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The map label for this gene is appC [H]

Identifier: 188586807

GI number: 188586807

Start: 2334184

End: 2335056

Strand: Direct

Name: appC [H]

Synonym: Nther_2198

Alternate gene names: 188586807

Gene position: 2334184-2335056 (Clockwise)

Preceding gene: 188586806

Following gene: 188586808

Centisome position: 73.74

GC content: 44.9

Gene sequence:

>873_bases
TTGGATACGCTGTTAAAGTTTTTCAGATCAGCATATGACATACTTTCTAAAGACAAAATTTCCTTTGTGGGAATCGGCAT
GTTAATATTTTTTATCTTAATAGCTGCTTTCGCCCCTATTTTAGCCCCACATGACACCGATGAAATGCACAGAGATTCAG
AAGGGGAAATTAGAAGGGTCGAAGGCCCATCCAGGGAACATCCCTTGGGTACAACCAATTACGGACGAGATGTAATGAGT
CAGTTGATTATGGGATCTAGAATTGCATTGGTTGTCGGTATCTTGGCTGCATTTTTTGTAACAATTATTGGAACCCACGT
GGGATTATTCGCCGGTTATTATGGAGGCTGGGTGGACAACCTGCTCATGAGGATAGTAGATATTATGTATGCCATACCTT
TTATCCCCTTTGTCATCATATTGGTGGCACTTTTGGAACCTAGCCTGGGGAATATTATTTTAGCTATTTCTCTTCTGACC
TGGAGAACAGTAGCCAGGATCATTCGTTCTCAGGTGTTAACAGTGGTACAGCGCCCCTATGTCAAGGCAGCCAGGGTAGC
AGGAGCCAGCAATCTTCGCATTATATATTTGTATATCTTACCAAATGTACTGCCCCTGGTACTTTTAGAAATGTCACTAA
TGATGGCCTGGGCTATACTGGCAGAAGCCAGTGTCAGCTTTATCGGTTTCGGAGATCCCGACTCCATCAGCTGGGGCCAA
ATGCTTCAAAATGCCTTTGTATCAGGCGCGGTTAGAAGGGCCTGGTGGTGGGTAATTCCACCGGGAGTTGCAATTTCCCT
GACCCTACTGGCAGTTTTCTTTGCATCCCGGGCTCTAGAAGTTGCAGTCAATCCCAGGTTAAGGAGGCGATAA

Upstream 100 bases:

>100_bases
TTCCTAGCTGATCTGTTGTACGGCTACCTAGATCCAAGGGTTGTTTACAATTAAAACATCAAATAAAAACAGATATTTTT
AAAAGCGAGGTGACAGACAA

Downstream 100 bases:

>100_bases
ATTATGTCACTATTAGAAGTAAAAAATCTCAAAATTTATTACGACACTAAAGGCAGCGATTTAAAAGCTGTAGACGATAT
AAGCTTTGATATCCCAGAAG

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDTLLKFFRSAYDILSKDKISFVGIGMLIFFILIAAFAPILAPHDTDEMHRDSEGEIRRVEGPSREHPLGTTNYGRDVMS
QLIMGSRIALVVGILAAFFVTIIGTHVGLFAGYYGGWVDNLLMRIVDIMYAIPFIPFVIILVALLEPSLGNIILAISLLT
WRTVARIIRSQVLTVVQRPYVKAARVAGASNLRIIYLYILPNVLPLVLLEMSLMMAWAILAEASVSFIGFGDPDSISWGQ
MLQNAFVSGAVRRAWWWVIPPGVAISLTLLAVFFASRALEVAVNPRLRRR

Sequences:

>Translated_290_residues
MDTLLKFFRSAYDILSKDKISFVGIGMLIFFILIAAFAPILAPHDTDEMHRDSEGEIRRVEGPSREHPLGTTNYGRDVMS
QLIMGSRIALVVGILAAFFVTIIGTHVGLFAGYYGGWVDNLLMRIVDIMYAIPFIPFVIILVALLEPSLGNIILAISLLT
WRTVARIIRSQVLTVVQRPYVKAARVAGASNLRIIYLYILPNVLPLVLLEMSLMMAWAILAEASVSFIGFGDPDSISWGQ
MLQNAFVSGAVRRAWWWVIPPGVAISLTLLAVFFASRALEVAVNPRLRRR
>Mature_290_residues
MDTLLKFFRSAYDILSKDKISFVGIGMLIFFILIAAFAPILAPHDTDEMHRDSEGEIRRVEGPSREHPLGTTNYGRDVMS
QLIMGSRIALVVGILAAFFVTIIGTHVGLFAGYYGGWVDNLLMRIVDIMYAIPFIPFVIILVALLEPSLGNIILAISLLT
WRTVARIIRSQVLTVVQRPYVKAARVAGASNLRIIYLYILPNVLPLVLLEMSLMMAWAILAEASVSFIGFGDPDSISWGQ
MLQNAFVSGAVRRAWWWVIPPGVAISLTLLAVFFASRALEVAVNPRLRRR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=260, Percent_Identity=41.1538461538462, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1787054, Length=267, Percent_Identity=34.0823970037453, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1787760, Length=261, Percent_Identity=34.0996168582375, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787498, Length=267, Percent_Identity=34.8314606741573, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789889, Length=235, Percent_Identity=31.063829787234, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787549, Length=275, Percent_Identity=29.8181818181818, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788505, Length=181, Percent_Identity=29.2817679558011, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 32233; Mature: 32233

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLLKFFRSAYDILSKDKISFVGIGMLIFFILIAAFAPILAPHDTDEMHRDSEGEIRRV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEC
EGPSREHPLGTTNYGRDVMSQLIMGSRIALVVGILAAFFVTIIGTHVGLFAGYYGGWVDN
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMRIVDIMYAIPFIPFVIILVALLEPSLGNIILAISLLTWRTVARIIRSQVLTVVQRPY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAARVAGASNLRIIYLYILPNVLPLVLLEMSLMMAWAILAEASVSFIGFGDPDSISWGQ
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHH
MLQNAFVSGAVRRAWWWVIPPGVAISLTLLAVFFASRALEVAVNPRLRRR
HHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MDTLLKFFRSAYDILSKDKISFVGIGMLIFFILIAAFAPILAPHDTDEMHRDSEGEIRRV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEC
EGPSREHPLGTTNYGRDVMSQLIMGSRIALVVGILAAFFVTIIGTHVGLFAGYYGGWVDN
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMRIVDIMYAIPFIPFVIILVALLEPSLGNIILAISLLTWRTVARIIRSQVLTVVQRPY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAARVAGASNLRIIYLYILPNVLPLVLLEMSLMMAWAILAEASVSFIGFGDPDSISWGQ
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHH
MLQNAFVSGAVRRAWWWVIPPGVAISLTLLAVFFASRALEVAVNPRLRRR
HHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]