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The map label for this gene is tuaD [H]

Identifier: 188586199

GI number: 188586199

Start: 1662078

End: 1663382

Strand: Direct

Name: tuaD [H]

Synonym: Nther_1581

Alternate gene names: 188586199

Gene position: 1662078-1663382 (Clockwise)

Preceding gene: 188586197

Following gene: 188586200

Centisome position: 52.51

GC content: 35.79

Gene sequence:

>1305_bases
ATGACTAATATAGGTATTGTTGGCGGTTTAGGTCATGTAGGTTTAATCCAATCAGCTTGTCTGGCTAAGCTGGGGTATAA
AGTTATAGCATACGATATCGACATGGAAAAGGTTAAAACAATTATGAAAGGTGAAATGCCTTTTCAAGAACAGGGGCTAA
CAGAATTAGTTACAGAAGGTTTAAATAATAATACTCTTTCGTTTACATCAGAAATTAGCGATTTAGCAGAAGCAGAAATT
GTTTTTATCTGTGTAGGAACACCTGCTTTACCCAATGGAAAATCAGATTTATCTCATGTTTATTCAGCAGTAGATCAAAT
TGCTCGAAATCGTAAAAAGAATTGTATAGCAGCAGTTAAAAGTACTGTACCAATAGGAACTTCTCGTAAACTTACCGAGT
ATCTCAAGGATAACAATTTATCAGATAAAGTTACTATGGTATCAAACCCTGAGTTCCTTCGAGAAGGTACAGGAGTTAAA
GACTTTTGGGAACCTGATAGAATAGTTATAGGCGCAGAAAGTAAAGAAGCTGCTAATAAAGTCAAACAATTATATTCACC
ATCAGAAGTTCCTGTAATAAACACCACTTGGGAGAACTCAGAATTAATCAAATACGCAAGTAATGCATTTTTAGCAACTA
AAATTTCATTTATTAATGAAATATCTCAACTTTGTGAAGATGTTGGAGCCGATATAAGAGTAATAAGTAAAGGAATTGGA
CTCGATCCTAGAATCAACCCCCATTTCCTACAAGCGGGAATTGGTTTTAGTGGTCCTTGCTTAGACAAAGATTTAAACTC
CTTAATAAACCAATTTAAAGAAAAACAAAAGAAACCACTCATATTAGAATCTGCTTTACAAGTAAACGAACAACAACGTG
CCAGTGTAGTAGAAAAACTACAAAAACATCTAGAAAATTTAAGAGATAAAGATATTGCCGTTTTCGGTATGGCTTTTAAG
GCTGAAACAGATGATGTAAGAAGTTCCCATAGTTTACCTATTATCCGTAAGCTTCTATCCCTTGGTGCAAATATAACTGT
TAATGATCCATGGGTTAAAAGTCCGGAGCAGGGTAGGATTTCAGAGGCCGAAGTAGCCGGGGTTGAATGGATCTCTTCTC
CTTACAGAGCTGCAAAAGACAAAGACGCAGTATTACTACAAACTGCCTGGCAGGAATATGAAAATTTGGACTACAAAAAA
CTTTGTGCTGAAATGAAAAAACCACTAGTCGTAGACGGAAGAAACCTATTTAATCGTGAAGAAATGGAATCCCATGGCAT
TGTTTATGTGGGGGTAGGTATATGA

Upstream 100 bases:

>100_bases
CTAGTCCTATAACGGTAACGACACCATAGCTACAGAATATGATGTACCAGCTATAAACAGACATTAATTATATTTAGTGT
TTAGATGAGAGGTGTTAACC

Downstream 100 bases:

>100_bases
AATATTTAGTAACAGGTGCTGCTGGCTTTATAGGTTCCCATCTTTGTAAAGAGCTGGTCACTCGTGGAAACAAAGTATGG
GGACTAGATAATCTTAGTCA

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTNIGIVGGLGHVGLIQSACLAKLGYKVIAYDIDMEKVKTIMKGEMPFQEQGLTELVTEGLNNNTLSFTSEISDLAEAEI
VFICVGTPALPNGKSDLSHVYSAVDQIARNRKKNCIAAVKSTVPIGTSRKLTEYLKDNNLSDKVTMVSNPEFLREGTGVK
DFWEPDRIVIGAESKEAANKVKQLYSPSEVPVINTTWENSELIKYASNAFLATKISFINEISQLCEDVGADIRVISKGIG
LDPRINPHFLQAGIGFSGPCLDKDLNSLINQFKEKQKKPLILESALQVNEQQRASVVEKLQKHLENLRDKDIAVFGMAFK
AETDDVRSSHSLPIIRKLLSLGANITVNDPWVKSPEQGRISEAEVAGVEWISSPYRAAKDKDAVLLQTAWQEYENLDYKK
LCAEMKKPLVVDGRNLFNREEMESHGIVYVGVGI

Sequences:

>Translated_434_residues
MTNIGIVGGLGHVGLIQSACLAKLGYKVIAYDIDMEKVKTIMKGEMPFQEQGLTELVTEGLNNNTLSFTSEISDLAEAEI
VFICVGTPALPNGKSDLSHVYSAVDQIARNRKKNCIAAVKSTVPIGTSRKLTEYLKDNNLSDKVTMVSNPEFLREGTGVK
DFWEPDRIVIGAESKEAANKVKQLYSPSEVPVINTTWENSELIKYASNAFLATKISFINEISQLCEDVGADIRVISKGIG
LDPRINPHFLQAGIGFSGPCLDKDLNSLINQFKEKQKKPLILESALQVNEQQRASVVEKLQKHLENLRDKDIAVFGMAFK
AETDDVRSSHSLPIIRKLLSLGANITVNDPWVKSPEQGRISEAEVAGVEWISSPYRAAKDKDAVLLQTAWQEYENLDYKK
LCAEMKKPLVVDGRNLFNREEMESHGIVYVGVGI
>Mature_433_residues
TNIGIVGGLGHVGLIQSACLAKLGYKVIAYDIDMEKVKTIMKGEMPFQEQGLTELVTEGLNNNTLSFTSEISDLAEAEIV
FICVGTPALPNGKSDLSHVYSAVDQIARNRKKNCIAAVKSTVPIGTSRKLTEYLKDNNLSDKVTMVSNPEFLREGTGVKD
FWEPDRIVIGAESKEAANKVKQLYSPSEVPVINTTWENSELIKYASNAFLATKISFINEISQLCEDVGADIRVISKGIGL
DPRINPHFLQAGIGFSGPCLDKDLNSLINQFKEKQKKPLILESALQVNEQQRASVVEKLQKHLENLRDKDIAVFGMAFKA
ETDDVRSSHSLPIIRKLLSLGANITVNDPWVKSPEQGRISEAEVAGVEWISSPYRAAKDKDAVLLQTAWQEYENLDYKKL
CAEMKKPLVVDGRNLFNREEMESHGIVYVGVGI

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=456, Percent_Identity=32.6754385964912, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=33.7016574585635, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI296040443, Length=312, Percent_Identity=35.5769230769231, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI48994968, Length=349, Percent_Identity=28.080229226361, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788340, Length=355, Percent_Identity=24.2253521126761, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=33.5526315789474, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17136908, Length=456, Percent_Identity=33.7719298245614, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47970; Mature: 47839

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIGIVGGLGHVGLIQSACLAKLGYKVIAYDIDMEKVKTIMKGEMPFQEQGLTELVTEG
CCCCEEECCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHCC
LNNNTLSFTSEISDLAEAEIVFICVGTPALPNGKSDLSHVYSAVDQIARNRKKNCIAAVK
CCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVPIGTSRKLTEYLKDNNLSDKVTMVSNPEFLREGTGVKDFWEPDRIVIGAESKEAANK
HCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHH
VKQLYSPSEVPVINTTWENSELIKYASNAFLATKISFINEISQLCEDVGADIRVISKGIG
HHHHCCCCCCCEEECCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCC
LDPRINPHFLQAGIGFSGPCLDKDLNSLINQFKEKQKKPLILESALQVNEQQRASVVEKL
CCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHH
QKHLENLRDKDIAVFGMAFKAETDDVRSSHSLPIIRKLLSLGANITVNDPWVKSPEQGRI
HHHHHHHCCCCEEEEEEEEECCCHHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCC
SEAEVAGVEWISSPYRAAKDKDAVLLQTAWQEYENLDYKKLCAEMKKPLVVDGRNLFNRE
CHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCHHHCCHH
EMESHGIVYVGVGI
HHHHCCEEEEEECC
>Mature Secondary Structure 
TNIGIVGGLGHVGLIQSACLAKLGYKVIAYDIDMEKVKTIMKGEMPFQEQGLTELVTEG
CCCEEECCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHCC
LNNNTLSFTSEISDLAEAEIVFICVGTPALPNGKSDLSHVYSAVDQIARNRKKNCIAAVK
CCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
STVPIGTSRKLTEYLKDNNLSDKVTMVSNPEFLREGTGVKDFWEPDRIVIGAESKEAANK
HCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHH
VKQLYSPSEVPVINTTWENSELIKYASNAFLATKISFINEISQLCEDVGADIRVISKGIG
HHHHCCCCCCCEEECCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCC
LDPRINPHFLQAGIGFSGPCLDKDLNSLINQFKEKQKKPLILESALQVNEQQRASVVEKL
CCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHH
QKHLENLRDKDIAVFGMAFKAETDDVRSSHSLPIIRKLLSLGANITVNDPWVKSPEQGRI
HHHHHHHCCCCEEEEEEEEECCCHHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCC
SEAEVAGVEWISSPYRAAKDKDAVLLQTAWQEYENLDYKKLCAEMKKPLVVDGRNLFNRE
CHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCHHHCCHH
EMESHGIVYVGVGI
HHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]