Click here to switch to the map view.

The map label for this gene is ahpC [C]

Identifier: 188586742

GI number: 188586742

Start: 2252827

End: 2253498

Strand: Direct

Name: ahpC [C]

Synonym: Nther_2133

Alternate gene names: 188586742

Gene position: 2252827-2253498 (Clockwise)

Preceding gene: 188586741

Following gene: 188586743

Centisome position: 71.17

GC content: 34.52

Gene sequence:

>672_bases
ATGACTTTTAATGAAAATCAAAATACTATGCCTTTATTAGGTGACAAATTTCCTGAGGTTGATGTTCAAACCACCCATGG
AACTCTAAAATTACCCCAGGATTATAAGGGGAAATGGTTTGTTTTATTTAGTCACCCTGGAGATTTCACGCCAGTTTGCA
CTACTGAATTCGTCAGTTTTGCACAAAAAGCAGATAAATTCAAAGAGTTAAATACTGAATTGATTGGTTTATCTGTTGAT
CAAGTTTTTTCCCATATAAAATGGGTGGAATGGATTAATGAAAATTTTGATGTAGAAATTCCTTTCCCCGTAATAGCTGA
TGAAATGGGAGAATTATCTAAAATGTTGGGCATGCTTCATCCAAACAAAGGTACTAATACAGTTCGAGCTGTCTTTGTAG
TTGATGATAAAGGTGTTCTCAGATTAATGAAATATTATCCTCAAGAAATTGGCAGAAATATTGAAGAAATACTTAGATCA
ATAAAAGCTTTACAGACTCATGAAAAAAATCAGGTGGCCCTTCCAGAAAACTGGCCAAATAATGAAACATTAGGTGATAA
AGTTATTATCCCTCCCGCCAGTACAGAGCAAGAAGCAAAGGAAAGGAAAAAACAAGCTGAAGCTGGAGAATTAGAGTACA
AAGATTGGTGGTTTTGCTACAAGAATCTATAA

Upstream 100 bases:

>100_bases
GAAAACATTCTTAGAAAATATCTCAAAAAACCATTGACAGATATAAAAATCTAGTTTAATATTAATATTAGTAATCATTA
CTAATAAGGAGGAATTACTG

Downstream 100 bases:

>100_bases
TTATAAATTAGGTTTATTGTTTATAACCTTAACCGCAGTTGTTTTGAACTGCGGTTTTTTATTTACAGTTATCACTGTTA
TATTTCTTATAAATAATTGT

Product: 1-Cys peroxiredoxin, 3-Cys thioredoxin peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTFNENQNTMPLLGDKFPEVDVQTTHGTLKLPQDYKGKWFVLFSHPGDFTPVCTTEFVSFAQKADKFKELNTELIGLSVD
QVFSHIKWVEWINENFDVEIPFPVIADEMGELSKMLGMLHPNKGTNTVRAVFVVDDKGVLRLMKYYPQEIGRNIEEILRS
IKALQTHEKNQVALPENWPNNETLGDKVIIPPASTEQEAKERKKQAEAGELEYKDWWFCYKNL

Sequences:

>Translated_223_residues
MTFNENQNTMPLLGDKFPEVDVQTTHGTLKLPQDYKGKWFVLFSHPGDFTPVCTTEFVSFAQKADKFKELNTELIGLSVD
QVFSHIKWVEWINENFDVEIPFPVIADEMGELSKMLGMLHPNKGTNTVRAVFVVDDKGVLRLMKYYPQEIGRNIEEILRS
IKALQTHEKNQVALPENWPNNETLGDKVIIPPASTEQEAKERKKQAEAGELEYKDWWFCYKNL
>Mature_222_residues
TFNENQNTMPLLGDKFPEVDVQTTHGTLKLPQDYKGKWFVLFSHPGDFTPVCTTEFVSFAQKADKFKELNTELIGLSVDQ
VFSHIKWVEWINENFDVEIPFPVIADEMGELSKMLGMLHPNKGTNTVRAVFVVDDKGVLRLMKYYPQEIGRNIEEILRSI
KALQTHEKNQVALPENWPNNETLGDKVIIPPASTEQEAKERKKQAEAGELEYKDWWFCYKNL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=200, Percent_Identity=42, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI5453549, Length=158, Percent_Identity=36.0759493670886, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4505591, Length=154, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI32455266, Length=154, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI32455264, Length=154, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI32189392, Length=154, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI5802974, Length=165, Percent_Identity=35.7575757575758, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI32483377, Length=165, Percent_Identity=35.7575757575758, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=50, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1786822, Length=133, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25153706, Length=197, Percent_Identity=32.994923857868, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193204376, Length=166, Percent_Identity=36.144578313253, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32565831, Length=167, Percent_Identity=35.9281437125749, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17554494, Length=167, Percent_Identity=32.3353293413174, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6319407, Length=194, Percent_Identity=43.8144329896907, Blast_Score=141, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323613, Length=152, Percent_Identity=35.5263157894737, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320661, Length=167, Percent_Identity=31.7365269461078, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652436, Length=199, Percent_Identity=39.6984924623116, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24652434, Length=199, Percent_Identity=39.6984924623116, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17975518, Length=199, Percent_Identity=39.6984924623116, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581278, Length=198, Percent_Identity=38.3838383838384, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI17738015, Length=173, Percent_Identity=35.2601156069364, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17157991, Length=154, Percent_Identity=35.7142857142857, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641739, Length=154, Percent_Identity=35.7142857142857, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24656348, Length=158, Percent_Identity=32.9113924050633, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17864676, Length=158, Percent_Identity=32.9113924050633, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357347, Length=153, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 25752; Mature: 25620

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFNENQNTMPLLGDKFPEVDVQTTHGTLKLPQDYKGKWFVLFSHPGDFTPVCTTEFVSF
CCCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHH
AQKADKFKELNTELIGLSVDQVFSHIKWVEWINENFDVEIPFPVIADEMGELSKMLGMLH
HHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCC
PNKGTNTVRAVFVVDDKGVLRLMKYYPQEIGRNIEEILRSIKALQTHEKNQVALPENWPN
CCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCC
NETLGDKVIIPPASTEQEAKERKKQAEAGELEYKDWWFCYKNL
CCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
TFNENQNTMPLLGDKFPEVDVQTTHGTLKLPQDYKGKWFVLFSHPGDFTPVCTTEFVSF
CCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHH
AQKADKFKELNTELIGLSVDQVFSHIKWVEWINENFDVEIPFPVIADEMGELSKMLGMLH
HHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCC
PNKGTNTVRAVFVVDDKGVLRLMKYYPQEIGRNIEEILRSIKALQTHEKNQVALPENWPN
CCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECCCCCCC
NETLGDKVIIPPASTEQEAKERKKQAEAGELEYKDWWFCYKNL
CCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]