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The map label for this gene is hisC [H]

Identifier: 188586659

GI number: 188586659

Start: 2165290

End: 2166411

Strand: Direct

Name: hisC [H]

Synonym: Nther_2049

Alternate gene names: 188586659

Gene position: 2165290-2166411 (Clockwise)

Preceding gene: 188586653

Following gene: 188586660

Centisome position: 68.4

GC content: 33.87

Gene sequence:

>1122_bases
ATGGGAACCAAAAAAACACAATTTCCTCAAGATTCTGCCAGAAAGGTTTTAAATGAGTTTTCACCATATATACCCGGGAA
AAGTTTAGAGGAAATTAAAGAAAAATACGGTTTGGATAAGGTGATTAAATTAGCCAGCAACGAAAACCCACACGGACCAT
CACCAAAAGCAGTAAAAAAACTAACCGATAACAAAGATATTCACTTGTATCCCCAGAAATCATATCAAAATTTACAGTCC
AAGATATCACAAAAGCTTGGTACAAATCCTGGACAAGTAATTATTGGTAATGGTTCGGATGAAATTATTAAACTACTGGC
TGCAGCTTTTATTAACCCTGGTGAAGAGGGGCTTATGGCTGATATTACTTTCCCTATATATAAAATGGCAGTGAAAGAAC
TTGATGGTAAAGTAACTCATATCCCCTTAAAAAAATATACCCACGATATTGATCAGTTTATTGCCCAAATAACAGATAAC
ACAAAATTAATATTTATATGTAACCCAAATAACCCTACTGGTTCCATCATAACCCATGAAGAGGCCGAAAAATTATTAAG
TAGTGTCAGTAAAGACACTATAGTAGTCTTTGATGAAGCATATCGAGAATATGTTACAAATCCTGAATTTCCAAAAACAG
AAATGTTAGTAGATAAATATCCTAATTTAATTGCTTTAAGAACTTTTTCTAAAATTTACGGTTTAGCTGCTCTAAGAGTT
GGTTACGGAATAGGTAGTGAGAAATTAATTGAAGTCCTTCACAAGGTTAAATTACCCTTTAATGTCAACGAACTAGGGTT
AAGAGCTGCCCAAGAAGCACTAGATGATACAGAACATCTGAATTATAGTAAAGAACAAAATGATCAGGGTAAAAAATGGC
TAGAATCCAAATTAAAGTCCAGTAAATTTTTCTCCCCAGTACCAAGTCAGGCCAATTTTTTACTTGTAAAGACTGAATTC
GATGCAGAAAAGCTGGCCGGTGAATTATTGAAACAAGGTGTTATAATAAGGGAAGGAACTTCCTTTGGAATGCCGGACCA
TTTTCGGATTACAATAGGTTCAAAATCAGATAATGAGTTTTTCATAGAAAAATTAAGTAATTGCGAGGTGAATTTGAAAT
GA

Upstream 100 bases:

>100_bases
ATTTTGTGAAGTAACTCAGGTGGTACCGCGAACCTTCGTCCTGTGTCTGACGAAGGTTTTTTTAATTGATCAGCTAAATT
TATGAATTGGAGTGATTGCA

Downstream 100 bases:

>100_bases
TCATTGTAATGAATAGACAAACTCAAGAAGAAAAAATAAATAAAGTGATAAATAGACTCTCTGAATTGGAATTAGAATGT
CATATATCTAAAGGCAAGAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MGTKKTQFPQDSARKVLNEFSPYIPGKSLEEIKEKYGLDKVIKLASNENPHGPSPKAVKKLTDNKDIHLYPQKSYQNLQS
KISQKLGTNPGQVIIGNGSDEIIKLLAAAFINPGEEGLMADITFPIYKMAVKELDGKVTHIPLKKYTHDIDQFIAQITDN
TKLIFICNPNNPTGSIITHEEAEKLLSSVSKDTIVVFDEAYREYVTNPEFPKTEMLVDKYPNLIALRTFSKIYGLAALRV
GYGIGSEKLIEVLHKVKLPFNVNELGLRAAQEALDDTEHLNYSKEQNDQGKKWLESKLKSSKFFSPVPSQANFLLVKTEF
DAEKLAGELLKQGVIIREGTSFGMPDHFRITIGSKSDNEFFIEKLSNCEVNLK

Sequences:

>Translated_373_residues
MGTKKTQFPQDSARKVLNEFSPYIPGKSLEEIKEKYGLDKVIKLASNENPHGPSPKAVKKLTDNKDIHLYPQKSYQNLQS
KISQKLGTNPGQVIIGNGSDEIIKLLAAAFINPGEEGLMADITFPIYKMAVKELDGKVTHIPLKKYTHDIDQFIAQITDN
TKLIFICNPNNPTGSIITHEEAEKLLSSVSKDTIVVFDEAYREYVTNPEFPKTEMLVDKYPNLIALRTFSKIYGLAALRV
GYGIGSEKLIEVLHKVKLPFNVNELGLRAAQEALDDTEHLNYSKEQNDQGKKWLESKLKSSKFFSPVPSQANFLLVKTEF
DAEKLAGELLKQGVIIREGTSFGMPDHFRITIGSKSDNEFFIEKLSNCEVNLK
>Mature_372_residues
GTKKTQFPQDSARKVLNEFSPYIPGKSLEEIKEKYGLDKVIKLASNENPHGPSPKAVKKLTDNKDIHLYPQKSYQNLQSK
ISQKLGTNPGQVIIGNGSDEIIKLLAAAFINPGEEGLMADITFPIYKMAVKELDGKVTHIPLKKYTHDIDQFIAQITDNT
KLIFICNPNNPTGSIITHEEAEKLLSSVSKDTIVVFDEAYREYVTNPEFPKTEMLVDKYPNLIALRTFSKIYGLAALRVG
YGIGSEKLIEVLHKVKLPFNVNELGLRAAQEALDDTEHLNYSKEQNDQGKKWLESKLKSSKFFSPVPSQANFLLVKTEFD
AEKLAGELLKQGVIIREGTSFGMPDHFRITIGSKSDNEFFIEKLSNCEVNLK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=28.3746556473829, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1788627, Length=297, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17567369, Length=241, Percent_Identity=26.9709543568465, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=357, Percent_Identity=28.8515406162465, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41851; Mature: 41720

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKKTQFPQDSARKVLNEFSPYIPGKSLEEIKEKYGLDKVIKLASNENPHGPSPKAVKK
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHH
LTDNKDIHLYPQKSYQNLQSKISQKLGTNPGQVIIGNGSDEIIKLLAAAFINPGEEGLMA
HCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEE
DITFPIYKMAVKELDGKVTHIPLKKYTHDIDQFIAQITDNTKLIFICNPNNPTGSIITHE
EEHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHH
EAEKLLSSVSKDTIVVFDEAYREYVTNPEFPKTEMLVDKYPNLIALRTFSKIYGLAALRV
HHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHH
GYGIGSEKLIEVLHKVKLPFNVNELGLRAAQEALDDTEHLNYSKEQNDQGKKWLESKLKS
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHH
SKFFSPVPSQANFLLVKTEFDAEKLAGELLKQGVIIREGTSFGMPDHFRITIGSKSDNEF
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCHH
FIEKLSNCEVNLK
HHHHHCCCEEECC
>Mature Secondary Structure 
GTKKTQFPQDSARKVLNEFSPYIPGKSLEEIKEKYGLDKVIKLASNENPHGPSPKAVKK
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHH
LTDNKDIHLYPQKSYQNLQSKISQKLGTNPGQVIIGNGSDEIIKLLAAAFINPGEEGLMA
HCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCEE
DITFPIYKMAVKELDGKVTHIPLKKYTHDIDQFIAQITDNTKLIFICNPNNPTGSIITHE
EEHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHH
EAEKLLSSVSKDTIVVFDEAYREYVTNPEFPKTEMLVDKYPNLIALRTFSKIYGLAALRV
HHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHH
GYGIGSEKLIEVLHKVKLPFNVNELGLRAAQEALDDTEHLNYSKEQNDQGKKWLESKLKS
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHH
SKFFSPVPSQANFLLVKTEFDAEKLAGELLKQGVIIREGTSFGMPDHFRITIGSKSDNEF
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCHH
FIEKLSNCEVNLK
HHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA