Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 188586639

GI number: 188586639

Start: 2141671

End: 2142666

Strand: Reverse

Name: gyaR [H]

Synonym: Nther_2029

Alternate gene names: 188586639

Gene position: 2142666-2141671 (Counterclockwise)

Preceding gene: 188586640

Following gene: 188586638

Centisome position: 67.69

GC content: 38.65

Gene sequence:

>996_bases
TTGTTAGATCATCCCAAGGTTTATGTCACTAGTAATATTCCCGAAGCTGGTTTAACCCTGTTAAAAGAAAAATTTAAGCT
TAATTTTCATCAGCCTTTAGGCCAACAAATAACTGAAGATGAATTAATTGAAGCAGCTAAGAGCCATGATGCTTTAATTA
CTACTTTAACTGATCCAGTTACCGAAAGAGTGGCTGCTGCTGGCCAAAATGGTGGTAAACTTAAAGTAGTAGCCAATTAT
GGTGCAGGTTATGATAACATTGCTGTGGATGCTTTTAGTAACGCGGATATTAGAGTCACTAATACTCCAGGAGTTCTTCA
CGAGACTACAGCAGATTTAACCTTTGCTTTAATAATGGGAATCGCCAGGAGAATAAATGAAGCCGAGAAATTTCTAAGAT
CGGGTCAATTTCAAGGCTGGAAACCAGATCTATTATTGGGTGAAGATGTTCATGATCGTACTATTGGTATAATTGGAATG
GGTGAGATAGGTCAAGCCGTTGCAAAAAGGGCTCTGGGTTTTAATATGGAGGTTATTTATTATAATAGATCTTATCTTTC
ACAAGAACGGGAACAGGAATTACAGGCCCAATACAAGTCTTTGGAAGAACTCCTGAGTGAGAGTGATTTTGTTTCTATAC
ATGTTCCCTTAACAAATAACACCCAACATATGATTACTGCTAAAGAATTTAGCCAGATGAAAAATTCGGCTTTTTTAATT
AATACTTCAAGAGGACCTGTAATTGATGAGCAAGCTCTGGTTGATGCATTGAAAACTGGGGAAATTCAGGGAGCCGCTCT
GGATGTGTTTGAAAAAGAGCCCGAGGTCCACCCTGAATTATTAGATCGACAGGATTGTTTATTAGTACCACATATTGGAA
GTGCTACTCACAAATGTAGAAATAATATGTCGGAAATGGCTTGCAAAAATGTTGAAGCTGTTCTAGACGGACAGGAACCA
CCAACCCCCGTTGATTCGATAGAACCTTGGAGGTGA

Upstream 100 bases:

>100_bases
AAGCACGGGAATATCTCTCTGGGATATAAATTAACTCTTCTACGAGTAAGATTAAGATCGGCAAAAAATCCCATCTTCCT
TTGTAAAGGAGGTAACTAGC

Downstream 100 bases:

>100_bases
AAAACATGAAATTAGAGGCAGATCTTCATATTCATACCATAGCAAGCGGTCATGCTTACTCAACTGTTAAGGAAATAGCT
GAGGCAGCAAGTAGAAAAAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MLDHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPVTERVAAAGQNGGKLKVVANY
GAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMGIARRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGM
GEIGQAVAKRALGFNMEVIYYNRSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLI
NTSRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHPELLDRQDCLLVPHIGSATHKCRNNMSEMACKNVEAVLDGQEP
PTPVDSIEPWR

Sequences:

>Translated_331_residues
MLDHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPVTERVAAAGQNGGKLKVVANY
GAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMGIARRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGM
GEIGQAVAKRALGFNMEVIYYNRSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLI
NTSRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHPELLDRQDCLLVPHIGSATHKCRNNMSEMACKNVEAVLDGQEP
PTPVDSIEPWR
>Mature_331_residues
MLDHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPVTERVAAAGQNGGKLKVVANY
GAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMGIARRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGM
GEIGQAVAKRALGFNMEVIYYNRSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLI
NTSRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHPELLDRQDCLLVPHIGSATHKCRNNMSEMACKNVEAVLDGQEP
PTPVDSIEPWR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=320, Percent_Identity=37.1875, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI23308577, Length=271, Percent_Identity=33.5793357933579, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI61743967, Length=293, Percent_Identity=34.4709897610922, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557497, Length=293, Percent_Identity=34.4709897610922, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI145580578, Length=293, Percent_Identity=34.4709897610922, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI4557499, Length=293, Percent_Identity=34.4709897610922, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI145580575, Length=293, Percent_Identity=34.4709897610922, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI87082289, Length=317, Percent_Identity=40.0630914826498, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787645, Length=299, Percent_Identity=29.4314381270903, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789279, Length=259, Percent_Identity=32.046332046332, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788660, Length=242, Percent_Identity=28.9256198347107, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081824, Length=234, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=291, Percent_Identity=32.9896907216495, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=29.8449612403101, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=38.8429752066116, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=312, Percent_Identity=29.1666666666667, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=306, Percent_Identity=29.0849673202614, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=241, Percent_Identity=27.8008298755187, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=34.2281879194631, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=362, Percent_Identity=25.1381215469613, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=164, Percent_Identity=30.4878048780488, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45552429, Length=322, Percent_Identity=35.7142857142857, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=35.7142857142857, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574284, Length=323, Percent_Identity=36.2229102167183, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=35.7142857142857, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=35.7142857142857, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28571528, Length=322, Percent_Identity=36.0248447204969, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=32.4921135646688, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24585516, Length=322, Percent_Identity=28.8819875776398, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=32.1192052980132, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36621; Mature: 36621

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPV
CCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHH
TERVAAAGQNGGKLKVVANYGAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMG
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHH
IARRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGMGEIGQAVAKRALGFNMEVIY
HHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEE
YNRSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLI
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEHHHHHHHCCCEEEE
NTSRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHPELLDRQDCLLVPHIGSATHKCR
ECCCCCCCCHHHHHHHHHCCCCCCCEEHHHHCCCCCCHHHHCCCCCEEECCCCCHHHHHH
NNMSEMACKNVEAVLDGQEPPTPVDSIEPWR
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDHPKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPV
CCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHH
TERVAAAGQNGGKLKVVANYGAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMG
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHH
IARRINEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGMGEIGQAVAKRALGFNMEVIY
HHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEE
YNRSYLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLI
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEHHHHHHHCCCEEEE
NTSRGPVIDEQALVDALKTGEIQGAALDVFEKEPEVHPELLDRQDCLLVPHIGSATHKCR
ECCCCCCCCHHHHHHHHHCCCCCCCEEHHHHCCCCCCHHHHCCCCCEEECCCCCHHHHHH
NNMSEMACKNVEAVLDGQEPPTPVDSIEPWR
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA