGGAGACGAGGAACTAGAGCAGGCATTAGAAGAACTTGAACAAGGCCTAGCA
GGCACAAGGGGGGAAGAGTA

Downstream 100 bases:

>100_bases
GTTAATAGGTTTTTAGATACTGATCGGCTTGATCATTGCTCATTGATTAGTTTCTAATCGCCTGGCCTGTTCAACCTGAT
CAATCTAATCATCCTAATCT

Product: transketolase subunit B

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MANIGEKIPTRKAYGETLIELGQERSDIVVLDADLSKSTKTAGFQKEFPERFFNVGISEADLMGTAAGFATTGKTVFAST
FAIFATGRAYDQVRNSICYPKLNVKIAATHCGLTVGEDGASHQMLEDMALMRALPNMKVMVPADATSARALVKEAASFKG
PCYIRLGRPGVPVIYEEGEQFTIGQGKLLKKGEDVTIVACGHMVERANKAAEELKEQGISAEVLDMYSVKPIDKQLIIDS
AKKTGAVVTAEEHNMFGGLGEAVASVLTEKCPVPLRKVAVNDTFGESGKAEDLMDKYGLTSQDIVEQSKNVIKFKQS

Sequences:

>Translated_317_residues
MANIGEKIPTRKAYGETLIELGQERSDIVVLDADLSKSTKTAGFQKEFPERFFNVGISEADLMGTAAGFATTGKTVFAST
FAIFATGRAYDQVRNSICYPKLNVKIAATHCGLTVGEDGASHQMLEDMALMRALPNMKVMVPADATSARALVKEAASFKG
PCYIRLGRPGVPVIYEEGEQFTIGQGKLLKKGEDVTIVACGHMVERANKAAEELKEQGISAEVLDMYSVKPIDKQLIIDS
AKKTGAVVTAEEHNMFGGLGEAVASVLTEKCPVPLRKVAVNDTFGESGKAEDLMDKYGLTSQDIVEQSKNVIKFKQS
>Mature_316_residues
ANIGEKIPTRKAYGETLIELGQERSDIVVLDADLSKSTKTAGFQKEFPERFFNVGISEADLMGTAAGFATTGKTVFASTF
AIFATGRAYDQVRNSICYPKLNVKIAATHCGLTVGEDGASHQMLEDMALMRALPNMKVMVPADATSARALVKEAASFKGP
CYIRLGRPGVPVIYEEGEQFTIGQGKLLKKGEDVTIVACGHMVERANKAAEELKEQGISAEVLDMYSVKPIDKQLIIDSA
KKTGAVVTAEEHNMFGGLGEAVASVLTEKCPVPLRKVAVNDTFGESGKAEDLMDKYGLTSQDIVEQSKNVIKFKQS

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=313, Percent_Identity=39.6166134185303, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI4507521, Length=313, Percent_Identity=39.6166134185303, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI225637463, Length=306, Percent_Identity=41.1764705882353, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI225637459, Length=306, Percent_Identity=41.1764705882353, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI225637461, Length=306, Percent_Identity=41.1764705882353, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI133778974, Length=305, Percent_Identity=37.7049180327869, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI4557353, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI34101272, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI291084858, Length=235, Percent_Identity=25.531914893617, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=31.6151202749141, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI48994911, Length=326, Percent_Identity=26.9938650306748, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788808, Length=328, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539652, Length=310, Percent_Identity=39.0322580645161, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17538422, Length=239, Percent_Identity=27.6150627615063, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17506935, Length=163, Percent_Identity=29.4478527607362, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325331, Length=354, Percent_Identity=26.271186440678, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319698, Length=243, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319593, Length=345, Percent_Identity=23.1884057971014, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24645119, Length=314, Percent_Identity=37.8980891719745, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI45551847, Length=314, Percent_Identity=37.8980891719745, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI45550715, Length=314, Percent_Identity=37.8980891719745, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24666278, Length=314, Percent_Identity=36.624203821656, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI160714832, Length=257, Percent_Identity=30.7392996108949, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI160714828, Length=257, Percent_Identity=30.7392996108949, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358145, Length=253, Percent_Identity=27.6679841897233, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650940, Length=253, Percent_Identity=27.6679841897233, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34155; Mature: 34023

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIGEKIPTRKAYGETLIELGQERSDIVVLDADLSKSTKTAGFQKEFPERFFNVGISEA
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHCCCHHHHHHHHHHHCCCCHH
DLMGTAAGFATTGKTVFASTFAIFATGRAYDQVRNSICYPKLNVKIAATHCGLTVGEDGA
HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCC
SHQMLEDMALMRALPNMKVMVPADATSARALVKEAASFKGPCYIRLGRPGVPVIYEEGEQ
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCE
FTIGQGKLLKKGEDVTIVACGHMVERANKAAEELKEQGISAEVLDMYSVKPIDKQLIIDS
EEECCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCHHHHHHC
AKKTGAVVTAEEHNMFGGLGEAVASVLTEKCPVPLRKVAVNDTFGESGKAEDLMDKYGLT
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHCCC
SQDIVEQSKNVIKFKQS
HHHHHHHHHHHEEECCC
>Mature Secondary Structure 
ANIGEKIPTRKAYGETLIELGQERSDIVVLDADLSKSTKTAGFQKEFPERFFNVGISEA
CCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHCCCHHHHHHHHHHHCCCCHH
DLMGTAAGFATTGKTVFASTFAIFATGRAYDQVRNSICYPKLNVKIAATHCGLTVGEDGA
HHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCC
SHQMLEDMALMRALPNMKVMVPADATSARALVKEAASFKGPCYIRLGRPGVPVIYEEGEQ
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCE
FTIGQGKLLKKGEDVTIVACGHMVERANKAAEELKEQGISAEVLDMYSVKPIDKQLIIDS
EEECCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCHHHHHHC
AKKTGAVVTAEEHNMFGGLGEAVASVLTEKCPVPLRKVAVNDTFGESGKAEDLMDKYGLT
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHEEECCCCCCCCCHHHHHHHHCCC
SQDIVEQSKNVIKFKQS
HHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]