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The map label for this gene is hisI [H]

Identifier: 188586606

GI number: 188586606

Start: 2105467

End: 2106102

Strand: Reverse

Name: hisI [H]

Synonym: Nther_1996

Alternate gene names: 188586606

Gene position: 2106102-2105467 (Counterclockwise)

Preceding gene: 188586607

Following gene: 188586605

Centisome position: 66.53

GC content: 36.95

Gene sequence:

>636_bases
ATGAATGTAAATTTTTCTCAAGATGGATTGATACCTTGTATTGCCCAGGATGCCAATACTGGAGAAGTATTAATGCTTGC
ATACATGAGTCAAGAAGCCTTTGAAAAGACCAGGGAATCAGGCTCTTTATGGTTTTGGAGTCGGAGTAAACAAAGATTGT
GGCAGAAGGGGGAAAGTTCAGGAAACACACTCATAGTCACTTCTTTGAAACTCGATTGTGACAAAGATACTTTACTTGCC
TTGGTTGAACCTCAAGGACCTGCATGTCACACAGGTGAGACCAGTTGTTTTTTCAATGAAGTTACAAGAACAGATGATAG
CAGGAATTACAGATTTGATGATAGAAGTAGTAATGGCATTTTGAATACTCTTAACCAACTAATTGAACAGCGTTTAGAAG
AGCAACCGGATAATTCTTATATAATTAAACTTACTAATAAAGGAGAGAATCAGGTCCTAAAAAAAGTTGGAGAAGAAGCC
ACCGAGTTGGTAACTGCCTGTAAAGACGAAGATAAAAAAGAAATCATCCACGAATCTGCGGATTTGATTTTTCATACATT
ACTAGCATTAAAGTATTTTCAAGTGGATTTATCGGAAGTTTTACAAGAACTCCACAATAGACATGCCGACAGATAA

Upstream 100 bases:

>100_bases
AGGCTAGTGGAGCCCTAGCAGCCTCAGTTTTTCACTTTGAAGAAATATCTGTCAAAGAGTTGAAGAACTATCTTAGTGAG
AAGGGAGTTGAGGTTCGATT

Downstream 100 bases:

>100_bases
CGAAAAGAAAACCGGTGCTCTAATATTTAAAACAAGGGGTGAGTTTTTGATAGACTATCATACTCATACTTGGAGATGTG
GTCATGCAGAAGGGAATATT

Product: phosphoribosyl-ATP diphosphatase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MNVNFSQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVTSLKLDCDKDTLLA
LVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEA
TELVTACKDEDKKEIIHESADLIFHTLLALKYFQVDLSEVLQELHNRHADR

Sequences:

>Translated_211_residues
MNVNFSQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVTSLKLDCDKDTLLA
LVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEA
TELVTACKDEDKKEIIHESADLIFHTLLALKYFQVDLSEVLQELHNRHADR
>Mature_211_residues
MNVNFSQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVTSLKLDCDKDTLLA
LVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEA
TELVTACKDEDKKEIIHESADLIFHTLLALKYFQVDLSEVLQELHNRHADR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=201, Percent_Identity=44.7761194029851, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319819, Length=187, Percent_Identity=32.620320855615, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24061; Mature: 24061

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNFSQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESS
CCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCC
GNTLIVTSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGI
CCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCH
LNTLNQLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESA
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLIFHTLLALKYFQVDLSEVLQELHNRHADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVNFSQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESS
CCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCC
GNTLIVTSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGI
CCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCH
LNTLNQLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESA
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLIFHTLLALKYFQVDLSEVLQELHNRHADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]